{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:18:18Z","timestamp":1790187498503,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T00:00:00Z","timestamp":1219968000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Neurol"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Frontotemporal lobar degeneration (FTLD) represents a clinically, pathologically and genetically heterogenous neurodegenerative disorder, often complicated by neurological signs such as motor neuron-related limb weakness, spasticity and paralysis, parkinsonism and gait disturbances. Linkage to chromosome 9p had been reported for pedigrees with the neurodegenerative disorder, frontotemporal lobar degeneration (FTLD) and motor neuron disease (MND). The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Clinical review and standard neuropathological analysis of brain sections from affected pedigree members. Genome-wide scan using microsatellite markers and single nucleotide polymorphism fine mapping. Examination of candidate genes by direct DNA sequencing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Neuropathological examination revealed cytoplasmic deposition of the TDP-43 protein in three affected individuals. Moreover, we identify a family member with clinical Alzheimer's disease, and FTLD-Ubiquitin neuropathology. Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease haplotype, suggesting that one individual carrying a meiotic recombination may represent a phenocopy. Re-analysis of linkage data using the new affection status revealed a maximal two-point LOD score of 3.24 and a multipoint LOD score of 3.41 at marker D9S1817. This provides the highest reported LOD scores from a single FTLD-MND pedigree.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our reported increase in the minimal disease region should inform other researchers that the chromosome 9 locus may be more telomeric than predicted by published recombination boundaries. Moreover, the existence of a family member with clinical Alzheimer's disease, and who shares the disease haplotype, highlights the possibility that late-onset AD patients in the other linked pedigrees may be mis-classified as sporadic dementia cases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2377-8-32","type":"journal-article","created":{"date-parts":[[2008,8,29]],"date-time":"2008-08-29T02:13:36Z","timestamp":1219976016000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Pedigree with frontotemporal lobar degeneration \u2013 motor neuron disease and Tar DNA binding protein-43 positive neuropathology: genetic linkage to chromosome 9"],"prefix":"10.1186","volume":"8","author":[{"given":"Agnes A","family":"Luty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John BJ","family":"Kwok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Blumbergs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William S","family":"Brooks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clement T","family":"Loy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Dobson-Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter K","family":"Panegyres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Hecker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garth A","family":"Nicholson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenda M","family":"Halliday","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,8,29]]},"reference":[{"issue":"11","key":"194_CR1","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1212\/WNL.58.11.1615","volume":"58","author":"E Ratnavalli","year":"2002","unstructured":"Ratnavalli E, Brayne C, Dawson K, Hodges JR: The prevalence of frontotemporal dementia. Neurology. 2002, 58 (11): 1615-1621.","journal-title":"Neurology"},{"issue":"11","key":"194_CR2","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S1474-4422(05)70223-4","volume":"4","author":"D Neary","year":"2005","unstructured":"Neary D, Snowden J, Mann D: Frontotemporal dementia. Lancet Neurol. 2005, 4 (11): 771-780. 