{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:15:10Z","timestamp":1780337710165,"version":"3.54.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,6,13]],"date-time":"2011-06-13T00:00:00Z","timestamp":1307923200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>A new lower-cost rapid-throughput human papillomavirus (HPV) test (<jats:italic>care<\/jats:italic>HPV, Qiagen, Gaithersburg, USA) has been shown to have high sensitivity for the detection of high grade cervical intraepithelial neoplasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed the outcomes and cost-effectiveness of<jats:italic>care<\/jats:italic>HPV screening in rural China, compared to visual inspection with acetic acid, when used alone (VIA) or in combination with Lugol's iodine (VIA\/VILI). Using data on sexual behaviour, test accuracy, diagnostic practices and costs from studies performed in rural China, we estimated the cost-effectiveness ratio (CER) and associated lifetime outcomes for once-lifetime and twice-lifetime screening strategies, and for routine screening at 5-yearly, 10-yearly and IARC-recommended intervals. The optimal age range for once-lifetime screening was also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For all strategies, the relative ordering of test technologies in reducing cervical cancer incidence and mortality was VIA (least effective); VIA\/VILI;<jats:italic>care<\/jats:italic>HPV@1.0 pg\/ml and<jats:italic>care<\/jats:italic>HPV@0.5 pg\/ml (most effective). For once-lifetime strategies, maximum effectiveness was achieved if screening occurred between 35-50 years. Assuming a participation rate of ~70%, once-lifetime screening at age 35 years would reduce cancer mortality by 8% (for VIA) to 12% (for<jats:italic>care<\/jats:italic>HPV@0.5) over the long term, with a CER of US$557 (for VIA) to $959 (for<jats:italic>care<\/jats:italic>HPV@1.0) per life year saved (LYS) compared to no intervention; referenced to a 2008 GDP per capita in Shanxi Province of $2,975. Correspondingly, regular screening with an age-standardised participation rate of 62% (which has been shown to be achievable in this setting) would reduce cervical cancer mortality by 19-28% (for 10-yearly screening) to 43-54% (using IARC-recommended intervals), with corresponding CERs ranging from $665 (for 10-yearly VIA) to $2,269 (for IARC-recommended intervals using<jats:italic>care<\/jats:italic>HPV@1.0) per LYS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This modelled analysis suggests that primary<jats:italic>care<\/jats:italic>HPV screening compares favourably to visual inspection screening methodologies in rural China, particularly if used as part of a regular screening program.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-11-239","type":"journal-article","created":{"date-parts":[[2011,6,14]],"date-time":"2011-06-14T06:19:04Z","timestamp":1308032344000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Evaluation of primary HPV-DNA testing in relation to visual inspection methods for cervical cancer screening in rural China: an epidemiologic and cost-effectiveness modelling study"],"prefix":"10.1186","volume":"11","author":[{"given":"Ju-Fang","family":"Shi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Canfell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie-Bin","family":"Lew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Legood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Ning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Simonella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon-Jung","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Xian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Lin","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,6,13]]},"reference":[{"key":"2738_CR1","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1158\/1055-9965.EPI-04-0680","volume":"14","author":"L Yang","year":"2005","unstructured":"Yang L, Parkin DM, Ferlay J, Li L, Chen Y: Estimates of cancer incidence in China for 2000 and projections for 2005. Cancer Epidemiology, Biomarkers & Prevention. 