{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:24:35Z","timestamp":1792103075613,"version":"4.4.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T00:00:00Z","timestamp":1275696000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1471-2407-10-260","type":"journal-article","created":{"date-parts":[[2010,6,5]],"date-time":"2010-06-05T14:13:46Z","timestamp":1275747226000},"source":"Crossref","is-referenced-by-count":69,"title":["Fractal dimension of chromatin is an independent prognostic factor for survival in melanoma"],"prefix":"10.1186","volume":"10","author":[{"given":"Valcinir","family":"Bedin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall L","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bianca CS","family":"de S\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Landman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konradin","family":"Metze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,6,5]]},"reference":[{"key":"2059_CR1","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.clindermatol.2008.09.007","volume":"27","author":"JA Carlson","year":"2009","unstructured":"Carlson JA, Ross JS, Slominski AJ: New techniques in dermatopathology that help to diagnose and prognosticate melanoma. Clinics in Dermatology. 2009, 27: 75-102. 10.1016\/j.clindermatol.2008.09.007.","journal-title":"Clinics in Dermatology"},{"key":"2059_CR2","doi-asserted-by":"publisher","first-page":"8065","DOI":"10.1200\/JCO.2005.02.4976","volume":"23","author":"PA Gimotty","year":"2005","unstructured":"Gimotty PA, Botbyl J, Soong SJ, Guerry D: A population-based validation of the American Joint Committee on Cancer melanoma staging system. J Clin Oncol. 2005, 23: 8065-75. 10.1200\/JCO.2005.02.4976.","journal-title":"J Clin Oncol"},{"issue":"6","key":"2059_CR3","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/00008390-200412000-00008","volume":"14","author":"BC de Sa","year":"2004","unstructured":"de Sa BC, Rezze GG, Scramin AP, Landman G, Neves RI: Cutaneous melanoma in childhood and adolescence: retrospective study of 32 patients. Melanoma Res. 2004, 14 (6): 487-92. 10.1097\/00008390-200412000-00008.","journal-title":"Melanoma Res"},{"issue":"3","key":"2059_CR4","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1097\/CMR.0b013e32831993f3","volume":"19","author":"BC de S\u00e1","year":"2009","unstructured":"de S\u00e1 BC, Fugimori ML, Ribeiro Kde C, Duprat Neto JP, Neves RI, Landman G: Proteins involved in pRb and p53 pathways are differentially expressed in thin and thick superficial spreading melanomas. Melanoma Res. 2009, 19 (3): 135-41. 10.1097\/CMR.0b013e32831993f3.","journal-title":"Melanoma Res"},{"issue":"11","key":"2059_CR5","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1111\/j.1600-0560.2007.00730.x","volume":"34","author":"DS Neto","year":"2007","unstructured":"Neto DS, Pantale\u00e3o L, de S\u00e1 BC, Landman G: Alpha-v-beta3 integrin expression in melanocytic nevi and cutaneous melanoma. J Cutan Pathol. 2007, 34 (11): 851-6. 10.1111\/j.1600-0560.2007.00730.x.","journal-title":"J Cutan Pathol"},{"key":"2059_CR6","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1186\/1471-2407-8-362","volume":"8","author":"IM Bachmann","year":"2008","unstructured":"Bachmann IM, Ladstein RG, Straume O, Naumov GN, Akslen LA: Tumor Necrosis is associated with increased alphavbeta3 integrin expression and poor prognosis in nodular cutaneous melanomas. BMC Cancer. 