{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T00:28:52Z","timestamp":1793665732925,"version":"4.5.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,8,28]],"date-time":"2010-08-28T00:00:00Z","timestamp":1282953600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Type 2 Diabetes Mellitus (T2DM) and diabetic symmetrical polyneuropathy (DSP) impact multiple modalities of sensation including light touch, temperature, position sense and vibration perception. No study to date has examined the mechanosensitivity of peripheral nerves during limb movement in this population. The objective was to determine the unique effects T2DM and DSP have on nerve mechanosensitivity in the lower extremity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross-sectional study included 43 people with T2DM. Straight leg raise neurodynamic tests were performed with ankle plantar flexion (PF\/SLR) and dorsiflexion (DF\/SLR). Hip flexion range of motion (ROM), lower extremity muscle activity and symptom profile, intensity and location were measured at rest, first onset of symptoms (P1) and maximally tolerated symptoms (P2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The addition of ankle dorsiflexion during SLR testing reduced the hip flexion ROM by 4.3\u00b0 \u00b1 6.5\u00b0 at P1 and by 5.4\u00b0 \u00b1 4.9\u00b0 at P2. Individuals in the T2DM group with signs of severe DSP (n = 9) had no difference in hip flexion ROM between PF\/SLR and DF\/SLR at P1 (1.4\u00b0 \u00b1 4.2\u00b0; paired t-test p = 0.34) or P2 (0.9\u00b0 \u00b1 2.5\u00b0; paired t-test p = 0.31). Movement induced muscle activity was absent during SLR with the exception of the tibialis anterior during DF\/SLR testing. Increases in symptom intensity during SLR testing were similar for both PF\/SLR and DF\/SLR. The addition of ankle dorsiflexion induced more frequent posterior leg symptoms when taken to P2.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Consistent with previous recommendations in the literature, P1 is an appropriate test end point for SLR neurodynamic testing in people with T2DM. However, our findings suggest that people with T2DM and severe DSP have limited responses to SLR neurodynamic testing, and thus may be at risk for harm from nerve overstretch and the information gathered will be of limited clinical value.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2377-10-75","type":"journal-article","created":{"date-parts":[[2010,8,31]],"date-time":"2010-08-31T06:13:55Z","timestamp":1283235235000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Mechanosensitivity during lower extremity neurodynamic testing is diminished in individuals with Type 2 Diabetes Mellitus and peripheral neuropathy: a cross sectional study"],"prefix":"10.1186","volume":"10","author":[{"given":"Benjamin S","family":"Boyd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Wanek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly S","family":"Topp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,8,28]]},"reference":[{"key":"356_CR1","doi-asserted-by":"publisher","first-page":"1973","DOI":"10.1007\/s001250100001","volume":"44","author":"NE Cameron","year":"2001","unstructured":"Cameron NE, Eaton SE, Cotter MA, Tesfaye S: Vascular factors and metabolic interactions in the pathogenesis of diabetic neuropathy. Diabetologia. 2001, 44: 1973-1988. 10.1007\/s001250100001.","journal-title":"Diabetologia"},{"key":"356_CR2","volume-title":"National diabetes fact sheet: general information and national estimates on diabetes in the United States","author":"Centers for Disease Control and Prevention","year":"2005","unstructured":"Centers for Disease Control and Prevention: National diabetes fact sheet: general information and national estimates on diabetes in the United States. 2005, Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, [http:\/\/www.cdc.gov\/diabetes\/pubs\/factsheet05.htm]"},{"key":"356_CR3","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1097\/01.nrl.0000144733.61110.25","volume":"10","author":"C Gooch","year":"2004","unstructured":"Gooch C, Podwall D: The diabetic neuropathies. Neurologist. 2004, 10: 311-322. 