{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:07:50Z","timestamp":1791331670143,"version":"4.3.1"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T00:00:00Z","timestamp":1358985600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Exercise programmes are beneficial for cancer patients however evidence is limited in patients with multiple myeloma (MM), a cancer that is characterised by osteolytic bone disease, giving rise to high levels of bone morbidity including fractures and bone pain.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted a single arm phase 2 study of an exercise programme (EP) as rehabilitation for treated MM patients, to evaluate feasibility, effects on QOL and physiological parameters. Patients were given individualised programmes, comprising stretching, aerobic and resistance exercises, carried out under supervision for 3 months then at home for a further 3 months.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Study uptake was high, 60 of 75 (80%) patients approached consented to the study. Screen failures (11, due to fracture risk and disease relapse) and patient withdrawals (12) resulted in a final 37 patients enrolling on the programme. These 37 patients demonstrated high attendance rates in the supervised classes (87%), and high levels of adherence in home exercising (73%). Patients reported better QOL following the EP, with improvement in FACT-G and Fatigue scores over time from baseline (p&lt;0.01 for both, one-way repeated measures ANOVA) to 6 months. Upper and lower limb strength also improved on the EP, from baseline to 6 months (p&lt;0.01 for both). There were no adverse reactions.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>An EP in MM patients is feasible and safe, with high attendance and adherence. Benefits in QOL, fatigue and muscle strength await confirmation in randomized studies, prompting urgent evaluation of the benefits of EP in the rehabilitation of MM patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-13-31","type":"journal-article","created":{"date-parts":[[2013,1,24]],"date-time":"2013-01-24T13:44:58Z","timestamp":1359035098000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":69,"title":["A mixed exercise training programme is feasible and safe and may improve quality of life and muscle strength in multiple myeloma survivors"],"prefix":"10.1186","volume":"13","author":[{"given":"Lara","family":"Groeneveldt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gill","family":"Mein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Garrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P","family":"Jewell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken Van","family":"Someren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley P","family":"D\u2019Sa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwee L","family":"Yong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,24]]},"reference":[{"key":"3701_CR1","doi-asserted-by":"publisher","first-page":"2962","DOI":"10.1182\/blood-2007-10-078022","volume":"111","author":"RA Kyle","year":"2008","unstructured":"Kyle RA, Rajkumar SV: Multiple myeloma. Blood. 2008, 111: 2962-2972. 10.1182\/blood-2007-10-078022.","journal-title":"Blood"},{"key":"3701_CR2","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1038\/leu.2008.336","volume":"23","author":"GD Roodman","year":"2009","unstructured":"Roodman GD: Pathogenesis of myeloma bone disease. Leukemia. 2009, 23: 435-441. 10.1038\/leu.2008.336.","journal-title":"Leukemia"},{"key":"3701_CR3","doi-asserted-by":"publisher","first-page":"2516","DOI":"10.1182\/blood-2007-10-116129","volume":"111","author":"SK Kumar","year":"2008","unstructured":"Kumar SK, Rajukumar SV, Dispenzieri A: Improved survival in multiple myeloma and the impact of novel therapies. Blood. 2008, 111: 2516-2520. 