{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:20:55Z","timestamp":1781191255747,"version":"3.54.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,9,18]],"date-time":"2006-09-18T00:00:00Z","timestamp":1158537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Tuberous sclerosis complex (TSC) is an autosomal dominant disease characterized by the development of multiple hamartomas in many internal organs. Mutations in either one of 2 genes, <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic>, have been attributed to the development of TSC. More than two-thirds of TSC patients are sporadic cases, and a wide variety of mutations in the coding region of the <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic> genes have been reported.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Mutational analysis of <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic> genes was performed in 84 Taiwanese TSC families using denaturing high-performance liquid chromatography (DHPLC) and direct sequencing.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Mutations were identified in a total of 64 (76 %) cases, including 9 <jats:italic>TSC1<\/jats:italic> mutations (7 sporadic and 2 familial cases) and 55 <jats:italic>TSC2<\/jats:italic> mutations (47 sporadic and 8 familial cases). Thirty-one of the 64 mutations found have not been described previously. The phenotype association is consistent with findings from other large studies, showing that disease resulting from mutations to <jats:italic>TSC1<\/jats:italic> is less severe than disease due to <jats:italic>TSC2<\/jats:italic> mutation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This study provides a representative picture of the distribution of mutations of the <jats:italic>TSC1<\/jats:italic> and <jats:italic>TSC2<\/jats:italic> genes in clinically ascertained TSC cases in the Taiwanese population. Although nearly half of the mutations identified were novel, the kinds and distribution of mutation were not different in this population compared to that seen in larger European and American studies.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2350-7-72","type":"journal-article","created":{"date-parts":[[2006,9,19]],"date-time":"2006-09-19T06:31:48Z","timestamp":1158647508000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Molecular and clinical analyses of 84 patients with tuberous sclerosis complex"],"prefix":"10.1186","volume":"7","author":[{"given":"Chia-Cheng","family":"Hung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Ning","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Chin","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horng-Huei","family":"Liou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Chuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pau-Chung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Ping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang-Tso","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Win-Li","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Nan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2006,9,18]]},"reference":[{"key":"180_CR1","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1111\/j.1749-6632.1991.tb37754.x","volume":"615","author":"JP Osborne","year":"1991","unstructured":"Osborne JP, Fryer A, Webb D: Epidemiology of tuberous sclerosis. Ann N Y Acad Sci. 1991, 615: 125-127.","journal-title":"Ann N Y Acad Sci"},{"key":"180_CR2","volume-title":"3rd edn New York: Oxford University Press","author":"SJRHWV Gomez MR","year":"1999","unstructured":"Gomez MR SJRHWV: Tuberous sclerosis complex. 3rd edn New York: Oxford University Press. 1999"},{"issue":"12","key":"180_CR3","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1177\/088307389801301206","volume":"13","author":"ES Roach","year":"1998","unstructured":"Roach ES, Gomez MR, Northrup H: Tuberous sclerosis complex consensus conference: revised clinical diagnostic criteria. J Child Neurol. 1998, 13 (12): 624-628.","journal-title":"J Child Neurol"},{"key":"180_CR4","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1111\/j.1469-1809.1994.tb01881.x","volume":"58 (Pt 2)","author":"S Povey","year":"1994","unstructured":"Povey S, Burley MW, Attwood J, Benham F, Hunt D, Jeremiah SJ, Franklin D, Gillett G, Malas S, Robson EB, et al: Two loci for tuberous sclerosis: one on 9q34 and one on 16p13. Ann Hum Genet. 