{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:24:14Z","timestamp":1773296654188,"version":"3.50.1"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,10,27]],"date-time":"2008-10-27T00:00:00Z","timestamp":1225065600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Med Genet"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1471-2350-9-94","type":"journal-article","created":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T07:14:41Z","timestamp":1225178081000},"source":"Crossref","is-referenced-by-count":23,"title":["Significant association of SREBP-2genetic polymorphisms with avascular necrosis in the Korean population"],"prefix":"10.1186","volume":"9","author":[{"given":"Tae-Ho","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong-In","family":"Baek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Min","family":"Hong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Jin","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Jin","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun-Ju","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eui Kyun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Un-Kyung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2008,10,27]]},"reference":[{"issue":"2","key":"388_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","volume":"32","author":"Y Assouline-Dayan","year":"2002","unstructured":"Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME: Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002, 32 (2): 94-124.","journal-title":"Semin Arthritis Rheum"},{"key":"388_CR2","doi-asserted-by":"crossref","unstructured":"Cruess RL, Ross D, Crawshaw E: The etiology of steroid-induced avascular necrosis of bone. A laboratory and clinical study. Clin Orthop Relat Res. 1975, 178-183. 10.1097\/00003086-197511000-00028. 113","DOI":"10.1097\/00003086-197511000-00028"},{"issue":"4","key":"388_CR3","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1302\/0301-620X.47B4.612","volume":"47","author":"R Merle D'Aubigne","year":"1965","unstructured":"Merle D'Aubigne R, Postel M, Mazabraud A, Massias P, Gueguen J, France P: Idiopathic necrosis of the femoral head in adults. J Bone Joint Surg Br. 1965, 47 (4): 612-633.","journal-title":"J Bone Joint Surg Br"},{"issue":"B","key":"388_CR4","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2106\/00004623-196446020-00004","volume":"47","author":"R Petterson","year":"1964","unstructured":"Petterson R, Bickel W, Dahlin D: Idiopathic avascular necrosis of the head of the femur. J Bone Joint Surg Br. 1964, 47 (B): 267-282.","journal-title":"J Bone Joint Surg Br"},{"key":"388_CR5","doi-asserted-by":"crossref","unstructured":"Wang GJ, Rawles JG, Hubbard SL, Stamp WG: Steroid-induced femoral head pressure changes and their response to lipid-clearing agents. Clin Orthop Relat Res. 1983, 298-302. 174","DOI":"10.1097\/00003086-198304000-00038"},{"issue":"2","key":"388_CR6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2106\/00004623-197052020-00012","volume":"52","author":"WG Boettcher","year":"1970","unstructured":"Boettcher WG, Bonfiglio M, Hamilton HH, Sheets RF, Smith K: Non-traumatic necrosis of the femoral head. I. Relation of altered hemostasis to etiology. J Bone Joint Surg Am. 1970, 52 (2): 312-321.","journal-title":"J Bone Joint Surg Am"},{"key":"388_CR7","doi-asserted-by":"crossref","unstructured":"Matsuo K, Hirohata T, Sugioka Y, Ikeda M, Fukuda A: Influence of alcohol intake, cigarette smoking, and occupational status on idiopathic osteonecrosis of the femoral head. Clin Orthop Relat Res. 1988, 115-123. 234","DOI":"10.1097\/00003086-198809000-00021"},{"key":"388_CR8","doi-asserted-by":"crossref","unstructured":"Wang Y, Li Y, Mao K, Li J, Cui Q, Wang GJ: Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res. 2003, 213-224. 10.1097\/01.blo.0000063602.67412.83. 