{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:44:48Z","timestamp":1773243888853,"version":"3.50.1"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T00:00:00Z","timestamp":1367884800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-2407-13-228","type":"journal-article","created":{"date-parts":[[2013,5,7]],"date-time":"2013-05-07T12:15:48Z","timestamp":1367928948000},"source":"Crossref","is-referenced-by-count":12,"title":["Polymorphisms in xenobiotic metabolizing genes (EPHX1, NQO1 and PON1) in lymphoma susceptibility: a case control study"],"prefix":"10.1186","volume":"13","author":[{"given":"Pablo","family":"Conesa-Zamora","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Ruiz-Cosano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Torres-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Espa\u00f1ol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda D","family":"Guti\u00e9rrez-Meca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Trujillo-Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"P\u00e9rez-Ceballos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roc\u00edo","family":"Gonz\u00e1lez-Conejero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Corral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Vicente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"P\u00e9rez-Guillermo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,5,7]]},"reference":[{"key":"3853_CR1","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2133\/dmpk.21.257","volume":"21","author":"T Shimada","year":"2006","unstructured":"Shimada T: Xenobiotic-Metabolizing Enzymes involved in Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons. Drug Metab Pharmacokinet. 2006, 21: 257-276. 10.2133\/dmpk.21.257.","journal-title":"Drug Metab Pharmacokinet"},{"key":"3853_CR2","first-page":"163","volume-title":"Introduction to biochemical toxicology","author":"RL Rose","year":"2001","unstructured":"Rose RL, Hodgson E: Adaptation to Toxicants. Chemical and Environmental Factors Affecting Metabolism of Xenobiotics. Introduction to biochemical toxicology. Edited by: Hodgson E, Smart RC. 2001, New York: Willey, 163-198."},{"key":"3853_CR3","doi-asserted-by":"publisher","first-page":"849","DOI":"10.1093\/aje\/kwi292","volume":"162","author":"L Fritschi","year":"2005","unstructured":"Fritschi L, Benke G, Hughes AM: Occupational Exposure to Pesticides and Risk of Non-Hodgkin\u2019s Lymphoma. Am J Epidemiol. 2005, 162: 849-857. 10.1093\/aje\/kwi292.","journal-title":"Am J Epidemiol"},{"key":"3853_CR4","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1158\/0008-5472.CAN-03-3604","volume":"64","author":"S Roulland","year":"2004","unstructured":"Roulland S, Lebailly P, Lecluse Y: Characterization of the t(14;18) BCL2-IGH translocation in farmers occupationally exposed to pesticides. Cancer Res. 2004, 64: 2264-2269. 10.1158\/0008-5472.CAN-03-3604.","journal-title":"Cancer Res"},{"key":"3853_CR5","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.cbi.2005.03.008","volume":"153\u2013154","author":"O Wong","year":"2005","unstructured":"Wong O, Fue H: Exposure to benzene and non-Hodgkin lymphoma, an epidemiologic overview and an ongoing case\u2013control study in Shanghai. Chem Biol Interact. 2005, 153\u2013154: 33-41.","journal-title":"Chem Biol Interact"},{"key":"3853_CR6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1007\/s10552-004-7845-0","volume":"16","author":"L Fritschi","year":"2005","unstructured":"Fritschi L, Benke G, Hughes AM: Risk of non-Hodgkin lymphoma associated with occupational exposure to solvents, metals, organic dusts and PCBs (Australia). Cancer Causes Control. 2005, 16: 599-607. 