{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T08:32:10Z","timestamp":1790929930639,"version":"4.1.0"},"reference-count":49,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T00:00:00Z","timestamp":1205971200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Cancer"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Recent studies suggest an association between chronic inflammation, modulating the tissue microenvironment, and tumor biology. Tumor environment consists of tumor, stromal and endothelial cells and infiltrating macrophages, T lymphocytes, and dendritic cells, producing an array of cytokines, chemokines and growth factors, accounting for a complex cell interaction and regulation of differentiation, activation, function and survival of tumor and surrounding cells, responsible for tumor progression and spreading or induction of antitumor immune responses and rejection. Tumor Necrosis Factor (TNF) family members (19 ligands and 29 receptors) represent a pleiotropic family of agents, related to a plethora of cellular events from proliferation and differentiation to apoptosis and tumor reduction. Among these members, BAFF and APRIL (CD257 and CD256 respectively) gained an increased interest, in view of their role in cell protection, differentiation and growth, in a number of lymphocyte, epithelial and mesenchymal structures.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We have assayed by immunohistochemistry 52 human breast cancer biopsies for the expression of BAFF and APRIL and correlated our findings with clinicopathological data and the evolution of the disease.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>BAFF was ubiquitely expressed in breast carcinoma cells, DCIS, normal-appearing glands and ducts and peritumoral adipocytes. In contrast, APRIL immunoreactive expression was higher in non-malignant as compared to malignant breast structures. APRIL but not BAFF immunoreactivity was higher in N+ tumors, and was inversely related with the grade of the tumors. Neither parameter was related to DFS or the OS of patients.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our data show, for the first time, an autocrine secretion of BAFF and APRIL from breast cancer cells, offering new perspectives for their role in neoplastic and normal breast cell biology and offering new perspectives for possible selective intervention in breast cancer.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2407-8-76","type":"journal-article","created":{"date-parts":[[2008,3,20]],"date-time":"2008-03-20T19:13:56Z","timestamp":1206040436000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["Expression of TNF-superfamily members BAFF and APRIL in breast cancer: Immunohistochemical study in 52 invasive ductal breast carcinomas"],"prefix":"10.1186","volume":"8","author":[{"given":"Vassiliki","family":"Pelekanou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilena","family":"Kampa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kafousi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Darivianaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Sanidas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios D","family":"Tsiftsis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios N","family":"Stathopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Tsapis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Castanas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,3,20]]},"reference":[{"key":"1014_CR1","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/S0092-8674(00)81683-9","volume":"100","author":"D Hanahan","year":"2000","unstructured":"Hanahan D, Weinberg RA: The hallmarks of cancer. Cell. 2000, 100: 57-70. 10.1016\/S0092-8674(00)81683-9.","journal-title":"Cell"},{"key":"1014_CR2","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1038\/nature01322","volume":"420","author":"LM Coussens","year":"2002","unstructured":"Coussens LM, Werb Z: Inflammation and cancer. Nature. 