10.1016\/S1474-4422(05)70223-4.","journal-title":"Lancet Neurol"},{"issue":"6","key":"194_CR3","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1212\/WNL.51.6.1546","volume":"51","author":"D Neary","year":"1998","unstructured":"Neary D, Snowden JS, Gustafson L, Passant U, Stuss D, Black S, Freedman M, Kertesz A, Robert PH, Albert M, Boone K, Miller BL, Cummings J, Benson DF: Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. Neurology. 1998, 51 (6): 1546-1554.","journal-title":"Neurology"},{"issue":"Spec No 2","key":"194_CR4","doi-asserted-by":"publisher","first-page":"R182","DOI":"10.1093\/hmg\/ddl202","volume":"15","author":"K Talbot","year":"2006","unstructured":"Talbot K, Ansorge O: Recent advances in the genetics of amyotrophic lateral sclerosis and frontotemporal dementia: common pathways in neurodegenerative disease. Hum Mol Genet. 2006, 15 (Spec No 2): R182-R187. 10.1093\/hmg\/ddl202.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"194_CR5","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-007-0237-2","volume":"114","author":"NJ Cairns","year":"2007","unstructured":"Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, Yokoo H, Murayama S, Woulfe J, Munoz DG, Dickson DW, Ince PG, Trojanowski JQ, Mann DM, Consortium for Frontotemporal Lobar Degeneration: Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathol (Berl). 2007, 114 (1): 5-22. 10.1007\/s00401-007-0237-2.","journal-title":"Acta Neuropathol (Berl)"},{"issue":"1","key":"194_CR6","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/S0888-7543(03)00214-3","volume":"83","author":"H-Y Wang","year":"2004","unstructured":"Wang H-Y, Wang I-F, Bose J, Shen C-KJ: Structural diversity and functional implications of the eukaryotic TDP gene family. Genomics. 2004, 83 (1): 130-139. 10.1016\/S0888-7543(03)00214-3.","journal-title":"Genomics"},{"issue":"5796","key":"194_CR7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1126\/science.1134108","volume":"314","author":"M Neumann","year":"2006","unstructured":"Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, Feiden W, Kretzschmar HA, Trojanowski JQ, Lee VM: Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science. 2006, 314 (5796): 130-133. 10.1126\/science.1134108.","journal-title":"Science"},{"issue":"3","key":"194_CR8","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.bbrc.2006.10.093","volume":"351","author":"T Arai","year":"2006","unstructured":"Arai T, Hasegawa M, Akiyama H, Ikeda K, Nonaka T, Mori H, Mann D, Tsuchiya K, Yoshida M, Hashizume Y, Oda T: TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Biochem Biophys Res Commun. 2006, 351 (3): 602-611. 10.1016\/j.bbrc.2006.10.093.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"194_CR9","doi-asserted-by":"publisher","first-page":"227","DOI":"10.2353\/ajpath.2007.070182","volume":"171","author":"NJ Cairns","year":"2007","unstructured":"Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, Goate AM, Morris JC, Mishra M, Kwong LK, Stieber A, Xu Y, Forman MS, Trojanowski JQ, Lee VM, Mackenzie IR: TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Am J Pathol. 2007, 171 (1): 227-240. 10.2353\/ajpath.2007.070182.","journal-title":"Am J Pathol"},{"issue":"4","key":"194_CR10","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/ana.21344","volume":"63","author":"MA Gitcho","year":"2008","unstructured":"Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, Goate AM, Cairns NJ: TDP-43 A315T mutation in familial motor neuron disease. Ann Neurol. 2008, 63 (4): 535-538. 10.1002\/ana.21344.","journal-title":"Ann Neurol"},{"issue":"5870","key":"194_CR11","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1126\/science.1154584","volume":"319","author":"J Sreedharan","year":"2008","unstructured":"Sreedharan J, Blair IP, Tripathi VB, Hu X, Vance C, Rogelj B, Ackerley S, Durnall JC, Williams KL, Buratti E, Baralle F, de Belleroche J, Mitchell JD, Leigh PN, Al-Chalabi A, Miller CC, Nicholson G, Shaw CE: TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis. Science. 