{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:12:59Z","timestamp":1790280779057,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T00:00:00Z","timestamp":1402272000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Nephrol"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2369-15-87","type":"journal-article","created":{"date-parts":[[2014,6,9]],"date-time":"2014-06-09T23:01:41Z","timestamp":1402354901000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease"],"prefix":"10.1186","volume":"15","author":[{"given":"Ruben","family":"Poesen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth","family":"Viaene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Verbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Augustijns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"Bammens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Kuypers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Evenepoel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Meijers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,9]]},"reference":[{"key":"781_CR1","doi-asserted-by":"publisher","first-page":"593","DOI":"10.1097\/MNH.0b013e32834b8a1d","volume":"20","author":"EP Rhee","year":"2011","unstructured":"Rhee EP, Thadhani R: New insights into uremia-induced alterations in metabolic pathways. Curr Opin Nephrol Hypertens. 2011, 20: 593-598. 10.1097\/MNH.0b013e32834b8a1d.","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"781_CR2","doi-asserted-by":"publisher","first-page":"1769","DOI":"10.1681\/ASN.2010121220","volume":"22","author":"PA Aronov","year":"2011","unstructured":"Aronov PA, Luo FJ, Plummer NS, Quan Z, Holmes S, Hostetter TH, Meyer TW: Colonic contribution to uremic solutes. J Am Soc Nephrol. 2011, 22: 1769-1776. 10.1681\/ASN.2010121220.","journal-title":"J Am Soc Nephrol"},{"key":"781_CR3","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.2215\/CJN.07971109","volume":"5","author":"BK Meijers","year":"2010","unstructured":"Meijers BK, Claes K, Bammens B, de Loor H, Viaene L, Verbeke K, Kuypers D, Vanrenterghem Y, Evenepoel P: p-Cresol and cardiovascular risk in mild-to-moderate kidney disease. Clin J Am Soc Nephrol. 2010, 5: 1182-1189. 10.2215\/CJN.07971109.","journal-title":"Clin J Am Soc Nephrol"},{"key":"781_CR4","doi-asserted-by":"publisher","first-page":"1174","DOI":"10.1038\/ki.2008.31","volume":"73","author":"BK Meijers","year":"2008","unstructured":"Meijers BK, Bammens B, De Moor B, Verbeke K, Vanrenterghem Y, Evenepoel P: Free p-cresol is associated with cardiovascular disease in hemodialysis patients. Kidney Int. 2008, 73: 1174-1180. 10.1038\/ki.2008.31.","journal-title":"Kidney Int"},{"key":"781_CR5","first-page":"2013","volume":"2013","author":"T Shafi","year":"2013","unstructured":"Shafi T, Meyer TW, Hostetter TH, Melamed ML, Liu Y, Banerjee T, Powe NR: Serum Levels of Free Retained Organic Solutes and Outcomes in Hemodialysis Patients [Abstract]. ASN Kidney Week. 2013, 2013: 2013-","journal-title":"ASN Kidney Week"},{"key":"781_CR6","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1038\/sj.ki.5000115","volume":"69","author":"B Bammens","year":"2006","unstructured":"Bammens B, Evenepoel P, Keuleers H, Verbeke K, Vanrenterghem Y: Free serum concentrations of the protein-bound retention solute p-cresol predict mortality in hemodialysis patients. Kidney Int. 2006, 69: 1081-1087. 10.1038\/sj.ki.5000115.","journal-title":"Kidney Int"},{"key":"781_CR7","doi-asserted-by":"publisher","first-page":"1183","DOI":"10.1093\/ndt\/gfp592","volume":"25","author":"S Liabeuf","year":"2010","unstructured":"Liabeuf S, Barreto DV, Barreto FC, Meert N, Glorieux G, Schepers E, Temmar M, Choukroun G, Vanholder R, Massy ZA: Free p-cresylsulphate is a predictor of mortality in patients at different stages of chronic kidney disease. Nephrol Dial Transplant. 