10.1097\/01.nrl.0000144733.61110.25.","journal-title":"Neurologist"},{"key":"356_CR4","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1038\/ncpendmet0046","volume":"1","author":"PH Groop","year":"2005","unstructured":"Groop PH, Forsblom C, Thomas MC: Mechanisms of disease: Pathway-selective insulin resistance and microvascular complications of diabetes. Nat Clin Pract Endocrinol Metab. 2005, 1: 100-110. 10.1038\/ncpendmet0046.","journal-title":"Nat Clin Pract Endocrinol Metab"},{"key":"356_CR5","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1136\/pgmj.2005.036137","volume":"82","author":"V Bansal","year":"2006","unstructured":"Bansal V, Kalita J, Misra UK: Diabetic neuropathy. Postgrad Med J. 2006, 82: 95-100. 10.1136\/pgmj.2005.036137.","journal-title":"Postgrad Med J"},{"key":"356_CR6","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1302\/0301-620X.87B12.16710","volume":"87","author":"HM Rathur","year":"2005","unstructured":"Rathur HM, Boulton AJ: Recent advances in the diagnosis and management of diabetic neuropathy. J Bone Joint Surg Br. 2005, 87: 1605-1610. 10.1302\/0301-620X.87B12.16710.","journal-title":"J Bone Joint Surg Br"},{"key":"356_CR7","unstructured":"Peripheral neuropathy. 2005, Philadelphia: Saunders, 4"},{"key":"356_CR8","doi-asserted-by":"crossref","unstructured":"Harrison's Principles of Internal Medicine. 2006, McGraw Hill, 16","DOI":"10.1016\/S1097-8690(05)71780-7"},{"key":"356_CR9","doi-asserted-by":"publisher","first-page":"411","DOI":"10.1002\/dmrr.657","volume":"22","author":"AP Garrow","year":"2006","unstructured":"Garrow AP, Boulton AJ: Vibration perception threshold--a valuable assessment of neural dysfunction in people with diabetes. Diabetes Metab Res Rev. 2006, 22: 411-419. 10.1002\/dmrr.657.","journal-title":"Diabetes Metab Res Rev"},{"key":"356_CR10","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1046\/j.1464-5491.2003.00931.x","volume":"20","author":"M Rahman","year":"2003","unstructured":"Rahman M, Griffin SJ, Rathmann W, Wareham NJ: How should peripheral neuropathy be assessed in people with diabetes in primary care? A population-based comparison of four measures. Diabet Med. 2003, 20: 368-374. 10.1046\/j.1464-5491.2003.00931.x.","journal-title":"Diabet Med"},{"key":"356_CR11","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ptsp.2005.10.002","volume":"7","author":"R Nee","year":"2006","unstructured":"Nee R, Butler DS: Management of peripheral neuropathic pain: Integrating neurobiology, neurodynamics, and clinical evidence. Phys Ther Sport. 2006, 7: 36-49. 10.1016\/j.ptsp.2005.10.002.","journal-title":"Phys Ther Sport"},{"key":"356_CR12","doi-asserted-by":"publisher","first-page":"780","DOI":"10.2519\/jospt.2009.3002","volume":"39","author":"BS Boyd","year":"2009","unstructured":"Boyd BS, Wanek L, Gray AT, Topp KS: Mechanosensitivity of the lower extremity nervous system during straight leg raise neurodynamic testing in healthy individuals. J Ortho Sports Phys Ther. 2009, 39: 780-790.","journal-title":"J Ortho Sports Phys Ther"},{"key":"356_CR13","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.math.2004.07.007","volume":"10","author":"M Coppieters","year":"2005","unstructured":"Coppieters M, Kurz K, Mortensen T, Richards N, Skaret I, McLaughlin L, Hodges P: The impact of neurodynamic testing on the perception of experimentally induced muscle pain. Man Ther. 2005, 10: 52-60. 10.1016\/j.math.2004.07.007.","journal-title":"Man Ther"},{"key":"356_CR14","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1186\/1471-2474-10-11","volume":"10","author":"AB Schmid","year":"2009","unstructured":"Schmid AB, Brunner F, Luomajoki H, Held U, Bachmann LM, Kunzer S, Coppieters MW: Reliability of clinical tests to evaluate nerve function and mechanosensitivity of the upper limb peripheral nervous system. BMC Musculoskelet Disord. 2009, 10: 11-10.1186\/1471-2474-10-11.","journal-title":"BMC Musculoskelet Disord"},{"key":"356_CR15","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0004-9514(14)60328-7","volume":"46","author":"R Boland","year":"2000","unstructured":"Boland R, Adams R: Effects of ankle dorsiflexion on range and reliability of straight leg raising. Austral Journal of Physiotherapy. 