1994, 58 (Pt 2): 107-127.","journal-title":"Ann Hum Genet"},{"issue":"5327","key":"180_CR5","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1126\/science.277.5327.805","volume":"277","author":"M van Slegtenhorst","year":"1997","unstructured":"van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ: Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science. 1997, 277 (5327): 805-808. 10.1126\/science.277.5327.805.","journal-title":"Science"},{"issue":"7","key":"180_CR6","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1016\/0092-8674(93)90618-Z","volume":"75","author":"The European Chromosome 16 Tuberous Sclerosis Consortium.","year":"1993","unstructured":"The European Chromosome 16 Tuberous Sclerosis Consortium.: Identification and characterization of the tuberous sclerosis gene on chromosome 16. The European Chromosome 16 Tuberous Sclerosis Consortium. Cell. 1993, 75 (7): 1305-1315.","journal-title":"Cell"},{"issue":"50","key":"180_CR7","doi-asserted-by":"publisher","first-page":"7475","DOI":"10.1038\/sj.onc.1209090","volume":"24","author":"A Astrinidis","year":"2005","unstructured":"Astrinidis A, Henske EP: Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene. 2005, 24 (50): 7475-7481. 10.1038\/sj.onc.1209090.","journal-title":"Oncogene"},{"key":"180_CR8","doi-asserted-by":"publisher","first-page":"R251","DOI":"10.1093\/hmg\/ddi260","volume":"14 Spec No. 2","author":"DJ Kwiatkowski","year":"2005","unstructured":"Kwiatkowski DJ, Manning BD: Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet. 2005, 14 Spec No. 2: R251-8. 10.1093\/hmg\/ddi260.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"180_CR9","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1086\/316951","volume":"68","author":"SL Dabora","year":"2001","unstructured":"Dabora SL, Jozwiak S, Franz DN, Roberts PS, Nieto A, Chung J, Choy YS, Reeve MP, Thiele E, Egelhoff JC, Kasprzyk-Obara J, Domanska-Pakiela D, Kwiatkowski DJ: Mutational analysis in a cohort of 224 tuberous sclerosis patients indicates increased severity of TSC2, compared with TSC1, disease in multiple organs. Am J Hum Genet. 2001, 68 (1): 64-80. 10.1086\/316951.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"180_CR10","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1086\/302381","volume":"64","author":"AC Jones","year":"1999","unstructured":"Jones AC, Shyamsundar MM, Thomas MW, Maynard J, Idziaszczyk S, Tomkins S, Sampson JR, Cheadle JP: Comprehensive mutation analysis of TSC1 and TSC2-and phenotypic correlations in 150 families with tuberous sclerosis. Am J Hum Genet. 1999, 64 (5): 1305-1315. 10.1086\/302381.","journal-title":"Am J Hum Genet"},{"issue":"12","key":"180_CR11","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1093\/hmg\/6.12.2155","volume":"6","author":"AC Jones","year":"1997","unstructured":"Jones AC, Daniells CE, Snell RG, Tachataki M, Idziaszczyk SA, Krawczak M, Sampson JR, Cheadle JP: Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis. Hum Mol Genet. 1997, 6 (12): 2155-2161. 10.1093\/hmg\/6.12.2155.","journal-title":"Hum Mol Genet"},{"issue":"11","key":"180_CR12","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1093\/hmg\/6.11.1991","volume":"6","author":"MM Maheshwar","year":"1997","unstructured":"Maheshwar MM, Cheadle JP, Jones AC, Myring J, Fryer AE, Harris PC, Sampson JR: The GAP-related domain of tuberin, the product of the TSC2 gene, is a target for missense mutations in tuberous sclerosis. Hum Mol Genet. 1997, 6 (11): 1991-1996. 10.1093\/hmg\/6.11.1991.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"180_CR13","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/hmg\/5.1.131","volume":"5","author":"MM Maheshwar","year":"1996","unstructured":"Maheshwar MM, Sandford R, Nellist M, Cheadle JP, Sgotto B, Vaudin M, Sampson JR: Comparative analysis and genomic structure of the tuberous sclerosis 2 (TSC2) gene in human and pufferfish. Hum Mol Genet. 1996, 5 (1): 131-137. 10.1093\/hmg\/5.1.131.","journal-title":"Hum Mol Genet"},{"issue":"4","key":"180_CR14","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1002\/humu.10265","volume":"22","author":"YN Su","year":"2003","unstructured":"Su YN, Lee CN, Hung CC, Chen CA, Cheng WF, Tsao PN, Yu CL, Hsieh FJ: Rapid detection of beta-globin gene (HBB) mutations coupling heteroduplex and primer-extension analysis by DHPLC. Hum Mutat. 2003, 22 (4): 326-336. 