10.1007\/s10552-004-7845-0.","journal-title":"Cancer Causes Control"},{"key":"3853_CR7","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.cbi.2005.03.027","volume":"153\u2013154","author":"SH Lamm","year":"2005","unstructured":"Lamm SH, Engel A, Byrd DM: Non-Hodgkin lymphoma and benzene exposure: a systematic literature review. Chem Biol Interact. 2005, 153\u2013154: 231-237.","journal-title":"Chem Biol Interact"},{"key":"3853_CR8","doi-asserted-by":"publisher","first-page":"1647","DOI":"10.1158\/1055-9965.EPI-06-0193","volume":"15","author":"AJ De Roos","year":"2006","unstructured":"De Roos AJ, Gold LS, Wang S: Metabolic gene variants and risk of non-Hodgkin\u2019s lymphoma. Cancer Epidemiol Biomarkers Prev. 2006, 15: 1647-1653. 10.1158\/1055-9965.EPI-06-0193.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3853_CR9","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1046\/j.1365-2141.2002.03606.x","volume":"118","author":"I Kerridge","year":"2002","unstructured":"Kerridge I, Lincz L, Scorgie F, Hickey D, Granter N, Spencer A: Association between xenobiotic gene polymorphisms and non-Hodgkin\u2019s lymphoma risk. Br J Haematol. 2002, 118: 477-481. 10.1046\/j.1365-2141.2002.03606.x.","journal-title":"Br J Haematol"},{"key":"3853_CR10","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1093\/hmg\/10.12.1265","volume":"10","author":"J Sarmanova","year":"2001","unstructured":"Sarmanova J, Benesova K, Gut I, Nedelcheva-Kristensen V, Tynkova L, Soucek P: Genetic polymorphisms of biotransformation enzymes in patients with Hodgkin\u2019s and non-Hodgkin\u2019s lymphomas. Hum Molec Genet. 2001, 10: 1265-1273. 10.1093\/hmg\/10.12.1265.","journal-title":"Hum Molec Genet"},{"key":"3853_CR11","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1093\/aje\/kwq360","volume":"173","author":"KH Barry","year":"2011","unstructured":"Barry KH, Zhang Y, Lan Q: Genetic variation in metabolic genes, occupational solvent exposure, and risk of non-hodgkin lymphoma. Am J Epidemiol. 2011, 173: 404-413. 10.1093\/aje\/kwq360.","journal-title":"Am J Epidemiol"},{"key":"3853_CR12","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1093\/aje\/kwm022","volume":"165","author":"C Infante-Rivard","year":"2007","unstructured":"Infante-Rivard C, Vermunt JK, Weinberg CR: Excess transmission of the NAD(P)H:quinone oxidoreductase 1 (NQO1) C609T polymorphism in families of children with acute lymphoblastic leukemia. Am J Epidemiol. 2007, 165: 1248-1254. 10.1093\/aje\/kwm022.","journal-title":"Am J Epidemiol"},{"key":"3853_CR13","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1097\/00001648-199909000-00004","volume":"10","author":"C Infante-Rivard","year":"1999","unstructured":"Infante-Rivard C, Labuda D, Krajinovic M, Sinnett D: Risk of childhood leukemia associated with exposure to pesticides and with gene polymorphisms. Epidemiology. 1999, 10: 481-487. 10.1097\/00001648-199909000-00004.","journal-title":"Epidemiology"},{"key":"3853_CR14","volume-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"SH Swerdlow","year":"2008","unstructured":"Swerdlow SH, Campo E, Harris NL: WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. 2008, Lyon, France: IARC Press"},{"key":"3853_CR15","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/mc.20814","volume":"51","author":"J Ruiz-Cosano","year":"2012","unstructured":"Ruiz-Cosano J, Conesa-Zamora P, Gonz\u00e1lez-Conejero R: Role of GSTT1 and M1 null genotypes as risk factors for B-cell lymphoma: influence of geographical factors and occupational exposure. Mol Carcinog. 2012, 51: 508-513. 