2005, 14: 243-250.","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"2738_CR2","volume-title":"Int J Cancer","author":"JF Shi","year":"2011","unstructured":"Shi JF, Canfell K, Lew JB, Qiao YL: The burden of cervical cancer in China: Synthesis of the evidence. Int J Cancer. 2011"},{"key":"2738_CR3","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/S1470-2045(08)70210-9","volume":"9","author":"YL Qiao","year":"2008","unstructured":"Qiao YL, Sellors JW, Eder PS, Bao YP, Lim JM, Zhao FH, Weigl B, Zhang WH, Peck RB, Li L, Chen F, Pan QJ, Lorincz AT: A new HPV-DNA test for cervical-cancer screening in developing regions: a cross-sectional study of clinical accuracy in rural China. Lancet Oncol. 2008, 9: 929-936. 10.1016\/S1470-2045(08)70210-9.","journal-title":"Lancet Oncol"},{"key":"2738_CR4","doi-asserted-by":"publisher","first-page":"2487","DOI":"10.1016\/j.vaccine.2010.12.085","volume":"29","author":"K Canfell","year":"2011","unstructured":"Canfell K, Shi JF, Lew JB, Walker RE, Zhao FH, Simonella L, Chen JF, Legood R, Smith MA, Nickson C, Qiao YL: Prevention of cervical cancer in rural China: Evaluation of HPV vaccination and primary HPV screening strategies. Vaccine. 2011, 29: 2487-2494. 10.1016\/j.vaccine.2010.12.085.","journal-title":"Vaccine"},{"key":"2738_CR5","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/sj.bjc.6603208","volume":"95","author":"M Dai","year":"2006","unstructured":"Dai M, Bao YP, Li N, Clifford GM, Vaccarella S, Snijders PJ, Huang RD, Sun LX, Meijer CJ, Qiao YL, Franceschi S: Human papillomavirus infection in Shanxi Province, People's Republic of China: a population-based study. British Journal of Cancer. 2006, 95: 96-101. 10.1038\/sj.bjc.6603208.","journal-title":"British Journal of Cancer"},{"key":"2738_CR6","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1006\/gyno.2001.6370","volume":"83","author":"J Belinson","year":"2001","unstructured":"Belinson J, Qiao YL, Pretorius R, Zhang WH, Elson P, Li L, Pan QJ, Fischer C, Lorincz A, Zahniser D: Shanxi Province Cervical Cancer Screening Study: a cross-sectional comparative trial of multiple techniques to detect cervical neoplasia. Gynecol Oncol. 2001, 83: 439-444. 10.1006\/gyno.2001.6370.","journal-title":"Gynecol Oncol"},{"key":"2738_CR7","volume-title":"IARC Handbooks of Cancer Prevention Volume 10: Cervix Cancer Screening","author":"IARC Working Group on the Evaluation of Cancer","year":"2005","unstructured":"IARC Working Group on the Evaluation of Cancer: IARC Handbooks of Cancer Prevention Volume 10: Cervix Cancer Screening. 2005, Lyon: IARC Press, 10","edition":"10"},{"key":"2738_CR8","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1002\/ijc.23633","volume":"123","author":"MA Smith","year":"2008","unstructured":"Smith MA, Canfell K, Brotherton JM, Lew JB, Barnabas RV: The predicted impact of vaccination on human papillomavirus infections in Australia. Int J Cancer. 2008, 123: 1854-1863. 10.1002\/ijc.23633.","journal-title":"Int J Cancer"},{"key":"2738_CR9","first-page":"e138","volume":"3","author":"RV Barnabas","year":"2006","unstructured":"Barnabas RV, Laukkanen P, Koskela P, Kontula O, Lehtinen M, Garnett GP: Epidemiology of HPV 16 and cervical cancer in Finland and the potential impact of vaccination: mathematical modelling analyses. PLoS Medicine \/ Public Library of Science. 2006, 3: e138-","journal-title":"PLoS Medicine \/ Public Library of Science"},{"key":"2738_CR10","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1038\/sj.bjc.6602002","volume":"91","author":"K Canfell","year":"2004","unstructured":"Canfell K, Barnabas R, Patnick J, Beral V: The predicted effect of changes in cervical screening practice in the UK: results from a modelling study. Br J Cancer. 