{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T05:18:25Z","timestamp":1793423905715,"version":"4.5.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T00:00:00Z","timestamp":1288742400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>This study aimed to show that SHOX2 DNA methylation is a tumor marker in patients with suspected lung cancer by using bronchial fluid aspirated during bronchoscopy. Such a biomarker would be clinically valuable, especially when, following the first bronchoscopy, a final diagnosis cannot be established by histology or cytology. A test with a low false positive rate can reduce the need for further invasive and costly procedures and ensure early treatment.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Marker discovery was carried out by differential methylation hybridization (DMH) and real-time PCR. The real-time PCR based HeavyMethyl technology was used for quantitative analysis of DNA methylation of SHOX2 using bronchial aspirates from two clinical centres in a case-control study. Fresh-frozen and Saccomanno-fixed samples were used to show the tumor marker performance in different sample types of clinical relevance.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Valid measurements were obtained from a total of 523 patient samples (242 controls, 281 cases). DNA methylation of SHOX2 allowed to distinguish between malignant and benign lung disease, i.e. abscesses, infections, obstructive lung diseases, sarcoidosis, scleroderma, stenoses, at high specificity (68% sensitivity [95% CI 62-73%], 95% specificity [95% CI 91-97%]).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Hypermethylation of SHOX2 in bronchial aspirates appears to be a clinically useful tumor marker for identifying subjects with lung carcinoma, especially if histological and cytological findings after bronchoscopy are ambiguous.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-10-600","type":"journal-article","created":{"date-parts":[[2010,11,3]],"date-time":"2010-11-03T19:29:07Z","timestamp":1288812547000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":167,"title":["SHOX2 DNA Methylation is a Biomarker for the diagnosis of lung cancer based on bronchial aspirates"],"prefix":"10.1186","volume":"10","author":[{"given":"Bernd","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Liebenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimo","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Schlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kneip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Seegebarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadja","family":"Flemming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Seemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Distler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rn","family":"Lewin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reimo","family":"Tetzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Weickmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Wille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Triantafillos","family":"Liloglou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaide","family":"Raji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Walshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Fleischhacker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Witt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John K","family":"Field","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,11,3]]},"reference":[{"key":"2399_CR1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3322\/CA.2007.0010","volume":"58","author":"A Jemal","year":"2008","unstructured":"Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ: Cancer Statistics, 2008. CA Cancer J Clin. 2008, 58: 71-96. 