2000, 46: 191-200.","journal-title":"Austral Journal of Physiotherapy"},{"key":"356_CR16","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1093\/ptj\/65.10.1478","volume":"65","author":"RL Gajdosik","year":"1985","unstructured":"Gajdosik RL, LeVeau BF, Bohannon RW: Effects of ankle dorsiflexion on active and passive unilateral straight leg raising. Phys Ther. 1985, 65: 1478-1482.","journal-title":"Phys Ther"},{"key":"356_CR17","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1356-689X(98)80004-0","volume":"3","author":"T Hall","year":"1998","unstructured":"Hall T, Zusman M, Elvey R: Adverse mechanical tension in the nervous system? Analysis of straight leg raise. Man Ther. 1998, 3: 140-146. 10.1016\/S1356-689X(98)80004-0.","journal-title":"Man Ther"},{"key":"356_CR18","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1054\/math.2001.0406","volume":"6","author":"B van der Heide","year":"2001","unstructured":"van der Heide B, Allison GT, Zusman M: Pain and muscular responses to a neural tissue provocation test in the upper limb. Man Ther. 2001, 6: 154-162. 10.1054\/math.2001.0406.","journal-title":"Man Ther"},{"key":"356_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1067\/mmt.2003.16","volume":"26","author":"MW Coppieters","year":"2003","unstructured":"Coppieters MW, Stappaerts KH, Wouters LL, Janssens K: Aberrant protective force generation during neural provocation testing and the effect of treatment in patients with neurogenic cervicobrachial pain. J Manipulative Physiol Ther. 2003, 26: 99-106. 10.1067\/mmt.2003.16.","journal-title":"J Manipulative Physiol Ther"},{"key":"356_CR20","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1097\/00000542-200207000-00011","volume":"97","author":"MW Coppieters","year":"2002","unstructured":"Coppieters MW, VanDeVelde M, Stappaerts KH: Positioning in anesthesiology: Toward a better understanding of stretch-induced perioperative neuropathies. Anesthesiology. 2002, 97: 75-81. 10.1097\/00000542-200207000-00011.","journal-title":"Anesthesiology"},{"key":"356_CR21","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.jvn.2005.06.004","volume":"23","author":"DC Zelman","year":"2005","unstructured":"Zelman DC, Gore M, Dukes E, Tai KS, Brandenburg N: Validation of a modified version of the Brief Pain Inventory for painful diabetic peripheral neuropathy. J Vasc Nurs. 2005, 23: 97-104. 10.1016\/j.jvn.2005.06.004.","journal-title":"J Vasc Nurs"},{"key":"356_CR22","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.2337\/diacare.17.11.1281","volume":"17","author":"EL Feldman","year":"1994","unstructured":"Feldman EL, Stevens MJ, Thomas PK, Brown MB, Canal N, Greene DA: A practical two-step quantitative clinical and electrophysiological assessment for the diagnosis and staging of diabetic neuropathy. Diabetes Care. 1994, 17: 1281-1289. 10.2337\/diacare.17.11.1281.","journal-title":"Diabetes Care"},{"key":"356_CR23","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1093\/ije\/24.2.381","volume":"24","author":"MA Pols","year":"1995","unstructured":"Pols MA, Peeters PH, Bueno-De-Mesquita HB, Ocke MC, Wentink CA, Kemper HC, Collette HJ: Validity and repeatability of a modified Baecke questionnaire on physical activity. Int J Epidemiol. 1995, 24: 381-388. 10.1093\/ije\/24.2.381.","journal-title":"Int J Epidemiol"},{"key":"356_CR24","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/S0003-9993(96)90033-7","volume":"77","author":"GG Simoneau","year":"1996","unstructured":"Simoneau GG, Derr JA, Ulbrecht JS, Becker MB, Cavanagh PR: Diabetic sensory neuropathy effect on ankle joint movement perception. Arch Phys Med Rehabil. 1996, 77: 453-460. 10.1016\/S0003-9993(96)90033-7.","journal-title":"Arch Phys Med Rehabil"},{"key":"356_CR25","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1046\/j.1464-5491.2001.00503.x","volume":"18","author":"RW van Deursen","year":"2001","unstructured":"van Deursen RW, Sanchez MM, Derr JA, Becker MB, Ulbrecht JS, Cavanagh PR: Vibration perception threshold testing in patients with diabetic neuropathy: ceiling effects and reliability. Diabet Med. 2001, 18: 469-475. 