{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:35:19Z","timestamp":1770903319298,"version":"3.50.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,4,19]],"date-time":"2010-04-19T00:00:00Z","timestamp":1271635200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Succinate dehydrogenase (SDH) has been associated with carcinogenesis in pheochromocytoma and paraganglioma. In the present study we investigated components of the oxidative phosphorylation system in human neuroblastoma tissue samples.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Spectrophotometric measurements, immunohistochemical analysis and Western blot analysis were used to characterize the aerobic mitochondrial energy metabolism in neuroblastomas (NB).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Compared to mitochondrial citrate synthase, SDH activity was severely reduced in NB (n = 14) versus kidney tissue. However no pathogenic mutations could be identified in any of the four subunits of SDH. Furthermore, no genetic alterations could be identified in the two novel SDH assembly factors SDHAF1 and SDH5. Alterations in genes encoding nfs-1, frataxin and isd-11 that could lead to a diminished SDH activity have not been detected in NB.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Because downregulation of other complexes of the oxidative phosphorylation system was also observed, a more generalized reduction of mitochondrial respiration seems to be present in neuroblastoma in contrast to the single enzyme defect found in hereditary pheochromocytomas.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-10-149","type":"journal-article","created":{"date-parts":[[2010,4,29]],"date-time":"2010-04-29T18:15:30Z","timestamp":1272564930000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma"],"prefix":"10.1186","volume":"10","author":[{"given":"Rene' G","family":"Feichtinger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes A","family":"Mayr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Neureiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Hauser-Kronberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Freimut H","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Sperl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Kofler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,4,19]]},"reference":[{"key":"1948_CR1","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1002\/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7","volume":"86","author":"H Shimada","year":"1999","unstructured":"Shimada H, Ambros IM, Dehner LP, Hata J, Joshi VV, Roald B, Stram DO, Gerbing RB, Lukens JN, Matthay KK, Castleberry RP: The International Neuroblastoma Pathology Classification (the Shimada system). Cancer. 1999, 86: 364-372. 10.1002\/(SICI)1097-0142(19990715)86:2<364::AID-CNCR21>3.0.CO;2-7.","journal-title":"Cancer"},{"key":"1948_CR2","doi-asserted-by":"publisher","first-page":"C1114","DOI":"10.1152\/ajpcell.00216.2006","volume":"291","author":"JJ Briere","year":"2006","unstructured":"Briere JJ, Favier J, Gimenez-Roqueplo AP, Rustin P: Tricarboxylic acid cycle dysfunction as a cause of human diseases and tumor formation. Am J Physiol Cell Physiol. 2006, 291: C1114-1120. 10.1152\/ajpcell.00216.2006.","journal-title":"Am J Physiol Cell Physiol"},{"key":"1948_CR3","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/S0005-2728(97)00019-4","volume":"1320","author":"C Hagerhall","year":"1997","unstructured":"Hagerhall C: Succinate: quinone oxidoreductases. Variations on a conserved theme. Biochim Biophys Acta. 1997, 1320: 107-141. 10.1016\/S0005-2728(97)00019-4.","journal-title":"Biochim Biophys Acta"},{"key":"1948_CR4","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1126\/science.1175689","volume":"325","author":"HX Hao","year":"2009","unstructured":"Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, et al: SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma. Science. 