410","DOI":"10.1097\/01.blo.0000063602.67412.83"},{"issue":"1","key":"388_CR9","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1385\/JCD:1:1:65","volume":"1","author":"IR Reid","year":"1998","unstructured":"Reid IR: Glucocorticoid-induced osteoporosis: assessment and treatment. J Clin Densitom. 1998, 1 (1): 65-73. 10.1385\/JCD:1:1:65.","journal-title":"J Clin Densitom"},{"issue":"24","key":"388_CR10","doi-asserted-by":"publisher","first-page":"11603","DOI":"10.1073\/pnas.90.24.11603","volume":"90","author":"X Hua","year":"1993","unstructured":"Hua X, Yokoyama C, Wu J, Briggs MR, Brown MS, Goldstein JL, Wang X: SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element. Proc Natl Acad Sci USA. 1993, 90 (24): 11603-11607. 10.1073\/pnas.90.24.11603.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"388_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/S0092-8674(00)80213-5","volume":"89","author":"MS Brown","year":"1997","unstructured":"Brown MS, Goldstein JL: The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor. Cell. 1997, 89 (3): 331-340. 10.1016\/S0092-8674(00)80213-5.","journal-title":"Cell"},{"issue":"9","key":"388_CR12","doi-asserted-by":"publisher","first-page":"1125","DOI":"10.1172\/JCI0215593","volume":"109","author":"JD Horton","year":"2002","unstructured":"Horton JD, Goldstein JL, Brown MS: SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest. 2002, 109 (9): 1125-1131.","journal-title":"J Clin Invest"},{"issue":"10","key":"388_CR13","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1074\/jbc.273.10.5785","volume":"273","author":"J Sakai","year":"1998","unstructured":"Sakai J, Nohturfft A, Goldstein JL, Brown MS: Cleavage of sterol regulatory element-binding proteins (SREBPs) at site-1 requires interaction with SREBP cleavage-activating protein. Evidence from in vivo competition studies. J Biol Chem. 1998, 273 (10): 5785-5793. 10.1074\/jbc.273.10.5785.","journal-title":"J Biol Chem"},{"issue":"2","key":"388_CR14","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1006\/abbi.2001.2615","volume":"397","author":"JL Goldstein","year":"2002","unstructured":"Goldstein JL, Rawson RB, Brown MS: Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis. Arch Biochem Biophys. 2002, 397 (2): 139-148. 10.1006\/abbi.2001.2615.","journal-title":"Arch Biochem Biophys"},{"issue":"4","key":"388_CR15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s100670200078","volume":"21","author":"KH Koo","year":"2002","unstructured":"Koo KH, Kim R, Kim YS, Ahn IO, Cho SH, Song HR, Park YS, Kim H, Wang GJ: Risk period for developing osteonecrosis of the femoral head in patients on steroid treatment. Clin Rheumatol. 2002, 21 (4): 299-303. 10.1007\/s100670200078.","journal-title":"Clin Rheumatol"},{"issue":"2","key":"388_CR16","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1093\/genetics\/117.2.331","volume":"117","author":"PW Hedrick","year":"1987","unstructured":"Hedrick PW: Gametic disequilibrium measures: proceed with caution. Genetics. 1987, 117 (2): 331-341.","journal-title":"Genetics"},{"issue":"2","key":"388_CR17","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21 (2): 263-265. 10.1093\/bioinformatics\/bth457.","journal-title":"Bioinformatics"},{"issue":"4","key":"388_CR18","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/00006416-200507000-00012","volume":"24","author":"SG Childs","year":"2005","unstructured":"Childs SG: Osteonecrosis: death of bone cells. Orthop Nurs. 2005, 24 (4): 295-301. 10.1097\/00006416-200507000-00012. quiz 302\u2013293","journal-title":"Orthop Nurs"},{"key":"388_CR19","doi-asserted-by":"crossref","unstructured":"de Camargo FP, de Godoy RM, Tovo R: Angiography in Perthes' disease. Clin Orthop Relat Res. 1984, 216-220. 191","DOI":"10.1097\/00003086-198412000-00028"},{"issue":"4","key":"388_CR20","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1080\/10623320600904211","volume":"13","author":"MA Kerachian","year":"2006","unstructured":"Kerachian MA, Harvey EJ, Cournoyer D, Chow TY, Seguin C: Avascular necrosis of the femoral head: vascular hypotheses. Endothelium. 