10.1046\/j.1464-5491.2001.00503.x.","journal-title":"Diabet Med"},{"key":"356_CR26","doi-asserted-by":"publisher","first-page":"836","DOI":"10.2337\/diacare.20.5.836","volume":"20","author":"D Fedele","year":"1997","unstructured":"Fedele D, Comi G, Coscelli C, Cucinotta D, Feldman EL, Ghirlanda G, Greene DA, Negrin P, Santeusanio F: A multicenter study on the prevalence of diabetic neuropathy in Italy. Italian Diabetic Neuropathy Committee. Diabetes Care. 1997, 20: 836-843. 10.2337\/diacare.20.5.836.","journal-title":"Diabetes Care"},{"key":"356_CR27","doi-asserted-by":"publisher","first-page":"S3","DOI":"10.1017\/S0317167100040671","volume":"21","author":"EL Feldman","year":"1994","unstructured":"Feldman EL, Stevens MJ: Clinical testing in diabetic peripheral neuropathy. Can J Neurol Sci. 1994, 21: S3-7.","journal-title":"Can J Neurol Sci"},{"key":"356_CR28","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/S1050-6411(00)00027-4","volume":"10","author":"HJ Hermens","year":"2000","unstructured":"Hermens HJ, Freriks B, Disselhorst-Klug C, Rau G: Development of recommendations for SEMG sensors and sensor placement procedures. J Electromyogr Kinesiol. 2000, 10: 361-374. 10.1016\/S1050-6411(00)00027-4.","journal-title":"J Electromyogr Kinesiol"},{"key":"356_CR29","first-page":"156","volume":"33","author":"TW Worrell","year":"1998","unstructured":"Worrell TW, Crisp E, Larosa C: Electromyographic Reliability and Analysis of Selected Lower Extremity Muscles During Lateral Step-Up Conditions. J Athl Train. 1998, 33: 156-162.","journal-title":"J Athl Train"},{"key":"356_CR30","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.jelekin.2003.11.001","volume":"14","author":"SJ Shultz","year":"2004","unstructured":"Shultz SJ, Carcia CR, Perrin DH: Knee joint laxity affects muscle activation patterns in the healthy knee. J Electromyogr Kinesiol. 2004, 14: 475-483. 10.1016\/j.jelekin.2003.11.001.","journal-title":"J Electromyogr Kinesiol"},{"key":"356_CR31","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/j.clineuro.2005.08.003","volume":"108","author":"A Moghtaderi","year":"2006","unstructured":"Moghtaderi A, Bakhshipour A, Rashidi H: Validation of Michigan neuropathy screening instrument for diabetic peripheral neuropathy. Clin Neurol Neurosurg. 2006, 108: 477-481. 10.1016\/j.clineuro.2005.08.003.","journal-title":"Clin Neurol Neurosurg"},{"key":"356_CR32","doi-asserted-by":"publisher","first-page":"330","DOI":"10.1016\/j.tvjl.2006.07.005","volume":"174","author":"CS Babbage","year":"2007","unstructured":"Babbage CS, Coppieters MW, McGowan CM: Strain and excursion of the sciatic nerve in the dog: biomechanical considerations in the development of a clinical test for increased neural mechanosensitivity. Vet J. 2007, 174: 330-336. 10.1016\/j.tvjl.2006.07.005.","journal-title":"Vet J"},{"key":"356_CR33","doi-asserted-by":"publisher","first-page":"764","DOI":"10.1016\/j.orthres.2004.11.008","volume":"23","author":"BS Boyd","year":"2005","unstructured":"Boyd BS, Puttlitz C, Gan J, Topp KS: Strain and excursion in the rat sciatic nerve during a modified straight leg raise are altered after traumatic nerve injury. J Orthop Res. 2005, 23: 764-770. 10.1016\/j.orthres.2004.11.008.","journal-title":"J Orthop Res"},{"key":"356_CR34","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1002\/jor.20210","volume":"24","author":"MW Coppieters","year":"2006","unstructured":"Coppieters MW, Alshami AM, Babri AS, Souvlis T, Kippers V, Hodges PW: Strain and excursion of the sciatic, tibial, and plantar nerves during a modified straight leg raising test. J Orthop Res. 2006, 24: 1883-1889. 10.1002\/jor.20210.","journal-title":"J Orthop Res"},{"key":"356_CR35","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0966-6362(02)00166-2","volume":"18","author":"OY Kwon","year":"2003","unstructured":"Kwon OY, Minor SD, Maluf KS, Mueller MJ: Comparison of muscle activity during walking in subjects with and without diabetic neuropathy. Gait Posture. 2003, 18: 105-113. 