10.3322\/CA.2007.0010.","journal-title":"CA Cancer J Clin"},{"key":"2399_CR2","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/1471-2466-8-2","volume":"8","author":"K Roth","year":"2008","unstructured":"Roth K, Hardie JA, Andreassen AH, Leh F, Eagan TM: Predictors of diagnostic yield in bronchoscopy: a retrospective cohort study comparing different combinations of sampling techniques. BMC Pulm Med. 2008, 8: 2-10.1186\/1471-2466-8-2.","journal-title":"BMC Pulm Med"},{"key":"2399_CR3","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1378\/chest.126.3.666","volume":"126","author":"A Gohari","year":"2004","unstructured":"Gohari A, Haramati LB: Complications of CT scan-guided lung biopsy: lesion size and depth matter. Chest. 2004, 126: 666-668. 10.1378\/chest.126.3.666.","journal-title":"Chest"},{"key":"2399_CR4","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1378\/chest.121.5.1521","volume":"121","author":"H Saji","year":"2002","unstructured":"Saji H, Nakamura H, Tsuchida T, Tsuboi M, Kawate N, Konaka C, Kato H: The incidence and the risk of pneumothorax and chest tube placement after percutaneous CT-guided lung biopsy: the angle of the needle trajectory is a novel predictor. Chest. 2002, 121: 1521-1526. 10.1378\/chest.121.5.1521.","journal-title":"Chest"},{"key":"2399_CR5","first-page":"451","volume":"47","author":"T Bunyaviroch","year":"2006","unstructured":"Bunyaviroch T, Coleman RE: PET evaluation of lung cancer. J Nucl Med. 2006, 47: 451-469.","journal-title":"J Nucl Med"},{"key":"2399_CR6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MCP.0b013e32819f8f06","volume":"13","author":"AK Greenberg","year":"2007","unstructured":"Greenberg AK, Lee MS: Biomarkers for lung cancer: clinical uses. Curr Opin Pulm Med. 2007, 13: 249-255. 10.1097\/MCP.0b013e32819f8f06.","journal-title":"Curr Opin Pulm Med"},{"key":"2399_CR7","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1097\/JTO.0b013e318158eed4","volume":"2","author":"J Chorostowska-Wynimko","year":"2007","unstructured":"Chorostowska-Wynimko J, Szpechcinski A: The impact of genetic markers on the diagnosis of lung cancer: a current perspective. J Thorac Oncol. 2007, 2: 1044-1051. 10.1097\/JTO.0b013e318158eed4.","journal-title":"J Thorac Oncol"},{"key":"2399_CR8","first-page":"181","volume":"1775","author":"M Fleischhacker","year":"2007","unstructured":"Fleischhacker M, Schmidt B: Circulating nucleic acids (CNAs) and cancer--a survey. Biochim Biophys Acta. 2007, 1775: 181-232.","journal-title":"Biochim Biophys Acta"},{"key":"2399_CR9","doi-asserted-by":"publisher","first-page":"7728","DOI":"10.1158\/1078-0432.CCR-05-0999","volume":"11","author":"V Schmiemann","year":"2005","unstructured":"Schmiemann V, B\u00f6cking A, Kazimirek M, Onofre AS, Gabbert HE, Kappes R, Gerharz CD, Grote HJ: Methylation assay for the diagnosis of lung cancer on bronchial aspirates: a cohort study. Clin Cancer Res. 2005, 11: 7728-7734. 10.1158\/1078-0432.CCR-05-0999.","journal-title":"Clin Cancer Res"},{"key":"2399_CR10","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1476-4598-7-81","volume":"7","author":"PP Anglim","year":"2008","unstructured":"Anglim PP, Alonzo TA, Laird-Offringa IA: DNA methylation-based biomarkers for early detection of non-small cell lung cancer: an update. Mol Cancer. 2008, 7: 81-10.1186\/1476-4598-7-81.","journal-title":"Mol Cancer"},{"key":"2399_CR11","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1186\/1476-4598-7-62","volume":"7","author":"PP Anglim","year":"2008","unstructured":"Anglim PP, Galler JS, Koss MN, Hagen JA, Turla S, Campan M, Weisenberger DJ, Laird PW, Siegmund KD, Laird-Offringa IA: Identification of a panel of sensitive and specific DNA methylation markers for squamous cell lung cancer. Mol Cancer. 2008, 7: 62-10.1186\/1476-4598-7-62.","journal-title":"Mol Cancer"},{"key":"2399_CR12","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1002\/ijc.23849","volume":"24","author":"A Daskalos","year":"2009","unstructured":"Daskalos A, Nikolaidis G, Xinarianos G, Savvari P, Cassidy A, Zakopoulou R, Kotsinas A, Gorgoulis V, Field JK, Liloglou T: Hypomethylation of retrotransposable elements correlates with genomic instability in non-small cell lung cancer. Int J Cancer. 