{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T01:25:04Z","timestamp":1775697904828,"version":"3.50.1"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2012,5,29]],"date-time":"2012-05-29T00:00:00Z","timestamp":1338249600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2012,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Abnormal NF-\u03baB2 activation has been implicated in the pathogenesis of multiple myeloma, a cancer of plasma cells. However, a causal role for aberrant NF-\u03baB2 signaling in the development of plasma cell tumors has not been established. Also unclear is the molecular mechanism that drives the tumorigenic process. We investigated these questions by using a transgenic mouse model with lymphocyte-targeted expression of p80HT, a lymphoma-associated NF-\u03baB2 mutant, and human multiple myeloma cell lines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a detailed histopathological characterization of lymphomas developed in p80HT transgenic mice and microarray gene expression profiling of p80HT B cells with the goal of identifying genes that drive plasma cell tumor development. We further verified the significance of our findings in human multiple myeloma cell lines.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Approximately 40% of p80HT mice showed elevated levels of monoclonal immunoglobulin (M-protein) in the serum and developed plasma cell tumors. Some of these mice displayed key features of human multiple myeloma with accumulation of plasma cells in the bone marrow, osteolytic bone lesions and\/or diffuse osteoporosis. Gene expression profiling of B cells from M-protein-positive p80HT mice revealed aberrant expression of genes known to be important in the pathogenesis of multiple myeloma, including cyclin D1, cyclin D2, Blimp1, survivin, IL-10 and IL-15. In vitro assays demonstrated a critical role of Stat3, a key downstream component of IL-10 signaling, in the survival of human multiple myeloma cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These findings provide a mouse model for human multiple myeloma with aberrant NF-\u03baB2 activation and suggest a molecular mechanism for NF-\u03baB2 signaling in the pathogenesis of plasma cell tumors by coordinated regulation of plasma cell generation, proliferation and survival.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-12-203","type":"journal-article","created":{"date-parts":[[2012,5,31]],"date-time":"2012-05-31T15:08:47Z","timestamp":1338476927000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["NF-\u03baB2 mutation targets survival, proliferation and differentiation pathways in the pathogenesis of plasma cell tumors"],"prefix":"10.1186","volume":"12","author":[{"given":"Brian A","family":"McCarthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingqiang","family":"Ren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed","family":"ElSalanty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim","family":"Zakhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Sharawy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjuan","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Han-Fei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2012,5,29]]},"reference":[{"issue":"Pt 2","key":"3189_CR1","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1042\/BJ20040544","volume":"382","author":"S Beinke","year":"2004","unstructured":"Beinke S, Ley SC: Functions of NF-\u03baB1 and NF-\u03baB2 in immune cell biology. Biochem J. 2004, 382 (Pt 2): 393-409.","journal-title":"Biochem J"},{"issue":"51","key":"3189_CR2","doi-asserted-by":"publisher","first-page":"6680","DOI":"10.1038\/sj.onc.1209954","volume":"25","author":"TD Gilmore","year":"2006","unstructured":"Gilmore TD: Introduction to NF-\u03baB: players, pathways, perspectives. Oncogene. 2006, 25 (51): 6680-6684. 10.1038\/sj.onc.1209954.","journal-title":"Oncogene"},{"issue":"51","key":"3189_CR3","doi-asserted-by":"publisher","first-page":"6817","DOI":"10.1038\/sj.onc.1209942","volume":"25","author":"DS Basseres","year":"2006","unstructured":"Basseres DS, Baldwin AS: Nuclear factor-\u03baB and inhibitor of \u03baB kinase pathways in oncogenic initiation and progression. Oncogene. 