{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:03:49Z","timestamp":1761743029720},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,12,1]],"date-time":"2007-12-01T00:00:00Z","timestamp":1196467200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The etiology of Ulcerative Colitis (UC) and Crohn's Disease (CD), considered together as Inflammatory Bowel Diseases (IBD), involves environmental and genetic factors. Although some genes are already known, the genetics underlying these diseases is complex and new candidates are continuously emerging. The <jats:italic>CD209<\/jats:italic> gene is located in a region linked previously to IBD and a <jats:italic>CD209<\/jats:italic> functional polymorphism (rs4804803) has been associated to other inflammatory conditions. Our aim was to study the potential involvement of this <jats:italic>CD209<\/jats:italic> variant in IBD susceptibility.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We performed a case-control study with 515 CD patients, 497 UC patients and 731 healthy controls, all of them white Spaniards. Samples were typed for the <jats:italic>CD209<\/jats:italic> single nucleotide polymorphism (SNP) rs4804803 by TaqMan technology. Frequency comparisons were performed using \u03c7<jats:sup>2<\/jats:sup> tests.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>No association between <jats:italic>CD209<\/jats:italic> and UC or CD was observed initially. However, stratification of UC patients by <jats:italic>HLA-DR3<\/jats:italic> status, a strong protective allele, showed that carriage of the <jats:italic>CD209<\/jats:italic>_G allele could increase susceptibility in the subgroup of <jats:italic>HLA-DR3<\/jats:italic>-positive individuals (p = 0.03 OR = 1.77 95% CI 1.04\u20133.02, <jats:italic>vs.<\/jats:italic> controls).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>A functional variant in the <jats:italic>CD209<\/jats:italic> gene, rs4804803, does not seem to be influencing Crohn's disease susceptibility. However, it could be involved in the etiology or pathology of Ulcerative Colitis in <jats:italic>HLA-DR3<\/jats:italic>-positive individuals but further studies are necessary.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2350-8-75","type":"journal-article","created":{"date-parts":[[2007,12,11]],"date-time":"2007-12-11T07:13:56Z","timestamp":1197357236000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["CD209 in inflammatory bowel disease: a case-control study in the Spanish population"],"prefix":"10.1186","volume":"8","author":[{"given":"Concepci\u00f3n","family":"N\u00fa\u00f1ez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Luis","family":"Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"G\u00f3mez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Taxonera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis M","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"L\u00f3pez-Nevot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilio G","family":"de la Concha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Urcelay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"issue":"9518","key":"269_CR1","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1016\/S0140-6736(06)68345-1","volume":"367","author":"DR Gaya","year":"2006","unstructured":"Gaya DR, Russell RK, Nimmo ER, Satsangi J: New genes in inflammatory bowel disease: lessons for complex diseases?. Lancet. 2006, 367 (9518): 1271-1284. 10.1016\/S0140-6736(06)68345-1.","journal-title":"Lancet"},{"issue":"11","key":"269_CR2","doi-asserted-by":"publisher","first-page":"2324","DOI":"10.1023\/A:1026629409481","volume":"44","author":"EG de la Concha","year":"1999","unstructured":"de la Concha EG, Fernandez-Arquero M, Martinez A, Vigil P, Vidal F, Lopez-Nava G, Diaz-Rubio M, Garcia-Paredes J: Amino acid polymorphism at residue 71 in HLA-DR beta chain plays a critical role in susceptibility to ulcerative colitis. Dig Dis Sci. 1999, 44 (11): 2324-2329. 10.1023\/A:1026629409481.","journal-title":"Dig Dis Sci"},{"issue":"4","key":"269_CR3","first-page":"279","volume":"3","author":"T Zhou","year":"2006","unstructured":"Zhou T, Chen Y, Hao L, Zhang Y: DC-SIGN and immunoregulation. Cell Mol Immunol. 