2009, 24: 81-87. 10.1002\/ijc.23849.","journal-title":"Int J Cancer"},{"key":"2399_CR13","doi-asserted-by":"publisher","first-page":"10911","DOI":"10.1158\/0008-5472.CAN-06-0400","volume":"66","author":"M Ehrich","year":"2006","unstructured":"Ehrich M, Field JK, Liloglou T, Xinarianos G, Oeth P, Nelson MR, Cantor CR, van den Boom D: Cytosine Methylation Profiles as a Molecular Marker in Non-Small Cell Lung Cancer. Cancer Res. 2006, 66: 10911-10918. 10.1158\/0008-5472.CAN-06-0400.","journal-title":"Cancer Res"},{"key":"2399_CR14","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrg1655","volume":"6","author":"KD Robertson","year":"2005","unstructured":"Robertson KD: DNA methylation and human disease. Nat Rev Genet. 2005, 6: 597-610. 10.1038\/nrg1655.","journal-title":"Nat Rev Genet"},{"key":"2399_CR15","doi-asserted-by":"publisher","first-page":"3215","DOI":"10.1101\/gad.1464906","volume":"20","author":"AH Ting","year":"2006","unstructured":"Ting AH, McGarvey KM, Baylin SB: The cancer epigenome--components and functional correlates. Genes Dev. 2006, 20: 3215-3231. 10.1101\/gad.1464906.","journal-title":"Genes Dev"},{"key":"2399_CR16","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1038\/nrc1045","volume":"3","author":"PW Laird","year":"2003","unstructured":"Laird PW: The power and the promise of DNA methylation markers. Nat Rev Cancer. 2003, 3: 253-266. 10.1038\/nrc1045.","journal-title":"Nat Rev Cancer"},{"key":"2399_CR17","doi-asserted-by":"publisher","first-page":"1539","DOI":"10.1016\/j.biocel.2007.03.006","volume":"39","author":"J Lewin","year":"2007","unstructured":"Lewin J, Plum A, Hildmann T, Rujan T, Eckhardt F, Liebenberg V, Lofton-Day C, Wasserkort R: Comparative DNA methylation analysis in normal and tumour tissues and in cancer cell lines using differential methylation hybridisation. Int J Biochem Cell Biol. 2007, 39: 1539-1550. 10.1016\/j.biocel.2007.03.006.","journal-title":"Int J Biochem Cell Biol"},{"key":"2399_CR18","first-page":"1633","volume":"27","author":"JK Field","year":"2005","unstructured":"Field JK, Smith DL, Duffy S, Cassidy A: The Liverpool Lung Project research protocol. Int J Oncol. 2005, 27: 1633-1645.","journal-title":"Int J Oncol"},{"key":"2399_CR19","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/978-1-59745-545-9_9","volume":"576","author":"A Fassbender","year":"2010","unstructured":"Fassbender A, Lewin J, K\u00f6nig K, Rujan T, Pelet C, Lesche R, Distler J, Schuster M: Quantitative DNA methylation profiling on a high-density oligonucleotide microarray. Methods Mol Biol. 2010, 576: 155-170. full_text.","journal-title":"Methods Mol Biol"},{"key":"2399_CR20","doi-asserted-by":"publisher","first-page":"737","DOI":"10.2144\/000113208","volume":"47","author":"C Kneip","year":"2009","unstructured":"Kneip C, Schmidt B, Fleischhacker M, Seegebarth A, Lewin J, Flemming N, Seemann S, Schlegel T, Witt C, Liebenberg V, Dietrich D: A novel method for sensitive and specific detection of DNA methylation biomarkers based on continuous DNA restriction during PCR cycling. Biotechniques. 2009, 47: 737-744. 10.2144\/000113208.","journal-title":"Biotechniques"},{"key":"2399_CR21","doi-asserted-by":"publisher","first-page":"e10","DOI":"10.1093\/nar\/gnh008","volume":"32","author":"SE Cottrell","year":"2004","unstructured":"Cottrell SE, Distler J, Goodman NS, Mooney SH, Kluth A, Olek A, Schwope I, Tetzner R, Ziebarth H, Berlin K: A real-time PCR assay for DNA-methylation using methylation-specific blockers. Nucleic Acids Res. 2004, 32: e10-10.1093\/nar\/gnh008.","journal-title":"Nucleic Acids Res"},{"key":"2399_CR22","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1006\/meth.2001.1262","volume":"25","author":"KJ Livak","year":"2001","unstructured":"Livak KJ, Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 2001, 25: 402-408. 