{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:20:55Z","timestamp":1778498455753,"version":"3.51.4"},"reference-count":7,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,16]],"date-time":"2006-03-16T00:00:00Z","timestamp":1142467200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15;19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy. The t(15;19) results in the fusion oncogene <jats:italic>BRD4-NUT<\/jats:italic>. Information concerning treatment of this rare disorder is scarce.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 30-year-old woman was admitted with a rapidly progressing tumor in the mediastinum, cervical lymph nodes, vertebral column and the epidural space. Pathological, cytogenetic, FISH and PCR analysis revealed a glycogenated carcinoma rarely expressing cytokeratins and showing t(15;19) and <jats:italic>BRD4-NUT<\/jats:italic> gene rearrangement. The patient was initially treated with a Ewing sarcoma chemotherapy regimen, but had rapid progression after two cycles. She then received docetaxel and radiotherapy, which resulted in almost complete disappearance of the tumor.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Docetaxel may be considered for initial chemotherapy in young patients presenting with a midline carcinoma with bone marrow involvement and cytogenetic and molecular genetic finding of a t(15;19)\/<jats:italic>BRD4-NUT-<\/jats:italic>rearrangement. We herein describe, in detail, the laboratory methods by which the <jats:italic>BRD4-NUT<\/jats:italic> -rearrangement can be detected.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-6-69","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:47:27Z","timestamp":1144327647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Midline carcinoma with t(15;19) and BRD4-NUTfusion oncogene in a 30-year-old female with response to docetaxel and radiotherapy"],"prefix":"10.1186","volume":"6","author":[{"given":"Jens","family":"Engleson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Soller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Panagopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Dahl\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Dictor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,3,16]]},"reference":[{"issue":"12","key":"421_CR1","first-page":"3327","volume":"51","author":"I Kubonishi","year":"1991","unstructured":"Kubonishi I, Takehara N, Iwata J, Sonobe H, Ohtsuki Y, Abe T, Miyoshi I: Novel t(15;19)(q15;p13) chromosome abnormality in a thymic carcinoma. Cancer Res. 1991, 51 (12): 3327-3328.","journal-title":"Cancer Res"},{"issue":"7","key":"421_CR2","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1002\/1097-0142(19931001)72:7<2273::AID-CNCR2820720735>3.0.CO;2-U","volume":"72","author":"AC Lee","year":"1993","unstructured":"Lee AC, Kwong YI, Fu KH, Chan GC, Ma L, Lau YL: Disseminated mediastinal carcinoma with chromosomal translocation (15;19). A distinctive clinicopathologic syndrome. Cancer. 1993, 72 (7): 2273-2276.","journal-title":"Cancer"},{"issue":"2","key":"421_CR3","first-page":"304","volume":"63","author":"CA French","year":"2003","unstructured":"French CA, Miyoshi I, Kubonishi I, Grier HE, Perez-Atayde AR, Fletcher JA: BRD4-NUT fusion oncogene: a novel mechanism in aggressive carcinoma. Cancer Res. 2003, 63 (2): 304-307.","journal-title":"Cancer Res"},{"issue":"20","key":"421_CR4","doi-asserted-by":"publisher","first-page":"4135","DOI":"10.1200\/JCO.2004.02.107","volume":"22","author":"CA French","year":"2004","unstructured":"French CA, Kutok JL, Faquin WC, Toretsky JA, Antonescu CR, Griffin CA, Nose V, Vargas SO, Moschovi M, Tzortzatou-Stathopoulou F, Miyoshi I, Perez-Atayde AR, Aster JC, Fletcher JA: Midline carcinoma of children and young adults with NUT rearrangement. J Clin Oncol. 2004, 22 (20): 4135-4139. 10.1200\/JCO.2004.02.107.","journal-title":"J Clin Oncol"},{"key":"421_CR5","unstructured":"Browser UCSCHG: ."},{"key":"421_CR6","unstructured":"."},{"issue":"5","key":"421_CR7","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1002\/ijc.10864","volume":"103","author":"A Dahlen","year":"2003","unstructured":"Dahlen A, Debiec-Rychter M, Pedeutour F, Domanski HA, Hoglund M, Bauer HC, Rydholm A, Sciot R, Mandahl N, Mertens F: Clustering of deletions on chromosome 13 in benign and low-malignant lipomatous tumors. Int J Cancer. 2003, 103 (5): 616-623. 10.1002\/ijc.10864.","journal-title":"Int J Cancer"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-69.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-6-69\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-69","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-6-69.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T22:17:08Z","timestamp":1630448228000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-6-69"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3,16]]},"references-count":7,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["421"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-6-69","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3,16]]},"assertion":[{"value":"7 November 2005","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2006","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 March 2006","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"69"}}