{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:07:56Z","timestamp":1790842076592,"version":"4.1.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Reasons underlying dialysis decision-making in Octogenarians and Nonagenarians have not been further explored in prospective studies.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>This regional, multicentre, non-interventional and prospective study was aimed to describe characteristics and quality of life (QoL) of elderly (\u226580 years of age) with advanced chronic kidney disease (stage 3b-5 CKD) newly referred to nephrologists. Predictive factors of death and dialysis initiation were also assessed using competing-risk analyses.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>All 155 included patients had an estimated glomerular filtration rate (eGFR) below 45 ml\/min\/1.73\u2009m<jats:sup>2<\/jats:sup>. Most patients had a non anaemic haemoglobin level (Hb) with no iron deficiency, and normal calcium and phosphate levels. They were well-fed and had a normal cognitive function and a good QoL. The 3-year probabilities of death and dialysis initiation reached 27% and 11%, respectively. The leading causes of death were cardiovascular (32%), cachexia (18%), cancer (9%), infection (3%), trauma (3%), dementia (3%), and unknown (32%). The reasons for dialysis initiation were based on uncontrolled biological abnormalities, such as hyperkalemia or acidosis (71%), uncontrolled digestive disorders (35%), uncontrolled pulmonary or peripheral oedema (29%), and uncontrolled malnutrition (12%). No patients with acute congestive heart failure or cancer initiated dialysis. Predictors of death found in both multivariate regression models (Cox and Fine &amp; Gray) included acute congestive heart failure, age, any walking impairment and Hb &lt;10\u2009g\/dL. Regarding dialysis initiation, eGFR &lt;23\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> was the only predictor found in the Cox multivariate regression model whereas eGFR &lt;23\u2009mL\/min\/1.73\u2009m<jats:sup>2<\/jats:sup> and diastolic blood pressure were both independently associated with dialysis initiation in the Fine &amp; Gray analysis. Such findings suggested that death and dialysis were independent events.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Octogenarians and Nonagenarians newly referred to nephrologists by general practitioners were highly selected patients, without any symptoms of the common geriatric syndrome. In this population, nephrologists\u2019 dialysis decision was based exclusively on uremic criteria.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2369-14-103","type":"journal-article","created":{"date-parts":[[2013,5,8]],"date-time":"2013-05-08T11:35:43Z","timestamp":1368012943000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Competing-risk analysis of death and dialysis initiation among elderly (\u226580 years) newly referred to nephrologists: a French prospective study"],"prefix":"10.1186","volume":"14","author":[{"given":"Bernadette","family":"Faller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Baptiste","family":"Beuscart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc","family":"Frimat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"and on behalf of the \u2018Association des n\u00e9phrologues de l\u2019Est\u2019","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"531_CR1","doi-asserted-by":"publisher","first-page":"936","DOI":"10.2215\/CJN.08731209","volume":"5","author":"M Rosner","year":"2010","unstructured":"Rosner M, Abdel-Rahman E, Williams ME, for the ASN Advisory Group on Geriatric Nephrology: Geriatric nephrology: responding to a growing challenge. Clin J Am Soc Nephrol. 