2009, 325: 1139-1142. 10.1126\/science.1175689.","journal-title":"Science"},{"key":"1948_CR5","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.ccr.2009.08.013","volume":"16","author":"WG Kaelin Jr","year":"2009","unstructured":"Kaelin WG: SDH5 mutations and familial paraganglioma: somewhere Warburg is smiling. Cancer Cell. 2009, 16: 180-182. 10.1016\/j.ccr.2009.08.013.","journal-title":"Cancer Cell"},{"key":"1948_CR6","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1038\/nature07397","volume":"455","author":"RE George","year":"2008","unstructured":"George RE, Sanda T, Hanna M, Frohling S, Luther W, Zhang J, Ahn Y, Zhou W, London WB, McGrady P, et al: Activating mutations in ALK provide a therapeutic target in neuroblastoma. Nature. 2008, 455: 975-978. 10.1038\/nature07397.","journal-title":"Nature"},{"key":"1948_CR7","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1038\/nature07398","volume":"455","author":"I Janoueix-Lerosey","year":"2008","unstructured":"Janoueix-Lerosey I, Lequin D, Brugieres L, Ribeiro A, de Pontual L, Combaret V, Raynal V, Puisieux A, Schleiermacher G, Pierron G, et al: Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature. 2008, 455: 967-970. 10.1038\/nature07398.","journal-title":"Nature"},{"key":"1948_CR8","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1086\/424530","volume":"75","author":"YP Mosse","year":"2004","unstructured":"Mosse YP, Laudenslager M, Khazi D, Carlisle AJ, Winter CL, Rappaport E, Maris JM: Germline PHOX2B mutation in hereditary neuroblastoma. Am J Hum Genet. 2004, 75: 727-730. 10.1086\/424530.","journal-title":"Am J Hum Genet"},{"key":"1948_CR9","doi-asserted-by":"publisher","first-page":"930","DOI":"10.1038\/nature07261","volume":"455","author":"YP Mosse","year":"2008","unstructured":"Mosse YP, Laudenslager M, Longo L, Cole KA, Wood A, Attiyeh EF, Laquaglia MJ, Sennett R, Lynch JE, Perri P, et al: Identification of ALK as a major familial neuroblastoma predisposition gene. Nature. 2008, 455: 930-935. 10.1038\/nature07261.","journal-title":"Nature"},{"key":"1948_CR10","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1038\/nature07399","volume":"455","author":"Y Chen","year":"2008","unstructured":"Chen Y, Takita J, Choi YL, Kato M, Ohira M, Sanada M, Wang L, Soda M, Kikuchi A, Igarashi T, et al: Oncogenic mutations of ALK kinase in neuroblastoma. Nature. 2008, 455: 971-974. 10.1038\/nature07399.","journal-title":"Nature"},{"key":"1948_CR11","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1136\/jmg.28.7.443","volume":"28","author":"ER Maher","year":"1991","unstructured":"Maher ER, Iselius L, Yates JR, Littler M, Benjamin C, Harris R, Sampson J, Williams A, Ferguson-Smith MA, Morton N: Von Hippel-Lindau disease: a genetic study. J Med Genet. 1991, 28: 443-447. 10.1136\/jmg.28.7.443.","journal-title":"J Med Genet"},{"key":"1948_CR12","first-page":"2852","volume":"54","author":"T Shuin","year":"1994","unstructured":"Shuin T, Kondo K, Torigoe S, Kishida T, Kubota Y, Hosaka M, Nagashima Y, Kitamura H, Latif F, Zbar B, et al: Frequent somatic mutations and loss of heterozygosity of the von Hippel-Lindau tumor suppressor gene in primary human renal cell carcinomas. Cancer Res. 1994, 54: 2852-2855.","journal-title":"Cancer Res"},{"key":"1948_CR13","first-page":"4845","volume":"54","author":"H Kanno","year":"1994","unstructured":"Kanno H, Kondo K, Ito S, Yamamoto I, Fujii S, Torigoe S, Sakai N, Hosaka M, Shuin T, Yao M: Somatic mutations of the von Hippel-Lindau tumor suppressor gene in sporadic central nervous system hemangioblastomas. Cancer Res. 1994, 54: 4845-4847.","journal-title":"Cancer Res"},{"key":"1948_CR14","first-page":"1358","volume":"55","author":"S Wizigmann-Voos","year":"1995","unstructured":"Wizigmann-Voos S, Breier G, Risau W, Plate KH: Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas. Cancer Res. 1995, 55: 1358-1364.","journal-title":"Cancer Res"},{"key":"1948_CR15","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1023\/A:1008213320642","volume":"8","author":"M Los","year":"1997","unstructured":"Los M, Aarsman CJ, Terpstra L, Wittebol-Post D, Lips CJ, Blijham GH, Voest EE: Elevated ocular levels of vascular endothelial growth factor in patients with von Hippel-Lindau disease. Ann Oncol. 