2008, 319 (5870): 1668-1672. 10.1126\/science.1154584.","journal-title":"Science"},{"issue":"4","key":"194_CR12","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/ana.21392","volume":"63","author":"A Yokoseki","year":"2008","unstructured":"Yokoseki A, Shiga A, Tan CF, Tagawa A, Kaneko H, Koyama A, Eguchi H, Tsujino A, Ikeuchi T, Kakita A, Okamoto K, Nishizawa M, Takahashi H, Onodera O: TDP-43 mutation in familial amyotrophic lateral sclerosis. Ann Neurol. 2008, 63 (4): 538-542. 10.1002\/ana.21392.","journal-title":"Ann Neurol"},{"issue":"5","key":"194_CR13","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/S1474-4422(08)70071-1","volume":"7","author":"VM Van Deerlin","year":"2008","unstructured":"Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, Elman LB, Clay D, Wood EM, Chen-Plotkin AS, Martinez-Lage M, Steinbart E, McCluskey L, Grossman M, Neumann M, Wu IL, Yang WS, Kalb R, Galasko DR, Montine TJ, Trojanowski JQ, Lee VM, Schellenberg GD, Yu CE: TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. Lancet Neurol. 2008, 7 (5): 409-16. 10.1016\/S1474-4422(08)70071-1.","journal-title":"Lancet Neurol"},{"issue":"5","key":"194_CR14","doi-asserted-by":"publisher","first-page":"572","DOI":"10.1038\/ng.132","volume":"40","author":"E Kabashi","year":"2008","unstructured":"Kabashi E, Valdmanis PN, Dion P, Spiegelman D, McConkey BJ, Velde Vande C, Bouchard JP, Lacomblez L, Pochigaeva K, Salachas F, Pradat PF, Camu W, Meininger V, Dupre N, Rouleau GA: TDRDBP mutations in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. Nat Genet. 2008, 40 (5): 572-574. 10.1038\/ng.132.","journal-title":"Nat Genet"},{"issue":"13","key":"194_CR15","doi-asserted-by":"publisher","first-page":"1664","DOI":"10.1001\/jama.284.13.1664","volume":"284","author":"BA Hosler","year":"2000","unstructured":"Hosler BA, Siddique T, Sapp PC, Sailor W, Huang MC, Hossain A, Daube JR, Nance M, Fan C, Kaplan J, Hung WY, McKenna-Yasek D, Haines JL, Pericak-Vance MA, Horvitz HR, Brown RH: Linkage of familial amyotrophic lateral sclerosis with frontotemporal dementia to chromosome 9q21-q22. JAMA. 2000, 284 (13): 1664-1669. 10.1001\/jama.284.13.1664.","journal-title":"JAMA"},{"issue":"Pt 4","key":"194_CR16","doi-asserted-by":"publisher","first-page":"868","DOI":"10.1093\/brain\/awl030","volume":"129","author":"C Vance","year":"2006","unstructured":"Vance C, Al-Chalabi A, Ruddy D, Smith BN, Hu X, Sreedharan J, Siddique T, Schelhaas HJ, Kusters B, Troost D, Baas F, de Jong V, Shaw CE: Familial amyotrophic lateral sclerosis with frontotemporal dementia is linked to a locus on chromosome 9p13.2-21.3. Brain. 2006, 129 (Pt 4): 868-876. 10.1093\/brain\/awl030.","journal-title":"Brain"},{"issue":"6","key":"194_CR17","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1212\/01.wnl.0000200048.53766.b4","volume":"66","author":"M Morita","year":"2006","unstructured":"Morita M, Al-Chalabi A, Andersen PM, Hosler B, Sapp P, Englund E, Mitchell JE, Habgood JJ, de Belleroche J, Xi J, Jongjaroenprasert W, Horvitz HR, Gunnarsson LG, Brown RH: A locus on chromosome 9p confers susceptibility to ALS and frontotemporal dementia. Neurology. 2006, 66 (6): 839-844. 10.1212\/01.wnl.0000200048.53766.b4.","journal-title":"Neurology"},{"issue":"2","key":"194_CR18","doi-asserted-by":"publisher","first-page":"240","DOI":"10.1001\/archneur.64.2.240","volume":"64","author":"PN Valdmanis","year":"2007","unstructured":"Valdmanis PN, Dupre N, Bouchard JP, Camu W, Salachas F, Meininger V, Strong M, Rouleau GA: Three families with amyotrophic lateral sclerosis and frontotemporal dementia with evidence of linkage to chromosome 9p. Arch Neurol. 2007, 64 (2): 240-245. 10.1001\/archneur.64.2.240.","journal-title":"Arch Neurol"},{"issue":"S61.006","key":"194_CR19","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1212\/01.wnl.0000234887.27166.69","volume":"67","author":"J Yan","year":"2006","unstructured":"Yan J, Siddique N, Slifer S, Bigio E, Mao H, Chen W, Liu E, Shi Y, Khan S, Haines J, Pericak-Vance M, Siddique T: A Major Novel Locus for ALS\/FTD on Chromosome 9p21 and its Pathological Correlates. Neurology. 