2010, 5: 936-942. 10.2215\/CJN.08731209.","journal-title":"Clin J Am Soc Nephrol"},{"key":"531_CR2","doi-asserted-by":"publisher","first-page":"2127","DOI":"10.1681\/ASN.2005010005","volume":"16","author":"M Kurella","year":"2005","unstructured":"Kurella M, Chertow GM, Fried LF, Cummings SR, Harris T, Simonsick E, Satterfield S, Ayonayon H, Yaffe K: Chronic kidney disease and cognitive impairment in the elderly: the health, aging, and body composition study. J Am Soc Nephrol. 2005, 16: 2127-2133. 10.1681\/ASN.2005010005.","journal-title":"J Am Soc Nephrol"},{"key":"531_CR3","doi-asserted-by":"publisher","first-page":"S23","DOI":"10.1053\/j.ajkd.2009.09.035","volume":"55","author":"LA Stevens","year":"2010","unstructured":"Stevens LA, Li S, Wang C, Huang C, Becker BN, Bomback AS, Weinstock Brown W, Rios Burrows N, Jurkovitz CT, McFarlane SI, Norris KC, Shlipak M, Whaley-Connell AT, Chen S, Bakris GL, McCullough PA: Prevalence of CKD and comorbid illness in elderly patients in the United States: results from the Kidney Early Evaluation Program (KEEP). Am J Kidney Dis. 2010, 55: S23-33. 10.1053\/j.ajkd.2009.09.035.","journal-title":"Am J Kidney Dis"},{"key":"531_CR4","doi-asserted-by":"publisher","first-page":"950","DOI":"10.1053\/j.ajkd.2008.12.036","volume":"53","author":"PJ Roderick","year":"2009","unstructured":"Roderick PJ, Atkins RJ, Smeeth L, Mylne A, Nitsch D, Hubbard RB, Bulpitt CJ, Fletcher AE: CKD and mortality risk in older people: a community-based population study in the United Kingdom. Am J Kidney Dis. 2009, 53: 950-960. 10.1053\/j.ajkd.2008.12.036.","journal-title":"Am J Kidney Dis"},{"key":"531_CR5","doi-asserted-by":"publisher","first-page":"1199","DOI":"10.1681\/ASN.2008080860","volume":"20","author":"S Anderson","year":"2009","unstructured":"Anderson S, Halter JB, Hazzard WR, Himmelfarb J, McFarland Horne F, Kaysen GA, Kusek JW, Nayfield SG, Schmader K, Tian Y, Ashworth JR, Clayton CP, Parker RP, Tarver ED, Woolard NF, High KP, for the workshop participants: Prediction, progression, and outcomes of chronic kidney disease in older adults. J Am Soc Nephrol. 2009, 20: 1199-1209. 10.1681\/ASN.2008080860.","journal-title":"J Am Soc Nephrol"},{"key":"531_CR6","doi-asserted-by":"publisher","first-page":"1020","DOI":"10.1016\/j.lpm.2011.06.020","volume":"40","author":"B Stengel","year":"2011","unstructured":"Stengel B: L\u2019insuffisance r\u00e9nale chronique : une \u00e9pid\u00e9mie ?. Presse Med. 2011, 40: 1020-1027. 10.1016\/j.lpm.2011.06.020.","journal-title":"Presse Med"},{"key":"531_CR7","doi-asserted-by":"publisher","first-page":"2038","DOI":"10.1001\/jama.298.17.2038","volume":"298","author":"J Coresh","year":"2007","unstructured":"Coresh J, Selvin E, Stevens LA, Manzi J, Kusek JW, Eggers P, Van Lente F, Levey AS: Prevalence of chronic kidney disease in United States. JAMA. 2007, 298: 2038-2047. 10.1001\/jama.298.17.2038.","journal-title":"JAMA"},{"key":"531_CR8","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1097\/01.ASN.0000054493.04151.80","volume":"14","author":"D Joly","year":"2003","unstructured":"Joly D, Anglicheau D, Alberti C, Nguyen A, Touam M, Gr\u00fcnfeld JP, Jungers P: Octogenarians reaching end-stage renal disease: cohort study of decision-making and clinical outcomes. J Am Soc Nephrol. 2003, 14: 1012-1021. 10.1097\/01.ASN.0000054493.04151.80.","journal-title":"J Am Soc Nephrol"},{"key":"531_CR9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.7326\/0003-4819-146-3-200702060-00006","volume":"146","author":"M Kurella","year":"2007","unstructured":"Kurella M, Covinsky KE, Collins AJ, Chertow GM: Octogenarians and nonagenarians starting dialysis in the United States. Ann Intern Med. 2007, 146: 177-183. 