{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:51:34Z","timestamp":1788025894231,"version":"build-2784847793"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T00:00:00Z","timestamp":1383696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Prospective observation of hemodynamic changes before and after formation of brain aneurysms is often difficult. We used a vessel surface repair method to carry out a retrospective hemodynamic study before and after aneurysm formation in a ruptured aneurysm of the posterior communicating artery (RPcomAA) and an unruptured aneurysm of the posterior communicating artery (URPcomAA).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Arterial geometries obtained from three-dimensional digital subtraction angiography of cerebral angiograms were used for flow simulation by employing finite-volume modeling. Hemodynamic parameters such as wall shear stress (WSS), blood-flow velocity, streamlines, pressure, and wall shear stress gradient (WSSG) in the aneurysm sac and at the site of aneurysm formation were analyzed in each model.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>At \u201caneurysm\u201d status, hemodynamic analyses at the neck, body, and dome of the aneurysm revealed the distal aneurysm neck to be subjected to the highest WSS and blood-flow velocity, whereas the aneurysm dome presented the lowest WSS and blood-flow velocity in both model types. More apparent changes in WSSG at the aneurysm dome with an inflow jet and narrowed impaction zone were revealed only in the RPcomAA. At \u201cpre-aneurysm\u201d status, hemodynamic analyses in both models showed that the region of aneurysm formation was subjected to extremely elevated WSS, WSSG, and blood-flow velocity.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These data suggest that hemodynamic analyses in patients with ruptured or unruptured aneurysms using the vessel surface repair method are feasible, economical, and simple. Our preliminary results indicated that the arterial wall was subjected to elevated WSS, WSSG and blood-flow velocity before aneurysm generation. However, more complicated flow patterns (often with an inflow jet or narrowed impaction zone) were more likely to be observed in ruptured aneurysm.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2377-13-166","type":"journal-article","created":{"date-parts":[[2013,11,6]],"date-time":"2013-11-06T20:01:25Z","timestamp":1383768085000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["New method for retrospective study of hemodynamic changes before and after aneurysm formation in patients with ruptured or unruptured aneurysms"],"prefix":"10.1186","volume":"13","author":[{"given":"Wei-Jie","family":"Le","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue-Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Qiao","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Min","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Sheng","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,11,6]]},"reference":[{"issue":"9342","key":"884_CR1","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1016\/S0140-6736(02)11314-6","volume":"360","author":"A Molyneux","year":"2002","unstructured":"Molyneux A, Kerr R, Stratton I, Sandercock P, Clarke M, Shrimpton J, Holman R, International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group: International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet. 2002, 360 (9342): 1267-1274. 10.1016\/S0140-6736(02)11314-6.","journal-title":"Lancet"},{"issue":"26","key":"884_CR2","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1056\/NEJMoa1113260","volume":"366","author":"A Morita","year":"2012","unstructured":"Morita A, Kirino T, Hashi K, Aoki N, Fukuhara S, Hashimoto N, Nakayama T, Sakai M, Teramoto A, Tominari S, Yoshimoto T, UCAS Japan Investigators: The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med. 2012, 366 (26): 2474-2482.","journal-title":"N Engl J Med"},{"issue":"8","key":"884_CR3","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.3174\/ajnr.A1600","volume":"30","author":"A Chien","year":"2009","unstructured":"Chien A, Castro MA, Tateshima S, Sayre J, Cebral J, Vi\u00f1uela F: Quantitative hemodynamic analysis of brain aneurysms at different locations. AJNR Am J Neuroradiol. 2009, 30 (8): 1507-1512. 10.3174\/ajnr.A1600.