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Using gene network analysis, we identified altered expression of transcripts involved in mitotic regulators, histones, and non-protein coding RNAs as the significant processes that differed between the hyperthermic response of mammary epithelial cells and breast cancer cells. We confirmed our data via qPCR and flow cytometric analysis to demonstrate that hyperthermia specifically disrupts the expression of key mitotic regulators and G2\/M phase progression in the breast cancer cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These data have identified molecular mechanisms by which breast cancer lines may exhibit enhanced susceptibility to hyperthermic shock.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2407-14-81","type":"journal-article","created":{"date-parts":[[2014,2,11]],"date-time":"2014-02-11T05:02:09Z","timestamp":1392094929000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["A genomics approach to identify susceptibilities of breast cancer cells to \u201cfever-range\u201d hyperthermia"],"prefix":"10.1186","volume":"14","author":[{"given":"Clarissa","family":"Amaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittal","family":"Kurisetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Stiles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice M","family":"Nyakeriga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arunkumar","family":"Arumugam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajkumar","family":"Lakshmanaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian E","family":"Botez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianne C","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brad A","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,2,11]]},"reference":[{"issue":"6","key":"4319_CR1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1615\/CritRevBiomedEng.v34.i6.30","volume":"34","author":"RW Habash","year":"2006","unstructured":"Habash RW, Bansal R, Krewski D, Alhafid HT: Thermal therapy, part 2: hyperthermia techniques. 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