2006, 3 (4): 279-283.","journal-title":"Cell Mol Immunol"},{"issue":"6","key":"269_CR4","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1086\/302913","volume":"66","author":"JD Rioux","year":"2000","unstructured":"Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA: Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. Am J Hum Genet. 2000, 66 (6): 1863-1870. 10.1086\/302913.","journal-title":"Am J Hum Genet"},{"issue":"5","key":"269_CR5","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/ng1550","volume":"37","author":"A Sakuntabhai","year":"2005","unstructured":"Sakuntabhai A, Turbpaiboon C, Casademont I, Chuansumrit A, Lowhnoo T, Kajaste-Rudnitski A, Kalayanarooj SM, Tangnararatchakit K, Tangthawornchaikul N, Vasanawathana S, Chaiyaratana W, Yenchitsomanus PT, Suriyaphol P, Avirutnan P, Chokephaibulkit K, Matsuda F, Yoksan S, Jacob Y, Lathrop GM, Malasit P, Despres P, Julier C: A variant in the CD209 promoter is associated with severity of dengue disease. Nat Genet. 2005, 37 (5): 507-13. Epub 2005 Apr 17.. 10.1038\/ng1550.","journal-title":"Nat Genet"},{"issue":"27","key":"269_CR6","doi-asserted-by":"publisher","first-page":"4397","DOI":"10.3748\/wjg.v12.i27.4397","volume":"12","author":"C Nunez","year":"2006","unstructured":"Nunez C, Rueda B, Martinez A, Maluenda C, Polanco I, Lopez-Nevot MA, Ortega E, Sierra E, Gomez de la Concha E, Urcelay E, Martin J: A functional variant in the CD209 promoter is associated with DQ2-negative celiac disease in the Spanish population. World J Gastroenterol. 2006, 12 (27): 4397-4400.","journal-title":"World J Gastroenterol"},{"issue":"6","key":"269_CR7","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1053\/gast.2000.20258","volume":"119","author":"EG de la Concha","year":"2000","unstructured":"de la Concha EG, Fernandez-Arquero M, Lopez-Nava G, Martin E, Allcock RJ, Conejero L, Paredes JG, Diaz-Rubio M: Susceptibility to severe ulcerative colitis is associated with polymorphism in the central MHC gene IKBL. Gastroenterology. 2000, 119 (6): 1491-1495. 10.1053\/gast.2000.20258.","journal-title":"Gastroenterology"},{"issue":"5","key":"269_CR8","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1097\/01.qco.0000244054.69253.f3","volume":"19","author":"S Subramanian","year":"2006","unstructured":"Subramanian S, Campbell BJ, Rhodes JM: Bacteria in the pathogenesis of inflammatory bowel disease. Curr Opin Infect Dis. 2006, 19 (5): 475-484. 10.1097\/01.qco.0000244054.69253.f3.","journal-title":"Curr Opin Infect Dis"},{"issue":"3","key":"269_CR9","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.bpg.2003.12.006","volume":"18","author":"RK Russell","year":"2004","unstructured":"Russell RK, Satsangi J: IBD: a family affair. Best Pract Res Clin Gastroenterol. 2004, 18 (3): 525-539. 10.1016\/j.bpg.2003.12.006.","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"2","key":"269_CR10","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.molmed.2005.12.005","volume":"12","author":"SH Pearce","year":"2006","unstructured":"Pearce SH, Merriman TR: Genetic progress towards the molecular basis of autoimmunity. Trends Mol Med. 2006, 12 (2): 90-98. 10.1016\/j.molmed.2005.12.005.","journal-title":"Trends Mol Med"},{"key":"269_CR11","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1111\/j.0105-2896.2005.00286.x","volume":"206","author":"SR Targan","year":"2005","unstructured":"Targan SR, Karp LC: Defects in mucosal immunity leading to ulcerative colitis. Immunol Rev. 2005, 206: 296-305. 10.1111\/j.0105-2896.2005.00286.x.","journal-title":"Immunol Rev"}],"container-title":["BMC Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-8-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2350-8-75\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-8-75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-8-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T08:51:36Z","timestamp":1630486296000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmedgenet.biomedcentral.com\/articles\/10.1186\/1471-2350-8-75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,12]]}},"alternative-id":["269"],"URL":"https:\/\/doi.org\/10.1186\/1471-2350-8-75","relation":{},"ISSN":["1471-2350"],"issn-type":[{"value":"1471-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12]]},"assertion":[{"value":"29 August 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2007","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 December 2007","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"75"}}