2008, 8: 362-10.1186\/1471-2407-8-362.","journal-title":"BMC Cancer"},{"key":"2059_CR7","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1471-2407-9-52","volume":"9","author":"A Winklmeier","year":"2009","unstructured":"Winklmeier A, Poser I, Hoek KS, Bosserhoff AK: Loss of full length CtBP1 expression enhances the invasive potential of human melanoma. BMC Cancer. 2009, 9: 52-10.1186\/1471-2407-9-52.","journal-title":"BMC Cancer"},{"key":"2059_CR8","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1186\/1471-2407-8-19","volume":"8","author":"JF Sousa","year":"2008","unstructured":"Sousa JF, Esperafico EM: Suppression subtractive hybridization profiles of radial growth phase and metastatic melanoma cell lines reveal novel potential targets. BMC Cancer. 2008, 8: 19-10.1186\/1471-2407-8-19.","journal-title":"BMC Cancer"},{"issue":"6","key":"2059_CR9","first-page":"415","volume":"31","author":"S Kaufmann","year":"2009","unstructured":"Kaufmann S, Kuphal S, Schubert T, Bosserhoff AK: Functional implication of Netrin expression in malignant melanoma. Cell Oncol. 2009, 31 (6): 415-22.","journal-title":"Cell Oncol"},{"issue":"12","key":"2059_CR10","doi-asserted-by":"publisher","first-page":"2744","DOI":"10.1007\/s00268-008-9736-0","volume":"32","author":"K Metze","year":"2008","unstructured":"Metze K, Ferreira RC, Adam RL, Leite NJ, Ward LS, de Matos PS: Chromatin texture is size dependent in follicular adenomas but not in hyperplastic nodules of the thyroid. World J Surg. 2008, 32 (12): 2744-6. 10.1007\/s00268-008-9736-0.","journal-title":"World J Surg"},{"key":"2059_CR11","first-page":"5","volume":"28","author":"RC Ferreira","year":"2006","unstructured":"Ferreira RC, de Matos PS, Adam RL, Leite NJ, Metze K: Application of the Minkowski fractal dimension for the differential diagnosis in thyroid Follicular neoplasias. Cellular Oncology. 2006, 28: 5-6.","journal-title":"Cellular Oncology"},{"key":"2059_CR12","first-page":"175","volume":"30","author":"MRB Mello","year":"2008","unstructured":"Mello MRB, Metze K, Adam RA, Pereira FG, Magalh\u00e3es MG, Machado Lorand-Metze I: Phenotypic subtypes of acute lymphoblastic leukemia associated with different nuclear chromatin texture. Analytical and Quantitative Cytology and Histology. 2008, 30: 175-184.","journal-title":"Analytical and Quantitative Cytology and Histology"},{"issue":"3 Suppl 1","key":"2059_CR13","doi-asserted-by":"publisher","first-page":"S26","DOI":"10.1186\/1746-1596-3-S1-S26","volume":"15","author":"E Moro-Rodr\u00edguez","year":"2008","unstructured":"Moro-Rodr\u00edguez E, Figols J, Alvira M, Uranga-Ocio JA, Garc\u00eda-Poblete E: 13 GFAP and alpha1a-AR staining and nuclear morphometry of oligodendrogliomas by confocal microscopy and image analysis: useful parameters for predicting survival in oligodendrogliomas. Diagn Pathol. 2008, 15 (3 Suppl 1): S26-10.1186\/1746-1596-3-S1-S26.","journal-title":"Diagn Pathol"},{"issue":"3","key":"2059_CR14","first-page":"175","volume":"30","author":"RL Adam","year":"2008","unstructured":"Adam RL, Leite NJ, Metze K: Image preprocessing improves Fourier-based texture analysis of nuclear chromatin. Anal Quant Cytol Histol. 2008, 30 (3): 175-84.","journal-title":"Anal Quant Cytol Histol"},{"issue":"2","key":"2059_CR15","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1159\/000204500","volume":"89","author":"K Metze","year":"1993","unstructured":"Metze K, Lorand-Metze IG: Interpretation of the AgNOR pattern in hematologic cytology. Acta Haematol. 1993, 89 (2): 110-2. 10.1159\/000204500.","journal-title":"Acta Haematol"},{"key":"2059_CR16","first-page":"234","volume":"24","author":"LX Li","year":"2002","unstructured":"Li LX, Crotty KA, Palmer AA, Kril JJ, Stankovic R, Scolyer RA, McCarthy SW: Differentiating benign nevi from malignant melanoma using DNA microdensitometry and karyometry and maturation: a zonal comparison, correlation and multivariate analysis. Anal Quant Cytol Histol. 