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Because mutations in<jats:italic>XPC<\/jats:italic>cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in<jats:italic>XPC<\/jats:italic>may alter DNA repair and thus susceptibility to cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this hospital-based case-control study, we investigated five<jats:italic>XPC<\/jats:italic>tagging, common single nucleotide polymorphisms (tagging SNPs) in 1,010 patients with newly diagnosed lung cancer and 1,011 matched cancer free controls in a Chinese population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In individual tagging SNP analysis, we found that rs3731055<jats:italic>AG+AA<\/jats:italic>variant genotypes were associated with a significantly decreased risk of lung adenocarcinoma [adjusted odds ratio (OR), 0.71; 95% confidence interval (CI), 0.56\u20130.90] but an increased risk of small cell carcinomas [adjusted OR, 1.79; 95% CI, 1.05\u20133.07]. Furthermore, we found that haplotype<jats:italic>ACCCA<\/jats:italic>was associated with a decreased risk of lung adenocarcinoma [OR, 0.78; 95% CI, 0.62\u20130.97] but an increased risk of small cell carcinomas [OR, 1.68; 95% CI, 1.04\u20132.71], which reflected the presence of rs3731055<jats:italic>A<\/jats:italic>allele in this haplotype. Further stratified analysis revealed that the protective effect of rs3731055<jats:italic>AG+AA<\/jats:italic>on risk of lung adenocarcinoma was more evident among young subjects (age \u2264 60) and never smokers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that inherited sequence variations in<jats:italic>XPC<\/jats:italic>may modulate risk of lung cancer, especially lung adenocarcinoma, in Chinese populations. However, these findings need to be verified in larger confirmatory studies with more comprehensively selected tagging SNPs.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2407-7-81","type":"journal-article","created":{"date-parts":[[2007,5,15]],"date-time":"2007-05-15T06:13:26Z","timestamp":1179209606000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Sequence variations in DNA repair gene XPCis associated with lung cancer risk in a Chinese population: a case-control study"],"prefix":"10.1186","volume":"7","author":[{"given":"Yun","family":"Bai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentao","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxia","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongliang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangfu","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbing","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daru","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tangchun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2007,5,13]]},"reference":[{"key":"731_CR1","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1093\/jnci\/dji289","volume":"97","author":"BK Edwards","year":"2005","unstructured":"Edwards BK, Brown ML, Wingo PA, Howe HL, Ward E, Ries LA, Schrag D, Jamison PM, Jemal A, Wu XC, Friedman C, Harlan L, et al: Annual report to the nation on the status of cancer, 1975\u20132002 featuring population-based trends in cancer treatment. 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