1997, 8: 1015-1022. 10.1023\/A:1008213320642.","journal-title":"Ann Oncol"},{"key":"1948_CR16","doi-asserted-by":"publisher","first-page":"10595","DOI":"10.1073\/pnas.93.20.10595","volume":"93","author":"O Iliopoulos","year":"1996","unstructured":"Iliopoulos O, Levy AP, Jiang C, Kaelin WG, Goldberg MA: Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein. Proc Natl Acad Sci USA. 1996, 93: 10595-10599. 10.1073\/pnas.93.20.10595.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1948_CR17","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1128\/MCB.18.2.732","volume":"18","author":"KM Lonergan","year":"1998","unstructured":"Lonergan KM, Iliopoulos O, Ohh M, Kamura T, Conaway RC, Conaway JW, Kaelin WG: Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B\/C and Cul2. Mol Cell Biol. 1998, 18: 732-741.","journal-title":"Mol Cell Biol"},{"key":"1948_CR18","doi-asserted-by":"publisher","first-page":"208","DOI":"10.1196\/annals.1353.023","volume":"1073","author":"PL Dahia","year":"2006","unstructured":"Dahia PL: Transcription association of VHL and SDH mutations link hypoxia and oxidoreductase signals in pheochromocytomas. Ann N Y Acad Sci. 2006, 1073: 208-220. 10.1196\/annals.1353.023.","journal-title":"Ann N Y Acad Sci"},{"key":"1948_CR19","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1371\/journal.pgen.0010008","volume":"1","author":"PL Dahia","year":"2005","unstructured":"Dahia PL, Ross KN, Wright ME, Hayashida CY, Santagata S, Barontini M, Kung AL, Sanso G, Powers JF, Tischler AS, et al: A HIF1alpha regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PLoS Genet. 2005, 1: 72-80. 10.1371\/journal.pgen.0010008.","journal-title":"PLoS Genet"},{"key":"1948_CR20","doi-asserted-by":"publisher","first-page":"3857","DOI":"10.1093\/hmg\/ddi410","volume":"14","author":"R Thierbach","year":"2005","unstructured":"Thierbach R, Schulz TJ, Isken F, Voigt A, Mietzner B, Drewes G, von Kleist-Retzow JC, Wiesner RJ, Magnuson MA, Puccio H, et al: Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet. 2005, 14: 3857-3864. 10.1093\/hmg\/ddi410.","journal-title":"Hum Mol Genet"},{"key":"1948_CR21","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.bbamcr.2006.05.011","volume":"1763","author":"R Lill","year":"2006","unstructured":"Lill R, Dutkiewicz R, Elsasser HP, Hausmann A, Netz DJ, Pierik AJ, Stehling O, Urzica E, Muhlenhoff U: Mechanisms of iron-sulfur protein maturation in mitochondria, cytosol and nucleus of eukaryotes. Biochim Biophys Acta. 2006, 1763: 652-667. 10.1016\/j.bbamcr.2006.05.011.","journal-title":"Biochim Biophys Acta"},{"key":"1948_CR22","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1146\/annurev.cellbio.22.010305.104538","volume":"22","author":"R Lill","year":"2006","unstructured":"Lill R, Muhlenhoff U: Iron-sulfur protein biogenesis in eukaryotes: components and mechanisms. Annu Rev Cell Dev Biol. 2006, 22: 457-486. 10.1146\/annurev.cellbio.22.010305.104538.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"1948_CR23","doi-asserted-by":"publisher","first-page":"5675","DOI":"10.1128\/MCB.00112-06","volume":"26","author":"A Biederbick","year":"2006","unstructured":"Biederbick A, Stehling O, Rosser R, Niggemeyer B, Nakai Y, Elsasser HP, Lill R: Role of human mitochondrial Nfs1 in cytosolic iron-sulfur protein biogenesis and iron regulation. Mol Cell Biol. 2006, 26: 5675-5687. 