10.7326\/0003-4819-146-3-200702060-00006.","journal-title":"Ann Intern Med"},{"key":"531_CR10","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/ndt\/gfn698","volume":"24","author":"C Couchoud","year":"2009","unstructured":"Couchoud C, Labeeuw M, Moranne O, Allot V, Esnault V, Frimat L, Stengel B, and for the French Renal Epidemiology and Information Network (REIN) registry: A clinical score to predict 6-month prognosis in elderly patients starting dialysis for end-stage renal disease. Nephrol Dial Transplant. 2009, 24: 1553-1561. 10.1093\/ndt\/gfn698.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR11","doi-asserted-by":"publisher","first-page":"2545","DOI":"10.1001\/jama.2012.6667","volume":"307","author":"M Kurella","year":"2012","unstructured":"Kurella M, Winkelmayer WC: Treated and untreated kidney failure in older adults. What\u2019s the right balance?. JAMA. 2012, 307: 2545-2546. 10.1001\/jama.2012.6667.","journal-title":"JAMA"},{"key":"531_CR12","doi-asserted-by":"publisher","first-page":"2446","DOI":"10.1093\/ndt\/gfi012","volume":"20","author":"R Clement","year":"2005","unstructured":"Clement R, Chevalet P, Rodat O, Ould-Aoudia V, Berger M: Withholding or withdrawing dialysis in the elderly: the perspective of a western region of France. Nephrol Dial Transplant. 2005, 20: 2446-2452. 10.1093\/ndt\/gfi012.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR13","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1093\/ndt\/gfm153","volume":"22","author":"FE Murtagh","year":"2007","unstructured":"Murtagh FE, Marsh JE, Donohoe P, Ekbal NJ, Sheerin NS, Harris FE: Dialysis or not? A comparative survival study of patients over 75 years with chronic kidney disease stage 5. Nephrol Dial Transplant. 2007, 22: 1955-1962. 10.1093\/ndt\/gfm153.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR14","doi-asserted-by":"publisher","first-page":"1608","DOI":"10.1093\/ndt\/gfq630","volume":"26","author":"SM Chandna","year":"2011","unstructured":"Chandna SM, Da Silva-Gane M, Marshall C, Warwicker P, Greenwood R, Farrington K: Survival of elderly patients with stage 5 CKD: comparison of conservative management and renal replacement therapy. Nephrol Dial Transplant. 2011, 26: 1608-1614. 10.1093\/ndt\/gfq630.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR15","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/ndt\/gfq372","volume":"26","author":"N Demoulin","year":"2011","unstructured":"Demoulin N, Beguin C, Labriola L, Jadoul M: Preparing renal replacement therapy in stage 4 CKD patients referred to nephrologists: a difficult balance between futility and insufficiency. A cohort study of 386 patients followed in Brussels. Nephrol Dial Transplant. 2011, 26: 220-226. 10.1093\/ndt\/gfq372.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR16","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1093\/aje\/kwp107","volume":"170","author":"B Lau","year":"2009","unstructured":"Lau B, Cole SR, Gange SJ: Competing risk regression models for epidemiologic data. Am J Epidemiol. 2009, 170: 244-256. 10.1093\/aje\/kwp107.","journal-title":"Am J Epidemiol"},{"key":"531_CR17","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR: Mini-Mental State\u201d: a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975, 12: 196-198.","journal-title":"J Psychiatr Res"},{"key":"531_CR18","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware","year":"1992","unstructured":"Ware JE, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097\/00005650-199206000-00002.","journal-title":"Med Care"},{"key":"531_CR19","doi-asserted-by":"publisher","first-page":"1104","DOI":"10.1093\/ije\/dyp164","volume":"38","author":"F Claudot","year":"2009","unstructured":"Claudot F, Alla F, Fresson J, Calvez T, Coudane H, Bona\u00efti-Pelli\u00e9 C: Ethics and observational studies in medical research: various rules in a common framework. Int J Epidemiol. 