2002, 24: 234-43.","journal-title":"Anal Quant Cytol Histol"},{"issue":"3","key":"2059_CR17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1097\/00000372-200306000-00002","volume":"25","author":"LX Li","year":"2003","unstructured":"Li LX, Crotty KA, Palmer AA, Kril JJ, Scolyer RA, Thompson JF, McCarthy SW: Argyrophilic staining of nucleolar organizer region count and morphometry in benign and malignant melanocytic lesions. Am J Dermatopathol. 2003, 25 (3): 190-7. 10.1097\/00000372-200306000-00002.","journal-title":"Am J Dermatopathol"},{"key":"2059_CR18","unstructured":"Cia EMM, Trevisan M, Metze K: Argyrophilic nucleolar organizer region (AgNOR) technique: a helpful tool for differential diagnosis in urinary cytology."},{"key":"2059_CR19","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1002\/(SICI)1097-0320(19980501)32:1<51::AID-CYTO7>3.0.CO;2-I","volume":"32","author":"I Lorand-Metze","year":"1998","unstructured":"Lorand-Metze I, Carvalho MA, Metze K: Relationship between morphometric analysis of nucleolar organizer regions and cell proliferation in acute leukemias. Cytometry. 1998, 32: 51-56. 10.1002\/(SICI)1097-0320(19980501)32:1<51::AID-CYTO7>3.0.CO;2-I.","journal-title":"Cytometry"},{"key":"2059_CR20","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/1746-1596-5-7","volume":"5","author":"M Jondet","year":"2010","unstructured":"Jondet M, Agoli-Agbo R, Dehennin L: Automatic measurement of epithelium differentiation and classification of cervical intraneoplasia by computerized image analysis. Diagn Pathol. 2010, 5: 7-10.1186\/1746-1596-5-7.","journal-title":"Diagn Pathol"},{"issue":"1-2","key":"2059_CR21","first-page":"55","volume":"28","author":"RL Adam","year":"2006","unstructured":"Adam RL, Silva RC, Pereira FG, Leite NJ, Lorand-Metze I, Metze K: The fractal dimension of nuclear chromatin as a prognostic factor in acute precursor B lymphoblastic leukemia. Cell Oncol. 2006, 28 (1-2): 55-9.","journal-title":"Cell Oncol"},{"issue":"1","key":"2059_CR22","first-page":"47","volume":"29","author":"R Montironi","year":"2007","unstructured":"Montironi R, Scarpelli M, Lopez-Beltran A, Mazzucchelli R, Alberts D, Ranger-Moore J, Bartels HG, Hamilton PW, Einspahr J, Bartels PH: Chromatin phenotype karyometry can predict recurrence in papillary urothelial neoplasms of low malignant potential. Cell Oncol. 2007, 29 (1): 47-58.","journal-title":"Cell Oncol"},{"issue":"6","key":"2059_CR23","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.febslet.2005.01.052","volume":"579","author":"DV Lebedev","year":"2005","unstructured":"Lebedev DV, Filatov MV, Kuklin AI, Islamov AKh, Kentzinger E, Pantina R, Toperverg BP, Isaev-Ivanov VV: Fractal nature of chromatin organization in interphase chicken erythrocyte nuclei: DNA structure exhibits biphasic fractal properties. FEBS Lett. 2005, 579 (6): 1465-8. 10.1016\/j.febslet.2005.01.052.","journal-title":"FEBS Lett"},{"key":"2059_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1126\/science.1181369","volume":"326","author":"E Lieberman-Aiden","year":"2009","unstructured":"Lieberman-Aiden E, van Berkum NL, Williams L, Imakaev M, Ragoczy T, Telling A, Amit I, Lajoie BR, Sabo PJ, Dorschner MO, Sandstrom R, Bernstein B, Bender MA, Groudine M, Gnirke A, Stamatoyannopoulos J, Mirny LA, Lander ES, Dekker J: Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 2009, 326: 289-293. 