2006, 25 (51): 6817-6830. 10.1038\/sj.onc.1209942.","journal-title":"Oncogene"},{"issue":"10","key":"3189_CR4","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","volume":"5","author":"M Karin","year":"2005","unstructured":"Karin M, Greten FR: NF-\u03baB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005, 5 (10): 749-759. 10.1038\/nri1703.","journal-title":"Nat Rev Immunol"},{"issue":"51","key":"3189_CR5","doi-asserted-by":"publisher","first-page":"6831","DOI":"10.1038\/sj.onc.1209939","volume":"25","author":"G Courtois","year":"2006","unstructured":"Courtois G, Gilmore TD: Mutations in the NF-\u03baB signaling pathway: implications for human disease. Oncogene. 2006, 25 (51): 6831-6843. 10.1038\/sj.onc.1209939.","journal-title":"Oncogene"},{"issue":"2","key":"3189_CR6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.ccr.2007.07.004","volume":"12","author":"CM Annunziata","year":"2007","unstructured":"Annunziata CM, Davis RE, Demchenko Y, Bellamy W, Gabrea A, Zhan F, Lenz G, Hanamura I, Wright G, Xiao W, et al: Frequent engagement of the classical and alternative NF-\u03baB pathways by diverse genetic abnormalities in multiple myeloma. Cancer Cell. 2007, 12 (2): 115-130. 10.1016\/j.ccr.2007.07.004.","journal-title":"Cancer Cell"},{"issue":"4","key":"3189_CR7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1016\/S0006-291X(03)01474-8","volume":"308","author":"E Derudder","year":"2003","unstructured":"Derudder E, Laferte A, Ferreira V, Mishal Z, Baud V, Tarantino N, Korner M: Identification and characterization of p100HB, a new mutant form of p100\/NF-\u03baB2. Biochem Biophys Res Commun. 2003, 308 (4): 744-749. 10.1016\/S0006-291X(03)01474-8.","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"3189_CR8","first-page":"2839","volume":"8","author":"NS Fracchiolla","year":"1993","unstructured":"Fracchiolla NS, Lombardi L, Salina M, Migliazza A, Baldini L, Berti E, Cro L, Polli E, Maiolo AT, Neri A: Structural alterations of the NF-\u03baB transcription factor lyt-10 in lymphoid malignancies. Oncogene. 1993, 8 (10): 2839-2845.","journal-title":"Oncogene"},{"key":"3189_CR9","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1182\/blood.V84.11.3850.bloodjournal84113850","volume":"84","author":"A Migliazza","year":"1994","unstructured":"Migliazza A, Lombardi L, Rocchi M, Trecca D, Chang C-C, Antonacci R, Stefano N, Ciana P, Maiolo AT, Neri A: Heterogeneous chromosomal aberrations generate 3' truncations of the NFKB2\/lyt-10 gene in lymphoid malignancies. Blood. 1994, 84: 3850-3860.","journal-title":"Blood"},{"key":"3189_CR10","doi-asserted-by":"publisher","first-page":"1075","DOI":"10.1016\/0092-8674(91)90285-7","volume":"67","author":"A Neri","year":"1991","unstructured":"Neri A, Chang C-C, Lombardi L, Salina M, Corradini P, Maiolo AT, Chaganti RSK, Dalla-Favera R: B cell lymphoma-associated chromosomal translocation involves candidate oncogene lyt-10, homologous to NF-\u03baB p50. Cell. 1991, 67: 1075-1087. 10.1016\/0092-8674(91)90285-7.","journal-title":"Cell"},{"key":"3189_CR11","first-page":"2335","volume":"9","author":"S Thakur","year":"1994","unstructured":"Thakur S, Lin HC, Tseng WT, Kumar S, Bravo R, Foss F, Gelinas C, Rabson AB: Rearrangement and altered expression of the NFKB-2 gene in human cutaneous T-lymphoma cells. Oncogene. 1994, 9: 2335-2344.","journal-title":"Oncogene"},{"key":"3189_CR12","first-page":"1931","volume":"9","author":"J Zhang","year":"1994","unstructured":"Zhang J, Chang CC, Lombardi L, Dalla-Favera R: Rearranged NFKB2 gene in the HUT78 T-lymphoma cell line codes for a constitutively nuclear factor lacking transcriptional repressor functions. Oncogene. 1994, 9: 1931-1937.","journal-title":"Oncogene"},{"issue":"2","key":"3189_CR13","doi-asserted-by":"publisher","first-page":"743","DOI":"10.1182\/blood-2006-11-058446","volume":"110","author":"B Zhang","year":"2007","unstructured":"Zhang B, Wang Z, Li T, Tsitsikov EN, Ding HF: NF-\u03baB2 mutation targets TRAF1 to induce lymphomagenesis. Blood. 