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However, the underlying molecular mechanisms are at present only partially understood.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Method<\/jats:title>\n            <jats:p>The effects of RES on activation of unfolded protein responses (UPR) were evaluated using Western blotting, semi-quantitative and real-time RT-PCR. Cell death was evaluated using Annexin V\/PI staining and subsequent FACS.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Similar as tunicamycin, treatment with RES lead to the activation of all 3 branches of the UPR, with early splicing of XBP-1 indicative of IRE1 activation, phosphorylation of eIF2\u03b1 consistent with ER resident kinase (PERK) activation, activating transcription factor 6 (ATF6) splicing, and increase in expression levels of the downstream molecules GRP78\/BiP, GRP94 and CHOP\/GADD153 in human Burkitt's lymphoma Raji and Daudi cell lines. RES was shown to induce cell death, which could be attenuated by thwarting upregulation of CHOP.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our data suggest that activation of the apoptotic arm of the UPR and its downstream effector CHOP\/GADD153 is involved, at least in part, in RES-induced apoptosis in Burkitt's lymphoma cells.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-10-445","type":"journal-article","created":{"date-parts":[[2010,8,20]],"date-time":"2010-08-20T07:16:41Z","timestamp":1282288601000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Resveratrol-induced cytotoxicity in human Burkitt's lymphoma cells is coupled to the unfolded protein response"],"prefix":"10.1186","volume":"10","author":[{"given":"Ying","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan-Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao-Qin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fang","family":"Niu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Zhuang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Qin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,8,20]]},"reference":[{"key":"2244_CR1","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1146\/annurev.phyto.37.1.285","volume":"37","author":"R Hammerschmidt","year":"1999","unstructured":"Hammerschmidt R: PHYTOALEXINS: What Have We Learned After 60 Years?. 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