10.1002\/humu.10265.","journal-title":"Hum Mutat"},{"issue":"6","key":"180_CR15","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1002\/humu.1130","volume":"17","author":"W Xiao","year":"2001","unstructured":"Xiao W, Oefner PJ: Denaturing high-performance liquid chromatography: A review. Hum Mutat. 2001, 17 (6): 439-474. 10.1002\/humu.1130.","journal-title":"Hum Mutat"},{"issue":"6","key":"180_CR16","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/sj.ejhg.5201402","volume":"13","author":"O Sancak","year":"2005","unstructured":"Sancak O, Nellist M, Goedbloed M, Elfferich P, Wouters C, Maat-Kievit A, Zonnenberg B, Verhoef S, Halley D, van den Ouweland A: Mutational analysis of the TSC1 and TSC2 genes in a diagnostic setting: genotype--phenotype correlations and comparison of diagnostic DNA techniques in Tuberous Sclerosis Complex. Eur J Hum Genet. 2005, 13 (6): 731-741. 10.1038\/sj.ejhg.5201402.","journal-title":"Eur J Hum Genet"},{"issue":"3","key":"180_CR17","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1136\/jmg.2003.012757","volume":"41","author":"JC Lewis","year":"2004","unstructured":"Lewis JC, Thomas HV, Murphy KC, Sampson JR: Genotype and psychological phenotype in tuberous sclerosis. J Med Genet. 2004, 41 (3): 203-207. 10.1136\/jmg.2003.012757.","journal-title":"J Med Genet"},{"issue":"6","key":"180_CR18","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s004390000316","volume":"106","author":"AC Jones","year":"2000","unstructured":"Jones AC, Sampson JR, Hoogendoorn B, Cohen D, Cheadle JP: Application and evaluation of denaturing HPLC for molecular genetic analysis in tuberous sclerosis. Hum Genet. 2000, 106 (6): 663-668. 10.1007\/s004390050040.","journal-title":"Hum Genet"},{"issue":"9","key":"180_CR19","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1056\/NEJM199903043400905","volume":"340","author":"J Kwiatkowska","year":"1999","unstructured":"Kwiatkowska J, Wigowska-Sowinska J, Napierala D, Slomski R, Kwiatkowski DJ: Mosaicism in tuberous sclerosis as a potential cause of the failure of molecular diagnosis. N Engl J Med. 1999, 340 (9): 703-707. 10.1056\/NEJM199903043400905.","journal-title":"N Engl J Med"},{"issue":"4","key":"180_CR20","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1086\/514888","volume":"61","author":"JR Sampson","year":"1997","unstructured":"Sampson JR, Maheshwar MM, Aspinwall R, Thompson P, Cheadle JP, Ravine D, Roy S, Haan E, Bernstein J, Harris PC: Renal cystic disease in tuberous sclerosis: role of the polycystic kidney disease 1 gene. Am J Hum Genet. 1997, 61 (4): 843-851.","journal-title":"Am J Hum Genet"},{"issue":"6","key":"180_CR21","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1086\/302412","volume":"64","author":"S Verhoef","year":"1999","unstructured":"Verhoef S, Bakker L, Tempelaars AM, Hesseling-Janssen AL, Mazurczak T, Jozwiak S, Fois A, Bartalini G, Zonnenberg BA, van Essen AJ, Lindhout D, Halley DJ, van den Ouweland AM: High rate of mosaicism in tuberous sclerosis complex. Am J Hum Genet. 1999, 64 (6): 1632-1637. 10.1086\/302412.","journal-title":"Am J Hum Genet"},{"issue":"3","key":"180_CR22","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1089\/gte.2005.9.226","volume":"9","author":"M Nellist","year":"2005","unstructured":"Nellist M, Sancak O, Goedbloed MA, van Veghel-Plandsoen M, Maat-Kievit A, Lindhout D, Eussen BH, de Klein A, Halley DJ, van den Ouweland AM: Large deletion at the TSC1 locus in a family with tuberous sclerosis complex. Genet Test. 2005, 9 (3): 226-230. 10.1089\/gte.2005.9.226.","journal-title":"Genet Test"},{"issue":"2","key":"180_CR23","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1007\/s004390100460","volume":"108","author":"L Longa","year":"2001","unstructured":"Longa L, Saluto A, Brusco A, Polidoro S, Padovan S, Allavena A, Carbonara C, Grosso E, Migone N: TSC1 and TSC2 deletions differ in size, preference for recombinatorial sequences, and location within the gene. Hum Genet. 2001, 108 (2): 156-166. 10.1007\/s004390100460.","journal-title":"Hum Genet"},{"key":"180_CR24","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1046\/j.1469-1809.1998.6260491.x","volume":"62 ( Pt 6)","author":"SL Dabora","year":"1998","unstructured":"Dabora SL, Sigalas I, Hall F, Eng C, Vijg J, Kwiatkowski DJ: Comprehensive mutation analysis of TSC1 using two-dimensional DNA electrophoresis with DGGE. Ann Hum Genet. 1998, 62 ( Pt 6): 491-504. 