{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:10:36Z","timestamp":1776215436494,"version":"3.50.1"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T00:00:00Z","timestamp":1142467200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Genetic polymorphisms in DNA repair genes may influence individual variation in DNA repair capacity, which may be associated with risk of developing cancer. For colorectal cancer the importance of mutations in mismatch repair genes has been extensively documented. Less is known about other DNA repair pathways in colorectal carcinogenesis. In this study we have focused on the<jats:italic>XRCC1<\/jats:italic>,<jats:italic>XRCC3<\/jats:italic>and<jats:italic>XPD<\/jats:italic>genes, involved in base excision repair, homologous recombinational repair and nucleotide excision repair, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We used a case-control study design (157 carcinomas, 983 adenomas and 399 controls) to test the association between five polymorphisms in these DNA repair genes (<jats:italic>XRCC1<\/jats:italic>Arg<jats:sup>194<\/jats:sup>Trp, Arg<jats:sup>280<\/jats:sup>His, Arg<jats:sup>399<\/jats:sup>Gln,<jats:italic>XRCC3<\/jats:italic>Thr<jats:sup>241<\/jats:sup>Met and<jats:italic>XPD<\/jats:italic>Lys<jats:sup>751<\/jats:sup>Gln), and risk of colorectal adenomas and carcinomas in a Norwegian cohort. Odds ratio (OR) and 95% confidence interval (95% CI) were estimated by binary logistic regression model adjusting for age, gender, cigarette smoking and alcohol consumption.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The<jats:italic>XRCC1<\/jats:italic>280His allele was associated with an increased risk of adenomas (OR 2.30, 95% CI 1.19\u20134.46). The<jats:italic>XRCC1<\/jats:italic>399Gln allele was associated with a reduction of risk of high-risk adenomas (OR 0.62, 95% CI 0.41\u20130.96). Carriers of the variant<jats:italic>XPD<\/jats:italic>751Gln allele had an increased risk of low-risk adenomas (OR 1.40, 95% CI 1.03\u20131.89), while no association was found with risk of carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggest an increased risk for advanced colorectal neoplasia in individuals with the<jats:italic>XRCC1<\/jats:italic>Arg<jats:sup>280<\/jats:sup>His polymorphism and a reduced risk associated with the<jats:italic>XRCC1<\/jats:italic>Arg<jats:sup>399<\/jats:sup>Gln polymorphism. Interestingly, individuals with the<jats:italic>XPD<\/jats:italic>Lys<jats:sup>751<\/jats:sup>Gln polymorphism had an increased risk of low-risk adenomas. This may suggest a role in regression of adenomas.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-6-67","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:46:50Z","timestamp":1144327610000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Polymorphisms of the XRCC1, XRCC3 and XPDgenes and risk of colorectal adenoma and carcinoma, in a Norwegian cohort: a case control study"],"prefix":"10.1186","volume":"6","author":[{"given":"Camilla Furu","family":"Skjelbred","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"S\u00e6b\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"Wallin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn Andersen","family":"Nex\u00f8","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per Christian","family":"Hagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger Marie Bowitz","family":"Lothe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steinar","family":"Aase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Egil","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inger-Lise","family":"Hansteen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Vogel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elin H","family":"Kure","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,3,16]]},"reference":[{"issue":"5","key":"419_CR1","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1016\/0092-8674(90)90186-I","volume":"61","author":"ER Fearon","year":"1990","unstructured":"Fearon ER, Vogelstein B: A genetic model for colorectal tumorigenesis. Cell. 1990, 61 (5): 759-767. 