{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T15:55:35Z","timestamp":1706716535472},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,23]],"date-time":"2013-07-23T00:00:00Z","timestamp":1374537600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Nervous system complications of primary Epstein-Barr virus (EBV) infection in adults are rare, but may occur with encephalitis, meningitis, myelitis, cranial and peripheral neuropathies, or radiculitis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>We describe an immune competent adult with a primary EBV infection complicated by lumbosacral polyradiculitis with pure radicular pain. Prior to the onset of radicular pain the 35-year-old woman had been suffering from infectious mononucleosis misdiagnosed for streptococcal tonsillitis. The diagnosis of primary EBV infection associated polyradiculitis was proven by serology and PCR in serum and CSF. Under initially started empiric therapy with intravenous acyclovir and analgesics the patient completely recovered within a few days.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>This case report highlights that EBV should be taken into consideration in the diagnostic work up of radicular pain syndromes, even in immune competent adults. There is no approved causal therapy for EBV infections. In accordance with our case, observations based on a few patients with EBV and nervous system involvement suggest, that acyclovir treatment might be associated a with better course. However, prospective randomized controlled trials addressing the question of the effectiveness of acyclovir in patients with primary EBV infection and neurological complications are lacking.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2377-13-96","type":"journal-article","created":{"date-parts":[[2013,7,24]],"date-time":"2013-07-24T13:18:59Z","timestamp":1374671939000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Primary Epstein-Barr virus infection with polyradiculitis: a case report"],"prefix":"10.1186","volume":"13","author":[{"given":"Tilmann","family":"Hottenrott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Rauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jochen","family":"B\u00e4uerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,7,23]]},"reference":[{"key":"815_CR1","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1097\/00019052-200006000-00012","volume":"13","author":"P Portegies","year":"2000","unstructured":"Portegies P, Corssmit N: Epstein-Barr virus and the nervous system. Curr Opin Neurol. 2000, 13: 301-304. 10.1097\/00019052-200006000-00012.","journal-title":"Curr Opin Neurol"},{"key":"815_CR2","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1002\/jmv.23470","volume":"85","author":"F de Ory","year":"2013","unstructured":"de Ory F, Avell\u00f3n A, Echevarr\u00eda JE, S\u00e1nchez-Seco MP, Trallero G, Cabrerizo M, Casas I, Pozo F, Fedele G, Vicente D, Pena MJ, Moreno A, Niubo J, Rabella N, Rubio G, P\u00e9rez-Ruiz M, Rodr\u00edguez-Iglesias M, Gimeno C, Eiros JM, Mel\u00f3n S, Blasco M, L\u00f3pez-Miragaya I, Varela E, Martinez-Sapi\u00f1a A, Rodr\u00edguez G, Marcos M\u00c1, Geg\u00fandez MI, Cilla G, Gabilondo I, Navarro JM, et al: Viral infections of the central nervous system in Spain: A prospective study. 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Scand J Infect Dis. 2011, 43: 136-144. 10.3109\/00365548.2010.531760.","journal-title":"Scand J Infect Dis"},{"key":"815_CR5","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/MOH.0b013e32834daa08","volume":"19","author":"EK Vouloumanou","year":"2012","unstructured":"Vouloumanou EK, Rafailidis PI, Falagas ME: Current diagnosis and management of infectious mononucleosis. Curr Opin Hematol. 2012, 19: 14-20. 10.1097\/MOH.0b013e32834daa08.","journal-title":"Curr Opin Hematol"},{"key":"815_CR6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1186\/1471-2334-11-281","volume":"11","author":"T Martelius","year":"2011","unstructured":"Martelius T, Lappalainen M, Palom\u00e4ki M, Anttila VJ: Clinical characteristics of patients with Epstein Barr virus in cerebrospinal fluid. 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