{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:10:22Z","timestamp":1790248222623,"version":"4.1.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,12,1]],"date-time":"2013-12-01T00:00:00Z","timestamp":1385856000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tumor cells benefit from their ability to avoid apoptosis and invade other tissues. The endoplasmic reticulum (ER) membrane protein Sec62 is a key player in these processes. Sec62 is essential for cell migration and protects tumor cells against thapsigargin-induced ER stress, which are both linked to cytosolic Ca<jats:sup>2+<\/jats:sup>.<jats:italic>SEC62<\/jats:italic>silencing leads to elevated cytosolic Ca<jats:sup>2+<\/jats:sup>and increased ER Ca<jats:sup>2+<\/jats:sup>leakage after thapsigargin treatment. Sec62 protein levels are significantly increased in different tumors, including prostate, lung and thyroid cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In lung cancer, the influence of Sec62 protein levels on patient survival was analyzed using the Kaplan-Meier method and log-rank test. To elucidate the underlying pathophysiological functions of Sec62, Ca<jats:sup>2+<\/jats:sup>imaging techniques, real-time cell analysis and cell migration assays were performed. The effects of treatment with the calmodulin antagonists, trifluoperazine (TFP) and ophiobolin A, on cellular Ca<jats:sup>2+<\/jats:sup>homeostasis, cell growth and cell migration were compared with the effects of siRNA-mediated Sec62 depletion or the expression of a mutated<jats:italic>SEC62<\/jats:italic>variant<jats:italic>in vitro<\/jats:italic>. Using Biacore analysis we examined the Ca<jats:sup>2+<\/jats:sup>-sensitive interaction of Sec62 with the Sec61 complex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sec62 overproduction significantly correlated with reduced patient survival. Therefore, Sec62 is not only a predictive marker for this type of tumor, but also an interesting therapeutic target. The present study suggests a regulatory function for Sec62 in the major Ca<jats:sup>2+<\/jats:sup>leakage channel in the ER, Sec61, by a direct and Ca<jats:sup>2+<\/jats:sup>-sensitive interaction. A Ca<jats:sup>2+<\/jats:sup>-binding motif in Sec62 is essential for its molecular function. Treatment of cells with calmodulin antagonists mimicked Sec62 depletion by inhibiting cell migration and rendering the cells sensitive to thapsigargin treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Targeting tumors that overproduce Sec62 with calmodulin antagonists in combination with targeted thapsigargin analogues may offer novel personalized therapeutic options.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-13-574","type":"journal-article","created":{"date-parts":[[2013,12,5]],"date-time":"2013-12-05T02:03:19Z","timestamp":1386208999000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":75,"title":["Targeting cell migration and the endoplasmic reticulum stress response with calmodulin antagonists: a clinically tested small molecule phenocopy of SEC62 gene silencing in human tumor cells"],"prefix":"10.1186","volume":"13","author":[{"given":"Maximilian","family":"Linxweiler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Schorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Sch\u00e4uble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Linxweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Langer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Joachim","family":"Sch\u00e4fers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Cavali\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,12,5]]},"reference":[{"key":"4217_CR1","doi-asserted-by":"publisher","first-page":"2893","DOI":"10.1002\/ijc.25516","volume":"127","author":"J Ferlay","year":"2010","unstructured":"Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM: Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010, 127: 2893-2917. 10.1002\/ijc.25516.","journal-title":"Int J Cancer"},{"key":"4217_CR2","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1016\/S0140-6736(08)61558-5","volume":"372","author":"R Beaglehole","year":"2008","unstructured":"Beaglehole R, Bonita R: Global public health: a scorecard. Lancet. 