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In this work, we investigated the placental alterations produced by tumour growth and the effects on the expression of apoptotic factors in placental tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adult female Wistar rats (90 days old, n = 54) were allocated to control (C), tumour-bearing (W), or ascitic fluid-injected (A) groups and were killed on the 16<jats:sup>th<\/jats:sup>, 19<jats:sup>th<\/jats:sup>or 21<jats:sup>st<\/jats:sup>day of pregnancy. Placental tissues were analysed using biochemical and histochemical assays.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The placental protein content and glutathione-S-transferase activity were decreased in groups W and A. Histochemical analysis showed an increase in the number of cells with cleaved PARP, caspase 3 and cytochrome-c in groups W and A, indicating that the tumour growth clearly damaged placental tissue and affected the levels of apoptotic factors. These results were confirmed by western blotting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Since trophoblastic cells are responsible for maintaining a normal placental function, the uncontrolled death of these cells in response to tumour cell growth or substances derived from ascitic fluid could have a negative impact on foetal development. Further knowledge of these events may help to preserve the foetus and placenta during development.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-6-168","type":"journal-article","created":{"date-parts":[[2006,6,27]],"date-time":"2006-06-27T07:29:52Z","timestamp":1151393392000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Cancer during pregnancy alters the activity of rat placenta and enhances the expression of cleaved PARP, cytochrome-c and caspase 3"],"prefix":"10.1186","volume":"6","author":[{"given":"M\u00e9rcia Tancredo","family":"Toledo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gislaine","family":"Ventrucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Cristina Cintra Gomes","family":"Marcondes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,6,26]]},"reference":[{"key":"520_CR1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1093\/humupd\/7.4.384","volume":"7","author":"B Weisz","year":"2001","unstructured":"Weisz B, Schiff E, Lishner M: Cancer in pregnancy: maternal and fetal implications. 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