{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T02:04:43Z","timestamp":1778378683109,"version":"3.51.4"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2011,1,4]],"date-time":"2011-01-04T00:00:00Z","timestamp":1294099200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Runt-related transcription factor 3 (RUNX3) is known as a tumor suppressor gene for gastric cancer and other cancers, this gene may be involved in the development of hepatocellular carcinoma (HCC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>RUNX3 expression was analyzed by immunoblot and immunohistochemistry in HCC cells and tissues, respectively. Hep3B cells, lacking endogenous RUNX3, were introduced with RUNX3 constructs. Cell proliferation was measured using the MTT assay and apoptosis was evaluated using DAPI staining. Apoptosis signaling was assessed by immunoblot analysis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>RUNX3 protein expression was frequently inactivated in the HCC cell lines (91%) and tissues (90%). RUNX3 expression inhibited 90 \u00b1 8% of cell growth at 72 h in serum starved Hep3B cells. Forty-eight hour serum starvation-induced apoptosis and the percentage of apoptotic cells reached 31 \u00b1 4% and 4 \u00b1 1% in RUNX3-expressing Hep3B and control cells, respectively. Apoptotic activity was increased by Bim expression and caspase-3 and caspase-9 activation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>RUNX3 expression enhanced serum starvation-induced apoptosis in HCC cell lines. RUNX3 is deleted or weakly expressed in HCC, which leads to tumorigenesis by escaping apoptosis.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-11-3","type":"journal-article","created":{"date-parts":[[2011,1,5]],"date-time":"2011-01-05T20:04:06Z","timestamp":1294257846000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Loss of runt-related transcription factor 3 expression leads hepatocellular carcinoma cells to escape apoptosis"],"prefix":"10.1186","volume":"11","author":[{"given":"Yutaka","family":"Nakanishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidenori","family":"Shiraha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Nishina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigetomi","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Matsubara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Horiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Iwamuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Takaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Uemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Kuwaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Hagihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Toshimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Takaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichiro","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nouso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahito","family":"Yagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhide","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,1,4]]},"reference":[{"issue":"7","key":"2496_CR1","doi-asserted-by":"publisher","first-page":"2557","DOI":"10.1053\/j.gastro.2007.04.061","volume":"132","author":"HB El-Serag","year":"2007","unstructured":"El-Serag HB, Rudolph KL: Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007, 132 (7): 2557-2576. 10.1053\/j.gastro.2007.04.061.","journal-title":"Gastroenterology"},{"key":"2496_CR2","volume-title":"Global Cancer Facts & Figures 2007","author":"M Garcia","year":"2007","unstructured":"Garcia M, Jernal A, Ward EM, M CM, Hao Y, Siegel RI, Thun MJ: Global Cancer Facts & Figures 2007. 