2006, 67 (S61.006): 186-b. 10.1212\/01.wnl.0000234887.27166.69.","journal-title":"Neurology"},{"key":"194_CR20","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1186\/1471-2377-6-44","volume":"6","author":"P Momeni","year":"2006","unstructured":"Momeni P, Schymick J, Jain S, Cookson MR, Cairns NJ, Greggio E, Greenway MJ, Berger S, Pickering-Brown S, Chi\u00f2 A, Fung HC, Holtzman DM, Huey ED, Wassermann EM, Adamson J, Hutton ML, Rogaeva E, St George-Hyslop P, Rothstein JD, Hardiman O, Grafman J, Singleton A, Hardy J, Traynor BJ: Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC Neurol. 2006, 6: 44-10.1186\/1471-2377-6-44.","journal-title":"BMC Neurol"},{"issue":"1","key":"194_CR21","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1007\/BF00294461","volume":"90","author":"GM Halliday","year":"1995","unstructured":"Halliday GM, Davies L, McRitchie DA, Cartwright H, Pamphlett R, Morris JG: Ubiquitin-positive achromatic neurons in corticobasal degeneration. Acta Neuropathol (Berl). 1995, 90 (1): 68-75. 10.1007\/BF00294461.","journal-title":"Acta Neuropathol (Berl)"},{"issue":"10","key":"194_CR22","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1097\/00005072-199710000-00002","volume":"56","author":"BT Hyman","year":"1997","unstructured":"Hyman BT, Trojanowski JQ: Consensus recommendations for the postmortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J Neuropathol Exp Neurol. 1997, 56 (10): 1095-1097. 10.1097\/00005072-199710000-00002.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"12","key":"194_CR23","doi-asserted-by":"publisher","first-page":"1863","DOI":"10.1212\/01.wnl.0000187889.17253.b1","volume":"65","author":"IG McKeith","year":"2005","unstructured":"McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, Costa D, Del Ser T, Dubois B, Galasko D, Gauthier S, Goetz CG, Gomez-Tortosa E, Halliday G, Hansen LA, Hardy J, Iwatsubo T, Kalaria RN, Kaufer D, Kenny RA, Korczyn A, Kosaka K, Lee VM, Lees A, Litvan I, Londos E, Lopez OL, Minoshima S, Mizuno Y, Molina JA, Mukaetova-Ladinska EB, Pasquier F, Perry RH, Schulz JB, Trojanowski JQ, Yamada M, Consortium on DLB: Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 2005, 65 (12): 1863-1872. 10.1212\/01.wnl.0000187889.17253.b1.","journal-title":"Neurology"},{"issue":"Suppl","key":"194_CR24","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/0022-510X(94)90191-0","volume":"124","author":"BR Brooks","year":"1994","unstructured":"Brooks BR: El Escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis. Subcommittee on Motor Neuron Diseases\/Amyotrophic Lateral Sclerosis of the World Federation of Neurology Research Group on Neuromuscular Diseases and the El Escorial \"Clinical limits of amyotrophic lateral sclerosis\" workshop contributors. J Neurol Sci. 1994, 124 (Suppl): 96-107. 10.1016\/0022-510X(94)90191-0.","journal-title":"J Neurol Sci"},{"issue":"11","key":"194_CR25","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1093\/jnen\/61.11.935","volume":"61","author":"DW Dickson","year":"2002","unstructured":"Dickson DW, Bergeron C, Chin SS, Duyckaerts C, Horoupian D, Ikeda K, Jellinger K, Lantos PL, Lippa CF, Mirra SS, Tabaton M, Vonsattel JP, Wakabayashi K, Litvan I: Office of Rare Diseases of the National Institutes of Health. Office of Rare Diseases neuropathologic criteria for corticobasal degeneration. J Neuropathol Exp Neurol. 2002, 61 (11): 935-946.","journal-title":"J Neuropathol Exp Neurol"},{"issue":"11","key":"194_CR26","doi-asserted-by":"publisher","first-page":"2015","DOI":"10.1212\/WNL.44.11.2015","volume":"44","author":"JJ Hauw","year":"1994","unstructured":"Hauw JJ, Daniel SE, Dickson D, Horoupian DS, Jellinger K, Lantos PL, McKee A, Tabaton M, Litvan I: Preliminary NINDS neuropathologic criteria for Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy). Neurology. 