2008, 372: 1988-1996. 10.1016\/S0140-6736(08)61558-5.","journal-title":"Lancet"},{"key":"4217_CR3","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1002\/ijc.24855","volume":"126","author":"FI Bray","year":"2009","unstructured":"Bray FI, Weiderpass E: Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970\u20132007. Int J Cancer. 2009, 126: 1454-1466.","journal-title":"Int J Cancer"},{"key":"4217_CR4","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1056\/NEJMra0802714","volume":"359","author":"RS Herbst","year":"2008","unstructured":"Herbst RS, Heymach JV, Lippman SM: Lung cancer. N Engl J Med. 2008, 359: 1367-1380. 10.1056\/NEJMra0802714.","journal-title":"N Engl J Med"},{"key":"4217_CR5","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.ajpath.2011.10.039","volume":"180","author":"M Linxweiler","year":"2012","unstructured":"Linxweiler M, Linxweiler J, Barth M, Benedix J, Jung V, Kim YJ, Bohle RM, Zimmermann R, Greiner M: Sec62 bridges the gap from 3q amplification to molecular cell biology in non-small cell lung cancer. Am J Pathol. 2012, 180: 473-483. 10.1016\/j.ajpath.2011.10.039.","journal-title":"Am J Pathol"},{"key":"4217_CR6","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1016\/0092-8674(95)90077-2","volume":"81","author":"S Panzner","year":"1995","unstructured":"Panzner S, Dreier L, Hartmann E, Kostka S, Rapoport TA: Posttranslational protein transport in yeast reconstituted with a purified complex of Sec proteins and Kar2p. Cell. 1995, 81: 561-570. 10.1016\/0092-8674(95)90077-2.","journal-title":"Cell"},{"key":"4217_CR7","doi-asserted-by":"publisher","first-page":"14550","DOI":"10.1074\/jbc.275.19.14550","volume":"275","author":"HA Meyer","year":"2000","unstructured":"Meyer HA, Grau H, Kraft R, Kostka S, Prehn S, Kalies KU, Hartmann E: Mammalian Sec61 is associated with Sec62 and Sec63. J Biol Chem. 2000, 275: 14550-14557. 10.1074\/jbc.275.19.14550.","journal-title":"J Biol Chem"},{"key":"4217_CR8","doi-asserted-by":"publisher","first-page":"7214","DOI":"10.1073\/pnas.97.13.7214","volume":"97","author":"J Tyedmers","year":"2000","unstructured":"Tyedmers J, Lerner M, Bies C, Dudek J, Skowronek MH, Haas IG, Heim N, Nastainczyk W, Volkmer J, Zimmermann R: Homologs of the yeast Sec complex subunits Sec62p and Sec63p are abundant proteins in dog pancreas microsomes. Proc Natl Acad Sci USA. 2000, 97: 7214-7219. 10.1073\/pnas.97.13.7214.","journal-title":"Proc Natl Acad Sci USA"},{"key":"4217_CR9","doi-asserted-by":"publisher","first-page":"2712","DOI":"10.1091\/mbc.E12-03-0228","volume":"23","author":"AK Lakkaraju","year":"2012","unstructured":"Lakkaraju AK, Thankappan R, Mary C, Garrison JL, Taunton J, Strub K: Efficient secretion of small proteins in mammalian cells relies on Sec62-dependent posttranslational translocation. Mol Biol Cell. 2012, 23: 2712-2722. 10.1091\/mbc.E12-03-0228.","journal-title":"Mol Biol Cell"},{"key":"4217_CR10","doi-asserted-by":"publisher","first-page":"1958","DOI":"10.1242\/jcs.096727","volume":"125","author":"S Lang","year":"2012","unstructured":"Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schauble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J, et al: Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci. 2012, 125: 1958-1969. 10.1242\/jcs.096727.","journal-title":"J Cell Sci"},{"key":"4217_CR11","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1091\/mbc.E09-08-0730","volume":"21","author":"L Muller","year":"2010","unstructured":"Muller L, Diaz de Escauriaza M, Lajoie P, Theis M, Jung M, Muller A, Burgard C, Greiner M, Snapp EL, Dudek J, Zimmermann R: Evolutionary gain of function for the ER membrane protein Sec62 from yeast to humans. Mol Biol Cell. 2010, 21: 691-703. 10.1091\/mbc.E09-08-0730.","journal-title":"Mol Biol Cell"},{"key":"4217_CR12","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.1002\/ijc.25580","volume":"128","author":"M Greiner","year":"2011","unstructured":"Greiner M, Kreutzer B, Jung V, Grobholz R, Hasenfus A, St\u00f6hr RF, Tornillo L, Dudek J, St\u00f6ckle M, Unteregger G, et al: Silencing of the SEC62 gene inhibits migratory and invasive potential of various tumor cells. Int J Cancer. 