10.1182\/blood-2007-10-116129.","journal-title":"Blood"},{"issue":"3","key":"3701_CR4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1046\/j.0902-4441.2003.00195.x","volume":"72","author":"N Gulbrandsen","year":"2004","unstructured":"Gulbrandsen N, Hjermstad MJ, Wisloff F: Interpretation of quality of life scores in multiple myeloma by comparison with a reference population and assessment of the clinical importance of score differences. Eur J Haematol. 2004, 72 (3): 172-180. 10.1046\/j.0902-4441.2003.00195.x.","journal-title":"Eur J Haematol"},{"issue":"7","key":"3701_CR5","first-page":"1163","volume":"28","author":"AR Poulos","year":"2001","unstructured":"Poulos AR, Gertz MA, Pankratz VS, Post-White J: Pain, mood disturbance, and quality of life in patients with multiple myeloma. Oncol Nurs Forum. 2001, 28 (7): 1163-1171.","journal-title":"Oncol Nurs Forum"},{"issue":"1","key":"3701_CR6","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.bbmt.2008.09.023","volume":"15","author":"AC Sherman","year":"2009","unstructured":"Sherman AC, Simonton S, Latif U, Plante TG, Anaissie EJ: Changes in quality-of-life and psychosocial adjustment among multiple myeloma patients treated with high-dose melphalan and autologous stem cell transplantation. Biol Blood Marrow Transplant. 2009, 15 (1): 12-20. 10.1016\/j.bbmt.2008.09.023.","journal-title":"Biol Blood Marrow Transplant"},{"issue":"4","key":"3701_CR7","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.soncn.2007.08.007","volume":"23","author":"MT Knobf","year":"2007","unstructured":"Knobf MT, Musanti R, Dorward J: Exercise and quality of life outcomes in patients with cancer. Semin Oncol Nurs. 2007, 23 (4): 285-296. 10.1016\/j.soncn.2007.08.007.","journal-title":"Semin Oncol Nurs"},{"key":"3701_CR8","doi-asserted-by":"publisher","first-page":"1588","DOI":"10.1158\/1055-9965.EPI-04-0703","volume":"14","author":"KH Schmitz","year":"2005","unstructured":"Schmitz KH, Holtzman J, Courneya KS, Masse LC, Duval S, Kane R: Controlled physical activity trials in cancer survivors: A systematic review and meta-analysis. Cancer Epidemiol Biomarkers Prev. 2005, 14: 1588-1595. 10.1158\/1055-9965.EPI-04-0703.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"3701_CR9","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1200\/JCO.2005.06.085","volume":"23","author":"DA Galvao","year":"2005","unstructured":"Galvao DA, Newton RU: Review of exercise intervention studies in cancer. J Clin Oncol. 2005, 23: 900-909.","journal-title":"J Clin Oncol"},{"key":"3701_CR10","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1038\/nrclinonc.2012.27","volume":"9","author":"SG Lakoski","year":"2012","unstructured":"Lakoski SG, Eves ND, Douglas PS, Jones LW: Exercise rehabilitation in patients with cancer. Nat Rev Clin Oncol. 2012, 9: 288-296. 10.1038\/nrclinonc.2012.27.","journal-title":"Nat Rev Clin Oncol"},{"key":"3701_CR11","doi-asserted-by":"publisher","first-page":"1113","DOI":"10.1038\/leu.2010.54","volume":"24","author":"R Wolin Ky Jr","year":"2012","unstructured":"Wolin Ky R, Tuchman H, Lucia A: Exercise in adult and pediatric hematological cancer survivor: an intervention review. Leukemia. 2012, 24: 1113-1120.","journal-title":"Leukemia"},{"key":"3701_CR12","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.jpainsymman.2007.06.013","volume":"35","author":"P-H Chang","year":"2008","unstructured":"Chang P-H, Lai Y-H, Shun S-C, Lin L-Y: Effects of a Walking Intervention on Fatigue-related Experiences of Hospitalized Acute Myelogenous Leukemia Patients Undergoing Chemotherapy: a Randomized Controlled Trial. J Pain Symptom Manage. 2008, 35: 524-534. 10.1016\/j.jpainsymman.2007.06.013.","journal-title":"J Pain Symptom Manage"},{"key":"3701_CR13","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1136\/bjsm.2002.003632","volume":"38","author":"SC Hayes","year":"2004","unstructured":"Hayes SC, Davies PS, Parker TW, Bashford J, Green A: Role of a Mixed Type, Moderate Intensity Exercise Programme After Peripheral Blood Stem Cell Transplantation. Br J Sports Med. 2004, 38: 304-309. 