{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T20:32:29Z","timestamp":1648672349543},"reference-count":39,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1186\/1471-2407-6-279","type":"journal-article","created":{"date-parts":[[2006,12,7]],"date-time":"2006-12-07T19:48:04Z","timestamp":1165520884000},"source":"Crossref","is-referenced-by-count":5,"title":["Split Course Hyperfractionated Accelerated Radio-Chemotherapy (SCHARC) for patients with advanced head and neck cancer: Influence of protocol deviations and hemoglobin on overall survival, a retrospective analysis"],"prefix":"10.1186","volume":"6","author":[{"given":"Peter","family":"Stadler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurt","family":"Putnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thore","family":"Kreimeyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa D","family":"Sprague","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Koelbl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christof","family":"Sch\u00e4fer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,12,7]]},"reference":[{"key":"631_CR1","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/sj.bjc.6602510","volume":"92","author":"TY Seiwert","year":"2005","unstructured":"Seiwert TY, Cohen EE: State-of-the-art management of locally advanced head and neck cancer. Br J Cancer. 2005, 92: 1341-8. 10.1038\/sj.bjc.6602510.","journal-title":"Br J Cancer"},{"key":"631_CR2","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1053\/j.seminoncol.2004.09.002","volume":"31","author":"J Bourhis","year":"2004","unstructured":"Bourhis J, Calais G, Lapeyre M, Tortochaux J, Alfonsi M, Sire C, et al: Concomitant radiochemotherapy or accelerated radiotherapy: analysis of two randomized trials of the French Head and Neck Cancer Group (GORTEC). Semin Oncol. 2004, 31: 822-6. 10.1053\/j.seminoncol.2004.09.002.","journal-title":"Semin Oncol"},{"key":"631_CR3","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1186\/1471-2407-6-28","volume":"6","author":"W Budach","year":"2006","unstructured":"Budach W, Hehr T, Budach V, Belka C, Dietz K: A meta-analysis of hyperfractionated and accelerated radiotherapy and combined chemotherapy and radiotherapy regimens in unresected locally advanced squamous cell carcinoma of the head and neck. BMC Cancer. 2006, 6: 28-10.1186\/1471-2407-6-28.","journal-title":"BMC Cancer"},{"key":"631_CR4","doi-asserted-by":"publisher","first-page":"1418","DOI":"10.1016\/j.ijrobp.2003.09.004","volume":"58","author":"DM Brizel","year":"2004","unstructured":"Brizel DM, Prosnitz RG, Hunter S, Fisher SR, Clough RL, Downey MA, et al: Necessity for adjuvant neck dissection in setting of concurrent chemoradiation for advanced head-and-neck cancer. Int J Radiat Oncol Biol Phys. 2004, 58: 1418-23. 10.1016\/j.ijrobp.2003.09.004.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"631_CR5","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1097\/01.MLG.0000162648.37638.76","volume":"115","author":"DK Frank","year":"2005","unstructured":"Frank DK, Hu KS, Culliney BE, Persky MS, Nussbaum M, Schantz SP, et al: Planned neck dissection after concomitant radiochemotherapy for advanced head and neck cancer. Laryngoscope. 2005, 115: 1015-20. 10.1097\/01.MLG.0000162648.37638.76.","journal-title":"Laryngoscope"},{"key":"631_CR6","doi-asserted-by":"publisher","first-page":"295","DOI":"10.2310\/7070.2004.00295","volume":"33","author":"M Corsten","year":"2004","unstructured":"Corsten M, Hong P: Number to treat analysis for planned neck dissection after organ preservation therapy with advanced neck disease. J Otolaryngol. 2004, 33: 295-8.","journal-title":"J Otolaryngol"},{"key":"631_CR7","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1007\/s00066-004-1307-1","volume":"180","author":"A Ernst-Stecken","year":"2004","unstructured":"Ernst-Stecken A, Grabenbauer G, Iro H, Plasswilm L, Sauer R: Phase II Trial of Hyperfractionated Accelerated Split-Course Radiochemotherapy with 5-FU and Cis-DDP in Advanced Head and Neck CancerResults and Toxicity. Strahlenther Onkol. 2004, 180: 805-10. 10.1007\/s00066-004-1307-1.","journal-title":"Strahlenther Onkol"},{"key":"631_CR8","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S0360-3016(99)00384-3","volume":"46","author":"A Becker","year":"2000","unstructured":"Becker A, Stadler P, Lavey RS, Hansgen G, Kuhnt T, Lautenschlager C, et al: Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2000, 46: 459-66. 10.1016\/S0360-3016(99)00384-3.