10.1128\/MCB.00112-06.","journal-title":"Mol Cell Biol"},{"key":"1948_CR24","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1038\/sj.emboj.7600906","volume":"25","author":"N Wiedemann","year":"2006","unstructured":"Wiedemann N, Urzica E, Guiard B, Muller H, Lohaus C, Meyer HE, Ryan MT, Meisinger C, Muhlenhoff U, Lill R, Pfanner N: Essential role of Isd11 in mitochondrial iron-sulfur cluster synthesis on Isu scaffold proteins. Embo J. 2006, 25: 184-195. 10.1038\/sj.emboj.7600906.","journal-title":"Embo J"},{"key":"1948_CR25","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1159\/000401202","volume":"22","author":"PL Pedersen","year":"1978","unstructured":"Pedersen PL: Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res. 1978, 22: 190-274.","journal-title":"Prog Exp Tumor Res"},{"key":"1948_CR26","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1126\/science.6264596","volume":"213","author":"E Racker","year":"1981","unstructured":"Racker E, Spector M: Warburg effect revisited: merger of biochemistry and molecular biology. Science. 1981, 213: 303-307. 10.1126\/science.6264596.","journal-title":"Science"},{"key":"1948_CR27","doi-asserted-by":"publisher","first-page":"1650","DOI":"10.1126\/science.1126863","volume":"312","author":"S Matoba","year":"2006","unstructured":"Matoba S, Kang JG, Patino WD, Wragg A, Boehm M, Gavrilova O, Hurley PJ, Bunz F, Hwang PM: p53 regulates mitochondrial respiration. Science. 2006, 312: 1650-1653. 10.1126\/science.1126863.","journal-title":"Science"},{"key":"1948_CR28","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/j.ccr.2007.04.001","volume":"11","author":"H Zhang","year":"2007","unstructured":"Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller KI, Dang CV, Semenza GL: HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007, 11: 407-420. 10.1016\/j.ccr.2007.04.001.","journal-title":"Cancer Cell"},{"key":"1948_CR29","doi-asserted-by":"publisher","first-page":"2270","DOI":"10.1158\/1078-0432.CCR-07-4131","volume":"14","author":"JA Mayr","year":"2008","unstructured":"Mayr JA, Meierhofer D, Zimmermann F, Feichtinger R, Kogler C, Ratschek M, Schmeller N, Sperl W, Kofler B: Loss of complex I due to mitochondrial DNA mutations in renal oncocytoma. Clin Cancer Res. 2008, 14: 2270-2275. 10.1158\/1078-0432.CCR-07-4131.","journal-title":"Clin Cancer Res"},{"key":"1948_CR30","doi-asserted-by":"publisher","first-page":"9001","DOI":"10.1073\/pnas.0703056104","volume":"104","author":"G Gasparre","year":"2007","unstructured":"Gasparre G, Porcelli AM, Bonora E, Pennisi LF, Toller M, Iommarini L, Ghelli A, Moretti M, Betts CM, Martinelli GN, et al: Disruptive mitochondrial DNA mutations in complex I subunits are markers of oncocytic phenotype in thyroid tumors. Proc Natl Acad Sci USA. 2007, 104: 9001-9006. 10.1073\/pnas.0703056104.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1948_CR31","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/0076-6879(69)13005-0","volume":"13","author":"PA Srere","year":"1969","unstructured":"Srere PA: Citrate synthase. Methods in enzymology. 1969, 13: 3-5. full_text.","journal-title":"Methods in enzymology"},{"key":"1948_CR32","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00401-002-0638-1","volume":"105","author":"A Berger","year":"2003","unstructured":"Berger A, Mayr JA, Meierhofer D, Fotschl U, Bittner R, Budka H, Grethen C, Huemer M, Kofler B, Sperl W: Severe depletion of mitochondrial DNA in spinal muscular atrophy. Acta Neuropathol. 2003, 105: 245-251.","journal-title":"Acta Neuropathol"},{"key":"1948_CR33","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.1093\/carcin\/bgh104","volume":"25","author":"D Meierhofer","year":"2004","unstructured":"Meierhofer D, Mayr JA, Foetschl U, Berger A, Fink K, Schmeller N, Hacker GW, Hauser-Kronberger C, Kofler B, Sperl W: Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma. Carcinogenesis. 2004, 25: 1005-1010. 