2011, 128: 2284-2295. 10.1002\/ijc.25580.","journal-title":"Int J Cancer"},{"key":"4217_CR13","doi-asserted-by":"publisher","first-page":"1074","DOI":"10.1002\/pros.21324","volume":"71","author":"M Greiner","year":"2011","unstructured":"Greiner M, Kreutzer B, Lang S, Jung V, Adolpho C, Unteregger G, Zimmermann R, Wullich B: Sec62 protein content is crucial for the ER stress tolerance of prostate cancer. Prostate. 2011, 71: 1074-1083. 10.1002\/pros.21324.","journal-title":"Prostate"},{"key":"4217_CR14","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1038\/415092a","volume":"415","author":"M Calfon","year":"2002","unstructured":"Calfon M, Zeng H, Urano F, Till JH, Hubbard SR, Harding HP, Clark SG, Ron D: IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA. Nature. 2002, 415: 92-96. 10.1038\/415092a.","journal-title":"Nature"},{"key":"4217_CR15","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1101\/gad.992302","volume":"16","author":"H Nishitoh","year":"2002","unstructured":"Nishitoh H, Matsuzawa A, Tobiume K, Saegusa K, Takeda K, Inoue K, Hori S, Kakizuka A, Ichijo H: ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev. 2002, 16: 1345-1355. 10.1101\/gad.992302.","journal-title":"Genes Dev"},{"key":"4217_CR16","doi-asserted-by":"publisher","first-page":"2482","DOI":"10.1158\/0008-5472.CAN-03-3501","volume":"64","author":"JB Huang","year":"2004","unstructured":"Huang JB, Kindzelskii AL, Clark AJ, Petty HR: Identification of channels promoting calcium spikes and waves in HT1080 tumor cells: their apparent roles in cell motility and invasion. Cancer Res. 2004, 64: 2482-2489. 10.1158\/0008-5472.CAN-03-3501.","journal-title":"Cancer Res"},{"key":"4217_CR17","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/emboj.2010.284","volume":"30","author":"F Erdmann","year":"2011","unstructured":"Erdmann F, Schauble N, Lang S, Jung M, Honigmann A, Ahmad M, Dudek J, Benedix J, Harsman A, Kopp A, et al: Interaction of calmodulin with Sec61alpha limits Ca2+ leakage from the endoplasmic reticulum. Embo J. 2011, 30: 17-31. 10.1038\/emboj.2010.284.","journal-title":"Embo J"},{"key":"4217_CR18","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1038\/nprot.2007.160","volume":"2","author":"K Hilpert","year":"2007","unstructured":"Hilpert K, Winkler DF, Hancock RE: Peptide arrays on cellulose support: SPOT synthesis, a time and cost efficient method for synthesis of large numbers of peptides in a parallel and addressable fashion. Nat Protoc. 2007, 2: 1333-1349. 10.1038\/nprot.2007.160.","journal-title":"Nat Protoc"},{"key":"4217_CR19","doi-asserted-by":"publisher","first-page":"119","DOI":"10.4049\/jimmunol.174.1.119","volume":"174","author":"E Aneiros","year":"2005","unstructured":"Aneiros E, Philipp S, Lis A, Freichel M, Cavalie A: Modulation of Ca2+ signaling by Na+\/Ca2+ exchangers in mast cells. J Immunol. 2005, 174: 119-130.","journal-title":"J Immunol"},{"key":"4217_CR20","doi-asserted-by":"publisher","first-page":"34423","DOI":"10.1074\/jbc.M109.018192","volume":"284","author":"SA Gross","year":"2009","unstructured":"Gross SA, Guzman GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalie A: TRPC5 is a Ca2\u2009+\u2009\u2212activated channel functionally coupled to Ca2\u2009+\u2009\u2212selective ion channels. J Biol Chem. 2009, 284: 34423-34432. 10.1074\/jbc.M109.018192.","journal-title":"J Biol Chem"},{"key":"4217_CR21","doi-asserted-by":"publisher","first-page":"26479","DOI":"10.1074\/jbc.M201845200","volume":"277","author":"RB Lomax","year":"2002","unstructured":"Lomax RB, Camello C, Van Coppenolle F, Petersen OH, Tepikin AV: Basal and physiological Ca(2+) leak from the endoplasmic reticulum of pancreatic acinar cells. Second messenger-activated channels and translocons. J Biol Chem. 2002, 277: 26479-26485. 