2004, 91: 530-536. 10.1038\/sj.bjc.6602002.","journal-title":"Br J Cancer"},{"key":"2738_CR11","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1470-2045(08)70103-7","volume":"9","author":"MR McCredie","year":"2008","unstructured":"McCredie MR, Sharples KJ, Paul C, Baranyai J, Medley G, Jones RW, Skegg DC: Natural history of cervical neoplasia and risk of invasive cancer in women with cervical intraepithelial neoplasia 3: a retrospective cohort study. Lancet Oncology. 2008, 9: 425-434. 10.1016\/S1470-2045(08)70103-7.","journal-title":"Lancet Oncology"},{"key":"2738_CR12","volume-title":"Automation Assisted and Liquid Based Cytology for Cervical Cancer Screening. MSAC reference 1122, Assessment report","author":"Medical Services Advisory Committee","year":"2009","unstructured":"Medical Services Advisory Committee: Automation Assisted and Liquid Based Cytology for Cervical Cancer Screening. MSAC reference 1122, Assessment report. 2009, Canberra, [http:\/\/www.msac.gov.au\/internet\/msac\/publishing.nsf\/Content\/BAE45713D7D0FDEBCA257817001CB46D\/$File\/1122_MSAC_Assessment_Report.pdf]"},{"key":"2738_CR13","doi-asserted-by":"publisher","first-page":"S43","DOI":"10.1016\/S0020-7292(06)60030-1","volume":"95","author":"MA Quinn","year":"2006","unstructured":"Quinn MA, Benedet JL, Odicino F, Maisonneuve P, Beller U, Creasman WT, Heintz AP, Ngan HY, Pecorelli S: Carcinoma of the cervix uteri. FIGO 6th Annual Report on the Results of Treatment in Gynecological Cancer. International Journal of Gynaecology & Obstetrics. 2006, 95: S43-103.","journal-title":"International Journal of Gynaecology & Obstetrics"},{"key":"2738_CR14","volume-title":"GPE Discussion Paper Series","author":"OB Ahmad","year":"2001","unstructured":"Ahmad OB, Boschi-Pinto C, Lopez AD, Murray CJL, Lozano R, Inoue M: Age standardization of rates: A new WHO standard. GPE Discussion Paper Series. 2001, No.31. Geneva: World Health Organization"},{"key":"2738_CR15","volume-title":"Cancer incidence in five continents Vol VIII","author":"DM Parkin","year":"2002","unstructured":"Parkin DM, Whelen SL, Ferlay J, Teppo L, Thomas DB: Cancer incidence in five continents Vol VIII. 2002, Lyon, France: IARC Scientific Publications"},{"key":"2738_CR16","first-page":"15","volume":"27","author":"N Li","year":"2006","unstructured":"Li N, Ma CP, Sun LX, Zhang YZ, Shao SL, Xing JX, Bao YP, Huang RD, He LJ, Qiao YL: Evaluation on the visual inspection with Lugol's iodine in cervical cancer screening program. Zhonghua Liu Xing Bing Xue Za Zhi. 2006, 27: 15-18.","journal-title":"Zhonghua Liu Xing Bing Xue Za Zhi"},{"key":"2738_CR17","doi-asserted-by":"publisher","first-page":"2218","DOI":"10.1002\/ijc.22991","volume":"121","author":"RG Pretorius","year":"2007","unstructured":"Pretorius RG, Bao YP, Belinson JL, Burchette RJ, Smith JS, Qiao YL: Inappropriate gold standard bias in cervical cancer screening studies. Int J Cancer. 2007, 121: 2218-2224. 10.1002\/ijc.22991.","journal-title":"Int J Cancer"},{"issue":"Suppl 12","key":"2738_CR18","doi-asserted-by":"publisher","first-page":"M53","DOI":"10.1016\/j.vaccine.2008.05.009","volume":"26","author":"JF Shi","year":"2008","unstructured":"Shi JF, Qiao YL, Smith JS, Dondog B, Bao YP, Dai M, Clifford GM, Franceschi S: Epidemiology and prevention of human papillomavirus and cervical cancer in China and Mongolia. Vaccine. 2008, 26 (Suppl 12): M53-M59.","journal-title":"Vaccine"},{"key":"2738_CR19","doi-asserted-by":"publisher","first-page":"414","DOI":"10.1177\/0272989X07302128","volume":"27","author":"RP Insinga","year":"2007","unstructured":"Insinga RP, Glass AG, Myers ER, Rush BB: Abnormal outcomes following cervical cancer screening: Event duration and health utility loss. Medical Decision Making. 2007, 27: 414-422. 