2010, 25: 1183-1191. 10.1093\/ndt\/gfp592.","journal-title":"Nephrol Dial Transplant"},{"key":"781_CR8","doi-asserted-by":"publisher","first-page":"938","DOI":"10.1093\/ndt\/gfq580","volume":"26","author":"IW Wu","year":"2011","unstructured":"Wu IW, Hsu KH, Lee CC, Sun CY, Hsu HJ, Tsai CJ, Tzen CY, Wang YC, Lin CY, Wu MS: p-Cresyl sulphate and indoxyl sulphate predict progression of chronic kidney disease. Nephrol Dial Transplant. 2011, 26: 938-947. 10.1093\/ndt\/gfq580.","journal-title":"Nephrol Dial Transplant"},{"key":"781_CR9","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1038\/ki.2011.504","volume":"81","author":"TW Meyer","year":"2012","unstructured":"Meyer TW, Hostetter TH: Uremic solutes from colon microbes. Kidney Int. 2012, 81: 949-954. 10.1038\/ki.2011.504.","journal-title":"Kidney Int"},{"key":"781_CR10","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1111\/j.1523-1755.2004.00354.x","volume":"65","author":"T Deguchi","year":"2004","unstructured":"Deguchi T, Kusuhara H, Takadate A, Endou H, Otagiri M, Sugiyama Y: Characterization of uremic toxin transport by organic anion transporters in the kidney. Kidney Int. 2004, 65: 162-174. 10.1111\/j.1523-1755.2004.00354.x.","journal-title":"Kidney Int"},{"key":"781_CR11","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.2215\/CJN.09981110","volume":"6","author":"S Eloot","year":"2011","unstructured":"Eloot S, Schepers E, Barreto DV, Barreto FC, Liabeuf S, Van Biesen W, Verbeke F, Glorieux G, Choukroun G, Massy Z, Vanholder R: Estimated glomerular filtration rate is a poor predictor of concentration for a broad range of uremic toxins. Clin J Am Soc Nephrol. 2011, 6: 1266-1273. 10.2215\/CJN.09981110.","journal-title":"Clin J Am Soc Nephrol"},{"key":"781_CR12","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.2215\/CJN.00300113","volume":"8","author":"R Poesen","year":"2013","unstructured":"Poesen R, Viaene L, Verbeke K, Claes K, Bammens B, Sprangers B, Naesens M, Vanrenterghem Y, Kuypers D, Evenepoel P, Meijers B: Renal Clearance and Intestinal Generation of p-Cresyl Sulfate and Indoxyl Sulfate in CKD. Clin J Am Soc Nephrol. 2013, 8: 1508-1514. 10.2215\/CJN.00300113.","journal-title":"Clin J Am Soc Nephrol"},{"key":"781_CR13","doi-asserted-by":"publisher","first-page":"604","DOI":"10.7326\/0003-4819-150-9-200905050-00006","volume":"150","author":"AS Levey","year":"2009","unstructured":"Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF, Feldman HI, Kusek JW, Eggers P, Van LF, Greene T, Coresh J: A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009, 150: 604-612. 10.7326\/0003-4819-150-9-200905050-00006.","journal-title":"Ann Intern Med"},{"key":"781_CR14","doi-asserted-by":"publisher","first-page":"4684","DOI":"10.1016\/j.chroma.2009.04.015","volume":"1216","author":"H de Loor","year":"2009","unstructured":"de Loor H, Meijers BK, Meyer TW, Bammens B, Verbeke K, Dehaen W, Evenepoel P: Sodium octanoate to reverse indoxyl sulfate and p-cresyl sulfate albumin binding in uremic and normal serum during sample preparation followed by fluorescence liquid chromatography. J Chromatogr A. 2009, 1216: 4684-4688. 10.1016\/j.chroma.2009.04.015.","journal-title":"J Chromatogr A"},{"key":"781_CR15","doi-asserted-by":"crossref","unstructured":"Intersalt: an international study of electrolyte excretion and blood pressure. Results for 24 hour urinary sodium and potassium excretion. Intersalt Cooperative Research Group. BMJ. 1988, 297: 319-328.","DOI":"10.1136\/bmj.297.6644.319"},{"key":"781_CR16","doi-asserted-by":"publisher","first-page":"1750","DOI":"10.1046\/j.1523-1755.2002.00606.x","volume":"62","author":"T Masud","year":"2002","unstructured":"Masud T, Manatunga A, Cotsonis G, Mitch WE: The precision of estimating protein intake of patients with chronic renal failure. Kidney Int. 2002, 62: 1750-1756. 