10.1074\/jbc.M201845200.","journal-title":"J Biol Chem"},{"key":"4217_CR22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.ceca.2008.02.002","volume":"44","author":"M Rehberg","year":"2008","unstructured":"Rehberg M, Lepier A, Solchenberger B, Osten P, Blum R: A new non-disruptive strategy to target calcium indicator dyes to the endoplasmic reticulum. Cell Calcium. 2008, 44: 386-399. 10.1016\/j.ceca.2008.02.002.","journal-title":"Cell Calcium"},{"key":"4217_CR23","doi-asserted-by":"publisher","first-page":"293","DOI":"10.4161\/chan.5.4.16160","volume":"5","author":"A Harsman","year":"2011","unstructured":"Harsman A, Kopp A, Wagner R, Zimmermann R, Jung M: Calmodulin regulation of the calcium-leak channel Sec61 is unique to vertebrates. Channels (Austin). 2011, 5: 293-298. 10.4161\/chan.5.4.16160.","journal-title":"Channels (Austin)"},{"key":"4217_CR24","volume-title":"J Vis Exp","author":"S Lang","year":"2011","unstructured":"Lang S, Schauble N, Cavalie A, Zimmermann R: Live cell calcium imaging combined with siRNA mediated gene silencing identifies Ca(2)(+) leak channels in the ER membrane and their regulatory mechanisms. J Vis Exp. 2011"},{"key":"4217_CR25","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1016\/j.cellsig.2010.11.005","volume":"23","author":"L Chen","year":"2011","unstructured":"Chen L, Meng Q, Jing X, Xu P, Luo D: A role for protein kinase C in the regulation of membrane fluidity and Ca2+ flux at the endoplasmic reticulum and plasma membranes of HEK293 and Jurkat cells. Cell Signal. 2011, 23: 497-505. 10.1016\/j.cellsig.2010.11.005.","journal-title":"Cell Signal"},{"key":"4217_CR26","doi-asserted-by":"publisher","first-page":"974","DOI":"10.1002\/ijc.2910550617","volume":"55","author":"K Nabeshima","year":"1993","unstructured":"Nabeshima K, Komada N, Kishi J, Koita H, Inoue T, Hayakawa T, Koono M: TPA-enhanced invasion of Matrigel associated with augmentation of cell motility but not metalloproteinase activity in a highly metastatic variant (L-10) of human rectal adenocarcinoma cell line RCM-1. Int J Cancer. 1993, 55: 974-981. 10.1002\/ijc.2910550617.","journal-title":"Int J Cancer"},{"key":"4217_CR27","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1002\/jcp.22226","volume":"225","author":"CW Lin","year":"2010","unstructured":"Lin CW, Shen SC, Chien CC, Yang LY, Shia LT, Chen YC: 12-O-tetradecanoylphorbol-13-acetate-induced invasion\/migration of glioblastoma cells through activating PKCalpha\/ERK\/NF-kappaB-dependent MMP-9 expression. J Cell Physiol. 2010, 225: 472-481. 10.1002\/jcp.22226.","journal-title":"J Cell Physiol"},{"key":"4217_CR28","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1038\/22578","volume":"400","author":"J Lee","year":"1999","unstructured":"Lee J, Ishihara A, Oxford G, Johnson B, Jacobson K: Regulation of cell movement is mediated by stretch-activated calcium channels. Nature. 1999, 400: 382-386. 10.1038\/22578.","journal-title":"Nature"},{"key":"4217_CR29","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1126\/science.1092053","volume":"302","author":"AJ Ridley","year":"2003","unstructured":"Ridley AJ, Schwartz MA, Burridge K, Firtel RA, Ginsberg MH, Borisy G, Parsons JT, Horwitz AR: Cell migration: integrating signals from front to back. Science. 2003, 302: 1704-1709. 10.1126\/science.1092053.","journal-title":"Science"},{"key":"4217_CR30","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1002\/bies.950190109","volume":"19","author":"MD Sjaastad","year":"1997","unstructured":"Sjaastad MD, Nelson WJ: Integrin-mediated calcium signaling and regulation of cell adhesion by intracellular calcium. Bioessays. 1997, 19: 47-55. 10.1002\/bies.950190109.","journal-title":"Bioessays"},{"key":"4217_CR31","doi-asserted-by":"publisher","first-page":"3282","DOI":"10.1038\/emboj.2012.189","volume":"31","author":"N Schauble","year":"2012","unstructured":"Schauble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan O, Linxweiler J, Dudek J, Blum R, Helms V, et al: BiP-mediated closing of the Sec61 channel limits Ca(2+) leakage from the ER. Embo J. 2012, 31: 3282-3296. 