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"631_CR9","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1007\/s00066-003-1066-4","volume":"179","author":"J Dunst","year":"2003","unstructured":"Dunst J, Stadler P, Becker A, Lautenschlager C, Pelz T, Hansgen G, et al: Tumor volume and tumor hypoxia in head and neck cancers. The amount of the hypoxic volume is important. Strahlenther Onkol. 2003, 179: 521-6. 10.1007\/s00066-003-1066-4.","journal-title":"Strahlenther Onkol"},{"key":"631_CR10","volume-title":"Radiother Oncol","author":"M Nordsmark","year":"2005","unstructured":"Nordsmark M, Bentzen SM, Rudat V, Brizel D, Lartigau E, Stadler P, et al: Prognostic value of tumor oxygenation in 397 head and neck tumors after primary radiation therapy. An international multi-center study. Radiother Oncol. 2005"},{"key":"631_CR11","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1016\/j.ijrobp.2004.07.710","volume":"61","author":"RG Prosnitz","year":"2005","unstructured":"Prosnitz RG, Yao B, Farrell CL, Clough R, Brizel DM: Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 2005, 61: 1087-95. 10.1016\/j.ijrobp.2004.07.710.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"631_CR12","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/S0360-3016(99)00115-7","volume":"44","author":"P Stadler","year":"1999","unstructured":"Stadler P, Becker A, Feldmann HJ, Hansgen G, Dunst J, Wurschmidt F, et al: Influence of the hypoxic subvolume on the survival of patients with head and neck cancer. Int J Radiat Oncol Biol Phys. 1999, 44: 749-54. 10.1016\/S0360-3016(99)00115-7.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"631_CR13","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00066-005-1277-y","volume":"181","author":"R Mayer","year":"2005","unstructured":"Mayer R, Hamilton-Farrell MR, van der Kleij AJ, Schmutz J, Granstrom G, Sicko Z, et al: Hyperbaric oxygen and radiotherapy. Strahlenther Onkol. 2005, 181: 113-23. 10.1007\/s00066-005-1277-y.","journal-title":"Strahlenther Onkol"},{"key":"631_CR14","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/S1470-2045(05)70292-8","volume":"6","author":"J Overgaard","year":"2005","unstructured":"Overgaard J, Eriksen JG, Nordsmark M, Alsner J, Horsman MR: Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial. Lancet Oncol. 2005, 6: 757-64. 10.1016\/S1470-2045(05)70292-8.","journal-title":"Lancet Oncol"},{"key":"631_CR15","doi-asserted-by":"publisher","first-page":"1255","DOI":"10.1016\/S0140-6736(03)14567-9","volume":"362","author":"M Henke","year":"2003","unstructured":"Henke M, Laszig R, Rube C, Schafer U, Haase KD, Schilcher B, et al: Erythropoietin to treat head and neck cancer patients with anaemia undergoing radiotherapy: randomised, double-blind, placebo-controlled trial. Lancet. 2003, 362: 1255-60. 10.1016\/S0140-6736(03)14567-9.","journal-title":"Lancet"},{"key":"631_CR16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0360-3016(99)00559-3","volume":"47","author":"A Trotti","year":"2000","unstructured":"Trotti A, Byhardt R, Stetz J, Gwede C, Corn B, Fu K, et al: Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy. Int J Radiat Oncol Biol Phys. 2000, 47: 13-47. 10.1016\/S0360-3016(99)00559-3.","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"631_CR17","doi-asserted-by":"crossref","unstructured":"LENT SOMA scales for all anatomic sites. Int J Radiat Oncol Biol Phys. 1995, 31: 1049-91. 10.1016\/0360-3016(95)90159-0.","DOI":"10.1016\/0360-3016(95)90159-0"},{"key":"631_CR18","doi-asserted-by":"publisher","first-page":"3008","DOI":"10.1200\/JCO.2005.12.060","volume":"23","author":"KK Ang","year":"2005","unstructured":"Ang KK, Harris J, Garden AS, Trotti A, Jones CU, Carrascosa L, et al: Concomitant boost radiation plus concurrent cisplatin for advanced head and neck carcinomas: radiation therapy oncology group phase II trial 99-14. J Clin Oncol. 2005, 23: 3008-15. 10.1200\/JCO.2005.12.060.","journal-title":"J Clin Oncol"},{"key":"631_CR19","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1002\/hed.20111","volume":"27","author":"GK Beckmann","year":"2005","unstructured":"Beckmann GK, Hoppe F, Pfreundner L, Flentje MP: Hyperfractionated accelerated radiotherapy in combination with weekly cisplatin for locally advanced head and neck cancer. Head Neck. 2005, 27: 36-43. 10.1002\/hed.20111.","journal-title":"Head Neck"},{"key":"631_CR20","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/PL00002314","volume":"176","author":"A Becker","year":"2000","unstructured":"Becker A, Stadler P, Krause U, Kuhnt T, Hansgen G, Dettmar P, et al: [No association between p53 overexpression and polarographically measured tumor oxygenation in patients with head and neck carcinomas]. Strahlenther Onkol. 