2009, 38: 1104-1108. 10.1093\/ije\/dyp164.","journal-title":"Int J Epidemiol"},{"key":"531_CR20","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O","volume":"18","author":"TA Gooley","year":"1999","unstructured":"Gooley TA, Leisenring W, Crowley J, Storer BE: Estimation of failure probabilities in the presence of competing risks: new representations of old estimators. Stat Med. 1999, 18: 695-706. 10.1002\/(SICI)1097-0258(19990330)18:6<695::AID-SIM60>3.0.CO;2-O.","journal-title":"Stat Med"},{"key":"531_CR21","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/9781118032985","volume-title":"The statistical analysis of failure time data","author":"JD Kalbfleisch","year":"2002","unstructured":"Kalbfleisch JD, Prentice RL: Competing risks and multistate models. The statistical analysis of failure time data. Edited by: Wiley series in probability and statistics. 2002, New Jersey: Balding DJ, 247-277. Second","edition":"Second"},{"key":"531_CR22","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1002\/sim.2712","volume":"26","author":"H Putter","year":"2007","unstructured":"Putter H, Fiocco M, Geskus RB: Tutorial in biostatistics: competing risks and multi-state models. Stat Med. 2007, 26: 2389-2430. 10.1002\/sim.2712.","journal-title":"Stat Med"},{"key":"531_CR23","doi-asserted-by":"publisher","first-page":"541","DOI":"10.2307\/2530374","volume":"34","author":"RL Prentice","year":"1978","unstructured":"Prentice RL, Kalbfleisch JD, Peterson AVJ, Flournoy N, Farewell VT, Breslow NE: The analysis of failure times in the presence of competing risks. Biometrics. 1978, 34: 541-554. 10.2307\/2530374.","journal-title":"Biometrics"},{"key":"531_CR24","doi-asserted-by":"publisher","first-page":"1686","DOI":"10.1016\/S0140-6736(02)08594-X","volume":"359","author":"SJ Pocock","year":"2002","unstructured":"Pocock SJ, Clayton TC, Altman DG: Survival plots of time-to-event outcomes in clinical trials: good practice and pitfalls. Lancet. 2002, 359: 1686-1689. 10.1016\/S0140-6736(02)08594-X.","journal-title":"Lancet"},{"key":"531_CR25","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1080\/01621459.1999.10474144","volume":"94","author":"JP Fine","year":"1999","unstructured":"Fine JP, Gray RJ: A proportional hazards model for the subdistribution of a competing risk. J Am Stat Assoc. 1999, 94: 496-509. 10.1080\/01621459.1999.10474144.","journal-title":"J Am Stat Assoc"},{"key":"531_CR26","doi-asserted-by":"publisher","first-page":"1453","DOI":"10.1016\/S0140-6736(07)61602-X","volume":"370","author":"E An Elm","year":"2007","unstructured":"An Elm E, Altman DG, Egger M, Pocock SJ, G\u00f8tzsche PC, Vandenbroucke JP: The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Lancet. 2007, 370: 1453-1457. 10.1016\/S0140-6736(07)61602-X.","journal-title":"Lancet"},{"key":"531_CR27","first-page":"1","volume":"45","author":"S Van Buuren","year":"2011","unstructured":"Van Buuren S, Groothuis-Oudshoorn K: MICE: Multivariate Imputation by Chained Equations in R. J Stat Softw. 2011, 45: 1-67.","journal-title":"J Stat Softw"},{"key":"531_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1186\/1471-2288-10-112","volume":"10","author":"A Marshall","year":"2010","unstructured":"Marshall A, Altman D, Holder R: Comparison of imputation methods for handling missing covariate data when fitting a Cox proportional hazards model: a resampling study. BMC Med Res Methodol. 