10.1006\/meth.2001.1262.","journal-title":"Methods"},{"key":"2399_CR23","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1006\/abio.1999.4085","volume":"270","author":"J Winer","year":"1999","unstructured":"Winer J, Jung CK, Shackel I, Williams PM: Development and validation of real-time quantitative reverse transcriptase-polymerase chain reaction for monitoring gene expression in cardiac myocytes in vitro. Anal Biochem. 1999, 270: 41-49. 10.1006\/abio.1999.4085.","journal-title":"Anal Biochem"},{"key":"2399_CR24","first-page":"3741","volume":"8","author":"EC Chan","year":"2002","unstructured":"Chan EC, Lam SY, Tsang KW, Lam B, JC Ho, Fu KH KH, Lam WK, Kwong YL: Aberrant promoter methylation in Chinese patients with non-small cell lung cancer: patterns in primary tumors and potential diagnostic application in bronchoalevolar lavage. Clin Cancer Res. 2002, 8: 3741-3746.","journal-title":"Clin Cancer Res"},{"key":"2399_CR25","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1158\/1078-0432.CCR-1111-3","volume":"10","author":"O Topaloglu","year":"2004","unstructured":"Topaloglu O, Hoque MO, Tokumaru Y, Lee J, Ratovitski E, Sidransky D, Moon CS: Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin Cancer Res. 2004, 10: 2284-2288. 10.1158\/1078-0432.CCR-1111-3.","journal-title":"Clin Cancer Res"},{"key":"2399_CR26","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1378\/chest.123.1_suppl.129S","volume":"123","author":"MP Rivera","year":"2003","unstructured":"Rivera MP, Detterbeck F, Mehta AC, American College of Chest Physicians: Diagnosis of lung cancer: the guidelines. Chest. 2003, 123: 129-136. 10.1378\/chest.123.1_suppl.129S.","journal-title":"Chest"},{"key":"2399_CR27","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/thorax.57.1.11","volume":"57","author":"GJ Herder","year":"2002","unstructured":"Herder GJ, Verboom P, Smit EF, van Velthoven PC, van den Bergh JH, Colder CD, van Mansom I, van Mourik JC, Postmus PE, Teule GJ, Hoekstra OS: Practice, efficacy and cost of staging suspected non-small cell lung cancer: a retrospective study in two Dutch hospitals. Thorax. 2002, 57: 11-14. 10.1136\/thorax.57.1.11.","journal-title":"Thorax"},{"key":"2399_CR28","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1002\/path.2246","volume":"213","author":"Hsu HS","year":"2007","unstructured":"HS Hsu, Chen TP, Wen CK, Hung CH, Chen CY, Chen JT, Wang YC: Multiple genetic and epigenetic biomarkers for lung cancer detection in cytologically negative sputum and a nested case-control study for risk assessment. J Pathol. 2007, 213: 412-419. 10.1002\/path.2246.","journal-title":"J Pathol"},{"key":"2399_CR29","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.lungcan.2004.07.996","volume":"45","author":"TC Kennedy","year":"2004","unstructured":"Kennedy TC, Hirsch FR: Using molecular markers in sputum for the early detection of lung cancer: a review. Lung Cancer. 2004, 45: 21-27. 10.1016\/j.lungcan.2004.07.996.","journal-title":"Lung Cancer"},{"key":"2399_CR30","doi-asserted-by":"publisher","first-page":"3163","DOI":"10.1242\/jcs.010389","volume":"120","author":"H Donninger","year":"2007","unstructured":"Donninger H, Vos MD, Clark GJ: The RASSF1A tumor suppressor. J Cell Sci. 2007, 120: 3163-3172. 10.1242\/jcs.010389.","journal-title":"J Cell Sci"},{"key":"2399_CR31","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1155\/2007\/291538","volume":"23","author":"LB Hesson","year":"2007","unstructured":"Hesson LB, Cooper WN, Latif F: The role of RASSF1A methylation in cancer. Dis Markers. 2007, 23: 73-87.","journal-title":"Dis Markers"},{"key":"2399_CR32","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1155\/2003\/354796","volume":"25","author":"HJ Grote","year":"2003","unstructured":"Grote HJ, Schmiemann V, Sarbia M, B\u00f6cking A: DNA extraction from bronchial aspirates for molecular cytology: which method to take?. Anal Cell Pathol. 