2002, 420: 860-867. 10.1038\/nature01322.","journal-title":"Nature"},{"key":"1014_CR3","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/j.ccr.2005.02.013","volume":"7","author":"F Balkwill","year":"2005","unstructured":"Balkwill F, Charles KA, Mantovani A: Smoldering and polarized inflammation in the initiation and promotion of malignant disease. Cancer Cell. 2005, 7: 211-217. 10.1016\/j.ccr.2005.02.013.","journal-title":"Cancer Cell"},{"key":"1014_CR4","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1038\/nri1703","volume":"5","author":"M Karin","year":"2005","unstructured":"Karin M, Greten FR: NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005, 5: 749-759. 10.1038\/nri1703.","journal-title":"Nat Rev Immunol"},{"key":"1014_CR5","doi-asserted-by":"publisher","first-page":"1175","DOI":"10.1172\/JCI31537","volume":"117","author":"WW Lin","year":"2007","unstructured":"Lin WW, Karin M: A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest. 2007, 117: 1175-1183. 10.1172\/JCI31537.","journal-title":"J Clin Invest"},{"key":"1014_CR6","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.semcancer.2005.07.006","volume":"16","author":"A Ben-Baruch","year":"2006","unstructured":"Ben-Baruch A: Inflammation-associated immune suppression in cancer: the roles played by cytokines, chemokines and additional mediators. Semin Cancer Biol. 2006, 16: 38-52. 10.1016\/j.semcancer.2005.07.006.","journal-title":"Semin Cancer Biol"},{"key":"1014_CR7","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1111\/j.0105-2896.2004.00199.x","volume":"202","author":"MJ Smyth","year":"2004","unstructured":"Smyth MJ, Cretney E, Kershaw MH, Hayakawa Y: Cytokines in cancer immunity and immunotherapy. Immunol Rev. 2004, 202: 275-293. 10.1111\/j.0105-2896.2004.00199.x.","journal-title":"Immunol Rev"},{"key":"1014_CR8","doi-asserted-by":"publisher","first-page":"5527","DOI":"10.1158\/0008-5472.CAN-05-4128","volume":"66","author":"R Kim","year":"2006","unstructured":"Kim R, Emi M, Tanabe K, Arihiro K: Tumor-driven evolution of immunosuppressive networks during malignant progression. Cancer Res. 2006, 66: 5527-5536. 10.1158\/0008-5472.CAN-05-4128.","journal-title":"Cancer Res"},{"key":"1014_CR9","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/S1567-5769(03)00060-2","volume":"3","author":"JW Hadden","year":"2003","unstructured":"Hadden JW: Immunodeficiency and cancer: prospects for correction. Int Immunopharmacol. 2003, 3: 1061-1071. 10.1016\/S1567-5769(03)00060-2.","journal-title":"Int Immunopharmacol"},{"key":"1014_CR10","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1038\/nature02924","volume":"431","author":"E Pikarsky","year":"2004","unstructured":"Pikarsky E, Porat RM, Stein I, Abramovitch R, Amit S, Kasem S, Gutkovich-Pyest E, Urieli-Shoval S, Galun E, Ben-Neriah Y: NF-kappaB functions as a tumour promoter in inflammation-associated cancer. Nature. 2004, 431: 461-466. 10.1038\/nature02924.","journal-title":"Nature"},{"key":"1014_CR11","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1038\/nm0105-20","volume":"11","author":"M Karin","year":"2005","unstructured":"Karin M: Inflammation and cancer: the long reach of Ras. Nat Med. 2005, 11: 20-21. 10.1038\/nm0105-20.","journal-title":"Nat Med"},{"key":"1014_CR12","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/S0968-0004(01)01995-8","volume":"27","author":"JL Bodmer","year":"2002","unstructured":"Bodmer JL, Schneider P, Tschopp J: The molecular architecture of the TNF superfamily. Trends Biochem Sci. 2002, 27: 19-26. 10.1016\/S0968-0004(01)01995-8.","journal-title":"Trends Biochem Sci"},{"key":"1014_CR13","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1084\/jem.188.6.1185","volume":"188","author":"M Hahne","year":"1998","unstructured":"Hahne M, Kataoka T, Schroter M, Hofmann K, Irmler M, Bodmer JL, Schneider P, Bornand T, Holler N, French LE, et al: APRIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth. J Exp Med. 1998, 188: 1185-1190. 