2010, 10: 112-10.1186\/1471-2288-10-112.","journal-title":"BMC Med Res Methodol"},{"key":"531_CR29","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1002\/sim.3177","volume":"27","author":"AM Wood","year":"2008","unstructured":"Wood AM, White IR, Royston P: How should variable selection be performed with multiply imputed data?. Stat Med. 2008, 27: 3227-3246. 10.1002\/sim.3177.","journal-title":"Stat Med"},{"key":"531_CR30","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/01621459.1996.10476908","volume":"91","author":"DB Rubin","year":"1996","unstructured":"Rubin DB: Multiple imputation after 18+ years. J Am Stat Assoc. 1996, 91: 473-489. 10.1080\/01621459.1996.10476908.","journal-title":"J Am Stat Assoc"},{"key":"531_CR31","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1093\/biomet\/77.1.147","volume":"77","author":"T Therneau","year":"1990","unstructured":"Therneau T, Gramsch P, Fleming T: Martingale-based residuals for survival models. Biometrika. 1990, 77: 147-160. 10.1093\/biomet\/77.1.147.","journal-title":"Biometrika"},{"key":"531_CR32","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Foundation for Statistical Computing","year":"2010","unstructured":"R Foundation for Statistical Computing: R: A Language and Environment for Statistical Computing. 2010, Vienna, Austria: , http:\/\/www.R-project.org\/,"},{"key":"531_CR33","doi-asserted-by":"publisher","first-page":"3286","DOI":"10.1093\/ndt\/gfr323","volume":"26","author":"B Stengel","year":"2011","unstructured":"Stengel B, Metzger M, Froissart M, Rainfray M, Berr C, Tzourio C, Helmer C: Epidemiology and prognostic significance of chronic kidney disease in the elderly - The three-city prospective cohort study. Nephrol Dial Transplant. 2011, 26: 3286-3295. 10.1093\/ndt\/gfr323.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR34","doi-asserted-by":"publisher","first-page":"2155","DOI":"10.1038\/sj.ki.5000270","volume":"69","author":"BR Hemmelgam","year":"2006","unstructured":"Hemmelgam BR, Zhang J, Manns BJ, Tonelli M, Larsen E, Ghali WA, Southern DA, McLaughlin K, Mortis G, Culleton BF: Progression of kidney dysfunction in the community-dwelling elderly. Kidney Int. 2006, 69: 2155-2161. 10.1038\/sj.ki.5000270.","journal-title":"Kidney Int"},{"key":"531_CR35","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s11606-010-1511-x","volume":"26","author":"LS Dalrymple","year":"2010","unstructured":"Dalrymple LS, Katz R, Kestenbaum B, Shlipak MG, Sarnak MJ, Stehman-Breen C, Seliger S, Siscovick D, Newman AB, Fried L: Chronic kidney disease and the risk of end-stage renal disease versus death. J Gen Intern Med. 2010, 26: 379-385.","journal-title":"J Gen Intern Med"},{"key":"531_CR36","volume-title":"Mesure de la sant\u00e9 perceptuelle et de la qualit\u00e9 de vie","author":"A Lepl\u00e8ge","year":"2002","unstructured":"Lepl\u00e8ge A, Coste J: Mesure de la sant\u00e9 perceptuelle et de la qualit\u00e9 de vie. 2002, Paris, Editions Estem: M\u00e9thodes et applications"},{"key":"531_CR37","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1093\/ndt\/gfm382","volume":"22","author":"A Visser","year":"2007","unstructured":"Visser A, Dijkstra GJ, Huisman RM, Gansevoort RT, de Jong PE, Reijneveld SA: Differences between physicians in the likelihood of referral and acceptance of elderly patients for dialysis-influence of age and comorbidity. Nephrol Dial Transplant. 2007, 22: 3255-3261. 10.1093\/ndt\/gfm382.