2007, Society AC. Atlanta, GA"},{"issue":"2","key":"2496_CR3","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1002\/ijc.1440","volume":"94","author":"DM Parkin","year":"2001","unstructured":"Parkin DM, Bray F, Ferlay J, Pisani P: Estimating the world cancer burden: Globocan 2000. Int J Cancer. 2001, 94 (2): 153-156. 10.1002\/ijc.1440.","journal-title":"Int J Cancer"},{"issue":"10","key":"2496_CR4","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1056\/NEJM199903113401001","volume":"340","author":"HB El-Serag","year":"1999","unstructured":"El-Serag HB, Mason AC: Rising incidence of hepatocellular carcinoma in the United States. N Engl J Med. 1999, 340 (10): 745-750. 10.1056\/NEJM199903113401001.","journal-title":"N Engl J Med"},{"issue":"5","key":"2496_CR5","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.1002\/hep.20460","volume":"40","author":"S Kremer-Tal","year":"2004","unstructured":"Kremer-Tal S, Reeves HL, Narla G, Thung SN, Schwartz M, Difeo A, Katz A, Bruix J, Bioulac-Sage P, Martignetti JA, et al: Frequent inactivation of the tumor suppressor Kruppel-like factor 6 (KLF6) in hepatocellular carcinoma. Hepatology. 2004, 40 (5): 1047-1052. 10.1002\/hep.20460.","journal-title":"Hepatology"},{"issue":"6","key":"2496_CR6","doi-asserted-by":"publisher","first-page":"1582","DOI":"10.1172\/JCI27236","volume":"116","author":"P Kaposi-Novak","year":"2006","unstructured":"Kaposi-Novak P, Lee JS, Gomez-Quiroz L, Coulouarn C, Factor VM, Thorgeirsson SS: Met-regulated expression signature defines a subset of human hepatocellular carcinomas with poor prognosis and aggressive phenotype. The Journal of clinical investigation. 2006, 116 (6): 1582-1595. 10.1172\/JCI27236.","journal-title":"The Journal of clinical investigation"},{"issue":"7012","key":"2496_CR7","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1038\/nature03043","volume":"431","author":"CM Shachaf","year":"2004","unstructured":"Shachaf CM, Kopelman AM, Arvanitis C, Karlsson A, Beer S, Mandl S, Bachmann MH, Borowsky AD, Ruebner B, Cardiff RD, et al: MYC inactivation uncovers pluripotent differentiation and tumour dormancy in hepatocellular cancer. Nature. 2004, 431 (7012): 1112-1117. 10.1038\/nature03043.","journal-title":"Nature"},{"issue":"5","key":"2496_CR8","first-page":"G859","volume":"290","author":"JK Sicklick","year":"2006","unstructured":"Sicklick JK, Li YX, Melhem A, Schmelzer E, Zdanowicz M, Huang J, Caballero M, Fair JH, Ludlow JW, McClelland RE, et al: Hedgehog signaling maintains resident hepatic progenitors throughout life. American journal of physiology. 2006, 290 (5): G859-870.","journal-title":"American journal of physiology"},{"issue":"4","key":"2496_CR9","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1159\/000058531","volume":"60","author":"H Azechi","year":"2001","unstructured":"Azechi H, Nishida N, Fukuda Y, Nishimura T, Minata M, Katsuma H, Kuno M, Ito T, Komeda T, Kita R, et al: Disruption of the p16\/cyclin D1\/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. Oncology. 2001, 60 (4): 346-354. 10.1159\/000058531.","journal-title":"Oncology"},{"issue":"8","key":"2496_CR10","doi-asserted-by":"publisher","first-page":"1929","DOI":"10.1002\/cncr.11266","volume":"97","author":"TH Hu","year":"2003","unstructured":"Hu TH, Huang CC, Lin PR, Chang HW, Ger LP, Lin YW, Changchien CS, Lee CM, Tai MH: Expression and prognostic role of tumor suppressor gene PTEN\/MMAC1\/TEP1 in hepatocellular carcinoma. Cancer. 2003, 97 (8): 1929-1940. 