2000, 176: 475-80. 10.1007\/PL00002314.","journal-title":"Strahlenther Onkol"},{"key":"631_CR21","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1007\/s00066-001-0809-3","volume":"177","author":"A Becker","year":"2001","unstructured":"Becker A, Stadler P, Krause U, Utzig D, Hansgen G, Lautenschlager C, et al: [Association between elevated serum VEGF and polarographically measured tumor hypoxia in head and neck carcinomas]. Strahlenther Onkol. 2001, 177: 182-8.","journal-title":"Strahlenther Onkol"},{"key":"631_CR22","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1007\/PL00002428","volume":"177","author":"J Dunst","year":"2001","unstructured":"Dunst J, Stadler P, Becker A, Kuhnt T, Lautenschlager C, Molls M, et al: Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancers. Strahlenther Onkol. 2001, 177: 469-73. 10.1007\/PL00002428.","journal-title":"Strahlenther Onkol"},{"key":"631_CR23","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1016\/S0360-3016(01)01523-1","volume":"50","author":"G Haensgen","year":"2001","unstructured":"Haensgen G, Krause U, Becker A, Stadler P, Lautenschlaeger C, Wohlrab W, et al: Tumor hypoxia, p53, and prognosis in cervical cancers. Int J Radiat Oncol Biol Phys. 2001, 50: 865-72. 10.1016\/S0360-3016(01)01523-1.","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl 4","key":"631_CR24","first-page":"13","volume":"174","author":"M Molls","year":"1998","unstructured":"Molls M, Stadler P, Becker A, Feldmann HJ, Dunst J: Relevance of oxygen in radiation oncology. Mechanisms of action, correlation to low hemoglobin levels. Strahlenther Onkol. 1998, 174 (Suppl 4): 13-6.","journal-title":"Strahlenther Onkol"},{"key":"631_CR25","doi-asserted-by":"publisher","first-page":"200","DOI":"10.1016\/j.radonc.2005.06.023","volume":"76","author":"HM Said","year":"2005","unstructured":"Said HM, Katzer A, Flentje M, Vordermark D: Response of the plasma hypoxia marker osteopontin to in vitro hypoxia in human tumor cells. Radiother Oncol. 2005, 76: 200-5. 10.1016\/j.radonc.2005.06.023.","journal-title":"Radiother Oncol"},{"key":"631_CR26","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1177\/172460080001500306","volume":"15","author":"P Stadler","year":"2000","unstructured":"Stadler P, Feldmann HJ, Creighton C, Zeilhoffer HF, Zimmermann V, Schmitt M, et al: Clinical evidence for correlation of insufficient tissue oxygen supply (hypoxia) and tumor-associated proteolysis in squamous cell carcinoma of the head and neck. Int J Biol Markers. 2000, 15: 235-6.","journal-title":"Int J Biol Markers"},{"key":"631_CR27","first-page":"4617","volume":"62","author":"N Harbeck","year":"2002","unstructured":"Harbeck N, Kates RE, Look MP, Meijer-van Gelder ME, Klijn JG, Kruger A, et al: Enhanced benefit from adjuvant chemotherapy in breast cancer patients classified high-risk according to urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (n = 3424). Cancer Res. 2002, 62: 4617-22.","journal-title":"Cancer Res"},{"key":"631_CR28","doi-asserted-by":"publisher","first-page":"1000","DOI":"10.1200\/JCO.20.4.1000","volume":"20","author":"N Harbeck","year":"2002","unstructured":"Harbeck N, Kates RE, Schmitt M: Clinical relevance of invasion factors urokinase-type plasminogen activator and plasminogen activator inhibitor type 1 for individualized therapy decisions in primary breast cancer is greatest when used in combination. J Clin Oncol. 2002, 20: 1000-7. 10.1200\/JCO.20.4.1000.","journal-title":"J Clin Oncol"},{"key":"631_CR29","doi-asserted-by":"publisher","first-page":"1110","DOI":"10.1001\/archotol.129.10.1110","volume":"129","author":"JJ Homer","year":"2003","unstructured":"Homer JJ, Prentice MG, Cawkwell L, Birchall M, Greenman J, Stafford ND: Angiogenesis and the expression of vascular endothelial growth factors A and C in squamous cell carcinoma of the piriform fossa. Arch Otolaryngol Head Neck Surg. 2003, 129: 1110-4. 10.1001\/archotol.129.10.1110.","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"631_CR30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1097\/00008390-200510000-00010","volume":"15","author":"ML Varney","year":"2005","unstructured":"Varney ML, Johansson SL, Singh RK: Tumour-associated macrophage infiltration, neovascularization and aggressiveness in malignant melanoma: role of monocyte chemotactic protein-1 and vascular endothelial growth factor-A. Melanoma Res. 2005, 15: 417-25. 