10.1084\/jem.188.6.1185.","journal-title":"J Exp Med"},{"key":"1014_CR14","first-page":"1021","volume":"60","author":"K Kelly","year":"2000","unstructured":"Kelly K, Manos E, Jensen G, Nadauld L, Jones DA: APRIL\/TRDL-1, a tumor necrosis factor-like ligand, stimulates cell death. Cancer Res. 2000, 60: 1021-1027.","journal-title":"Cancer Res"},{"key":"1014_CR15","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1002\/jlb.65.5.680","volume":"65","author":"HB Shu","year":"1999","unstructured":"Shu HB, Hu WH, Johnson H: TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol. 1999, 65: 680-683.","journal-title":"J Leukoc Biol"},{"key":"1014_CR16","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1038\/35010115","volume":"404","author":"JA Gross","year":"2000","unstructured":"Gross JA, Johnston J, Mudri S, Enselman R, Dillon SR, Madden K, Xu W, Parrish-Novak J, Foster D, Lofton-Day C, et al: TACI and BCMA are receptors for a TNF homologue implicated in B-cell autoimmune disease. Nature. 2000, 404: 995-999. 10.1038\/35010115.","journal-title":"Nature"},{"key":"1014_CR17","doi-asserted-by":"publisher","first-page":"1747","DOI":"10.1084\/jem.189.11.1747","volume":"189","author":"P Schneider","year":"1999","unstructured":"Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, et al: BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999, 189: 1747-1756. 10.1084\/jem.189.11.1747.","journal-title":"J Exp Med"},{"key":"1014_CR18","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1126\/science.285.5425.260","volume":"285","author":"PA Moore","year":"1999","unstructured":"Moore PA, Belvedere O, Orr A, Pieri K, LaFleur DW, Feng P, Soppet D, Charters M, Gentz R, Parmelee D, et al: BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science. 1999, 285: 260-263. 10.1126\/science.285.5425.260.","journal-title":"Science"},{"key":"1014_CR19","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1093\/intimm\/7.7.1093","volume":"7","author":"MP Gras","year":"1995","unstructured":"Gras MP, Laabi Y, Linares-Cruz G, Blondel MO, Rigaut JP, Brouet JC, Leca G, Haguenauer-Tsapis R, Tsapis A: BCMAp: an integral membrane protein in the Golgi apparatus of human mature B lymphocytes. Int Immunol. 1995, 7: 1093-1106. 10.1093\/intimm\/7.7.1093.","journal-title":"Int Immunol"},{"key":"1014_CR20","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrd1982","volume":"5","author":"SR Dillon","year":"2006","unstructured":"Dillon SR, Gross JA, Ansell SM, Novak AJ: An APRIL to remember: novel TNF ligands as therapeutic targets. Nat Rev Drug Discov. 2006, 5: 235-246. 10.1038\/nrd1982.","journal-title":"Nat Rev Drug Discov"},{"key":"1014_CR21","doi-asserted-by":"publisher","first-page":"1322","DOI":"10.4049\/jimmunol.165.3.1322","volume":"165","author":"A Hatzoglou","year":"2000","unstructured":"Hatzoglou A, Roussel J, Bourgeade MF, Rogier E, Madry C, Inoue J, Devergne O, Tsapis A: TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. J Immunol. 2000, 165: 1322-1330.","journal-title":"J Immunol"},{"key":"1014_CR22","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S1359-6101(03)00023-6","volume":"14","author":"F Mackay","year":"2003","unstructured":"Mackay F, Ambrose C: The TNF family members BAFF and APRIL: the growing complexity. Cytokine Growth Factor Rev. 2003, 14: 311-324. 10.1016\/S1359-6101(03)00023-6.","journal-title":"Cytokine Growth Factor Rev"},{"key":"1014_CR23","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/j.molimm.2004.06.041","volume":"42","author":"LG Ng","year":"2005","unstructured":"Ng LG, Mackay CR, Mackay F: The BAFF\/APRIL system: life beyond B lymphocytes. Mol Immunol. 2005, 42: 763-772. 