10.1136\/bjsm.2002.003632.","journal-title":"Br J Sports Med"},{"key":"3701_CR14","doi-asserted-by":"publisher","first-page":"4605","DOI":"10.1200\/JCO.2008.20.0634","volume":"27","author":"KS Courneya","year":"2009","unstructured":"Courneya KS, Sellar CM, Stevinson C, McNeely ML: Randomized controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J Clin Oncol. 2009, 27: 4605-4612. 10.1200\/JCO.2008.20.0634.","journal-title":"J Clin Oncol"},{"issue":"5","key":"3701_CR15","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1097\/00002820-200310000-00012","volume":"26","author":"EA Coleman","year":"2003","unstructured":"Coleman EA, Coon S, Hall-Barrow J, Richards K, Gaylor D, Stewart B: Feasibility of exercise during treatment for multiple myeloma. Cancer Nurs. 2003, 26 (5): 410-419. 10.1097\/00002820-200310000-00012.","journal-title":"Cancer Nurs"},{"key":"3701_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1188\/08.ONF.E1-E11","volume":"35","author":"EA Coleman","year":"2008","unstructured":"Coleman EA, Coon SK, Kennedy RL: Effects of exercise in combination with epoetin alfa during high-dose chemotherapy and autologous peripheral blood stem cell transplantation for multiple myeloma. Onc Nurs Forum. 2008, 35: 1-9. 10.1188\/08.ONF.E1-E11.","journal-title":"Onc Nurs Forum"},{"key":"3701_CR17","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1038\/bmt.2010.288","volume":"46","author":"RH Knols","year":"2011","unstructured":"Knols RH, de Bruin ED, Uebelhart D, Aufdemkampe G, Schanz U, Stenner-Liewen F: Effects of an outpatient physical exercise programme on hematopoietic stem-cell transplantation recipients: a randomized clinical trial. Bone Marrow Transplant. 2011, 46: 1245-1255. 10.1038\/bmt.2010.288.","journal-title":"Bone Marrow Transplant"},{"issue":"11","key":"3701_CR18","doi-asserted-by":"publisher","first-page":"780","DOI":"10.1007\/s00520-004-0668-4","volume":"12","author":"LW Jones","year":"2004","unstructured":"Jones LW, Courneya KS, Vallance JK, Ladha AB, Mant MJ, Belch AR: Association between exercise and quality of life in multiple myeloma cancer survivors. Support Care Cancer. 2004, 12 (11): 780-788. 10.1007\/s00520-004-0668-4.","journal-title":"Support Care Cancer"},{"issue":"11","key":"3701_CR19","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1080\/026404102320761787","volume":"20","author":"MJ Chen","year":"2002","unstructured":"Chen MJ, Fan X, Moe ST: Criterion-related validity of the Borg ratings of perceived exertion scale in healthy individuals: a meta-analysis. J Sports Sci. 2002, 20 (11): 873-899. 10.1080\/026404102320761787.","journal-title":"J Sports Sci"},{"key":"3701_CR20","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1186\/1477-7525-1-79","volume":"1","author":"K Webster","year":"2003","unstructured":"Webster K, Cella D, Yost K: The Functional Assessment of Chronic Illness Therapy (FACIT) Measurement System: properties, applications, and interpretation. Health Qual Life Outcomes. 2003, 1: 79-10.1186\/1477-7525-1-79.","journal-title":"Health Qual Life Outcomes"},{"issue":"9","key":"3701_CR21","doi-asserted-by":"publisher","first-page":"900","DOI":"10.1016\/S0895-4356(02)00435-3","volume":"55","author":"GH Guyatt","year":"2002","unstructured":"Guyatt GH, Norman GR, Juniper EF, Griffith LE: A critical look at transition ratings. J Clin Epidemiol. 2002, 55 (9): 900-908. 10.1016\/S0895-4356(02)00435-3.","journal-title":"J Clin Epidemiol"},{"issue":"6","key":"3701_CR22","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1016\/S0885-3924(02)00529-8","volume":"24","author":"D Cella","year":"2002","unstructured":"Cella D, Eton DT, Lai JS, Peterman AH, Merkel DE: Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J Pain Symptom Manage. 