10.1016\/0092-8674(90)90186-I.","journal-title":"Cell"},{"issue":"2","key":"419_CR2","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/S0092-8674(00)81333-1","volume":"87","author":"KW Kinzler","year":"1996","unstructured":"Kinzler KW, Vogelstein B: Lessons from hereditary colorectal cancer. Cell. 1996, 87 (2): 159-170. 10.1016\/S0092-8674(00)81333-1.","journal-title":"Cell"},{"issue":"11","key":"419_CR3","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1093\/jnci\/91.11.916","volume":"91","author":"JD Potter","year":"1999","unstructured":"Potter JD: Colorectal cancer: molecules and populations. J Natl Cancer Inst. 1999, 91 (11): 916-932. 10.1093\/jnci\/91.11.916.","journal-title":"J Natl Cancer Inst"},{"issue":"11","key":"419_CR4","first-page":"1332","volume":"11","author":"MM De Jong","year":"2002","unstructured":"De Jong MM, Nolte IM, Te Meerman GJ, Van Der Graaf WT, De Vries EG, Sijmons RH, Hofstra RM, Kleibeuker JH: Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility. Cancer Epidemiol Biomarkers Prev. 2002, 11 (11): 1332-1352.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"419_CR5","first-page":"939","volume":"11","author":"MC Stern","year":"2002","unstructured":"Stern MC, Umbach DM, Lunn RM, Taylor JA: DNA repair gene XRCC3 codon 241 polymorphism, its interaction with smoking and XRCC1 polymorphisms, and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2002, 11 (9): 939-943.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"419_CR6","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1097\/00008571-200203000-00008","volume":"12","author":"N Ishibe","year":"2002","unstructured":"Ishibe N, Sinha R, Hein DW, Kulldorff M, Strickland P, Fretland AJ, Chow WH, Kadlubar FF, Lang NP, Rothman N: Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas. Pharmacogenetics. 2002, 12 (2): 145-150. 10.1097\/00008571-200203000-00008.","journal-title":"Pharmacogenetics"},{"issue":"1\u20132","key":"419_CR7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/S0027-5107(02)00217-8","volume":"509","author":"JG de Boer","year":"2002","unstructured":"de Boer JG: Polymorphisms in DNA repair and environmental interactions. Mutat Res. 2002, 509 (1\u20132): 201-210.","journal-title":"Mutat Res"},{"issue":"4","key":"419_CR8","first-page":"604","volume":"58","author":"MR Shen","year":"1998","unstructured":"Shen MR, Jones IM, Mohrenweiser H: Nonconservative amino acid substitution variants exist at polymorphic frequency in DNA repair genes in healthy humans. Cancer Res. 1998, 58 (4): 604-608.","journal-title":"Cancer Res"},{"issue":"12","key":"419_CR9","first-page":"1513","volume":"11","author":"EL Goode","year":"2002","unstructured":"Goode EL, Ulrich CM, Potter JD: Polymorphisms in DNA repair genes and associations with cancer risk. Cancer Epidemiol Biomarkers Prev . 2002, 11 (12): 1513-1530.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11\u201312","key":"419_CR10","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1023\/B:BIGI.0000043957.03420.7e","volume":"42","author":"U Vogel","year":"2004","unstructured":"Vogel U, Nexo BA, Wallin H, Overvad K, Tjonneland A, Raaschou-Nielsen O: No association between base excision repair gene polymorphisms and risk of lung cancer. Biochem Genet. 2004, 42 (11\u201312): 453-460. 10.1023\/B:BIGI.0000043957.03420.7e.","journal-title":"Biochem Genet"},{"issue":"5","key":"419_CR11","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1093\/carcin\/bgg043","volume":"24","author":"BA Nexo","year":"2003","unstructured":"Nexo BA, Vogel U, Olsen A, Ketelsen T, Bukowy Z, Thomsen BL, Wallin H, Overvad K, Tjonneland A: A specific haplotype of single nucleotide polymorphisms on chromosome 19q13.2\u20133 encompassing the gene RAI is indicative of post-menopausal breast cancer before age 55. Carcinogenesis. 