10.1177\/0272989X07302128.","journal-title":"Medical Decision Making"},{"key":"2738_CR20","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/1478-7547-6-4","volume":"6","author":"SL Kulasingam","year":"2008","unstructured":"Kulasingam SL, Benard S, Barnabas RV, Largeron N, Myers ER: Adding a quadrivalent human papillomavirus vaccine to the UK cervical cancer screening programme: A cost-effectiveness analysis. Cost Eff Resour Alloc. 2008, 6: 4-10.1186\/1478-7547-6-4.","journal-title":"Cost Eff Resour Alloc"},{"key":"2738_CR21","doi-asserted-by":"publisher","first-page":"1352","DOI":"10.1111\/j.1471-0528.2007.01525.x","volume":"114","author":"O Wu","year":"2007","unstructured":"Wu O, Briggs A, Dutton S, Hirst A, Maresh M, Nicholson A, McPherson K, Murray CJL: Uterine artery embolisation or hysterectomy for the treatment of symptomatic uterine fibroids: a cost-utility analysis of the HOPEFUL study. Bjog. 2007, 114: 1352-1362.","journal-title":"Bjog"},{"key":"2738_CR22","volume-title":"Making choices in health: WHO guide to cost-effectiveness analysis","author":"ET Tan-Torres","year":"2003","unstructured":"Tan-Torres ET, Baltussen R, Adam T, Hutubessy R, Acharya A, Evans DB, Murray CJL: Making choices in health: WHO guide to cost-effectiveness analysis. 2003, Geneva: World Health Organization"},{"key":"2738_CR23","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198529446.001.0001","volume-title":"Methods for the Economic Evaluation of Health Care Programmes","author":"MF Drummond","year":"2005","unstructured":"Drummond MF, Sculpher MJ, Torrance GW, O'Brien BJ, Stoddart GL: Methods for the Economic Evaluation of Health Care Programmes. 2005, New York: Oxford University Press"},{"key":"2738_CR24","volume-title":"One-year time deposit interest rate of China","author":"The People's Bank of China","year":"2008","unstructured":"The People's Bank of China: One-year time deposit interest rate of China. 2008, [http:\/\/www.pbc.gov.cn\/publish\/zhengcehuobisi\/631\/1269\/12692\/12692_.html]"},{"key":"2738_CR25","volume-title":"Statistical communique of Shanxi Province on the 2008 civil economic and social development","author":"Statistics Bureau of Shanxi Province","year":"2009","unstructured":"Statistics Bureau of Shanxi Province: Statistical communique of Shanxi Province on the 2008 civil economic and social development. 2009, China Development Gateway, [http:\/\/cn.chinagate.cn\/reports\/2009-03\/07\/content_17397726.htm]"},{"key":"2738_CR26","volume-title":"Macroeconomics and health: investing in health for economic development Report of the Commission on Macroeconomics and Health","author":"WHO Commission on Macroeconomics and Health","year":"2001","unstructured":"WHO Commission on Macroeconomics and Health: Macroeconomics and health: investing in health for economic development Report of the Commission on Macroeconomics and Health. 2001, Geneva: World Health Organization"},{"key":"2738_CR27","doi-asserted-by":"publisher","first-page":"2158","DOI":"10.1056\/NEJMsa044278","volume":"353","author":"SJ Goldie","year":"2005","unstructured":"Goldie SJ, Gaffikin L, Goldhaber-Fiebert JD, Gordillo-Tobar A, Levin C, Mahe C, Wright TC: Cost-effectiveness of cervical-cancer screening in five developing countries. N Engl J Med. 2005, 353: 2158-2168. 10.1056\/NEJMsa044278.","journal-title":"N Engl J Med"},{"key":"2738_CR28","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/1750-9378-4-8","volume":"4","author":"M Schiffman","year":"2009","unstructured":"Schiffman M, Clifford G, Buonaguro FM: Classification of weakly carcinogenic human papillomavirus types: addressing the limits of epidemiology at the borderline. Infect Agent Cancer. 2009, 4: 8-10.1186\/1750-9378-4-8.","journal-title":"Infect Agent Cancer"},{"key":"2738_CR29","volume-title":"GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No 10 [Internet]","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Parkin DM: GLOBOCAN 2008, Cancer Incidence and Mortality Worldwide: IARC CancerBase No 10 [Internet]. 