2002, 24 (6): 547-561. 10.1016\/S0885-3924(02)00529-8.","journal-title":"J Pain Symptom Manage"},{"key":"3701_CR23","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1186\/1477-7525-1-29","volume":"1","author":"RP Snaith","year":"2003","unstructured":"Snaith RP: The Hospital Anxiety And Depression Scale. Health Qual Life Outcomes. 2003, 1: 29-10.1186\/1477-7525-1-29.","journal-title":"Health Qual Life Outcomes"},{"issue":"8","key":"3701_CR24","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1249\/00005768-199108000-00014","volume":"23","author":"CB Ebbeling","year":"1991","unstructured":"Ebbeling CB, Ward A, Puleo EM, Widrick J, Rippe JM: Development of a single-stage submaximal treadmill walking test. Med Sci Sports Exerc. 1991, 23 (8): 966-973.","journal-title":"Med Sci Sports Exerc"},{"key":"3701_CR25","volume-title":"Designing Qualitative Research","author":"C Marshall","year":"1995","unstructured":"Marshall C, Rossman G: Designing Qualitative Research. 1995, London: Sage publications, 2","edition":"2"},{"key":"3701_CR26","volume-title":"Qualitative Methods in Health Research","author":"J Green","year":"2006","unstructured":"Green J, Thorogood N: Qualitative Methods in Health Research. 2006, London: Sage Publications"},{"issue":"9","key":"3701_CR27","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1182\/blood.V90.9.3390","volume":"90","author":"F Dimeo","year":"1997","unstructured":"Dimeo F, Fetscher S, Lange W, Mertelsmann R, Keul J: Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood. 1997, 90 (9): 3390-3394.","journal-title":"Blood"},{"issue":"4","key":"3701_CR28","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.ctrv.2008.11.008","volume":"35","author":"M Maddocks","year":"2009","unstructured":"Maddocks M, Mockett S, Wilcock A: Is exercise an acceptable and practical therapy for people with or cured of cancer? A systematic review. Cancer Treat Rev. 2009, 35 (4): 383-390. 10.1016\/j.ctrv.2008.11.008.","journal-title":"Cancer Treat Rev"},{"issue":"2","key":"3701_CR29","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1519\/00139143-200708000-00007","volume":"30","author":"CH Zehnacker","year":"2007","unstructured":"Zehnacker CH, Bemis-Dougherty A: Effect of weighted exercises on bone mineral density in post menopausal women. A systematic review. J Geriatr Phys Ther. 2007, 30 (2): 79-88. 10.1519\/00139143-200708000-00007.","journal-title":"J Geriatr Phys Ther"},{"issue":"7","key":"3701_CR30","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s00198-007-0541-7","volume":"19","author":"SR Hourigan","year":"2008","unstructured":"Hourigan SR, Nitz JC, Brauer SG, O'Neill S, Wong J, Richardson CA: Positive effects of exercise on falls and fracture risk in osteopenic women. Osteoporos Int. 2008, 19 (7): 1077-1086. 10.1007\/s00198-007-0541-7.","journal-title":"Osteoporos Int"},{"issue":"3","key":"3701_CR31","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1200\/JCO.2007.15.4963","volume":"27","author":"RJ Segal","year":"2009","unstructured":"Segal RJ, Reid RD, Courneya KS: Randomized controlled trial of resistance or aerobic exercise in men receiving radiation therapy for prostate cancer. J Clin Oncol. 2009, 27 (3): 344-351.","journal-title":"J Clin Oncol"},{"issue":"7000","key":"3701_CR32","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1136\/bmj.311.7000.299","volume":"311","author":"J Kitzinger","year":"1995","unstructured":"Kitzinger J: Qualitative research. Introducing focus groups. BMJ. 1995, 311 (7000): 299-302. 10.1136\/bmj.311.7000.299.","journal-title":"BMJ"},{"issue":"4","key":"3701_CR33","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1046\/j.1365-2648.1997.00395.x","volume":"26","author":"J Reed","year":"1997","unstructured":"Reed J, Payton VR: Focus groups: issues of analysis and interpretation. J Adv Nurs. 1997, 26 (4): 765-771. 