{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:56:05Z","timestamp":1773755765570,"version":"3.50.1"},"reference-count":22,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In this population-based study (on 24041 women), we report on the prevalent genotypes of HPVs and the prevalent genotypes of HPV persistent infection in the northeast of China.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Our results showed that in HPV infected women (45.6% in total), (95% CI, 44.97%\u201346.23%), 17.35% (95%CI, 16.87%\u201317.83%) suffered persistent infection. The most common high-risk HPV types in persistent positivity were HPV-16 (18.21%; 95%CI, 17.04%\u201319.38%), HPV-58 (13.2%; 95%CI, 12.17%\u201314.23%), HPV-18 (8.66%; 95%CI, 7.81%\u20139.51%), HPV-52 (7.06%; 95% CI, 6.28%\u20137.84%) and HPV-33 (6.78%; 95% CI, 6.02%\u20137.54%). The prevalence of persistent infections with HPV-16,\u201358, \u221218, \u221252 and 33 in cervicitis were lower compared to those in CIN (all P\u2009&lt;\u20090.05). HPV-58, \u221233 and multiple HPV persistent positivity were significantly associated with older age (all P\u2009&lt;\u20090.05). HPV-18 persistent positivity was significantly associated with adenocarcinoma and lymphatic metastasis (all P\u2009&lt;\u20090.05). HPV-18 persistent positivity was associated with cervical cancer prognosis (P &lt;0.0001). Multivariate analyses showed that HPV-18 persistent positivity, (RR\u2009=\u20091.704, 95%CI\u2009=\u20091.095\u20132.654, p\u2009=\u20090.028) and lymphatic metastasis (RR\u2009=\u20092.304, 95%CI\u2009=\u20091.354\u20133.254, P\u2009=\u20090.015) were independent predictors for 3-year survival in cervical cancer.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>we provided extensive results of HPV genotype prevalence and distribution in the northeast of China. HPV genotyping is worthwhile to perform because of its independent prognostic value in cervical cancer<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-12-160","type":"journal-article","created":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T10:14:21Z","timestamp":1335867261000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China"],"prefix":"10.1186","volume":"12","author":[{"given":"Shizhuo","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heng","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shulan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Luan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuyan","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"3173_CR1","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1016\/S0140-6736(95)91086-7","volume":"345","author":"J Cuzick","year":"1995","unstructured":"Cuzick J, Szarewski A, Terry G, et al: Human papillomavirus testing in primary cervical cancer screening. 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