10.1038\/emboj.2012.189.","journal-title":"Embo J"},{"key":"4217_CR32","doi-asserted-by":"publisher","first-page":"3859","DOI":"10.1091\/mbc.11.11.3859","volume":"11","author":"S Wittke","year":"2000","unstructured":"Wittke S, Dunnwald M, Johnsson N: Sec62p, a component of the endoplasmic reticulum protein translocation machinery, contains multiple binding sites for the Sec-complex. Mol Biol Cell. 2000, 11: 3859-3871. 10.1091\/mbc.11.11.3859.","journal-title":"Mol Biol Cell"},{"key":"4217_CR33","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1210\/en.2009-1045","volume":"151","author":"RJ Christie","year":"2009","unstructured":"Christie RJ, Nishiyama N, Kataoka K: Delivering the code: polyplex carriers for deoxyribonucleic acid and ribonucleic acid interference therapies. Endocrinology. 2009, 151: 466-473.","journal-title":"Endocrinology"},{"key":"4217_CR34","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/nrd3010","volume":"9","author":"AL Jackson","year":"2010","unstructured":"Jackson AL, Linsley PS: Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application. Nat Rev Drug Discov. 2010, 9: 57-67. 10.1038\/nrd3010.","journal-title":"Nat Rev Drug Discov"},{"key":"4217_CR35","first-page":"422","volume":"6","author":"S Koehn","year":"2010","unstructured":"Koehn S, Schaefer HW, Ludwig M, Haag N, Schubert US, Seyfarth L, Imhof D, Markert UR, Poehlmann TG: Cell-specific RNA interference by peptide-inhibited-peptidase-activated siRNAs. J RNAi Gene Silencing. 2010, 6: 422-430.","journal-title":"J RNAi Gene Silencing"},{"key":"4217_CR36","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nbt0211-93","volume":"29","author":"C Schmidt","year":"2011","unstructured":"Schmidt C: RNAi momentum fizzles as pharma shifts priorities. Nat Biotechnol. 2011, 29: 93-94. 10.1038\/nbt0211-93.","journal-title":"Nat Biotechnol"},{"key":"4217_CR37","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.cell.2009.02.010","volume":"136","author":"L Bonetta","year":"2009","unstructured":"Bonetta L: RNA-based therapeutics: ready for delivery?. Cell. 2009, 136: 581-584. 10.1016\/j.cell.2009.02.010.","journal-title":"Cell"},{"key":"4217_CR38","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1007\/s10549-008-0097-z","volume":"115","author":"CM Coticchia","year":"2009","unstructured":"Coticchia CM, Revankar CM, Deb TB, Dickson RB, Johnson MD: Calmodulin modulates Akt activity in human breast cancer cell lines. Breast Cancer Res Treat. 2009, 115: 545-560. 10.1007\/s10549-008-0097-z.","journal-title":"Breast Cancer Res Treat"},{"key":"4217_CR39","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1111\/j.1476-5381.2010.00762.x","volume":"160","author":"YP Hwang","year":"2010","unstructured":"Hwang YP, Jeong HG: Metformin blocks migration and invasion of tumour cells by inhibition of matrix metalloproteinase-9 activation through a calcium and protein kinase Calpha-dependent pathway: phorbol-12-myristate-13-acetate-induced\/extracellular signal-regulated kinase\/activator protein-1. Br J Pharmacol. 2010, 160: 1195-1211. 10.1111\/j.1476-5381.2010.00762.x.","journal-title":"Br J Pharmacol"},{"key":"4217_CR40","doi-asserted-by":"publisher","first-page":"25867","DOI":"10.1074\/jbc.M110.135632","volume":"285","author":"HJ Jung","year":"2010","unstructured":"Jung HJ, Kim JH, Shim JS, Kwon HJ: A novel Ca2+\/calmodulin antagonist HBC inhibits angiogenesis and down-regulates hypoxia-inducible factor. J Biol Chem. 2010, 285: 25867-25874. 10.1074\/jbc.M110.135632.","journal-title":"J Biol Chem"},{"key":"4217_CR41","doi-asserted-by":"publisher","first-page":"24776","DOI":"10.1074\/jbc.M110.202804","volume":"286","author":"K Yuan","year":"2011","unstructured":"Yuan K, Jing G, Chen J, Liu H, Zhang K, Li Y, Wu H, McDonald JM, Chen Y: Calmodulin mediates Fas-induced FADD-independent survival signaling in pancreatic cancer cells via activation of Src-extracellular signal-regulated kinase (ERK). J Biol Chem. 2011, 286: 24776-24784. 10.1074\/jbc.M110.202804.","journal-title":"J Biol Chem"},{"key":"4217_CR42","doi-asserted-by":"publisher","first-page":"2303","DOI":"10.1158\/1535-7163.MCT-06-0402","volume":"6","author":"AG Polischouk","year":"2007","unstructured":"Polischouk AG, Holgersson A, Zong D, Stenerlow B, Karlsson HL, Moller L, Viktorsson K, Lewensohn R: The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death. Mol Cancer Ther. 2007, 6: 2303-2309. 