10.1126\/science.1181369.","journal-title":"Science"},{"key":"2059_CR25","doi-asserted-by":"publisher","first-page":"3785","DOI":"10.1038\/emboj.2009.340","volume":"28","author":"A Bancaud","year":"2009","unstructured":"Bancaud A, Huet S, Daigle N, Mozziconacci J, Beaudouin J, Ellenberg J: Molecular crowding affects diffusion and binding of nuclear proteins in heterochromatin and reveals the fractal organization of chromatin. EMBO J. 2009, 28: 3785-3798. 10.1038\/emboj.2009.340.","journal-title":"EMBO J"},{"key":"2059_CR26","first-page":"345","volume-title":"Nuclear fractal dimension as a prognostic factor in oral squamous cell carcinoma. Oral Oncology","author":"L Goutzanis","year":"2008","unstructured":"Goutzanis L, Papadogeorgakis N, Pavlopoulos PM, Katti K, Petsinis V, Plochoras I, Pantelidaki C, Kavantzas N, Patsouris E, Alexandridis C: Nuclear fractal dimension as a prognostic factor in oral squamous cell carcinoma. Oral Oncology. 2008, 44 (4): 345-353."},{"key":"2059_CR27","doi-asserted-by":"crossref","unstructured":"Mashiah A, Wolach O, Sandbank J: Lymphoma and leukemia cells possess fractal dimensions that correlate with their biological features. Acta Haematologica. 2008, 142-150. 10.1159\/000125551. 119","DOI":"10.1159\/000125551"},{"issue":"3B","key":"2059_CR28","first-page":"2141","volume":"25","author":"A Delides","year":"2005","unstructured":"Delides A, Panayiotides I, Alegakis A, Kyroudi A, Banis C, Pavlaki A, Helidonis E, Kittas C: Fractal dimension as a prognostic factor for laryngeal carcinoma. Anticancer Res. 2005, 25 (3B): 2141-4.","journal-title":"Anticancer Res"},{"issue":"S1","key":"2059_CR29","first-page":"7","volume":"455","author":"K Metze","year":"2009","unstructured":"Metze K, Ferro DP, Falconi MA, Adam RL, Ortega M, Lima CP, De Souza AC, Lorand-Metze I: Fractal characteristics of nuclear chromatin in routinely stained cytology are independent prognostic factors in patients with multiple myeloma. Virchows Archiv. 2009, 455 (S1): 7-11.","journal-title":"Virchows Archiv"},{"key":"2059_CR30","doi-asserted-by":"publisher","first-page":"844","DOI":"10.1038\/nm0798-844","volume":"4","author":"J Kononen","year":"1998","unstructured":"Kononen J, Bubendorf L, Kallioniemi A, B\u00e4rlund M, Schraml P, Leighton S, Torhorst J, Mihatsch MJ, Sauter G, Kallioniemi OP: Tissue microarrays for high- throughput molecular profiling of tumor specimens. Nat Med. 1998, 4: 844-7. 10.1038\/nm0798-844.","journal-title":"Nat Med"},{"key":"2059_CR31","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1109\/21.259692","volume":"24","author":"N Sarkar","year":"1994","unstructured":"Sarkar N, Chaudhuri BB: An efficient differential box-counting approach to computed fractal dimension of images. IEEE Transactions on Systems Man and Cybernetics. 1994, 24: 115-120. 10.1109\/21.259692.","journal-title":"IEEE Transactions on Systems Man and Cybernetics"},{"issue":"6","key":"2059_CR32","first-page":"503","volume":"31","author":"K Metze","year":"2009","unstructured":"Metze K, Lorand-Metze I, Leite NJ, Adam RL: Goodness-of-fit of the fractal dimension as a prognostic factor. Cell Oncol. 2009, 31 (6): 503-4.","journal-title":"Cell Oncol"},{"key":"2059_CR33","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.leukres.2003.11.001","volume":"28","author":"I Lorand-Metze","year":"2004","unstructured":"Lorand-Metze I, Pinheiro MP, Ribeiro E, de Paula EV, Metze K: Factors influencing survival in myelodysplastic syndromes in a Brazilian population: comparison of FAB andWHO classifications. Leukemia Research. 2004, 28: 587-594. 