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"11","key":"884_CR4","doi-asserted-by":"publisher","first-page":"2997","DOI":"10.1161\/STROKEAHA.108.521617","volume":"39","author":"L Boussel","year":"2008","unstructured":"Boussel L, Rayz V, McCulloch C, Martin A, Acevedo-Bolton G, Lawton M, Higashida R, Smith WS, Young WL, Saloner D: Aneurysm growth occurs at region of low wall shear stress: patient-specific correlation of hemodynamics and growth in a longitudinal study. Stroke. 2008, 39 (11): 2997-3002. 10.1161\/STROKEAHA.108.521617.","journal-title":"Stroke"},{"issue":"4","key":"884_CR5","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1161\/CIRCULATIONAHA.109.880724","volume":"121","author":"PE Norman","year":"2010","unstructured":"Norman PE, Powell JT: Site specificity of aneurysmal disease. Circulation. 2010, 121 (4): 560-568. 10.1161\/CIRCULATIONAHA.109.880724.","journal-title":"Circulation"},{"issue":"6","key":"884_CR6","doi-asserted-by":"publisher","first-page":"1240","DOI":"10.3171\/2009.10.JNS09759","volume":"112","author":"AM Nixon","year":"2010","unstructured":"Nixon AM, Gunel M, Sumpio BE: The critical role of hemodynamics in the development of cerebral vascular disease. J Neurosurg. 2010, 112 (6): 1240-1253. 10.3171\/2009.10.JNS09759.","journal-title":"J Neurosurg"},{"issue":"3","key":"884_CR7","doi-asserted-by":"publisher","first-page":"587","DOI":"10.3174\/ajnr.A2339","volume":"32","author":"Z Kulcs\u00e1r","year":"2011","unstructured":"Kulcs\u00e1r Z, Ugron A, Marosfoi M, Berentei Z, Pa\u00e1l G, Szikora I: Hemodynamics of cerebral aneurysm initiation: the role of wall shear stress and spatial wall shear stress gradient. AJNR Am J Neuroradiol. 2011, 32 (3): 587-594. 10.3174\/ajnr.A2339.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"884_CR8","doi-asserted-by":"publisher","first-page":"595","DOI":"10.3174\/ajnr.A2324","volume":"32","author":"Z Zeng","year":"2011","unstructured":"Zeng Z, Kallmes DF, Durka MJ, Ding Y, Lewis D, Kadirvel R, Robertson AM: Hemodynamics and anatomy of elastase-induced rabbit aneurysm models: similarity to human cerebral aneurysms?. AJNR Am J Neuroradiol. 2011, 32 (3): 595-601. 10.3174\/ajnr.A2324.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"884_CR9","first-page":"2550","volume":"26","author":"JR Cebral","year":"2005","unstructured":"Cebral JR, Castro MA, Burgess JE, Pergolizzi RS, Sheridan MJ, Putman CM: Characterization of cerebral aneurysms for assessing risk of rupture by using patient-specific computational hemodynamics models. AJNR Am J Neuroradiol. 2005, 26 (10): 2550-2559.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"6","key":"884_CR10","first-page":"1079","volume":"20","author":"L Parlea","year":"1999","unstructured":"Parlea L, Fahrig R, Holdsworth DW, Lownie SP: An analysis of the geometry of saccular intracranial aneurysms. AJNR Am J Neuroradiol. 1999, 20 (6): 1079-1089.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"3","key":"884_CR11","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1097\/00006123-200103000-00007","volume":"48","author":"H Ujiie","year":"2001","unstructured":"Ujiie H, Tamano Y, Sasaki K, Hori T: Is the aspect ratio a reliable index for predicting the rupture of a saccular aneurysm?. Neurosurgery. 2001, 48 (3): 495-502. 10.1097\/00006123-200103000-00007.","journal-title":"Neurosurgery"},{"issue":"3","key":"884_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.3171\/jns.2003.99.3.0447","volume":"99","author":"B Weir","year":"2003","unstructured":"Weir B, Amidei C, Kongable G, Findlay JM, Kassell NF, Kelly J, Dai L, Karrison TG: The aspect ratio (dome\/neck) of ruptured and unruptured aneurysms. J Neurosurg. 2003, 99 (3): 447-451. 10.3171\/jns.2003.99.3.0447.","journal-title":"J Neurosurg"},{"issue":"8","key":"884_CR13","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1161\/STROKEAHA.110.585992","volume":"41","author":"E Metaxa","year":"2010","unstructured":"Metaxa E, Tremmel M, Natarajan SK, Xiang J, Paluch RA, Mandelbaum M, Siddiqui AH, Kolega J, Mocco J, Meng H: Characterization of critical hemodynamics contributing to aneurysmal remodeling at the basilar terminus in a rabbit model. Stroke. 2010, 41 (8): 1774-1782. 10.1161\/STROKEAHA.110.585992.","journal-title":"Stroke"},{"issue":"3","key":"884_CR14","doi-asserted-by":"crossref","first-page":"L529","DOI":"10.1152\/ajplung.2001.281.3.L529","volume":"281","author":"AB Fisher","year":"2001","unstructured":"Fisher AB, Chien S, Barakat AI, Nerem RM: Endothelial cellular response to altered shear stress. Am J Physiol Lung Cell Mol Physiol. 2001, 281 (3): L529-L533.