2010, Lyon, France: International Agency for Research on Cancer"},{"key":"2738_CR30","doi-asserted-by":"publisher","first-page":"1385","DOI":"10.1056\/NEJMoa0808516","volume":"360","author":"R Sankaranarayanan","year":"2009","unstructured":"Sankaranarayanan R, Nene BM, Shastri SS, Jayant K, Muwonge R, Budukh AM, Hingmire S, Malvi SG, Thorat R, Kothari A, Chinoy R, Kelkar R, Kane S, Desai S, Keskar VR, Rajeshwarkar R, Panse N, Dinshaw KA: HPV screening for cervical cancer in rural India. N Engl J Med. 2009, 360: 1385-1394. 10.1056\/NEJMoa0808516.","journal-title":"N Engl J Med"},{"key":"2738_CR31","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1002\/ijc.25150","volume":"127","author":"CE Levin","year":"2010","unstructured":"Levin CE, Sellors J, Shi JF, Ma L, Qiao YL, Ortendahl J, Goldie SJ: Cost-effectiveness analysis of cervical cancer prevention based on a rapid human papillomavirus screening test in a high-risk region of China. Int J Cancer. 2010, 127: 1404-1411. 10.1002\/ijc.25150.","journal-title":"Int J Cancer"},{"key":"2738_CR32","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ijc.23489","volume":"123","author":"M Arbyn","year":"2008","unstructured":"Arbyn M, Sankaranarayanan R, Muwonge R, Keita N, Dolo A, Mbalawa CG, Nouhou H, Sakande B, Wesley R, Somanathan T, Sharma A, Shastri S, Basu P: Pooled analysis of the accuracy of five cervical cancer screening tests assessed in eleven studies in Africa and India. Int J Cancer. 2008, 123: 153-160. 10.1002\/ijc.23489.","journal-title":"Int J Cancer"},{"key":"2738_CR33","volume-title":"Investigate for malignant tumour mortality in China","author":"National Office for Cancer Prevention and Control of Chinese Ministry of Health","year":"1979","unstructured":"National Office for Cancer Prevention and Control of Chinese Ministry of Health: Investigate for malignant tumour mortality in China. 1979, Beijing: People's Medical Publishing House"},{"key":"2738_CR34","volume-title":"Investigate for malignant tumour mortality in China (1990-1992)","author":"National Office for Cancer Prevention and Control of Chinese Ministry of Health","year":"2008","unstructured":"National Office for Cancer Prevention and Control of Chinese Ministry of Health: Investigate for malignant tumour mortality in China (1990-1992). 2008, Beijing: People's Medical Publishing House"},{"key":"2738_CR35","volume-title":"The Third National Retrospective Sampling Death Survey","author":"Z Chen","year":"2008","unstructured":"Chen Z: The Third National Retrospective Sampling Death Survey. 2008, Beijing: Peking Union Medical University Press"},{"key":"2738_CR36","volume-title":"Cancer Incidence in Five Continents, Vol IX","author":"MP Curado","year":"2007","unstructured":"Curado MP, Edwards B, Shin HR, Storm H, Frelay J, Heanue M, Boyle P: Cancer Incidence in Five Continents, Vol IX. 2007, IARC Scientific Publications No. 160 edn. Lyon, France: IARC"},{"key":"2738_CR37","doi-asserted-by":"crossref","unstructured":"Editorial: Women's health in rural China. Lancet. 2009, 374: 358-","DOI":"10.1016\/S0140-6736(09)61394-5"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-11-239\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-239","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-239.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,7]],"date-time":"2024-04-07T14:36:30Z","timestamp":1712500590000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-11-239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,13]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["2738"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-11-239","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,13]]},"assertion":[{"value":"8 March 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"239"}}