10.1016\/S0966-6362(02)00166-2.","journal-title":"Gait Posture"},{"key":"356_CR36","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1186\/1471-2474-9-99","volume":"9","author":"C Giacomozzi","year":"2008","unstructured":"Giacomozzi C, D'Ambrogi E, Cesinaro S, Macellari V, Uccioli L: Muscle performance and ankle joint mobility in long-term patients with diabetes. BMC Musculoskelet Disord. 2008, 9: 99-10.1186\/1471-2474-9-99.","journal-title":"BMC Musculoskelet Disord"},{"key":"356_CR37","first-page":"17","volume":"6","author":"AO Sanya","year":"1999","unstructured":"Sanya AO, Obi CS: Range of motion in selected joints of diabetic and non-diabetic subjects. Afr J Health Sci. 1999, 6: 17-21.","journal-title":"Afr J Health Sci"},{"key":"356_CR38","doi-asserted-by":"publisher","first-page":"928","DOI":"10.1097\/00005768-199806000-00023","volume":"30","author":"MP McHugh","year":"1998","unstructured":"McHugh MP, Kremenic IJ, Fox MB, Gleim GW: The role of mechanical and neural restraints to joint range of motion during passive stretch. Med Sci Sports Exerc. 1998, 30: 928-932. 10.1097\/00005768-199806000-00023.","journal-title":"Med Sci Sports Exerc"},{"key":"356_CR39","first-page":"959","volume":"72","author":"LN Goeken","year":"1991","unstructured":"Goeken LN, Hof AL: Instrumental straight-leg raising: a new approach to Lasegue's test. Arch Phys Med Rehabil. 1991, 72: 959-966.","journal-title":"Arch Phys Med Rehabil"},{"key":"356_CR40","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1097\/01.brs.0000164099.92112.29","volume":"30","author":"JD Childs","year":"2005","unstructured":"Childs JD, Piva SR, Fritz JM: Responsiveness of the numeric pain rating scale in patients with low back pain. Spine. 2005, 30: 1331-1334. 10.1097\/01.brs.0000164099.92112.29.","journal-title":"Spine"},{"key":"356_CR41","doi-asserted-by":"publisher","first-page":"e1000047","DOI":"10.1371\/journal.pmed.1000047","volume":"6","author":"J Scholz","year":"2009","unstructured":"Scholz J, Mannion RJ, Hord DE, Griffin RS, Rawal B, Zheng H, Scoffings D, Phillips A, Guo J, Laing RJ, et al: A novel tool for the assessment of pain: validation in low back pain. PLoS Med. 2009, 6: e1000047-10.1371\/journal.pmed.1000047.","journal-title":"PLoS Med"},{"key":"356_CR42","doi-asserted-by":"publisher","first-page":"11287","DOI":"10.1523\/JNEUROSCI.2659-06.2006","volume":"26","author":"K Orstavik","year":"2006","unstructured":"Orstavik K, Namer B, Schmidt R, Schmelz M, Hilliges M, Weidner C, Carr RW, Handwerker H, Jorum E, Torebjork HE: Abnormal function of C-fibers in patients with diabetic neuropathy. J Neurosci. 2006, 26: 11287-11294. 10.1523\/JNEUROSCI.2659-06.2006.","journal-title":"J Neurosci"},{"key":"356_CR43","doi-asserted-by":"publisher","first-page":"246","DOI":"10.2519\/jospt.2005.35.4.246","volume":"35","author":"JW Youdas","year":"2005","unstructured":"Youdas JW, Krause DA, Hollman JH, Harmsen WS, Laskowski E: The influence of gender and age on hamstring muscle length in healthy adults. J Orthop Sports Phys Ther. 2005, 35: 246-252.","journal-title":"J Orthop Sports Phys Ther"},{"key":"356_CR44","doi-asserted-by":"publisher","first-page":"E388","DOI":"10.1097\/00007632-200209010-00025","volume":"27","author":"R Rebain","year":"2002","unstructured":"Rebain R, Baxter GD, McDonough S: A systematic review of the passive straight leg raising test as a diagnostic aid for low back pain (1989 to 2000). Spine. 2002, 27: E388-395. 10.1097\/00007632-200209010-00025.","journal-title":"Spine"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-10-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2377-10-75\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-10-75","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-10-75.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T17:32:13Z","timestamp":1636306333000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/1471-2377-10-75"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8,28]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["356"],"URL":"https:\/\/doi.org\/10.1186\/1471-2377-10-75","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8,28]]},"assertion":[{"value":"21 November 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 August 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"75"}}