2003, 24 (5): 899-904. 10.1093\/carcin\/bgg043.","journal-title":"Carcinogenesis"},{"issue":"1","key":"419_CR12","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/S0304-3835(00)00537-1","volume":"159","author":"SZ Abdel-Rahman","year":"2000","unstructured":"Abdel-Rahman SZ, Soliman AS, Bondy ML, Omar S, El-Badawy SA, Khaled HM, Seifeldin IA, Levin B: Inheritance of the 194Trp and the 399Gln variant alleles of the DNA repair gene XRCC1 are associated with increased risk of early-onset colorectal carcinoma in Egypt. Cancer Lett . 2000, 159 (1): 79-86. 10.1016\/S0304-3835(00)00537-1.","journal-title":"Cancer Lett"},{"key":"419_CR13","volume-title":"Int J Cancer","author":"YC Hong","year":"2005","unstructured":"Hong YC, Lee KH, Kim WC, Choi SK, Woo ZH, Shin SK, Kim H: Polymorphisms of XRCC1 gene, alcohol consumption and colorectal cancer. Int J Cancer. 2005"},{"issue":"2","key":"419_CR14","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/sj.bjc.6601061","volume":"89","author":"R Mort","year":"2003","unstructured":"Mort R, Mo L, McEwan C, Melton DW: Lack of involvement of nucleotide excision repair gene polymorphisms in colorectal cancer. Br J Cancer. 2003, 89 (2): 333-337. 10.1038\/sj.bjc.6601061.","journal-title":"Br J Cancer"},{"issue":"1","key":"419_CR15","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2407-5-12","volume":"5","author":"C-C Yeh","year":"2005","unstructured":"Yeh C-C, Sung F-C, Tang R, Chang-Chieh C, Hsieh L-L: Polymorphisms of the XRCC1, XRCC3, & XPD genes, and colorectal cancer risk: a case-control study in Taiwan. BMC Cancer. 2005, 5 (1): 12-10.1186\/1471-2407-5-12.","journal-title":"BMC Cancer"},{"issue":"2","key":"419_CR16","first-page":"119","volume":"10","author":"D Ratnasinghe","year":"2001","unstructured":"Ratnasinghe D, Yao SX, Tangrea JA, Qiao YL, Andersen MR, Barrett MJ, Giffen CA, Erozan Y, Tockman MS, Taylor PR: Polymorphisms of the DNA repair gene XRCC1 and lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2001, 10 (2): 119-123.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11 Pt 1","key":"419_CR17","first-page":"1168","volume":"12","author":"N Moullan","year":"2003","unstructured":"Moullan N, Cox DG, Angele S, Romestaing P, Gerard JP, Hall J: Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy. Cancer Epidemiol Biomarkers Prev. 2003, 12 (11 Pt 1): 1168-1174.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"419_CR18","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1038\/35036399","volume":"2","author":"CS Griffin","year":"2000","unstructured":"Griffin CS, Simpson PJ, Wilson CR, Thacker J: Mammalian recombination-repair genes XRCC2 and XRCC3 promote correct chromosome segregation. Nat Cell Biol. 2000, 2 (10): 757-761. 10.1038\/35036399.","journal-title":"Nat Cell Biol"},{"issue":"2","key":"419_CR19","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0921-8777(99)00010-5","volume":"434","author":"X Cui","year":"1999","unstructured":"Cui X, Brenneman M, Meyne J, Oshimura M, Goodwin EH, Chen DJ: The XRCC2 and XRCC3 repair genes are required for chromosome stability in mammalian cells. Mutat Res. 1999, 434 (2): 75-88.","journal-title":"Mutat Res"},{"issue":"9","key":"419_CR20","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1093\/carcin\/22.9.1437","volume":"22","author":"G Matullo","year":"2001","unstructured":"Matullo G, Palli D, Peluso M, Guarrera S, Carturan S, Celentano E, Krogh V, Munnia A, Tumino R, Polidoro S, Piazza A, Vineis P: XRCC1, XRCC3, XPD gene polymorphisms, smoking and (32)P-DNA adducts in a sample of healthy subjects. Carcinogenesis. 2001, 22 (9): 1437-1445. 