2007, 110 (2): 743-751. 10.1182\/blood-2006-11-058446.","journal-title":"Blood"},{"issue":"19","key":"3189_CR14","doi-asserted-by":"publisher","first-page":"5887","DOI":"10.1158\/1078-0432.CCR-05-2501","volume":"12","author":"T Hideshima","year":"2006","unstructured":"Hideshima T, Neri P, Tassone P, Yasui H, Ishitsuka K, Raje N, Chauhan D, Podar K, Mitsiades C, Dang L, et al: MLN120B, a novel I\u03baB kinase beta inhibitor, blocks multiple myeloma cell growth in vitro and in vivo. Clin Cancer Res. 2006, 12 (19): 5887-5894. 10.1158\/1078-0432.CCR-05-2501.","journal-title":"Clin Cancer Res"},{"issue":"2","key":"3189_CR15","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1111\/j.1365-2141.2007.06629.x","volume":"138","author":"M Jourdan","year":"2007","unstructured":"Jourdan M, Moreaux J, Vos JD, Hose D, Mahtouk K, Abouladze M, Robert N, Baudard M, Reme T, Romanelli A, et al: Targeting NF-\u03baB pathway with an IKK2 inhibitor induces inhibition of multiple myeloma cell growth. Br J Haematol. 2007, 138 (2): 160-168. 10.1111\/j.1365-2141.2007.06629.x.","journal-title":"Br J Haematol"},{"issue":"17","key":"3189_CR16","doi-asserted-by":"publisher","first-page":"3541","DOI":"10.1182\/blood-2009-09-243535","volume":"115","author":"YN Demchenko","year":"2010","unstructured":"Demchenko YN, Glebov OK, Zingone A, Keats JJ, Bergsagel PL, Kuehl WM: Classical and\/or alternative NF-\u03baB pathway activation in multiple myeloma. Blood. 2010, 115 (17): 3541-3552. 10.1182\/blood-2009-09-243535.","journal-title":"Blood"},{"issue":"2","key":"3189_CR17","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.ccr.2007.07.003","volume":"12","author":"JJ Keats","year":"2007","unstructured":"Keats JJ, Fonseca R, Chesi M, Schop R, Baker A, Chng WJ, Van Wier S, Tiedemann R, Shi CX, Sebag M, et al: Promiscuous mutations activate the noncanonical NF-\u03baB pathway in multiple myeloma. Cancer Cell. 2007, 12 (2): 131-144. 10.1016\/j.ccr.2007.07.003.","journal-title":"Cancer Cell"},{"issue":"3","key":"3189_CR18","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/j.1460-2075.1989.tb03431.x","volume":"8","author":"H Pircher","year":"1989","unstructured":"Pircher H, Mak TW, Lang R, Ballhausen W, Ruedi E, Hengartner H, Zinkernagel RM, Burki K: T cell tolerance to Mlsa encoded antigens in T cell receptor V beta 8.1 chain transgenic mice. EMBO J. 1989, 8 (3): 719-727.","journal-title":"EMBO J"},{"issue":"5","key":"3189_CR19","doi-asserted-by":"publisher","first-page":"P3","DOI":"10.1186\/gb-2003-4-5-p3","volume":"4","author":"G Dennis","year":"2003","unstructured":"Dennis G, Sherman BT, Hosack DA, Yang J, Gao W, Lane HC, Lempicki RA: DAVID: Database for Annotation, Visualization, and Integrated Discovery. Genome Biol. 2003, 4 (5): P3-10.1186\/gb-2003-4-5-p3.","journal-title":"Genome Biol"},{"issue":"5","key":"3189_CR20","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","volume":"121","author":"The International Myeloma Working G","year":"2003","unstructured":"The International Myeloma Working G: Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol. 2003, 121 (5): 749-757.","journal-title":"Br J Haematol"},{"issue":"5","key":"3189_CR21","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1080\/10428190290021579","volume":"43","author":"T Otsuki","year":"2002","unstructured":"Otsuki T, Yata K, Sakaguchi H, Uno M, Fujii T, Wada H, Sugihara T, Ueki A: IL-10 in myeloma cells. Leuk Lymphoma. 2002, 43 (5): 969-974.","journal-title":"Leuk Lymphoma"},{"issue":"1","key":"3189_CR22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1182\/blood.V91.1.173","volume":"91","author":"K Agematsu","year":"1998","unstructured":"Agematsu K, Nagumo H, Oguchi Y, Nakazawa T, Fukushima K, Yasui K, Ito S, Kobata T, Morimoto C, Komiyama A: Generation of plasma cells from peripheral blood memory B cells: synergistic effect of interleukin-10 and CD27\/CD70 interaction. Blood. 