10.1002\/cncr.11266.","journal-title":"Cancer"},{"issue":"48","key":"2496_CR11","doi-asserted-by":"publisher","first-page":"7104","DOI":"10.1038\/sj.onc.1204902","volume":"20","author":"A Tannapfel","year":"2001","unstructured":"Tannapfel A, Busse C, Weinans L, Benicke M, Katalinic A, Geissler F, Hauss J, Wittekind C: INK4a-ARF alterations and p53 mutations in hepatocellular carcinomas. Oncogene. 2001, 20 (48): 7104-7109. 10.1038\/sj.onc.1204902.","journal-title":"Oncogene"},{"issue":"19","key":"2496_CR12","doi-asserted-by":"publisher","first-page":"10351","DOI":"10.1073\/pnas.94.19.10351","volume":"94","author":"T Yamada","year":"1997","unstructured":"Yamada T, De Souza AT, Finkelstein S, Jirtle RL: Loss of the gene encoding mannose 6-phosphate\/insulin-like growth factor II receptor is an early event in liver carcinogenesis. Proc Natl Acad Sci USA. 1997, 94 (19): 10351-10355. 10.1073\/pnas.94.19.10351.","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2496_CR13","first-page":"281","volume":"54","author":"Y Fujimoto","year":"1994","unstructured":"Fujimoto Y, Hampton LL, Wirth PJ, Wang NJ, Xie JP, Thorgeirsson SS: Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res. 1994, 54 (1): 281-285.","journal-title":"Cancer Res"},{"issue":"6","key":"2496_CR14","doi-asserted-by":"publisher","first-page":"1246","DOI":"10.1053\/jhep.2000.7298","volume":"31","author":"H Kawai","year":"2000","unstructured":"Kawai H, Suda T, Aoyagi Y, Isokawa O, Mita Y, Waguri N, Kuroiwa T, Igarashi M, Tsukada K, Mori S, et al: Quantitative evaluation of genomic instability as a possible predictor for development of hepatocellular carcinoma: comparison of loss of heterozygosity and replication error. Hepatology. 2000, 31 (6): 1246-1250. 10.1053\/jhep.2000.7298.","journal-title":"Hepatology"},{"issue":"3","key":"2496_CR15","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1002\/hep.22110","volume":"47","author":"N Nishida","year":"2008","unstructured":"Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A: Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology. 2008, 47 (3): 908-918. 10.1002\/hep.22110.","journal-title":"Hepatology"},{"issue":"3","key":"2496_CR16","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/S0002-9440(10)63469-4","volume":"163","author":"B Yang","year":"2003","unstructured":"Yang B, Guo M, Herman JG, Clark DP: Aberrant promoter methylation profiles of tumor suppressor genes in hepatocellular carcinoma. Am J Pathol. 2003, 163 (3): 1101-1107.","journal-title":"Am J Pathol"},{"issue":"3","key":"2496_CR17","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1006\/scbi.2000.0319","volume":"10","author":"MA Buendia","year":"2000","unstructured":"Buendia MA: Genetics of hepatocellular carcinoma. Semin Cancer Biol. 2000, 10 (3): 185-200. 10.1006\/scbi.2000.0319.","journal-title":"Semin Cancer Biol"},{"issue":"17","key":"2496_CR18","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1158\/0008-5472.CAN-05-0743","volume":"65","author":"K Ito","year":"2005","unstructured":"Ito K, Liu Q, Salto-Tellez M, Yano T, Tada K, Ida H, Huang C, Shah N, Inoue M, Rajnakova A, et al: RUNX3, a novel tumor suppressor, is frequently inactivated in gastric cancer by protein mislocalization. Cancer Res. 2005, 65 (17): 7743-7750.","journal-title":"Cancer Res"},{"issue":"1","key":"2496_CR19","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/S0959-437X(03)00007-8","volume":"13","author":"Y Ito","year":"2003","unstructured":"Ito Y, Miyazono K: RUNX transcription factors as key targets of TGF-beta superfamily signaling. Curr Opin Genet Dev. 2003, 13 (1): 43-47. 