10.1093\/carcin\/22.9.1437.","journal-title":"Carcinogenesis"},{"issue":"12","key":"419_CR21","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1093\/hmg\/11.12.1399","volume":"11","author":"B Kuschel","year":"2002","unstructured":"Kuschel B, Auranen A, McBride S, Novik KL, Antoniou A, Lipscombe JM, Day NE, Easton DF, Ponder BA, Pharoah PD, Dunning A: Variants in DNA double-strand break repair genes and breast cancer susceptibility. Hum Mol Genet. 2002, 11 (12): 1399-1407. 10.1093\/hmg\/11.12.1399.","journal-title":"Hum Mol Genet"},{"issue":"1","key":"419_CR22","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.canlet.2004.04.033","volume":"213","author":"NR Jacobsen","year":"2004","unstructured":"Jacobsen NR, Raaschou-Nielsen O, Nexo B, Wallin H, Overvad K, Tjonneland A, Vogel U: XRCC3 polymorphisms and risk of lung cancer. Cancer Lett. 2004, 213 (1): 67-72. 10.1016\/j.canlet.2004.04.033.","journal-title":"Cancer Lett"},{"issue":"20","key":"419_CR23","first-page":"5612","volume":"60","author":"SL Winsey","year":"2000","unstructured":"Winsey SL, Haldar NA, Marsh HP, Bunce M, Marshall SE, Harris AL, Wojnarowska F, Welsh KI: A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer. Cancer Res. 2000, 60 (20): 5612-5616.","journal-title":"Cancer Res"},{"issue":"6","key":"419_CR24","first-page":"584","volume":"12","author":"NR Jacobsen","year":"2003","unstructured":"Jacobsen NR, Nexo BA, Olsen A, Overvad K, Wallin H, Tjonneland A, Vogel U: No association between the DNA repair gene XRCC3 T241M polymorphism and risk of skin cancer and breast cancer. Cancer Epidemiol Biomarkers Prev. 2003, 12 (6): 584-585.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"2","key":"419_CR25","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/S0959-437X(97)80124-4","volume":"7","author":"T Lindahl","year":"1997","unstructured":"Lindahl T, Karran P, Wood RD: DNA excision repair pathways. Curr Opin Genet Dev. 1997, 7 (2): 158-169. 10.1016\/S0959-437X(97)80124-4.","journal-title":"Curr Opin Genet Dev"},{"issue":"1\u20132","key":"419_CR26","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0027-5107(99)00020-2","volume":"424","author":"E Braithwaite","year":"1999","unstructured":"Braithwaite E, Wu X, Wang Z: Repair of DNA lesions: mechanisms and relative repair efficiencies. Mutat Res. 1999, 424 (1\u20132): 207-219.","journal-title":"Mutat Res"},{"issue":"1","key":"419_CR27","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1073\/pnas.89.1.261","volume":"89","author":"WL Flejter","year":"1992","unstructured":"Flejter WL, McDaniel LD, Johns D, Friedberg EC, Schultz RA: Correction of xeroderma pigmentosum complementation group D mutant cell phenotypes by chromosome and gene transfer: involvement of the human ERCC2 DNA repair gene. Proc Natl Acad Sci U S A. 1992, 89 (1): 261-265.","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"7","key":"419_CR28","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1101\/gad.13.7.768","volume":"13","author":"WL de Laat","year":"1999","unstructured":"de Laat WL, Jaspers NG, Hoeijmakers JH: Molecular mechanism of nucleotide excision repair. Genes Dev. 1999, 13 (7): 768-785.","journal-title":"Genes Dev"},{"issue":"6449","key":"419_CR29","doi-asserted-by":"publisher","first-page":"852","DOI":"10.1038\/365852a0","volume":"365","author":"P Sung","year":"1993","unstructured":"Sung P, Bailly V, Weber C, Thompson LH, Prakash L, Prakash S: Human xeroderma pigmentosum group D gene encodes a DNA helicase. Nature. 1993, 365 (6449): 852-855. 10.1038\/365852a0.","journal-title":"Nature"},{"issue":"5","key":"419_CR30","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1093\/emboj\/18.5.1357","volume":"18","author":"F Coin","year":"1999","unstructured":"Coin F, Bergmann E, Tremeau-Bravard A, Egly JM: Mutations in XPB and XPD helicases found in xeroderma pigmentosum patients impair the transcription function of TFIIH. Embo J. 1999, 18 (5): 1357-1366. 