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"3","key":"884_CR15","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1159\/000091648","volume":"43","author":"RS Reneman","year":"2006","unstructured":"Reneman RS, Arts T, Hoeks AP: Wall shear stress-an important determinant of endothelial cell function and structure \u2013in the arterial system in vivo. J Vasc Res. 2006, 43 (3): 251-269. 10.1159\/000091648.","journal-title":"J Vasc Res"},{"issue":"6","key":"884_CR16","doi-asserted-by":"publisher","first-page":"666","DOI":"10.3171\/jns.1972.37.6.0666","volume":"37","author":"GG Ferguson","year":"1972","unstructured":"Ferguson GG: Physical factors in the initiation, growth, and rupture of human intracranial saccular aneurysms. J Neurosurg. 1972, 37 (6): 666-677. 10.3171\/jns.1972.37.6.0666.","journal-title":"J Neurosurg"},{"issue":"11","key":"884_CR17","doi-asserted-by":"publisher","first-page":"2500","DOI":"10.1161\/01.STR.0000144648.89172.0f","volume":"35","author":"M Shojima","year":"2004","unstructured":"Shojima M, Oshima M, Takagi K, Torii R, Hayakawa M, Katada K, Morita A, Kirino T: Magnitueude and role of wall shear stress on cerebral aneurysm computational fluid dynamic study of 20 middle cerebral artery aneurysms. Stroke. 2004, 35 (11): 2500-10.1161\/01.STR.0000144648.89172.0f.","journal-title":"Stroke"},{"issue":"2","key":"884_CR18","doi-asserted-by":"publisher","first-page":"304","DOI":"10.3174\/ajnr.A1819","volume":"31","author":"JR Cebral","year":"2010","unstructured":"Cebral JR, Sheridan M, Putman CM: Hemodynamics and bleb formation in intracranial aneurysms. AJNR Am J Neuroradiol. 2010, 31 (2): 304-310. 10.3174\/ajnr.A1819.","journal-title":"AJNR Am J Neuroradiol"},{"issue":"10","key":"884_CR19","doi-asserted-by":"publisher","first-page":"2287","DOI":"10.1161\/01.STR.0000140636.30204.da","volume":"35","author":"J Fr\u00f6sen","year":"2004","unstructured":"Fr\u00f6sen J, Piippo A, Paetau A, Kangasniemi M, Niemel\u00e4 M, Hernesniemi J, J\u00e4\u00e4skel\u00e4inen J: Remodeling of saccular cerebral artery aneurysm wall is associated with rupture: histological analysis of 24 unruptured and 42 ruptured cases. Stroke. 2004, 35 (10): 2287-2293. 10.1161\/01.STR.0000140636.30204.da.","journal-title":"Stroke"},{"issue":"1","key":"884_CR20","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1161\/01.STR.0000252129.18605.c8","volume":"38","author":"T Aoki","year":"2007","unstructured":"Aoki T, Kataoka H, Morimoto M, Nozaki K, Hashimoto N: Macrophage-derived matrix metalloproteinase-2 and \u22129 promote the progression of cerebral aneurysms in rats. Stroke. 2007, 38 (1): 162-169. 10.1161\/01.STR.0000252129.18605.c8.","journal-title":"Stroke"},{"key":"884_CR21","first-page":"428","volume-title":"First International Symposium on 3D Data Processing","author":"J Davis","year":"2002","unstructured":"Davis J, Marschne SR, Garr M, Marc L: Filling holes in complex surfaces using volumetric diffusion. First International Symposium on 3D Data Processing. 2002, 428-861."},{"key":"884_CR22","first-page":"1598","volume":"10","author":"X Liu","year":"2012","unstructured":"Liu X, Li C, Wang XJ: Hole-filling algorithm for high-curvature region in triangular mesh models. TELKOMNIKA. 2012, 10: 1598-1603.","journal-title":"TELKOMNIKA"},{"key":"884_CR23","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1146\/annurev.bioeng.10.061807.160439","volume":"10","author":"JD Humphrey","year":"2008","unstructured":"Humphrey JD, Taylor CA: Intracranial and abdominal aortic aneurysms: similarities, differences, and need for a New class of computational models. Annu Rev Biomed Eng. 2008, 10: 221-246. 10.1146\/annurev.bioeng.10.061807.160439.","journal-title":"Annu Rev Biomed Eng"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-13-166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2377-13-166\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-13-166","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-13-166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T02:05:37Z","timestamp":1630548337000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/1471-2377-13-166"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11,6]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["884"],"URL":"https:\/\/doi.org\/10.1186\/1471-2377-13-166","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11,6]]},"assertion":[{"value":"27 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 October 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 November 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"166"}}