10.1046\/j.1365-2648.1997.00395.x.","journal-title":"J Adv Nurs"},{"issue":"7592","key":"3701_CR34","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1136\/bmj.39094.648553.AE","volume":"334","author":"N Mutrie","year":"2007","unstructured":"Mutrie N, Campbell AM, Whyte F, McConnachie A, Emslie C, Lee L: Benefits of supervised group exercise programme for women being treated for early stage breast cancer: pragmatic randomised controlled trial. BMJ. 2007, 334 (7592): 517-10.1136\/bmj.39094.648553.AE.","journal-title":"BMJ"},{"issue":"11","key":"3701_CR35","first-page":"30","volume":"21","author":"AL Schwartz","year":"2007","unstructured":"Schwartz AL: Understanding and treating cancer-related fatigue. Oncology (Williston Park). 2007, 21 (11): 30-34. discussion 34\u20135","journal-title":"Oncology (Williston Park)"},{"key":"3701_CR36","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B","volume":"85","author":"FC Dimeo","year":"1999","unstructured":"Dimeo FC, Stieglitz R, Novelli-Fischer U, Keul J: Effects of physical activity on the fatigue and psychological status of cancer patients during chemotherapy. Cancer. 1999, 85: 2273-2277. 10.1002\/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B.","journal-title":"Cancer"},{"key":"3701_CR37","doi-asserted-by":"publisher","first-page":"1713","DOI":"10.1200\/JCO.2006.09.5083","volume":"25","author":"A Daley","year":"2007","unstructured":"Daley A, Crank H, Saxton JM, Mutrie N, Coleman R, Roalfe A: Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol. 2007, 25: 1713-1725. 10.1200\/JCO.2006.09.5083.","journal-title":"J Clin Oncol"},{"issue":"8","key":"3701_CR38","doi-asserted-by":"publisher","first-page":"1495","DOI":"10.1093\/annonc\/mdn068","volume":"19","author":"F Dimeo","year":"2008","unstructured":"Dimeo F, Schwartz S, Wesel N, Voigt A, Thiel E: Effects of an endurance and resistance exercise program on persistent cancer-related fatigue after treatment. Ann Oncol. 2008, 19 (8): 1495-1499. 10.1093\/annonc\/mdn068.","journal-title":"Ann Oncol"},{"issue":"3","key":"3701_CR39","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1188\/03.ONF.441-454","volume":"30","author":"S Young-McCaughan","year":"2003","unstructured":"Young-McCaughan S, Mays MZ, Arzola SM, Yoder LH, Dramiga SA, Leclerc KM: Research and commentary: Change in exercise tolerance, activity and sleep patterns, and quality of life in patients with cancer participating in a structured exercise program. Oncol Nurs Forum. 2003, 30 (3): 441-454. 10.1188\/03.ONF.441-454. discussion 41\u201354","journal-title":"Oncol Nurs Forum"},{"key":"3701_CR40","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1007\/s00520-009-0757-5","volume":"18","author":"M-F Tang","year":"2010","unstructured":"Tang M-F, Liou T-H, Lin C-C: Improving sleep quality for cancer patients: benefits of a home-based exercise intervention. Support Care Cancer. 2010, 18: 1329-1339. 10.1007\/s00520-009-0757-5.","journal-title":"Support Care Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-31.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-13-31\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-31","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-31.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T22:29:16Z","timestamp":1630535356000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-13-31"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,24]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["3701"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-13-31","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,24]]},"assertion":[{"value":"12 August 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 January 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 January 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"31"}}