10.1093\/emboj\/18.5.1357.","journal-title":"Embo J"},{"issue":"6","key":"419_CR31","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1093\/mutage\/17.6.463","volume":"17","author":"S Benhamou","year":"2002","unstructured":"Benhamou S, Sarasin A: ERCC2\/XPD gene polymorphisms and cancer risk. Mutagenesis. 2002, 17 (6): 463-469. 10.1093\/mutage\/17.6.463.","journal-title":"Mutagenesis"},{"issue":"1","key":"419_CR32","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/aje\/kwi018","volume":"161","author":"S Benhamou","year":"2005","unstructured":"Benhamou S, Sarasin A: ERCC2 \/XPD gene polymorphisms and lung cancer: a HuGE review. Am J Epidemiol. 2005, 161 (1): 1-14. 10.1093\/aje\/kwi018.","journal-title":"Am J Epidemiol"},{"issue":"6","key":"419_CR33","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1080\/00365520310003002","volume":"38","author":"G Gondal","year":"2003","unstructured":"Gondal G, Grotmol T, Hofstad B, Bretthauer M, Eide TJ, Hoff G: The Norwegian Colorectal Cancer Prevention (NORCCAP) screening study: baseline findings and implementations for clinical work-up in age groups 50\u201364 years. Scand J Gastroenterol. 2003, 38 (6): 635-642. 10.1080\/00365520310003002.","journal-title":"Scand J Gastroenterol"},{"key":"419_CR34","unstructured":"ClinicalTrials.gov. [http:\/\/www.clinicaltrials.gov]"},{"issue":"3","key":"419_CR35","doi-asserted-by":"publisher","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","volume":"16","author":"SA Miller","year":"1988","unstructured":"Miller SA, Dykes DD, Polesky HF: A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res . 1988, 16 (3): 1215-","journal-title":"Nucleic Acids Res"},{"issue":"1\u20132","key":"419_CR36","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1016\/j.mrfmmm.2003.11.001","volume":"546","author":"U Vogel","year":"2004","unstructured":"Vogel U, Laros I, Jacobsen NR, Thomsen BL, Bak H, Olsen A, Bukowy Z, Wallin H, Overvad K, Tjonneland A, Nexo BA, Raaschou-Nielsen O: Two regions in chromosome 19q13.2\u20133 are associated with risk of lung cancer. Mutat Res. 2004, 546 (1\u20132): 65-74.","journal-title":"Mutat Res"},{"key":"419_CR37","unstructured":"Hplus. [http:\/\/qge.fhcrc.org\/hplus]"},{"issue":"5","key":"419_CR38","doi-asserted-by":"publisher","first-page":"1231","DOI":"10.1086\/375140","volume":"72","author":"LP Zhao","year":"2003","unstructured":"Zhao LP, Li SS, Khalid N: A method for the assessment of disease associations with single-nucleotide polymorphism haplotypes and environmental variables in case-control studies. Am J Hum Genet . 2003, 72 (5): 1231-1250. 10.1086\/375140.","journal-title":"Am J Hum Genet"},{"issue":"7","key":"419_CR39","doi-asserted-by":"publisher","first-page":"853","DOI":"10.3109\/00365528609011130","volume":"21","author":"G Hoff","year":"1986","unstructured":"Hoff G, Foerster A, Vatn MH, Sauar J, Larsen S: Epidemiology of polyps in the rectum and colon. Recovery and evaluation of unresected polyps 2 years after detection. Scand J Gastroenterol. 1986, 21 (7): 853-862.","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"419_CR40","doi-asserted-by":"publisher","first-page":"449","DOI":"10.1136\/gut.39.3.449","volume":"39","author":"B Hofstad","year":"1996","unstructured":"Hofstad B, Vatn MH, Andersen SN, Huitfeldt HS, Rognum T, Larsen S, Osnes M: Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years. Gut. 1996, 39 (3): 449-456.","journal-title":"Gut"},{"issue":"4","key":"419_CR41","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1002\/ijc.20277","volume":"111","author":"F Loeve","year":"2004","unstructured":"Loeve F, Boer R, Zauber AG, Van Ballegooijen M, Van Oortmarssen GJ, Winawer SJ, Habbema JD: National Polyp Study data: evidence for regression of adenomas. Int J Cancer. 2004, 111 (4): 633-639. 