1998, 91 (1): 173-180.","journal-title":"Blood"},{"issue":"1","key":"3189_CR23","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1046\/j.1365-2141.1999.01510.x","volume":"106","author":"H Hjorth-Hansen","year":"1999","unstructured":"Hjorth-Hansen H, Waage A, Borset M: Interleukin-15 blocks apoptosis and induces proliferation of the human myeloma cell line OH-2 and freshly isolated myeloma cells. Br J Haematol. 1999, 106 (1): 28-34. 10.1046\/j.1365-2141.1999.01510.x.","journal-title":"Br J Haematol"},{"issue":"11","key":"3189_CR24","doi-asserted-by":"publisher","first-page":"5002","DOI":"10.1182\/blood-2006-03-012542","volume":"109","author":"NJ Bahlis","year":"2007","unstructured":"Bahlis NJ, King AM, Kolonias D, Carlson LM, Liu HY, Hussein MA, Terebelo HR, Byrne GE, Levine BL, Boise LH, et al: CD28-mediated regulation of multiple myeloma cell proliferation and survival. Blood. 2007, 109 (11): 5002-5010. 10.1182\/blood-2006-03-012542.","journal-title":"Blood"},{"issue":"6","key":"3189_CR25","first-page":"1521","volume":"4","author":"N Robillard","year":"1998","unstructured":"Robillard N, Jego G, Pellat-Deceunynck C, Pineau D, Puthier D, Mellerin MP, Barille S, Rapp MJ, Harousseau JL, Amiot M, et al: CD28, a marker associated with tumoral expansion in multiple myeloma. Clin Cancer Res. 1998, 4 (6): 1521-1526.","journal-title":"Clin Cancer Res"},{"issue":"12","key":"3189_CR26","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1038\/nri2204","volume":"7","author":"SL Nutt","year":"2007","unstructured":"Nutt SL, Fairfax KA, Kallies A: BLIMP1 guides the fate of effector B and T cells. Nat Rev Immunol. 2007, 7 (12): 923-927. 10.1038\/nri2204.","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"3189_CR27","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","volume":"106","author":"PL Bergsagel","year":"2005","unstructured":"Bergsagel PL, Kuehl WM, Zhan F, Sawyer J, Barlogie B, Shaughnessy J: Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma. Blood. 2005, 106 (1): 296-303. 10.1182\/blood-2005-01-0034.","journal-title":"Blood"},{"issue":"6","key":"3189_CR28","doi-asserted-by":"crossref","first-page":"2048","DOI":"10.1182\/blood.V89.6.2048","volume":"89","author":"V Gattei","year":"1997","unstructured":"Gattei V, Degan M, Gloghini A, De Iuliis A, Improta S, Rossi FM, Aldinucci D, Perin V, Serraino D, Babare R, et al: CD30 Ligand Is Frequently Expressed in Human Hematopoietic Malignancies of Myeloid and Lymphoid Origin. Blood. 1997, 89 (6): 2048-2059.","journal-title":"Blood"},{"issue":"5","key":"3189_CR29","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/sj.leu.2404602","volume":"21","author":"M Romagnoli","year":"2007","unstructured":"Romagnoli M, Trichet V, David C, Clement M, Moreau P, Bataille R, Barille-Nion S: Significant impact of survivin on myeloma cell growth. Leukemia. 2007, 21 (5): 1070-1078.","journal-title":"Leukemia"},{"key":"3189_CR30","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","volume":"19","author":"KW Moore","year":"2001","unstructured":"Moore KW, de Waal Malefyt R, Coffman RL, O\u2019Garra A: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol. 2001, 19: 683-765. 10.1146\/annurev.immunol.19.1.683.","journal-title":"Annu Rev Immunol"},{"key":"3189_CR31","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1146\/annurev.immunol.22.012703.104622","volume":"22","author":"S Pestka","year":"2004","unstructured":"Pestka S, Krause CD, Sarkar D, Walter MR, Shi Y, Fisher PB: Interleukin-10 and related cytokines and receptors. Annu Rev Immunol. 2004, 22: 929-979. 10.1146\/annurev.immunol.22.012703.104622.","journal-title":"Annu Rev Immunol"},{"issue":"11","key":"3189_CR32","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.4161\/cbt.3.11.1172","volume":"3","author":"JV Alvarez","year":"2004","unstructured":"Alvarez JV, Frank DA: Genome-wide analysis of STAT target genes: Elucidating the mechanism of STAT-mediated oncogenesis. Cancer Biol Ther. 2004, 3 (11): 1045-1050. 