10.1002\/mc.20814.","journal-title":"Mol Carcinog"},{"key":"3853_CR16","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1186\/1471-2458-7-40","volume":"7","author":"J Garc\u00eda-P\u00e9rez","year":"2007","unstructured":"Garc\u00eda-P\u00e9rez J, Boldo E, Ramis R: Description of industrial pollution in Spain. BMC Public Health. 2007, 7: 40-10.1186\/1471-2458-7-40.","journal-title":"BMC Public Health"},{"key":"3853_CR17","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1007\/s11356-008-0091-3","volume":"16","author":"L Cirera","year":"2009","unstructured":"Cirera L, Rodr\u00edguez M, Gim\u00e9nez J: Effects of public health interventions on industrial emissions and ambient air in Cartagena, Spain. Environ Sci Pollut Res Int. 2009, 16: 152-161. 10.1007\/s11356-008-0091-3.","journal-title":"Environ Sci Pollut Res Int"},{"key":"3853_CR18","first-page":"11406","volume":"123","author":"D Real","year":"1979","unstructured":"Real D: 1197\/1979 de 20 de Febrero, por el que se declara aplicable a parte del t\u00e9rmino municipal de Cartagena (Murcia) las medidas y beneficios previstos en la Ley 38\/1972 de Diciembre, y Reglamentaci\u00f3n complementaria de protecci\u00f3n del ambiente atmosf\u00e9rico]. Spanish Government Official Bulletin (BOE). 1979, 123: 11406-","journal-title":"Spanish Government Official Bulletin (BOE)"},{"key":"3853_CR19","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1136\/oem.2004.015743","volume":"62","author":"G L\u00f3pez-Abente","year":"2005","unstructured":"L\u00f3pez-Abente G, Hern\u00e1ndez-Barrera V, Poll\u00e1n M: Municipal pleural cancer mortality in Spain. Occup Environ Med. 2005, 62: 195-199. 10.1136\/oem.2004.015743.","journal-title":"Occup Environ Med"},{"key":"3853_CR20","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1471-2458-6-17","volume":"6","author":"G Lopez-Abente","year":"2006","unstructured":"Lopez-Abente G, Aragones N, Ramis R: Municipal distribution of bladder cancer mortality in Spain: possible role of mining and industry. BMC Public Health. 2006, 6: 17-10.1186\/1471-2458-6-17.","journal-title":"BMC Public Health"},{"key":"3853_CR21","volume-title":"QUANTO 1.1: A Computer program for power and sample size calculations for genetic-epidemiology studies","author":"WJ Gauderman","year":"2006","unstructured":"Gauderman WJ, Morrison JM: QUANTO 1.1: A Computer program for power and sample size calculations for genetic-epidemiology studies. 2006, http:\/\/hydra.usc.edu\/gxe ,"},{"key":"3853_CR22","doi-asserted-by":"crossref","unstructured":"Li Z, Zhang Z, He Z, Tang W, Li T, Zeng Z, He L, Shi Y: A partition-ligation-combination-subdivision EM algorithm for haplotype inference with multiallelic markers: update of the SHEsis ( http:\/\/analysis.bio-x.cn ). Cell Res. 2009, 19: 519-523. 10.1038\/cr.2009.33.","DOI":"10.1038\/cr.2009.33"},{"key":"3853_CR23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1093\/hmg\/3.3.421","volume":"3","author":"C Hassett","year":"1994","unstructured":"Hassett C, Aicher L, Sidhu JS, Omiecinski CJ: Human microsomal epoxide hydrolase: genetic polymorphism and functional expression in vitro of amino acid variants. Hum Molec Genet. 1994, 3: 421-428. 10.1093\/hmg\/3.3.421.","journal-title":"Hum Molec Genet"},{"key":"3853_CR24","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1007\/s00204-011-0760-8","volume":"86","author":"TB Tumer","year":"2012","unstructured":"Tumer TB, Sahin G, Arin\u00e7 E: Association between polymorphisms of EPHX1 and XRCC1 genes and the risk of childhood acute lymphoblastic leukemia. Arch Toxicol. 2012, 86: 431-439. 10.1007\/s00204-011-0760-8.","journal-title":"Arch Toxicol"},{"key":"3853_CR25","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/em.20510","volume":"51","author":"S Silveira Vda","year":"2010","unstructured":"Silveira Vda S, Canalle R, Scrideli CA, Queiroz RG, Tone LG: Role of the CYP2D6, EPHX1, MPO, and NQO1 genes in the susceptibility to acute lymphoblastic leukemia in Brazilian children. Environ Mol Mutagen. 