10.1002\/ijc.20277.","journal-title":"Int J Cancer"},{"key":"419_CR42","volume-title":"Cancer Lett","author":"R Hansen","year":"2005","unstructured":"Hansen R, Saebo M, Skjelbred CF, Nexo BA, Hagen PC, Bock G, Bowitz Lothe IM, Johnson E, Aase S, Hansteen IL, Vogel U, Kure EH: GPX Pro198Leu and OGG1 Ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer. Cancer Lett. 2005"},{"issue":"11","key":"419_CR43","first-page":"2557","volume":"59","author":"RM Lunn","year":"1999","unstructured":"Lunn RM, Langlois RG, Hsieh LL, Thompson CL, Bell DA: XRCC1 polymorphisms: effects on aflatoxin B1-DNA adducts and glycophorin A variant frequency. Cancer Res. 1999, 59 (11): 2557-2561.","journal-title":"Cancer Res"},{"issue":"1\u20132","key":"419_CR44","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.mrgentox.2005.01.007","volume":"582","author":"T Takanami","year":"2005","unstructured":"Takanami T, Nakamura J, Kubota Y, Horiuchi S: The Arg280His polymorphism in X-ray repair cross-complementing gene 1 impairs DNA repair ability. Mutat Res. 2005, 582 (1\u20132): 135-145.","journal-title":"Mutat Res"},{"issue":"6","key":"419_CR45","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1158\/1055-9965.1090.13.6","volume":"13","author":"GJ Tranah","year":"2004","unstructured":"Tranah GJ, Giovannucci E, Ma J, Fuchs C, Hankinson SE, Hunter DJ: XRCC2 and XRCC3 polymorphisms are not associated with risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2004, 13 (6): 1090-1091.","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"11","key":"419_CR46","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/jnci\/85.11.875","volume":"85","author":"E Giovannucci","year":"1993","unstructured":"Giovannucci E, Stampfer MJ, Colditz GA, Rimm EB, Trichopoulos D, Rosner BA, Speizer FE, Willett WC: Folate, methionine, and alcohol intake and risk of colorectal adenoma. J Natl Cancer Inst. 1993, 85 (11): 875-884.","journal-title":"J Natl Cancer Inst"},{"issue":"1","key":"419_CR47","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cancergencyto.2005.05.001","volume":"163","author":"MJ Jin","year":"2005","unstructured":"Jin MJ, Chen K, Song L, Fan CH, Chen Q, Zhu YM, Ma XY, Yao KY: The association of the DNA repair gene XRCC3 Thr241Met polymorphism with susceptibility to colorectal cancer in a Chinese population. Cancer Genet Cytogenet. 2005, 163 (1): 38-43. 10.1016\/j.cancergencyto.2005.05.001.","journal-title":"Cancer Genet Cytogenet"},{"issue":"3","key":"419_CR48","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1056\/NEJM200007203430301","volume":"343","author":"DA Lieberman","year":"2000","unstructured":"Lieberman DA, Weiss DG, Bond JH, Ahnen DJ, Garewal H, Chejfec G: Use of colonoscopy to screen asymptomatic adults for colorectal cancer. Veterans Affairs Cooperative Study Group 380. N Engl J Med . 2000, 343 (3): 162-168. 10.1056\/NEJM200007203430301.","journal-title":"N Engl J Med"},{"issue":"3","key":"419_CR49","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1056\/NEJM200007203430302","volume":"343","author":"TF Imperiale","year":"2000","unstructured":"Imperiale TF, Wagner DR, Lin CY, Larkin GN, Rogge JD, Ransohoff DF: Risk of advanced proximal neoplasms in asymptomatic adults according to the distal colorectal findings. N Engl J Med. 2000, 343 (3): 169-174. 10.1056\/NEJM200007203430302.","journal-title":"N Engl J Med"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-6-67\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-67","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-67.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T23:13:24Z","timestamp":1683414804000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-6-67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,16]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["419"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-6-67","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,16]]},"assertion":[{"value":"23 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"67"}}