10.1158\/1535-7163.MCT-06-0402.","journal-title":"Mol Cancer Ther"},{"key":"4217_CR43","first-page":"5364","volume":"49","author":"K Satyamoorthy","year":"1989","unstructured":"Satyamoorthy K, Perchellet JP: Modulation by adriamycin, daunomycin, verapamil, and trifluoperazine of the biochemical processes linked to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 1989, 49: 5364-5370.","journal-title":"Cancer Res"},{"issue":"12","key":"4217_CR44","doi-asserted-by":"publisher","first-page":"1168","DOI":"10.1038\/mp.2012.121","volume":"17","author":"WT Carpenter Jr","year":"2012","unstructured":"Carpenter WT, Davis JM: Another view of the history of antipsychotic drug discovery and development. Mol Psychiatry. 2012, 17 (12): 1168-1173. 10.1038\/mp.2012.121.","journal-title":"Mol Psychiatry"},{"key":"4217_CR45","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1016\/S0010-440X(99)90082-2","volume":"40","author":"WW Shen","year":"1999","unstructured":"Shen WW: A history of antipsychotic drug development. Compr Psychiatry. 1999, 40: 407-414. 10.1016\/S0010-440X(99)90082-2.","journal-title":"Compr Psychiatry"},{"key":"4217_CR46","doi-asserted-by":"publisher","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","volume":"15","author":"A Ghantous","year":"2010","unstructured":"Ghantous A, Gali-Muhtasib H, Vuorela H, Saliba NA, Darwiche N: What made sesquiterpene lactones reach cancer clinical trials?. Drug Discov Today. 2010, 15: 668-678. 10.1016\/j.drudis.2010.06.002.","journal-title":"Drug Discov Today"},{"key":"4217_CR47","doi-asserted-by":"publisher","first-page":"276","DOI":"10.2174\/1871520610909030276","volume":"9","author":"SB Christensen","year":"2009","unstructured":"Christensen SB, Skytte DM, Denmeade SR, Dionne C, M\u00f8ller JV, Nissen P, Isaacs JT: A Trojan horse in drug development: targeting of thapsigargins towards prostate cancer cells. Anticancer Agents Med Chem. 2009, 9: 276-294. 10.2174\/1871520610909030276.","journal-title":"Anticancer Agents Med Chem"},{"key":"4217_CR48","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1111\/j.1742-7843.2009.00413.x","volume":"104","author":"J-K Huang","year":"2009","unstructured":"Huang J-K, Huang C-C, Lu T, Chang H-T, Lin K-L, Tsai J-Y, Liao W-C, Chien J-M, Jan C-R: Effect of MK-886 on Ca2+ level and viability in PC3 human prostate cancer cells. Basic Clin Pharmacol Toxicol. 2009, 104: 441-447. 10.1111\/j.1742-7843.2009.00413.x.","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"4217_CR49","doi-asserted-by":"publisher","first-page":"14","DOI":"10.4161\/cbt.4.1.1505","volume":"4","author":"SR Denmeade","year":"2005","unstructured":"Denmeade SR, Isaacs JT: The SERCA pump as a therapeutic target: making a \u201csmart bomb\u201d for prostate cancer. Cancer Biol Ther. 2005, 4: 14-22. 10.4161\/cbt.4.1.1505.","journal-title":"Cancer Biol Ther"},{"key":"4217_CR50","doi-asserted-by":"publisher","first-page":"140ra186","DOI":"10.1126\/scitranslmed.3003886","volume":"4","author":"SR Denmeade","year":"2012","unstructured":"Denmeade SR, Mhaka AM, Rosen DM, Brennen WN, Dalrymple S, Dach I, Olesen C, Gurel B, Demarzo AM, Wilding G: Engineering a prostate-specific membrane antigen-activated tumor endothelial cell prodrug for cancer therapy. Sci Transl Med. 2012, 4: 140ra186-","journal-title":"Sci Transl Med"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-13-574\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-13-574.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T22:49:12Z","timestamp":1716245352000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-13-574"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,12]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["4217"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-13-574","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,12]]},"assertion":[{"value":"10 April 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 November 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"574"}}