10.1097\/00008390-200510000-00010.","journal-title":"Melanoma Res"},{"key":"631_CR31","first-page":"669","volume":"27","author":"Z Von Marschall","year":"2005","unstructured":"Von Marschall Z, Scholz A, Stacker SA, Achen MG, Jackson DG, Alves F, et al: Vascular endothelial growth factor-D induces lymphangiogenesis and lymphatic metastasis in models of ductal pancreatic cancer. Int J Oncol. 2005, 27: 669-79.","journal-title":"Int J Oncol"},{"key":"631_CR32","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s00066-002-0925-8","volume":"178","author":"J Dunst","year":"2002","unstructured":"Dunst J, Becker A, Lautenschlager C, Markau S, Becker H, Fischer K, et al: Anemia and elevated systemic levels of vascular endothelial growth factor (VEGF). Strahlenther Onkol. 2002, 178: 436-41. 10.1007\/s00066-002-0925-8.","journal-title":"Strahlenther Onkol"},{"key":"631_CR33","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1159\/000081890","volume":"66","author":"O Pradier","year":"2004","unstructured":"Pradier O, Christiansen H, Ambrosch P, Kron M, Schmidberger H, Hess CF: A long-term follow-up study after split-course irradiation with concurrent chemotherapy (carboplatin) for locally advanced head and neck cancer and a review of the literature. ORL J Otorhinolaryngol Relat Spec. 2004, 66: 325-31.","journal-title":"ORL J Otorhinolaryngol Relat Spec"},{"key":"631_CR34","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S0167-8140(97)01904-X","volume":"43","author":"O Hansen","year":"1997","unstructured":"Hansen O, Overgaard J, Hansen HS, Overgaard M, Hoyer M, Jorgensen KE, et al: Importance of overall treatment time for the outcome of radiotherapy of advanced head and neck carcinoma: dependency on tumor differentiation. Radiother Oncol. 1997, 43: 47-51. 10.1016\/S0167-8140(97)01904-X.","journal-title":"Radiother Oncol"},{"key":"631_CR35","doi-asserted-by":"publisher","first-page":"147","DOI":"10.3109\/02841868809090334","volume":"27","author":"J Overgaard","year":"1988","unstructured":"Overgaard J, Hjelm-Hansen M, Johansen LV, Andersen AP: Comparison of conventional and split-course radiotherapy as primary treatment in carcinoma of the larynx. Acta Oncol. 1988, 27: 147-52.","journal-title":"Acta Oncol"},{"key":"631_CR36","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1016\/S0167-8140(98)00032-2","volume":"48","author":"P Stadler","year":"1998","unstructured":"Stadler P, Feldmann HJ, Creighton C, Kau R, Molls M: Changes in tumor oxygenation during combined treatment with split-course radiotherapy and chemotherapy in patients with head and neck cancer. Radiother Oncol. 1998, 48: 157-64. 10.1016\/S0167-8140(98)00032-2.","journal-title":"Radiother Oncol"},{"key":"631_CR37","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/S0959-8049(97)10172-1","volume-title":"Eur J Cancer","author":"P Stadler","year":"1998","unstructured":"Stadler P: Comments on Variations in tumour oxygen tension (pO2) during accelerated radiotherapy of head and neck carcinoma. Eur J Cancer. Edited by: Lartigau et al. 1998, 34: 856-861. 10.1016\/S0959-8049(97)10172-1. Eur J Cancer 1999; 35: 161-2"},{"key":"631_CR38","doi-asserted-by":"publisher","first-page":"856","DOI":"10.1016\/S0959-8049(97)10172-1","volume":"34","author":"E Lartigau","year":"1998","unstructured":"Lartigau E, Lusinchi A, Weeger P, Wibault P, Luboinski B, Eschwege F, et al: Variations in tumour oxygen tension (pO2) during accelerated radiotherapy of head and neck carcinoma. Eur J Cancer. 1998, 34: 856-61. 10.1016\/S0959-8049(97)10172-1.","journal-title":"Eur J Cancer"},{"key":"631_CR39","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1177\/000348949910800111","volume":"108","author":"R Jund","year":"1999","unstructured":"Jund R, Feldmann HJ, Wollenberg B, Stadler P, Molls M: Changes in head and neck tumor hypoxic fraction during split-course radiochemotherapy. Ann Otol Rhinol Laryngol. 1999, 108: 73-8.","journal-title":"Ann Otol Rhinol Laryngol"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-6-279\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-279.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,21]],"date-time":"2019-01-21T22:34:36Z","timestamp":1548110076000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-6-279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["631"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-6-279","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"article-number":"279"}}