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR38","doi-asserted-by":"publisher","first-page":"277","DOI":"10.2215\/CJN.02600706","volume":"2","author":"MB Patwardhan","year":"2007","unstructured":"Patwardhan MB, Samsa GP, Matchar DB, Haley WE: Advanced chronic kidney disease practice patterns among nephrologists and non-nephrologists: a database analysis. Clin J Am Soc Nephrol. 2007, 2: 277-283. 10.2215\/CJN.02600706.","journal-title":"Clin J Am Soc Nephrol"},{"key":"531_CR39","doi-asserted-by":"publisher","first-page":"S41","DOI":"10.1016\/S1769-7255(11)70008-6","volume":"7","author":"C Couchoud","year":"2011","unstructured":"Couchoud C, Lassalle M, Stengel B, Jacquelinet C: Renal Epidemiology and Information Network: 2009 annual report. Nephrol Ther. 2011, 7: S41-S214.","journal-title":"Nephrol Ther"},{"key":"531_CR40","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1136\/bmj.a1530","volume":"337","author":"E Crowe","year":"2008","unstructured":"Crowe E, Halpin D, Stevens P, on behalf of the Guideline Development Group: Early identification and management of chronic kidney disease: summary of NICE guidance. BMJ. 2008, 337: 812-814. 10.1136\/bmj.a812.","journal-title":"BMJ"},{"key":"531_CR41","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1046\/j.1532-5415.2003.51062.x","volume":"51","author":"C Loos","year":"2003","unstructured":"Loos C, Brian\u00e7on S, Frimat L, Hanesse B, Kessler M: Effect of end-stage renal disease on the quality of life of older patients. J Am Geriatr Soc. 2003, 51: 229-233. 10.1046\/j.1532-5415.2003.51062.x.","journal-title":"J Am Geriatr Soc"},{"key":"531_CR42","doi-asserted-by":"publisher","first-page":"2507","DOI":"10.1001\/jama.2012.6455","volume":"307","author":"BR Hemmelgarn","year":"2012","unstructured":"Hemmelgarn BR, James MT, Manns BJ, O\u2019Hare AM, Muntner P, Ravani P, Quinn RR, Turin TC, Tan Z, Tonelli M, for the Alberta Kidney Disease Network: Rates of treated and untreated kidney failure in older vs younger adults. JAMA. 2012, 307: 2507-2515. 10.1001\/jama.2012.6455.","journal-title":"JAMA"},{"key":"531_CR43","doi-asserted-by":"publisher","first-page":"e28453","DOI":"10.1371\/journal.pone.0028453","volume":"6","author":"S Hiremath","year":"2011","unstructured":"Hiremath S, Knoll G, Weinstein MC: Should the arteriovenous fistula be created before starting dialysis? a decision analytic approach. PLoS One. 2011, 6: e28453-10.1371\/journal.pone.0028453.","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"531_CR44","first-page":"S176","volume":"48","author":"K\/DOQI Workgroup","year":"2006","unstructured":"K\/DOQI Workgroup: Clinical practice guidelines for vascular access. Am J Kidney Dis. 2006, 48 (Suppl 1): S176-S247.","journal-title":"Am J Kidney Dis"},{"issue":"Suppl 2","key":"531_CR45","first-page":"ii88","volume":"22","author":"J Tordoir","year":"2007","unstructured":"Tordoir J, Canaud B, Haage P, Konner K, Basci A, Fouque D, Kooman J, Martin-Malo A, Pedrini L, Pizzarelli F, Tattersall J, Vennegoor M, Wanner C, Wee P, Vanholder R: EBPG on vascular access. Nephrol Dial Transplant. 2007, 22 (Suppl 2): ii88-117.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR46","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1053\/j.ajkd.2011.05.001","volume":"58","author":"K Uhlig","year":"2011","unstructured":"Uhlig K, Boyd C: Guidelines for the older adult with CKD. Am J Kidney Dis. 2011, 58: 162-165. 