2003, 25: 83-88.","journal-title":"Anal Cell Pathol"},{"key":"2399_CR33","first-page":"1624","volume":"61","author":"T Liloglou","year":"2001","unstructured":"Liloglou T, Maloney P, Xinarianos G, Hulbert M, Walshaw MJ, Gosney JR, Turnbull L, Field JK: Cancer-specific genomic instability in bronchial lavage: a molecular tool for lung cancer detection. Cancer Res. 2001, 61: 1624-1628.","journal-title":"Cancer Res"},{"key":"2399_CR34","doi-asserted-by":"publisher","first-page":"2406","DOI":"10.1073\/pnas.95.5.2406","volume":"95","author":"RJ Blaschke","year":"1998","unstructured":"Blaschke RJ, Monaghan AP, Schiller S, Schechinger B, Rao E, Padilla-Nash H, Ried T, Rappold GA: SHOT, a SHOX-related homeobox gene, is implicated in craniofacial, brain, heart, and limb development. Proc Natl Acad Sci USA. 1998, 95: 2406-2411. 10.1073\/pnas.95.5.2406.","journal-title":"Proc Natl Acad Sci USA"},{"key":"2399_CR35","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.ydbio.2007.03.518","volume":"306","author":"L Yu","year":"2007","unstructured":"Yu L, Liu H, Yan M, Yang J, Long F, Muneoka K, Chen Y: Shox2 is required for chondrocyte proliferation and maturation in proximal limb skeleton. Dev Biol. 2007, 306: 549-559. 10.1016\/j.ydbio.2007.03.518.","journal-title":"Dev Biol"},{"key":"2399_CR36","doi-asserted-by":"publisher","first-page":"5525","DOI":"10.1038\/sj.onc.1206853","volume":"22","author":"M Ohira","year":"2003","unstructured":"Ohira M, Morohashi A, Inuzuka H, Shishikura T, Kawamoto T, Kageyama H, Nakamura Y, Isogai E, Takayasu H, Sakiyama S, Suzuki Y, Sugano S, Goto T, Sato S, Nakagawara A: Expression profiling and characterization of 4200 genes cloned from primary neuroblastomas: identification of 305 genes differentially expressed between favorable and unfavorable subsets. Oncogene. 2003, 22: 5525-5536. 10.1038\/sj.onc.1206853.","journal-title":"Oncogene"},{"key":"2399_CR37","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1038\/sj.onc.1209920","volume":"26","author":"A Naderi Naderi","year":"2007","unstructured":"Naderi Naderi A, Teschendorff AE, Barbosa-Morais NL, Pinder SE, Green AR, Powe DG, Robertson JF, Aparicio S, Ellis IO, Brenton JD, Caldas C: A gene-expression signature to predict survival in breast cancer across independent data sets. Oncogene. 2007, 26: 1507-1516. 10.1038\/sj.onc.1209920.","journal-title":"Oncogene"},{"key":"2399_CR38","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/S0065-230X(08)00405-3","volume":"101","author":"KL Christensen","year":"2008","unstructured":"Christensen KL, Patrick AN, McCoy EL, Ford HL: The six family of homeobox genes in development and cancer. Adv Cancer Res. 2008, 101: 93-126. 10.1016\/S0065-230X(08)00405-3.","journal-title":"Adv Cancer Res"},{"key":"2399_CR39","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1042\/CS20080068","volume":"116","author":"V Boggaram","year":"2009","unstructured":"Boggaram V: Thyroid transcription factor-1 (TTF-1\/Nkx2.1\/TITF1) gene regulation in the lung. Clin Sci (Lond). 2009, 116: 27-35. 10.1042\/CS20080068.","journal-title":"Clin Sci (Lond)"},{"key":"2399_CR40","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1038\/nrc907","volume":"2","author":"C Abate-Shen","year":"2002","unstructured":"Abate-Shen C: Deregulated homeobox gene expression in cancer: cause or consequence?. Nat Rev Cancer. 2002, 2: 777-785. 10.1038\/nrc907.","journal-title":"Nat Rev Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-10-600\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-10-600.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T06:09:39Z","timestamp":1630476579000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-10-600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11,3]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["2399"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-10-600","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11,3]]},"assertion":[{"value":"11 June 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 November 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"600"}}