10.1016\/j.leukres.2003.11.001.","journal-title":"Leukemia Research"},{"issue":"4","key":"2059_CR34","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/107327480501200403","volume":"12","author":"J Homsi","year":"2005","unstructured":"Homsi J, Kashani-Sabet M, Messina JL, Daud A: Cutaneous melanoma:prognostic factors. Cancer Control. 2005, 12 (4): 223-9.","journal-title":"Cancer Control"},{"key":"2059_CR35","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1097\/00008390-200312000-00007","volume":"13","author":"LXL Li","year":"2003","unstructured":"Li LXL, Crotty KA, Scolyer RA, Thompson JF, Kril JJ, Palmer AA, McCarthy SW: Use of multiple cytometric markers improves discrimination between benign and malignant melanocytic lesions: a study of DNA microdensitometry, karyometry, argyrophilic staining of nucleolar organizer regions and MIB1- Ki67 immunoreactivity. Melanoma Research. 2003, 13: 581-586. 10.1097\/00008390-200312000-00007.","journal-title":"Melanoma Research"},{"key":"2059_CR36","doi-asserted-by":"crossref","unstructured":"Kossard S, WilkinsoN B: Nucleolar organizer regions and image-analysis nuclear morphometry of small-cell (nevoid) melanoma. Journal of Cutaneous Pathology. 22 (2): 132-136. 10.1111\/j.1600-0560.1995.tb01395.x.","DOI":"10.1111\/j.1600-0560.1995.tb01395.x"},{"key":"2059_CR37","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1111\/j.1600-0560.1993.tb00648.x","volume":"20","author":"E Rieger","year":"1993","unstructured":"Rieger E, Hofmann-Wellenhof R, Soyer HP, Kofler R, Cerroni L, Smolle J, Kerl H: Comparison of proliferative activity as assessed by proliferating cell nuclear antigen (PCNA) and Ki-67 monoclonal antibodies in melanocytic skin lesions. A quantitative immunohistochemical study. J Cutan Pathol. 1993, 20: 229-36. 10.1111\/j.1600-0560.1993.tb00648.x.","journal-title":"J Cutan Pathol"},{"issue":"4","key":"2059_CR38","doi-asserted-by":"publisher","first-page":"231","DOI":"10.2174\/138920209788488526","volume":"10","author":"J Rother","year":"2009","unstructured":"Rother J, Jones D: Molecular markers of tumor progression in melanoma. Curr Genomics. 2009, 10 (4): 231-9. 10.2174\/138920209788488526.","journal-title":"Curr Genomics"},{"issue":"4","key":"2059_CR39","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/cyto.1131","volume":"46","author":"M Bal\u00e1zs","year":"2001","unstructured":"Bal\u00e1zs M, Ad\u00e1m Z, Treszl A, B\u00e9g\u00e1ny A, Hunyadi J, Ad\u00e1ny R: Chromosomal imbalances in primary and metastatic melanomas revealed by comparative genomic hybridization. Cytometry. 2001, 46 (4): 222-32. 10.1002\/cyto.1131.","journal-title":"Cytometry"},{"issue":"4","key":"2059_CR40","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.cell.2007.01.028","volume":"128","author":"T Misteli","year":"2007","unstructured":"Misteli T: Beyond the Sequence: Cellular Organization of Genome Function. Cell. 2007, 128 (4): 787-800. 10.1016\/j.cell.2007.01.028.","journal-title":"Cell"},{"key":"2059_CR41","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1016\/j.cell.2004.08.011","volume":"118","author":"N Gilbert","year":"2004","unstructured":"Gilbert N, Boyle S, Fiegler H, Woodfine K, Carter NP, Bickmore WA: Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell. 2004, 118: 555-566. 10.1016\/j.cell.2004.08.011.","journal-title":"Cell"},{"issue":"1","key":"2059_CR42","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1471-2407-10-63","volume":"10","author":"M Mascolo","year":"2010","unstructured":"Mascolo M, Vecchione ML, Ilardi G, Scalvenzi M, Molea G, Di Benedetto M, Nugnes L, Siano M, De Rosa G, Staibano S: Overexpression of Chromatin Assembly Factor-1\/p60 helps to predict the prognosis of melanoma patients. BMC Cancer. 