2006, 13 (4): 237-244. 10.1080\/10623320600904211.","journal-title":"Endothelium"},{"key":"388_CR21","doi-asserted-by":"crossref","unstructured":"Mont MA, Jones LC, Einhorn TA, Hungerford DS, Reddi AH: Osteonecrosis of the femoral head. Potential treatment with growth and differentiation factors. Clin Orthop Relat Res. 1998, S314-335. 10.1097\/00003086-199810001-00032. 355 Suppl","DOI":"10.1097\/00003086-199810001-00032"},{"issue":"20","key":"388_CR22","doi-asserted-by":"publisher","first-page":"2835","DOI":"10.1001\/jama.1986.03380200073024","volume":"256","author":"WP Castelli","year":"1986","unstructured":"Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB: Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. Jama. 1986, 256 (20): 2835-2838. 10.1001\/jama.256.20.2835.","journal-title":"Jama"},{"issue":"6","key":"388_CR23","first-page":"387","volume":"47","author":"M Dobiasova","year":"1998","unstructured":"Dobiasova M, Frohlich J: Understanding the mechanism of LCAT reaction may help to explain the high predictive value of LDL\/HDL cholesterol ratio. Physiol Res. 1998, 47 (6): 387-397.","journal-title":"Physiol Res"},{"issue":"4","key":"388_CR24","first-page":"430","volume":"2","author":"H Mielants","year":"1975","unstructured":"Mielants H, Veys EM, DeBussere A, Jeught van der J: Avascular necrosis and its relation to lipid and purine metabolism. J Rheumatol. 1975, 2 (4): 430-436.","journal-title":"J Rheumatol"},{"issue":"9","key":"388_CR25","first-page":"609","volume":"26","author":"JT Moskal","year":"1997","unstructured":"Moskal JT, Topping RE, Franklin LL: Hypercholesterolemia: an association with osteonecrosis of the femoral head. Am J Orthop. 1997, 26 (9): 609-612.","journal-title":"Am J Orthop"},{"issue":"4","key":"388_CR26","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1002\/ajh.2830440405","volume":"44","author":"PJ Van Veldhuizen","year":"1993","unstructured":"Van Veldhuizen PJ, Neff J, Murphey MD, Bodensteiner D, Skikne BS: Decreased fibrinolytic potential in patients with idiopathic avascular necrosis and transient osteoporosis of the hip. Am J Hematol. 1993, 44 (4): 243-248. 10.1002\/ajh.2830440405.","journal-title":"Am J Hematol"},{"key":"388_CR27","doi-asserted-by":"crossref","unstructured":"Ono K, Tohjima T, Komazawa T: Risk factors of avascular necrosis of the femoral head in patients with systemic lupus erythematosus under high-dose corticosteroid therapy. Clin Orthop Relat Res. 1992, 89-97. 277","DOI":"10.1097\/00003086-199204000-00011"},{"issue":"9","key":"388_CR28","doi-asserted-by":"publisher","first-page":"1915","DOI":"10.1194\/jlr.M600127-JLR200","volume":"47","author":"N Iwamoto","year":"2006","unstructured":"Iwamoto N, Abe-Dohmae S, Sato R, Yokoyama S: ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res. 2006, 47 (9): 1915-1927. 10.1194\/jlr.M600127-JLR200.","journal-title":"J Lipid Res"},{"issue":"3","key":"388_CR29","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2106\/00004623-199503000-00018","volume":"77","author":"MA Mont","year":"1995","unstructured":"Mont MA, Hungerford DS: Non-traumatic avascular necrosis of the femoral head. J Bone Joint Surg Am. 1995, 77 (3): 459-474.","journal-title":"J Bone Joint Surg Am"}],"container-title":["BMC Medical Genetics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-9-94.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2350-9-94\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2350-9-94","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T11:55:07Z","timestamp":1632052507000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmedgenet.biomedcentral.com\/articles\/10.1186\/1471-2350-9-94"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,27]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["388"],"URL":"https:\/\/doi.org\/10.1186\/1471-2350-9-94","relation":{},"ISSN":["1471-2350"],"issn-type":[{"value":"1471-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,27]]},"article-number":"94"}}