10.1053\/j.ajkd.2011.05.001.","journal-title":"Am J Kidney Dis"},{"key":"531_CR47","doi-asserted-by":"publisher","first-page":"809","DOI":"10.7326\/0003-4819-153-12-201012210-00007","volume":"153","author":"RM Leipzig","year":"2010","unstructured":"Leipzig RM, Whitlock EP, Wolff TA, Barton MB, Michael YL, Harris R, Petitti D, Wilt T, Siu A, for the U.S. Preventive Services Task Force Geriatric Workgroup: : Reconsidering the approach to prevention recommendations for older adults. Ann Intern Med. 2010, 153: 809-814. 10.7326\/0003-4819-153-12-201012210-00007.","journal-title":"Ann Intern Med"},{"key":"531_CR48","doi-asserted-by":"publisher","first-page":"3083","DOI":"10.1093\/ndt\/gfr515","volume":"26","author":"PJ Roderick","year":"2011","unstructured":"Roderick PJ: Chronic kidney disease in older people: a cause for concern?. Nephrol Dial Transplant. 2011, 26: 3083-3086. 10.1093\/ndt\/gfr515.","journal-title":"Nephrol Dial Transplant"},{"key":"531_CR49","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1053\/j.ajkd.2009.02.013","volume":"53","author":"AM O\u2019Hare","year":"2009","unstructured":"O\u2019Hare AM: The management of older adults with a low eGFR: moving toward an individualized approach. Am J Kidney Dis. 2009, 53: 925-927. 10.1053\/j.ajkd.2009.02.013.","journal-title":"Am J Kidney Dis"},{"key":"531_CR50","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11136-007-9286-1","volume":"17","author":"C Loos-Ayav","year":"2008","unstructured":"Loos-Ayav C, Frimat L, Kessler M, Chanliau J, Durand PY, Brian\u00e7on S: Changes in health-related quality of life in patients of self-care vs. in-center dialysis during the first year. Qual Life Res. 2008, 17: 1-9. 10.1007\/s11136-007-9286-1.","journal-title":"Qual Life Res"},{"key":"531_CR51","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1016\/0895-4356(95)00510-2","volume":"48","author":"J Concato","year":"1995","unstructured":"Concato J, Peduzzi P, Holford TR, Feinstein AR: Importance of events per independent variable in proportional hazards analysis. I. Background, goals, and general strategy. J Clin Epidemiol. 1995, 48: 1495-501. 10.1016\/0895-4356(95)00510-2.","journal-title":"J Clin Epidemiol"},{"key":"531_CR52","doi-asserted-by":"publisher","first-page":"899","DOI":"10.2215\/CJN.05371008","volume":"4","author":"R Botev","year":"2009","unstructured":"Botev R, Malli\u00e9 JP, Couchoud C, Sch\u00fcck O, Fauvel JP, Wetzels JFM, Lee N, De Santo NG, Cirillo M: Estimating glomerular filtration rate: Cockcroft\u2013Gault and Modification of Diet in Renal Disease formulas compared to renal inulin clearance. Clin J Am Soc Nephrol. 2009, 4: 899-906. 10.2215\/CJN.05371008.","journal-title":"Clin J Am Soc Nephrol"},{"key":"531_CR53","doi-asserted-by":"publisher","first-page":"1394","DOI":"10.1093\/gerona\/gls162","volume":"67","author":"O Moranne","year":"2012","unstructured":"Moranne O, Couchoud C, Vigneau C, and PSPA Study Investigators: Characteristics and treatment course of patients older than 75 years, reaching end-stage renal failure in France. The PSPA study. J Gerontol A Biol Aci Med Sci. 2012, 67: 1394-1399. 10.1093\/gerona\/gls162.","journal-title":"J Gerontol A Biol Aci Med Sci"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2369-14-103\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-103","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:47:51Z","timestamp":1630540071000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/1471-2369-14-103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["531"],"URL":"https:\/\/doi.org\/10.1186\/1471-2369-14-103","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]},"assertion":[{"value":"2 November 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 April 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 May 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"103"}}