1994, 44 (11): 2015-2019.","journal-title":"Neurology"},{"issue":"1\u20132","key":"194_CR27","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.jns.2007.01.049","volume":"257","author":"K Nagata","year":"2007","unstructured":"Nagata K, Saito H, Ueno T, Sato M, Nakase T, Maeda T, Satoh Y, Komatsu H, Suzuki M, Kondoh Y: Clinical diagnosis of vascular dementia. J Neurol Sci. 2007, 257 (1\u20132): 44-48. 10.1016\/j.jns.2007.01.049.","journal-title":"J Neurol Sci"},{"issue":"6","key":"194_CR28","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1038\/sj.mp.4001025","volume":"7","author":"RF Badenhop","year":"2002","unstructured":"Badenhop RF, Moses MJ, Scimone A, Mitchell PB, Ewen-White KR, Rosso A, Donald JA, Adams LJ, Schofield PR: A genome screen of 13 bipolar affective disorder pedigrees provide evidence for susceptibility loci on chromosome 3 as well as chromosome 9, 13 and 19. Mol Psychiatry. 2002, 7 (6): 594-603. 10.1038\/sj.mp.4001025.","journal-title":"Mol Psychiatry"},{"issue":"8","key":"194_CR29","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1093\/bioinformatics\/bth488","volume":"21","author":"H Thiele","year":"2005","unstructured":"Thiele H, Nurnberg P: HaploPainter: a tool for drawing pedigrees with complex haplotypes. Bioinformatics. 2005, 21 (8): 1730-1732. 10.1093\/bioinformatics\/bth488.","journal-title":"Bioinformatics"},{"issue":"8","key":"194_CR30","doi-asserted-by":"crossref","first-page":"429","DOI":"10.5694\/j.1326-5377.1997.tb126655.x","volume":"167","author":"LM Waite","year":"1997","unstructured":"Waite LM, Broe GA, Creasey H, Grayson DA, Cullen JS, O'Toole B, Edelbrock D, Dobson M: Neurodegenerative and other chronic disorders among people aged 75 years and over in the community. Med J Aust. 1997, 167 (8): 429-432.","journal-title":"Med J Aust"},{"key":"194_CR31","volume-title":"American Academy of Neurology, 59th Annual Meeting","author":"J Yan","year":"2007","unstructured":"Yan J, Siddique N, Slifer S, Bigio E, Mao H, Chen W, Liu E, Shi Y, Khan S, Haines J, Pericak-Vance M, Siqque T: Fine-Mapping and Candidate Gene Sequencing of the Chromosome 9p Locus of ALS\/FTD: P07.054. American Academy of Neurology, 59th Annual Meeting. 2007"},{"issue":"3","key":"194_CR32","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/S0304-3940(01)01785-2","volume":"304","author":"DM Mann","year":"2001","unstructured":"Mann DM, McDonagh AM, Pickering-Brown SM, Kowa H, Iwatsubo T: Amyloid beta protein deposition in patients with frontotemporal lobar degeneration: relationship to age and apolipoprotein E genotype. Neurosci Lett. 2001, 304 (3): 161-164. 10.1016\/S0304-3940(01)01785-2.","journal-title":"Neurosci Lett"},{"issue":"3","key":"194_CR33","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng917","volume":"31","author":"A Kong","year":"2002","unstructured":"Kong A, Gudbjartsson DF, Sainz J, Jonsdottir GM, Gudjonsson SA, Richardsson B, Sigurdardottir S, Barnard J, Hallbeck B, Masson G, Shlien A, Palsson ST, Frigge ML, Thorgeirsson TE, Gulcher JR, Stefansson K: A high-resolution recombination map of the human genome. Nat Genet. 2002, 31 (3): 241-247.","journal-title":"Nat Genet"}],"container-title":["BMC Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-8-32.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2377-8-32\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-8-32","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2377-8-32.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T18:25:09Z","timestamp":1630434309000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcneurol.biomedcentral.com\/articles\/10.1186\/1471-2377-8-32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,8,29]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["194"],"URL":"https:\/\/doi.org\/10.1186\/1471-2377-8-32","relation":{},"ISSN":["1471-2377"],"issn-type":[{"value":"1471-2377","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,8,29]]},"assertion":[{"value":"20 June 2008","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 August 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"32"}}