10.1093\/carcin\/bgh104.","journal-title":"Carcinogenesis"},{"key":"1948_CR34","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0009-8981(94)90055-8","volume":"228","author":"P Rustin","year":"1994","unstructured":"Rustin P, Chretien D, Bourgeron T, Gerard B, Rotig A, Saudubray JM, Munnich A: Biochemical and molecular investigations in respiratory chain deficiencies. Clin Chim Acta. 1994, 228: 35-51. 10.1016\/0009-8981(94)90055-8.","journal-title":"Clin Chim Acta"},{"key":"1948_CR35","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1016\/j.ymgme.2009.06.012","volume":"98","author":"B Acham-Roschitz","year":"2009","unstructured":"Acham-Roschitz B, Plecko B, Lindbichler F, Bittner R, Mache CJ, Sperl W, Mayr JA: A novel mutation of the RRM2B gene in an infant with early fatal encephalomyopathy, central hypomyelination, and tubulopathy. Mol Genet Metab. 2009, 98: 300-304. 10.1016\/j.ymgme.2009.06.012.","journal-title":"Mol Genet Metab"},{"key":"1948_CR36","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1128\/MCB.01338-07","volume":"28","author":"RD Guzy","year":"2008","unstructured":"Guzy RD, Sharma B, Bell E, Chandel NS, Schumacker PT: Loss of the SdhB, but Not the SdhA, subunit of complex II triggers reactive oxygen species-dependent hypoxia-inducible factor activation and tumorigenesis. Mol Cell Biol. 2008, 28: 718-731. 10.1128\/MCB.01338-07.","journal-title":"Mol Cell Biol"},{"key":"1948_CR37","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1038\/sj.bjc.6602202","volume":"91","author":"D Astuti","year":"2004","unstructured":"Astuti D, Morris M, Krona C, Abel F, Gentle D, Martinsson T, Kogner P, Neumann HP, Voutilainen R, Eng C, et al: Investigation of the role of SDHB inactivation in sporadic phaeochromocytoma and neuroblastoma. Br J Cancer. 2004, 91: 1835-1841. 10.1038\/sj.bjc.6602202.","journal-title":"Br J Cancer"},{"key":"1948_CR38","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1186\/1471-2407-4-55","volume":"4","author":"K De Preter","year":"2004","unstructured":"De Preter K, Vandesompele J, Hoebeeck J, Vandenbroecke C, Smet J, Nuyts A, Laureys G, Combaret V, Van Roy N, Roels F, et al: No evidence for involvement of SDHD in neuroblastoma pathogenesis. BMC Cancer. 2004, 4: 55-10.1186\/1471-2407-4-55.","journal-title":"BMC Cancer"},{"key":"1948_CR39","doi-asserted-by":"publisher","first-page":"4101","DOI":"10.1210\/jc.82.12.4101","volume":"82","author":"H Brauch","year":"1997","unstructured":"Brauch H, Hoeppner W, Jahnig H, Wohl T, Engelhardt D, Spelsberg F, Ritter MM: Sporadic pheochromocytomas are rarely associated with germline mutations in the vhl tumor suppressor gene or the ret protooncogene. J Clin Endocrinol Metab. 1997, 82: 4101-4104. 10.1210\/jc.82.12.4101.","journal-title":"J Clin Endocrinol Metab"},{"key":"1948_CR40","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1002\/ijc.21888","volume":"119","author":"J Hoebeeck","year":"2006","unstructured":"Hoebeeck J, Vandesompele J, Nilsson H, De Preter K, Van Roy N, De Smet E, Yigit N, De Paepe A, Laureys G, Pahlman S, Speleman F: The von Hippel-Lindau tumor suppressor gene expression level has prognostic value in neuroblastoma. Int J Cancer. 2006, 119: 624-629. 10.1002\/ijc.21888.","journal-title":"Int J Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-10-149\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-149.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T05:57:21Z","timestamp":1630475841000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-10-149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4,19]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["1948"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-10-149","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4,19]]},"assertion":[{"value":"29 July 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 April 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"149"}}