10.1016\/S0959-437X(03)00007-8.","journal-title":"Curr Opin Genet Dev"},{"issue":"44","key":"2496_CR20","doi-asserted-by":"publisher","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","volume":"274","author":"J Hanai","year":"1999","unstructured":"Hanai J, Chen LF, Kanno T, Ohtani-Fujita N, Kim WY, Guo WH, Imamura T, Ishidou Y, Fukuchi M, Shi MJ, et al: Interaction and functional cooperation of PEBP2\/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. J Biol Chem. 1999, 274 (44): 31577-31582. 10.1074\/jbc.274.44.31577.","journal-title":"J Biol Chem"},{"issue":"1","key":"2496_CR21","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0092-8674(02)00690-6","volume":"109","author":"QL Li","year":"2002","unstructured":"Li QL, Ito K, Sakakura C, Fukamachi H, Inoue K, Chi XZ, Lee KY, Nomura S, Lee CW, Han SB, et al: Causal relationship between the loss of RUNX3 expression and gastric cancer. Cell. 2002, 109 (1): 113-124. 10.1016\/S0092-8674(02)00690-6.","journal-title":"Cell"},{"issue":"8","key":"2496_CR22","doi-asserted-by":"publisher","first-page":"5267","DOI":"10.1074\/jbc.M512151200","volume":"281","author":"Y Yamamura","year":"2006","unstructured":"Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y: RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem. 2006, 281 (8): 5267-5276. 10.1074\/jbc.M512151200.","journal-title":"J Biol Chem"},{"issue":"4","key":"2496_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1349-7006.2005.00033.x","volume":"96","author":"K Araki","year":"2005","unstructured":"Araki K, Osaki M, Nagahama Y, Hiramatsu T, Nakamura H, Ohgi S, Ito H: Expression of RUNX3 protein in human lung adenocarcinoma: Implications for tumor progression and prognosis. Cancer Sci. 2005, 96 (4): 227-231. 10.1111\/j.1349-7006.2005.00033.x.","journal-title":"Cancer Sci"},{"issue":"40","key":"2496_CR24","doi-asserted-by":"publisher","first-page":"6736","DOI":"10.1038\/sj.onc.1207731","volume":"23","author":"JL Ku","year":"2004","unstructured":"Ku JL, Kang SB, Shin YK, Kang HC, Hong SH, Kim IJ, Shin JH, Han IO, Park JG: Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Oncogene. 2004, 23 (40): 6736-6742. 10.1038\/sj.onc.1207731.","journal-title":"Oncogene"},{"issue":"3","key":"2496_CR25","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1136\/jcp.2003.013011","volume":"57","author":"J Li","year":"2004","unstructured":"Li J, Kleeff J, Guweidhi A, Esposito I, Berberat PO, Giese T, Buchler MW, Friess H: RUNX3 expression in primary and metastatic pancreatic cancer. J Clin Pathol. 2004, 57 (3): 294-299. 10.1136\/jcp.2003.013011.","journal-title":"J Clin Pathol"},{"issue":"13","key":"2496_CR26","doi-asserted-by":"publisher","first-page":"2401","DOI":"10.1038\/sj.onc.1207395","volume":"23","author":"M Wada","year":"2004","unstructured":"Wada M, Yazumi S, Takaishi S, Hasegawa K, Sawada M, Tanaka H, Ida H, Sakakura C, Ito K, Ito Y, et al: Frequent loss of RUNX3 gene expression in human bile duct and pancreatic cancer cell lines. Oncogene. 2004, 23 (13): 2401-2407. 10.1038\/sj.onc.1207395.","journal-title":"Oncogene"},{"issue":"2","key":"2496_CR27","doi-asserted-by":"publisher","first-page":"380","DOI":"10.1111\/j.1478-3231.2005.1059.x","volume":"25","author":"T Mori","year":"2005","unstructured":"Mori T, Nomoto S, Koshikawa K, Fujii T, Sakai M, Nishikawa Y, Inoue S, Takeda S, Kaneko T, Nakao A: Decreased expression and frequent allelic inactivation of the RUNX3 gene at 1p36 in human hepatocellular carcinoma. Liver Int. 2005, 25 (2): 380-388. 10.1111\/j.1478-3231.2005.1059.x.","journal-title":"Liver Int"},{"issue":"3","key":"2496_CR28","doi-asserted-by":"crossref","first-page":"376","DOI":"10.3748\/wjg.v10.i3.376","volume":"10","author":"WH Xiao","year":"2004","unstructured":"Xiao WH, Liu WW: Hemizygous deletion and hypermethylation of RUNX3 gene in hepatocellular carcinoma. World J Gastroenterol. 