{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:35:49Z","timestamp":1791275749150,"version":"4.1.0"},"reference-count":11,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T00:00:00Z","timestamp":1375228800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-2369-14-166","type":"journal-article","created":{"date-parts":[[2013,7,31]],"date-time":"2013-07-31T06:14:36Z","timestamp":1375251276000},"source":"Crossref","is-referenced-by-count":41,"title":["A young child with pseudohypoaldosteronism type II by a mutation of Cullin 3"],"prefix":"10.1186","volume":"14","author":[{"given":"Shoji","family":"Tsuji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyoko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gen","family":"Unishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reiko","family":"Takewa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahisa","family":"Kimata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiyoshi","family":"Isobe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoko","family":"Chiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Uchida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunari","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,31]]},"reference":[{"issue":"4","key":"587_CR1","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1111\/imj.1970.19.4.287","volume":"19","author":"RD Gordon","year":"1970","unstructured":"Gordon RD, Geddes RA, Pawsey CG, O'Halloran MW: Hypertension and severe hyperkalaemia associated with suppression of renin and aldosterone and completely reversed by dietary sodium restriction. Australas Ann Med. 1970, 19 (4): 287-294.","journal-title":"Australas Ann Med"},{"issue":"5532","key":"587_CR2","doi-asserted-by":"publisher","first-page":"1107","DOI":"10.1126\/science.1062844","volume":"293","author":"FH Wilson","year":"2001","unstructured":"Wilson FH, Disse-Nicodeme S, Choate KA, Ishikawa K, Nelson-Williams C, Desitter I, Gunel M, Milford DV, Lipkin GW, Achard JM, et al: Human hypertension caused by mutations in WNK kinases. Science. 2001, 293 (5532): 1107-1112. 10.1126\/science.1062844.","journal-title":"Science"},{"issue":"5","key":"587_CR3","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.cmet.2007.03.009","volume":"5","author":"SS Yang","year":"2007","unstructured":"Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin SH, Moriguchi T, Shibuya H, et al: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A\/+) knockin mouse model. Cell Metab. 2007, 5 (5): 331-344. 10.1016\/j.cmet.2007.03.009.","journal-title":"Cell Metab"},{"issue":"7383","key":"587_CR4","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1038\/nature10814","volume":"482","author":"LM Boyden","year":"2012","unstructured":"Boyden LM, Choi M, Choate KA, Nelson-Williams CJ, Farhi A, Toka HR, Tikhonova IR, Bjornson R, Mane SM, Colussi G, et al: Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities. Nature. 2012, 482 (7383): 98-102. 10.1038\/nature10814.","journal-title":"Nature"},{"issue":"4","key":"587_CR5","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/ng.2218","volume":"44","author":"H Louis-Dit-Picard","year":"2012","unstructured":"Louis-Dit-Picard H, Barc J, Trujillano D, Miserey-Lenkei S, Bouatia-Naji N, Pylypenko O, Beaurain G, Bonnefond A, Sand O, Simian C, et al: KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron. Nat Genet. 2012, 44 (4): 456-460. 10.1038\/ng.2218. S451-453","journal-title":"Nat Genet"},{"issue":"3","key":"587_CR6","doi-asserted-by":"publisher","first-page":"858","DOI":"10.1016\/j.celrep.2013.02.024","volume":"3","author":"M Wakabayashi","year":"2013","unstructured":"Wakabayashi M, Mori T, Isobe K, Sohara E, Susa K, Araki Y, Chiga M, Kikuchi E, Nomura N, Mori Y, et al: Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension. Cell Rep. 2013, 3 (3): 858-868. 10.1016\/j.celrep.2013.02.024.","journal-title":"Cell Rep"},{"issue":"1","key":"587_CR7","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1042\/BJ20121903","volume":"451","author":"A Ohta","year":"2013","unstructured":"Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T: The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction. Biochem J. 2013, 451 (1): 111-122. 10.1042\/BJ20121903.","journal-title":"Biochem J"},{"issue":"19","key":"587_CR8","doi-asserted-by":"publisher","first-page":"7838","DOI":"10.1073\/pnas.1304592110","volume":"110","author":"S Shibata","year":"2013","unstructured":"Shibata S, Zhang J, Puthumana J, Stone KL, Lifton RP: Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4. Proc Natl Acad Sci USA. 2013, 110 (19): 7838-7843. 10.1073\/pnas.1304592110.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"7","key":"587_CR9","doi-asserted-by":"publisher","first-page":"3248","DOI":"10.1210\/jcem.87.7.8449","volume":"87","author":"H Mayan","year":"2002","unstructured":"Mayan H, Vered I, Mouallem M, Tzadok-Witkon M, Pauzner R, Farfel Z: Pseudohypoaldosteronism type II: marked sensitivity to thiazides, hypercalciuria, normomagnesemia, and low bone mineral density. J Clin Endocrinol Metab. 2002, 87 (7): 3248-3254. 10.1210\/jc.87.7.3248.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"587_CR10","doi-asserted-by":"publisher","first-page":"4025","DOI":"10.1210\/jc.2004-0037","volume":"89","author":"H Mayan","year":"2004","unstructured":"Mayan H, Munter G, Shaharabany M, Mouallem M, Pauzner R, Holtzman EJ, Farfel Z: Hypercalciuria in familial hyperkalemia and hypertension accompanies hyperkalemia and precedes hypertension: description of a large family with the Q565E WNK4 mutation. J Clin Endocrinol Metab. 2004, 89 (8): 4025-4030. 10.1210\/jc.2004-0037.","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"587_CR11","doi-asserted-by":"publisher","first-page":"3010","DOI":"10.1210\/jc.2008-2572","volume":"94","author":"H Mayan","year":"2009","unstructured":"Mayan H, Melnikov S, Novikov I, Holtzman EJ, Farfel Z: Familial hyperkalemia and hypertension: pathogenetic insights based on lithium clearance. J Clin Endocrinol Metab. 2009, 94 (8): 3010-3016. 10.1210\/jc.2008-2572.","journal-title":"J Clin Endocrinol Metab"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2369-14-166\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-14-166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T23:00:28Z","timestamp":1548198028000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/1471-2369-14-166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,31]]},"references-count":11,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["587"],"URL":"https:\/\/doi.org\/10.1186\/1471-2369-14-166","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,31]]},"article-number":"166"}}