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The enzyme is encoded by the polymorphic gene <jats:italic>PON1<\/jats:italic>, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous <jats:italic>PON1<\/jats:italic> polymorphisms and the risk of developing astrocytoma and meningioma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Seventy one consecutive patients with brain tumors (43 with astrocytoma grade II\/III and 28 with meningioma) with ages ranging 21 to 76 years, and 220 healthy controls subjects were analyzed for the frequency of the nonsynonymous <jats:italic>PON1<\/jats:italic> genotypes L55M rs854560 and Q192R rs662. All participants were adult Caucasian individuals recruited in the central area of Spain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The frequencies of the <jats:italic>PON1<\/jats:italic> genotypes and allelic variants of the polymorphisms <jats:italic>PON1<\/jats:italic> L55M and <jats:italic>PON1<\/jats:italic> Q192R did not differ significantly between patients with astrocytoma and meningioma and controls. The minor allele frequencies were as follows: <jats:italic>PON1<\/jats:italic> 55L, 0.398, 0.328 and 0.286 for patients with astrocytoma, meningioma and control individuals, respectively; <jats:italic>PON1<\/jats:italic> 192R, 0.341, 0.362 and 0.302 for patients with astrocytoma, meningioma and control individuals, respectively. Correction for age, gender, or education, made no difference in odds ratios and the <jats:italic>p<\/jats:italic> values remained non-significant. Haplotype association analyses did not identify any significant association with the risk of developing astrocytoma or meningioma.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Common nonsynonymous <jats:italic>PON1<\/jats:italic> polymorphisms are not related with the risk of developing astrocytoma and meningioma.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2377-10-71","type":"journal-article","created":{"date-parts":[[2010,8,19]],"date-time":"2010-08-19T20:15:48Z","timestamp":1282248948000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma"],"prefix":"10.1186","volume":"10","author":[{"given":"Carmen","family":"Mart\u00ednez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hortensia","family":"Alonso-Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix J","family":"Jim\u00e9nez-Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 AG","family":"Ag\u00fandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Garc\u00eda-Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,19]]},"reference":[{"issue":"2","key":"352_CR1","doi-asserted-by":"publisher","first-page":"74","DOI":"10.3322\/canjclin.55.2.74","volume":"55","author":"DM Parkin","year":"2005","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P: Global cancer statistics, 2002. 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