10.4161\/cbt.3.11.1172.","journal-title":"Cancer Biol Ther"},{"issue":"7","key":"3189_CR33","doi-asserted-by":"publisher","first-page":"4805","DOI":"10.4049\/jimmunol.180.7.4805","volume":"180","author":"SA Diehl","year":"2008","unstructured":"Diehl SA, Schmidlin H, Nagasawa M, van Haren SD, Kwakkenbos MJ, Yasuda E, Beaumont T, Scheeren FA, Spits H: STAT3-mediated up-regulation of BLIMP1 Is coordinated with BCL6 down-regulation to control human plasma cell differentiation. J Immunol. 2008, 180 (7): 4805-4815.","journal-title":"J Immunol"},{"issue":"18","key":"3189_CR34","doi-asserted-by":"publisher","first-page":"7391","DOI":"10.1073\/pnas.0609757104","volume":"104","author":"K Siddiquee","year":"2007","unstructured":"Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip MLR, Jove R, McLaughlin MM, Lawrence NJ, et al: Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci. 2007, 104 (18): 7391-7396. 10.1073\/pnas.0609757104.","journal-title":"Proc Natl Acad Sci"},{"issue":"2","key":"3189_CR35","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/j.ccr.2008.01.022","volume":"13","author":"WM Kuehl","year":"2008","unstructured":"Kuehl WM: Modeling Multiple Myeloma by AID-Dependent Conditional Activation of MYC. Cancer Cell. 2008, 13 (2): 85-87. 10.1016\/j.ccr.2008.01.022.","journal-title":"Cancer Cell"},{"issue":"2","key":"3189_CR36","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.ccr.2008.01.007","volume":"13","author":"M Chesi","year":"2008","unstructured":"Chesi M, Robbiani DF, Sebag M, Chng WJ, Affer M, Tiedemann R, Valdez R, Palmer SE, Haas SS, Stewart AK, et al: AID-dependent activation of a MYC transgene induces multiple myeloma in a conditional mouse model of post-germinal center malignancies. Cancer Cell. 2008, 13 (2): 167-180. 10.1016\/j.ccr.2008.01.007.","journal-title":"Cancer Cell"},{"issue":"10","key":"3189_CR37","doi-asserted-by":"publisher","first-page":"3082","DOI":"10.1182\/blood.V98.10.3082","volume":"98","author":"H Avet-Loiseau","year":"2001","unstructured":"Avet-Loiseau H, Gerson F, Magrangeas F: Minvielle Sp, Harousseau J-L, Bataille Rg: Rearrangements of the c-myc oncogene are present in 15\u2009% of primary human multiple myeloma tumors. Blood. 2001, 98 (10): 3082-3086. 10.1182\/blood.V98.10.3082.","journal-title":"Blood"},{"issue":"10","key":"3189_CR38","doi-asserted-by":"publisher","first-page":"1777","DOI":"10.1084\/jem.185.10.1777","volume":"185","author":"DE Speiser","year":"1997","unstructured":"Speiser DE, Lee SY, Wong B, Arron J, Santana A, Kong YY, Ohashi PS, Choi Y: A regulatory role for TRAF1 in antigen-induced apoptosis of T cells. J Exp Med. 1997, 185 (10): 1777-1783. 10.1084\/jem.185.10.1777.","journal-title":"J Exp Med"},{"issue":"2","key":"3189_CR39","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1182\/blood.V95.2.610","volume":"95","author":"I Tinhofer","year":"2000","unstructured":"Tinhofer I, Marschitz I, Henn T, Egle A, Greil R: Expression of functional interleukin-15 receptor and autocrine production of interleukin-15 as mechanisms of tumor propagation in multiple myeloma. Blood. 2000, 95 (2): 610-618.","journal-title":"Blood"},{"issue":"3","key":"3189_CR40","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1002\/stem.5530120304","volume":"12","author":"J Banchereau","year":"1994","unstructured":"Banchereau J, Briere F, Liu YJ, Rousset F: Molecular control of B lymphocyte growth and differentiation. Stem Cells. 1994, 12 (3): 278-288. 10.1002\/stem.5530120304.","journal-title":"Stem Cells"},{"key":"3189_CR41","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1146\/annurev.immunol.21.120601.141138","volume":"21","author":"KL Calame","year":"2003","unstructured":"Calame KL, Lin KI, Tunyaplin C: Regulatory mechanisms that determine the development and function of plasma cells. Annu Rev Immunol. 2003, 21: 205-230. 10.1146\/annurev.immunol.21.120601.141138.","journal-title":"Annu Rev Immunol"},{"issue":"5","key":"3189_CR42","doi-asserted-by":"publisher","first-page":"1890","DOI":"10.1073\/pnas.89.5.1890","volume":"89","author":"F Rousset","year":"1992","unstructured":"Rousset F, Garcia E, Defrance T, Peronne C, Vezzio N, Hsu DH, Kastelein R, Moore KW, Banchereau J: Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci U S A. 1992, 89 (5): 1890-1893. 