2004, 10 (3): 376-380.","journal-title":"World J Gastroenterol"},{"key":"2496_CR29","doi-asserted-by":"crossref","unstructured":"Li X, Zhang Y, Qiao T, Wu K, Ding J, Liu J, Fan D: RUNX3 Inhibits Growth of HCC Cells and HCC Xenografts in Mice in Combination With Adriamycin. Cancer Biol Ther. 2008, 7 (5): 10.1158\/1535-7163.MCT-07-2187.","DOI":"10.4161\/cbt.7.5.5664"},{"issue":"3","key":"2496_CR30","first-page":"985","volume":"9","author":"IO Ng","year":"1994","unstructured":"Ng IO, Chung LP, Tsang SW, Lam CL, Lai EC, Fan ST, Ng M: p53 gene mutation spectrum in hepatocellular carcinomas in Hong Kong Chinese. Oncogene. 1994, 9 (3): 985-990.","journal-title":"Oncogene"},{"issue":"12","key":"2496_CR31","doi-asserted-by":"publisher","first-page":"4474","DOI":"10.1128\/MCB.01926-05","volume":"26","author":"T Yano","year":"2006","unstructured":"Yano T, Ito K, Fukamachi H, Chi XZ, Wee HJ, Inoue K, Ida H, Bouillet P, Strasser A, Bae SC, et al: The RUNX3 tumor suppressor upregulates Bim in gastric epithelial cells undergoing transforming growth factor beta-induced apoptosis. Mol Cell Biol. 2006, 26 (12): 4474-4488. 10.1128\/MCB.01926-05.","journal-title":"Mol Cell Biol"},{"issue":"2","key":"2496_CR32","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/emboj\/17.2.384","volume":"17","author":"L O'Connor","year":"1998","unstructured":"O'Connor L, Strasser A, O'Reilly LA, Hausmann G, Adams JM, Cory S, Huang DC: Bim: a novel member of the Bcl-2 family that promotes apoptosis. Embo J. 1998, 17 (2): 384-395.","journal-title":"Embo J"},{"issue":"3","key":"2496_CR33","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/S1097-2765(00)80456-6","volume":"3","author":"H Puthalakath","year":"1999","unstructured":"Puthalakath H, Huang DC, O'Reilly LA, King SM, Strasser A: The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex. Molecular cell. 1999, 3 (3): 287-296. 10.1016\/S1097-2765(00)80456-6.","journal-title":"Molecular cell"},{"issue":"6","key":"2496_CR34","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1016\/S0092-8674(00)80595-4","volume":"96","author":"A Brunet","year":"1999","unstructured":"Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J, Greenberg ME: Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell. 1999, 96 (6): 857-868. 10.1016\/S0092-8674(00)80595-4.","journal-title":"Cell"},{"key":"2496_CR35","volume-title":"Int J Cancer","author":"C Guo","year":"2005","unstructured":"Guo C, Ding J, Yao L, Sun L, Lin T, Song Y, Fan D: Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. Int J Cancer. 2005"},{"issue":"9","key":"2496_CR36","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1111\/j.1365-2362.2004.01401.x","volume":"34","author":"M Osaki","year":"2004","unstructured":"Osaki M, Moriyama M, Adachi K, Nakada C, Takeda A, Inoue Y, Adachi H, Sato K, Oshimura M, Ito H: Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma. Eur J Clin Invest. 2004, 34 (9): 605-612. 10.1111\/j.1365-2362.2004.01401.x.","journal-title":"Eur J Clin Invest"},{"issue":"2","key":"2496_CR37","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.surg.2004.05.005","volume":"136","author":"A Torquati","year":"2004","unstructured":"Torquati A, O'Rear L, Longobardi L, Spagnoli A, Richards WO, Daniel Beauchamp R: RUNX3 inhibits cell proliferation and induces apoptosis by reinstating transforming growth factor beta responsiveness in esophageal adenocarcinoma cells. Surgery. 2004, 136 (2): 310-316. 10.1016\/j.surg.2004.05.005.","journal-title":"Surgery"},{"issue":"28","key":"2496_CR38","doi-asserted-by":"publisher","first-page":"29409","DOI":"10.1074\/jbc.M313120200","volume":"279","author":"YH Jin","year":"2004","unstructured":"Jin YH, Jeon EJ, Li QL, Lee YH, Choi JK, Kim WJ, Lee KY, Bae SC: Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem. 2004, 279 (28): 29409-29417. 