10.1046\/j.1523-1755.2002.00606.x.","journal-title":"Kidney Int"},{"key":"781_CR17","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1038\/ki.1985.10","volume":"27","author":"BJ Maroni","year":"1985","unstructured":"Maroni BJ, Steinman TI, Mitch WE: A method for estimating nitrogen intake of patients with chronic renal failure. Kidney Int. 1985, 27: 58-65. 10.1038\/ki.1985.10.","journal-title":"Kidney Int"},{"key":"781_CR18","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1093\/ndt\/gfq818","volume":"26","author":"BK Meijers","year":"2011","unstructured":"Meijers BK, Evenepoel P: The gut-kidney axis: indoxyl sulfate, p-cresyl sulfate and CKD progression. Nephrol Dial Transplant. 2011, 26: 759-761. 10.1093\/ndt\/gfq818.","journal-title":"Nephrol Dial Transplant"},{"key":"781_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1681\/ASN.2012050503","volume":"24","author":"L Koppe","year":"2013","unstructured":"Koppe L, Pillon NJ, Vella RE, Croze ML, Pelletier CC, Chambert S, Massy Z, Glorieux G, Vanholder R, Dugenet Y, Soula HA, Fouque D, Soulage CO: p-Cresyl sulfate promotes insulin resistance associated with CKD. J Am Soc Nephrol. 2013, 24: 88-99. 10.1681\/ASN.2012050503.","journal-title":"J Am Soc Nephrol"},{"key":"781_CR20","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1093\/ajcn\/63.5.766","volume":"63","author":"A Birkett","year":"1996","unstructured":"Birkett A, Muir J, Phillips J, Jones G, O\u2019Dea K: Resistant starch lowers fecal concentrations of ammonia and phenols in humans. Am J Clin Nutr. 1996, 63: 766-772.","journal-title":"Am J Clin Nutr"},{"key":"781_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1111\/j.1365-2672.1996.tb04331.x","volume":"81","author":"EA Smith","year":"1996","unstructured":"Smith EA, Macfarlane GT: Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J Appl Bacteriol. 1996, 81: 288-302. 10.1111\/j.1365-2672.1996.tb04331.x.","journal-title":"J Appl Bacteriol"},{"key":"781_CR22","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1136\/gut.41.1.70","volume":"41","author":"B Geypens","year":"1997","unstructured":"Geypens B, Claus D, Evenepoel P, Hiele M, Maes B, Peeters M, Rutgeerts P, Ghoos Y: Influence of dietary protein supplements on the formation of bacterial metabolites in the colon. Gut. 1997, 41: 70-76. 10.1136\/gut.41.1.70.","journal-title":"Gut"},{"key":"781_CR23","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1038\/ki.2012.345","volume":"83","author":"ND Vaziri","year":"2013","unstructured":"Vaziri ND, Wong J, Pahl M, Piceno YM, Yuan J, Desantis TZ, Ni Z, Nguyen TH, Andersen GL: Chronic kidney disease alters intestinal microbial flora. Kidney Int. 2013, 83: 308-315. 10.1038\/ki.2012.345.","journal-title":"Kidney Int"}],"container-title":["BMC Nephrology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-15-87.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2369-15-87\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-15-87","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2369-15-87.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T04:21:17Z","timestamp":1630556477000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcnephrol.biomedcentral.com\/articles\/10.1186\/1471-2369-15-87"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,9]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["781"],"URL":"https:\/\/doi.org\/10.1186\/1471-2369-15-87","relation":{},"ISSN":["1471-2369"],"issn-type":[{"value":"1471-2369","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,9]]},"assertion":[{"value":"5 December 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 June 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"87"}}