2010, 51: 48-56.","journal-title":"Environ Mol Mutagen"},{"key":"3853_CR26","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1002\/em.21723","volume":"53","author":"PS Chauhan","year":"2012","unstructured":"Chauhan PS, Ihsan R, Mishra AK, Yadav DS, Saluja S, Mittal V: High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia. Environ Mol Mutagen. 2012, 53: 619-630. 10.1002\/em.21723.","journal-title":"Environ Mol Mutagen"},{"key":"3853_CR27","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1016\/j.leukres.2008.12.006","volume":"33","author":"SV da Silva","year":"2009","unstructured":"da Silva SV, Canalle R, Scrideli CA, Queiroz RG, Bettiol H, Valera ET: Polymorphisms of xenobiotic metabolizing enzymes and DNA repair genes and outcome in childhood acute lymphoblastic leukemia. Leuk Res. 2009, 33: 898-901. 10.1016\/j.leukres.2008.12.006.","journal-title":"Leuk Res"},{"key":"3853_CR28","doi-asserted-by":"publisher","first-page":"8150","DOI":"10.1073\/pnas.96.14.8150","volume":"96","author":"JL Moran","year":"1999","unstructured":"Moran JL, Siegel D, Ross D: A potential mechanism underlying the increased susceptibility of individuals with a polymorphism in NAD(P)H:quinone oxidoreductase 1 (NQO1) to benzene toxicity. Proc Nat Acad Sci. 1999, 96: 8150-8155. 10.1073\/pnas.96.14.8150.","journal-title":"Proc Nat Acad Sci"},{"key":"3853_CR29","first-page":"2839","volume":"57","author":"N Rothman","year":"1997","unstructured":"Rothman N, Smith MT, Hayes RB: Benzene poisoning, a risk factor for hematological malignancy, is associated with the NQO1 609C-T mutation and rapid fractional excretion of chlorzoxazone. Cancer Res. 1997, 57: 2839-2842.","journal-title":"Cancer Res"},{"key":"3853_CR30","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1002\/hon.965","volume":"29","author":"JY Chan","year":"2011","unstructured":"Chan JY, Ugrasena DG, Lum DW, Lu Y, Yeoh AE: Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol. 2011, 29: 116-123. 10.1002\/hon.965.","journal-title":"Hematol Oncol"},{"key":"3853_CR31","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/ijc.1589","volume":"97","author":"M Krajinovic","year":"2002","unstructured":"Krajinovic M, Sinnett H, Richer C, Labuda D, Sinnett D: Role of NQO1, MPO and CYP2E1 genetic polymorphisms in the susceptibility to childhood acute lymphoblastic leukemia. Int J Cancer. 2002, 97: 230-236. 10.1002\/ijc.1589.","journal-title":"Int J Cancer"},{"key":"3853_CR32","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.3324\/haematol.10260","volume":"92","author":"M Stanulla","year":"2007","unstructured":"Stanulla M, Dynybil C, Bartels DB, D\u00f6rdelmann M, L\u00f6ning L, Claviez A: The NQO1 C609T polymorphism is associated with risk of secondary malignant neoplasms after treatment for childhood acute lymphoblastic leukemia: a matched-pair analysis from the ALL-BFM study group. Haematologica. 2007, 92: 1581-1582. 10.3324\/haematol.10260.","journal-title":"Haematologica"},{"key":"3853_CR33","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1093\/aje\/kwn246","volume":"168","author":"N Guha","year":"2008","unstructured":"Guha N, Chang JS, Chokkalingam AP, Wiemels JL, Smith MT, Buffler PA: NQO1 polymorphisms and de novo childhood leukemia: a HuGE review and meta-analysis. Am J Epidemiol. 2008, 168: 1221-1232.","journal-title":"Am J Epidemiol"},{"key":"3853_CR34","first-page":"1511","volume":"90","author":"M Eguchi-Ishimae","year":"2005","unstructured":"Eguchi-Ishimae M, Eguchi M, Ishii E, Knight D, Sadakane Y, Isoyama K: The association of a distinctive allele of NAD(P)H:quinine oxidoreductase with pediatric acute lymphoblastic leukemias with MLL fusion genes in Japan. Haematologica. 