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This study aims to determine adipocytokine and other biological changes in recently diagnosed breast cancer patients before therapy is started.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 109 female Saudi subjects [56 newly diagnosed, treatment-na\u00efve, histologically-confirmed breast cancer cases and 53 age- and BMI-matched controls] were enrolled in this study. Anthropometric data were collected. Serum insulin, adipocytokines and plasminogen activator inhibitor-1 (PAI-1) concentrations were measured using a customized multiplex Luminex assay. Hypersensitive C-Reactive Protein (CRP), tumor necrosis factor-alpha (TNF-\u03b1), and angiotensin II (ANG II) were measured using ELISA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A few days in the diagnosis, breast cancer subjects had significantly higher systolic blood pressure (<jats:italic>p<\/jats:italic>\u2009=\u20090.03), glucose (<jats:italic>p<\/jats:italic>\u2009=\u20090.01), triglycerides (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), leptin (<jats:italic>p<\/jats:italic>\u2009=\u20090.044), resistin (<jats:italic>p<\/jats:italic>\u2009=\u20090.04), ANG II (<jats:italic>p<\/jats:italic>\u2009=\u20090.02), TNF-\u03b1 (<jats:italic>p<\/jats:italic>\u2009=\u20090.045), and CRP (<jats:italic>p<\/jats:italic>\u2009=\u20090.04) than the controls. On the other hand, HDL (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) and adiponectin (<jats:italic>p<\/jats:italic>\u2009=\u20090.02) were significantly lower in cancer subjects than controls. A significant association was found between elevated triglycerides (TG) and breast cancer [OR (95% CI), 6.1(1.8, 15.6),<jats:italic>p<\/jats:italic>\u2009=\u20090.004], as well as elevated ANG II [OR (95% CI), 5.2(1.2, 14.3),<jats:italic>p<\/jats:italic>\u2009=\u20090.03]. On the other hand, aPAI and HDL correlated negatively with breast cancer [OR (95% CI), 0.076(0.01, 0.34),<jats:italic>p<\/jats:italic>\u2009=\u20090.001; 0.30(0.09, 0.95),<jats:italic>p<\/jats:italic>0.04, respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating ANGII and triglycerides were positively associated with early breast cancer. In contrast, HDL-cholesterol correlated negatively with ANG II and aPAI in these patients. This suggests that patients with recently diagnosed breast cancer have biochemical changes consistent with an activated stress response and\/or that patients with metabolic syndrome manifestations have a higher risk of developing this disease.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-13-54","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T14:43:48Z","timestamp":1359989028000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Metabolic syndrome biomarkers and early breast cancer in Saudi women: evidence for the presence of a systemic stress response and\/or a pre-existing metabolic syndrome-related neoplasia risk?"],"prefix":"10.1186","volume":"13","author":[{"given":"Majed S","family":"Alokail","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasser","family":"Al-Daghri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal","family":"Abdulkareem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hossam M","family":"Draz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sobhy M","family":"Yakout","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdullah M","family":"Alnaami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaun","family":"Sabico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal M","family":"Alenad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George P","family":"Chrousos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,4]]},"reference":[{"key":"3657_CR1","volume-title":"Obesity and overweight fact sheet","author":"World Health Organization","year":"2012","unstructured":"World Health Organization: Obesity and overweight fact sheet. 2012, http:\/\/www.who.int\/mediacentre\/factsheets\/fs311\/en\/, May ,"},{"key":"3657_CR2","doi-asserted-by":"publisher","first-page":"1625","DOI":"10.1056\/NEJMoa021423","volume":"348","author":"EE Calle","year":"2003","unstructured":"Calle EE, Rodriquez C, Walker-Thurmond K, Thun MJ: Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. 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