10.1046\/j.1469-1809.1998.6260491.x.","journal-title":"Ann Hum Genet"},{"key":"180_CR25","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1046\/j.1469-1809.1999.6350383.x","volume":"63 ( Pt 5)","author":"YS Choy","year":"1999","unstructured":"Choy YS, Dabora SL, Hall F, Ramesh V, Niida Y, Franz D, Kasprzyk-Obara J, Reeve MP, Kwiatkowski DJ: Superiority of denaturing high performance liquid chromatography over single-stranded conformation and conformation-sensitive gel electrophoresis for mutation detection in TSC2. Ann Hum Genet. 1999, 63 ( Pt 5): 383-391. 10.1046\/j.1469-1809.1999.6350383.x.","journal-title":"Ann Hum Genet"},{"issue":"6","key":"180_CR26","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1007\/s100380050185","volume":"44","author":"H Zhang","year":"1999","unstructured":"Zhang H, Nanba E, Yamamoto T, Ninomiya H, Ohno K, Mizuguchi M, Takeshita K: Mutational analysis of TSC1 and TSC2 genes in Japanese patients with tuberous sclerosis complex. J Hum Genet. 1999, 44 (6): 391-396. 10.1007\/s100380050185.","journal-title":"J Hum Genet"},{"issue":"Pt 6","key":"180_CR27","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1046\/j.1529-8817.2003.00059.x","volume":"67","author":"PS Roberts","year":"2003","unstructured":"Roberts PS, Ramesh V, Dabora S, Kwiatkowski DJ: A 34 bp deletion within TSC2 is a rare polymorphism, not a pathogenic mutation. Ann Hum Genet. 2003, 67 (Pt 6): 495-503. 10.1046\/j.1529-8817.2003.00059.x.","journal-title":"Ann Hum Genet"},{"issue":"6","key":"180_CR28","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1002\/(SICI)1098-1004(1998)12:6<408::AID-HUMU7>3.0.CO;2-P","volume":"12","author":"RL Beauchamp","year":"1998","unstructured":"Beauchamp RL, Banwell A, McNamara P, Jacobsen M, Higgins E, Northrup H, Short P, Sims K, Ozelius L, Ramesh V: Exon scanning of the entire TSC2 gene for germline mutations in 40 unrelated patients with tuberous sclerosis. Hum Mutat. 1998, 12 (6): 408-416. 10.1002\/(SICI)1098-1004(1998)12:6<408::AID-HUMU7>3.0.CO;2-P.","journal-title":"Hum Mutat"},{"issue":"2","key":"180_CR29","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1002\/pd.1085","volume":"25","author":"CP Chen","year":"2005","unstructured":"Chen CP, Su YN, Hung CC, Lee CN, Hsieh FJ, Chang TY, Chen MR, Wang W: Molecular genetic analysis of the TSC genes in two families with prenatally diagnosed rhabdomyomas. Prenat Diagn. 2005, 25 (2): 176-178. 10.1002\/pd.1085.","journal-title":"Prenat Diagn"},{"issue":"4","key":"180_CR30","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1016\/S1525-1578(10)60586-7","volume":"7","author":"T Ichikawa","year":"2005","unstructured":"Ichikawa T, Wakisaka A, Daido S, Takao S, Tamiya T, Date I, Koizumi S, Niida Y: A case of solitary subependymal giant cell astrocytoma: two somatic hits of TSC2 in the tumor, without evidence of somatic mosaicism. J Mol Diagn. 2005, 7 (4): 544-549.","journal-title":"J Mol Diagn"},{"issue":"5","key":"180_CR31","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/(SICI)1098-1004(199911)14:5<412::AID-HUMU7>3.0.CO;2-K","volume":"14","author":"Y Niida","year":"1999","unstructured":"Niida Y, Lawrence-Smith N, Banwell A, Hammer E, Lewis J, Beauchamp RL, Sims K, Ramesh V, Ozelius L: Analysis of both TSC1 and TSC2 for germline mutations in 126 unrelated patients with tuberous sclerosis. Hum Mutat. 1999, 14 (5): 412-422. 10.1002\/(SICI)1098-1004(199911)14:5<412::AID-HUMU7>3.0.CO;2-K.","journal-title":"Hum Mutat"}],"container-title":["BMC Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-7-72.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2350-7-72\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-7-72","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-7-72.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:29:44Z","timestamp":1630456184000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenet.biomedcentral.com\/articles\/10.1186\/1471-2350-7-72"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,9,18]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["180"],"URL":"https:\/\/doi.org\/10.1186\/1471-2350-7-72","relation":{},"ISSN":["1471-2350"],"issn-type":[{"value":"1471-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,9,18]]},"assertion":[{"value":"28 February 2006","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 September 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"72"}}