2005, 90: 1511-1515.","journal-title":"Haematologica"},{"key":"3853_CR35","doi-asserted-by":"publisher","first-page":"568","DOI":"10.1002\/pbc.20098","volume":"43","author":"S Sirma","year":"2004","unstructured":"Sirma S, Agaoglu L, Yildiz I, Cayli D, Horgusluoglu E, Anak S: NAD(P)H:quinine oxidoreductase 1 null genotype is not associated with pediatric de novo acute leukemia. Pediatr Blood Cancer. 2004, 43: 568-570. 10.1002\/pbc.20098.","journal-title":"Pediatr Blood Cancer"},{"key":"3853_CR36","doi-asserted-by":"publisher","first-page":"1239","DOI":"10.1194\/jlr.M400511-JLR200","volume":"46","author":"DI Draganov","year":"2005","unstructured":"Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN: Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. J Lipid Res. 2005, 46: 1239-1247. 10.1194\/jlr.M400511-JLR200.","journal-title":"J Lipid Res"},{"key":"3853_CR37","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1038\/ng0193-73","volume":"3","author":"R Humbert","year":"1993","unstructured":"Humbert R, Adler DA, Disteche CM, Hassett C, Omiecinski CJ, Furlong CE: The molecular basis of the human serum paraoxonase activity polymorphism. Nature Genet. 1993, 3: 73-76. 10.1038\/ng0193-73.","journal-title":"Nature Genet"},{"key":"3853_CR38","volume-title":"Toxicology","author":"M Kokouva","year":"2012","unstructured":"Kokouva M, Koureas M, Dardiotis E, Almpanidou P, Kalogeraki A, Kyriakou D: Relationship between the paraoxonase 1 (PON1) M55L and Q192R polymorphisms and lymphohaematopoietic cancers in a Greek agricultural population. Toxicology. 2012, in press"},{"key":"3853_CR39","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/ng.626","volume":"42","author":"L Conde","year":"2010","unstructured":"Conde L, Halperin E, Akers NK, Brown KM, Smedby KE, Rothman N: Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32. Nat Genet. 2010, 42: 661-4. 10.1038\/ng.626.","journal-title":"Nat Genet"},{"key":"3853_CR40","doi-asserted-by":"publisher","first-page":"e1001378","DOI":"10.1371\/journal.pgen.1001378","volume":"7","author":"KE Smedby","year":"2011","unstructured":"Smedby KE, Foo JN, Skibola CF, Darabi H, Conde L, Hjalgrim H: GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma. PLoS Genet. 2011, 7: e1001378-10.1371\/journal.pgen.1001378.","journal-title":"PLoS Genet"},{"key":"3853_CR41","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/ng.419","volume":"41","author":"CF Skibola","year":"2009","unstructured":"Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma. Nat Genet. 2009, 41: 873-5. 10.1038\/ng.419.","journal-title":"Nat Genet"},{"key":"3853_CR42","doi-asserted-by":"publisher","first-page":"e1003220","DOI":"10.1371\/journal.pgen.1003220","volume":"9","author":"J Vijai","year":"2013","unstructured":"Vijai J, Kirchhoff T, Schrader KA, Brown J, Dutra-Clarke AV, Manschreck C: Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies. PLoS Genet. 2013, 9: e1003220-10.1371\/journal.pgen.1003220.","journal-title":"PLoS Genet"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-228.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-13-228\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-228","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T07:16:08Z","timestamp":1715325368000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-13-228"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,7]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["3853"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-13-228","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,7]]},"article-number":"228"}}