10.1074\/jbc.M313120200.","journal-title":"J Biol Chem"},{"issue":"43","key":"2496_CR39","doi-asserted-by":"publisher","first-page":"41779","DOI":"10.1074\/jbc.M305350200","volume":"278","author":"G Li","year":"2003","unstructured":"Li G, Wang S, Gelehrter TD: Identification of glucocorticoid receptor domains involved in transrepression of transforming growth factor-beta action. J Biol Chem. 2003, 278 (43): 41779-41788. 10.1074\/jbc.M305350200.","journal-title":"J Biol Chem"},{"issue":"6","key":"2496_CR40","first-page":"309","volume":"56","author":"H Mouri","year":"2002","unstructured":"Mouri H, Sakaguchi K, Sawayama T, Senoh T, Ohta T, Nishimura M, Fujiwara A, Terao M, Shiratori Y, Tsuji T: Suppressive effects of transforming growth factor-beta1 produced by hepatocellular carcinoma cell lines on interferon-gamma production by peripheral blood mononuclear cells. Acta Med Okayama. 2002, 56 (6): 309-315.","journal-title":"Acta Med Okayama"},{"issue":"6317","key":"2496_CR41","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/350429a0","volume":"350","author":"B Bressac","year":"1991","unstructured":"Bressac B, Kew M, Wands J, Ozturk M: Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature. 1991, 350 (6317): 429-431. 10.1038\/350429a0.","journal-title":"Nature"},{"issue":"3","key":"2496_CR42","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1055\/s-2007-1007113","volume":"19","author":"M Ozturk","year":"1999","unstructured":"Ozturk M: Genetic aspects of hepatocellular carcinogenesis. Semin Liver Dis. 1999, 19 (3): 235-242. 10.1055\/s-2007-1007113.","journal-title":"Semin Liver Dis"},{"issue":"1","key":"2496_CR43","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1038\/71600","volume":"6","author":"H Higashitsuji","year":"2000","unstructured":"Higashitsuji H, Itoh K, Nagao T, Dawson S, Nonoguchi K, Kido T, Mayer RJ, Arii S, Fujita J: Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas. Nature medicine. 2000, 6 (1): 96-99. 10.1038\/71600.","journal-title":"Nature medicine"},{"issue":"1","key":"2496_CR44","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jmv.1890440113","volume":"44","author":"CC Hsia","year":"1994","unstructured":"Hsia CC, Di Bisceglie AM, Kleiner DE, Farshid M, Tabor E: RB tumor suppressor gene expression in hepatocellular carcinomas from patients infected with the hepatitis B virus. Journal of medical virology. 1994, 44 (1): 67-73. 10.1002\/jmv.1890440113.","journal-title":"Journal of medical virology"},{"issue":"26","key":"2496_CR45","doi-asserted-by":"publisher","first-page":"15406","DOI":"10.1073\/pnas.95.26.15406","volume":"95","author":"DM Li","year":"1998","unstructured":"Li DM, Sun H: PTEN\/MMAC1\/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells. Proc Natl Acad Sci USA. 1998, 95 (26): 15406-15411. 10.1073\/pnas.95.26.15406.","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-11-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-11-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T20:13:20Z","timestamp":1630613600000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-11-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1,4]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["2496"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-11-3","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,1,4]]},"assertion":[{"value":"10 August 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2011","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 January 2011","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}