2010, 10 (1): 63-10.1186\/1471-2407-10-63.","journal-title":"BMC Cancer"},{"key":"2059_CR43","doi-asserted-by":"crossref","unstructured":"Rothhammer T, Bosserhoff AK: Epigenetic events in malignant melanoma. Pigment Cell Res. 20: 92-111. 10.1111\/j.1600-0749.2007.00367.x.","DOI":"10.1111\/j.1600-0749.2007.00367.x"},{"issue":"3","key":"2059_CR44","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1111\/1523-1747.ep12343580","volume":"106","author":"U Mossbacher","year":"1996","unstructured":"Mossbacher U, Knollmayer S, Binder M, Steiner A, Wolff K, Pehamberger H: Increased nuclear volume in metastasizing \"thick\" melanomas. J Invest Dermatol. 1996, 106 (3): 437-40. 10.1111\/1523-1747.ep12343580.","journal-title":"J Invest Dermatol"},{"issue":"1","key":"2059_CR45","first-page":"62","volume":"19","author":"LA Talve","year":"1997","unstructured":"Talve LA, Collan YU, Ekfors TO: Primary malignant melanoma of the skin. Relationships of nuclear DNA content, nuclear morphometric variables, Clark level and tumor thickness. Anal Quant Cytol Histol. 1997, 19 (1): 62-74.","journal-title":"Anal Quant Cytol Histol"},{"issue":"10","key":"2059_CR46","doi-asserted-by":"publisher","first-page":"3825","DOI":"10.1073\/pnas.72.10.3825","volume":"72","author":"BB Mandelbrot","year":"1975","unstructured":"Mandelbrot BB: Stochastic models for the Earth's relief, the shape and the fractal dimension of the coastlines, and the number-area rule for islands. Proc Natl Acad Sci USA. 1975, 72 (10): 3825-3828. 10.1073\/pnas.72.10.3825.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"Pt 1","key":"2059_CR47","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1111\/j.1365-2818.1981.tb01198.x","volume":"21","author":"D Paumgartner","year":"1981","unstructured":"Paumgartner D, Losa G, Weibel ER: Resolution effect on the stereological estimation of surface and volume and its interpretation in terms of fractal dimensions. J Microsc. 1981, 21 (Pt 1): 51-63.","journal-title":"J Microsc"},{"key":"2059_CR48","doi-asserted-by":"crossref","unstructured":"Grosberg AY, Nechaev S, Shakhnovich E: The role of topological constraints in the kinetics of collapse of macromolecules. J Phys France. 49: 2095-2100. 10.1051\/jphys:0198800490120209500.","DOI":"10.1051\/jphys:0198800490120209500"},{"issue":"1","key":"2059_CR49","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/emboj.2009.375","volume":"29","author":"JG McNally","year":"2010","unstructured":"McNally JG, Mazza D: Fractal geometry in the nucleus. EMBO Journal. 2010, 29 (1): 2-3. 10.1038\/emboj.2009.375.","journal-title":"EMBO Journal"},{"key":"2059_CR50","first-page":"132","volume-title":"Geophysical Journal International","author":"G Gonzato","year":"1998","unstructured":"Gonzato G, Mulargia F, Marzocchi W: Practical application of fractal analysis: Problems and solutions. Geophysical Journal International. 1998, 132-275."}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-10-260\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-260","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,29]],"date-time":"2019-05-29T17:36:26Z","timestamp":1559151386000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-10-260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,5]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["2059"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-10-260","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.4063956.3836054","asserted-by":"object"}]},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,5]]},"article-number":"260"}}