10.1073\/pnas.89.5.1890.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"3189_CR43","doi-asserted-by":"publisher","first-page":"1103","DOI":"10.1038\/ni1201-1103","volume":"2","author":"KL Calame","year":"2001","unstructured":"Calame KL: Plasma cells: finding new light at the end of B cell development. Nat Immunol. 2001, 2 (12): 1103-1108. 10.1038\/ni1201-1103.","journal-title":"Nat Immunol"},{"issue":"23","key":"3189_CR44","doi-asserted-by":"publisher","first-page":"5911","DOI":"10.1182\/blood-2008-08-172866","volume":"113","author":"K D\u2019Costa","year":"2009","unstructured":"D\u2019Costa K, Emslie D, Metcalf D, Smyth GK, Karnowski A, Kallies A, Nutt SL, Corcoran LM: Blimp1 is limiting for transformation in a mouse plasmacytoma model. Blood. 2009, 113 (23): 5911-5919. 10.1182\/blood-2008-08-172866.","journal-title":"Blood"},{"issue":"53","key":"3189_CR45","doi-asserted-by":"publisher","first-page":"8581","DOI":"10.1038\/sj.onc.1207113","volume":"22","author":"DC Altieri","year":"2003","unstructured":"Altieri DC: Survivin, versatile modulation of cell division and apoptosis in cancer. Oncogene. 2003, 22 (53): 8581-8589. 10.1038\/sj.onc.1207113.","journal-title":"Oncogene"},{"issue":"6","key":"3189_CR46","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1002\/ijc.20954","volume":"115","author":"H Kawakami","year":"2005","unstructured":"Kawakami H, Tomita M, Matsuda T, Ohta T, Tanaka Y, Fujii M, Hatano M, Tokuhisa T, Mori N: Transcriptional activation of survivin through the NF-kappaB pathway by human T-cell leukemia virus type I tax. Int J Cancer. 2005, 115 (6): 967-974. 10.1002\/ijc.20954.","journal-title":"Int J Cancer"},{"issue":"7015","key":"3189_CR47","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1038\/nature03094","volume":"432","author":"J Massague","year":"2004","unstructured":"Massague J: G1 cell-cycle control and cancer. Nature. 2004, 432 (7015): 298-306. 10.1038\/nature03094.","journal-title":"Nature"},{"issue":"2","key":"3189_CR48","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S1535-6108(04)00019-4","volume":"5","author":"EM Hurt","year":"2004","unstructured":"Hurt EM, Wiestner A, Rosenwald A, Shaffer AL, Campo E, Grogan T, Bergsagel PL, Kuehl WM, Staudt LM: Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma. Cancer Cell. 2004, 5 (2): 191-199. 10.1016\/S1535-6108(04)00019-4.","journal-title":"Cancer Cell"},{"issue":"8","key":"3189_CR49","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1128\/MCB.19.8.5785","volume":"19","author":"DC Guttridge","year":"1999","unstructured":"Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS: NF-\u03baB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol. 1999, 19 (8): 5785-5799.","journal-title":"Mol Cell Biol"},{"issue":"4","key":"3189_CR50","doi-asserted-by":"publisher","first-page":"2690","DOI":"10.1128\/MCB.19.4.2690","volume":"19","author":"M Hinz","year":"1999","unstructured":"Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M: NF-\u03baB function in growth control: regulation of cyclin D1 expression and G0\/G1-to-S-phase transition. Mol Cell Biol. 1999, 19 (4): 2690-2698.","journal-title":"Mol Cell Biol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-12-203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-12-203\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-12-203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-12-203.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T20:39:07Z","timestamp":1630615147000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-12-203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,29]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,12]]}},"alternative-id":["3189"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-12-203","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,29]]},"assertion":[{"value":"2 December 2011","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2012","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 May 2012","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"203"}}