10.1016\/j.molimm.2004.06.041.","journal-title":"Mol Immunol"},{"key":"1014_CR24","doi-asserted-by":"publisher","first-page":"7164","DOI":"10.4049\/jimmunol.177.10.7164","volume":"177","author":"A Kato","year":"2006","unstructured":"Kato A, Truong-Tran AQ, Scott AL, Matsumoto K, Schleimer RP: Airway epithelial cells produce B cell-activating factor of TNF family by an IFN-beta-dependent mechanism. J Immunol. 2006, 177: 7164-7172.","journal-title":"J Immunol"},{"key":"1014_CR25","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1016\/j.dci.2007.03.006","volume":"31","author":"ZB Guan","year":"2007","unstructured":"Guan ZB, Dan WB, Shui Y, Ye JL, Zhang SQ: cDNA cloning, expression and bioactivity of porcine BAFF. Dev Comp Immunol. 2007, 31: 1211-1219. 10.1016\/j.dci.2007.03.006.","journal-title":"Dev Comp Immunol"},{"key":"1014_CR26","doi-asserted-by":"publisher","first-page":"3005","DOI":"10.1038\/sj.onc.1207350","volume":"23","author":"F Deshayes","year":"2004","unstructured":"Deshayes F, Lapree G, Portier A, Richard Y, Pencalet P, Mahieu-Caputo D, Horellou P, Tsapis A: Abnormal production of the TNF-homologue APRIL increases the proliferation of human malignant glioblastoma cell lines via a specific receptor. Oncogene. 2004, 23: 3005-3012. 10.1038\/sj.onc.1207350.","journal-title":"Oncogene"},{"key":"1014_CR27","doi-asserted-by":"publisher","first-page":"F35","DOI":"10.1084\/jem.192.11.F35","volume":"192","author":"CF Ware","year":"2000","unstructured":"Ware CF: APRIL and BAFF connect autoimmunity and cancer. J Exp Med. 2000, 192: F35-38. 10.1084\/jem.192.11.F35.","journal-title":"J Exp Med"},{"key":"1014_CR28","unstructured":"Part VII, Breast. Cancer Staging Manual. Edited by Cancer AJCo. 2002, New York : Springer, 221-240."},{"key":"1014_CR29","first-page":"716","volume":"109","author":"KS McCarty Jr","year":"1985","unstructured":"McCarty KS, Miller LS, Cox EB, Konrath J, McCarty KS: Estrogen receptor analyses. Correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med. 1985, 109: 716-721.","journal-title":"Arch Pathol Lab Med"},{"key":"1014_CR30","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1093\/embo-reports\/kve198","volume":"2","author":"M Lopez-Fraga","year":"2001","unstructured":"Lopez-Fraga M, Fernandez R, Albar JP, Hahne M: Biologically active APRIL is secreted following intracellular processing in the Golgi apparatus by furin convertase. EMBO Rep. 2001, 2: 945-951. 10.1093\/embo-reports\/kve198.","journal-title":"EMBO Rep"},{"key":"1014_CR31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1016\/S0962-8924(98)01382-8","volume":"9","author":"SS Molloy","year":"1999","unstructured":"Molloy SS, Anderson ED, Jean F, Thomas G: Bi-cycling the furin pathway: from TGN localization to pathogen activation and embryogenesis. Trends Cell Biol. 1999, 9: 28-35. 10.1016\/S0962-8924(98)01382-8.","journal-title":"Trends Cell Biol"},{"key":"1014_CR32","doi-asserted-by":"publisher","first-page":"32401","DOI":"10.1074\/jbc.272.51.32401","volume":"272","author":"Y Chicheportiche","year":"1997","unstructured":"Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL: TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem. 1997, 272: 32401-32410. 10.1074\/jbc.272.51.32401.","journal-title":"J Biol Chem"},{"key":"1014_CR33","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1182\/blood.V97.1.198","volume":"97","author":"B Nardelli","year":"2001","unstructured":"Nardelli B, Belvedere O, Roschke V, Moore PA, Olsen HS, Migone TS, Sosnovtseva S, Carrell JA, Feng P, Giri JG, Hilbert DM: Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood. 2001, 97: 198-204. 10.1182\/blood.V97.1.198.","journal-title":"Blood"},{"key":"1014_CR34","doi-asserted-by":"publisher","first-page":"1373","DOI":"10.1084\/jem.192.9.1373","volume":"192","author":"M Nakayama","year":"2000","unstructured":"Nakayama M, Kayagaki N, Yamaguchi N, Okumura K, Yagita H: Involvement of TWEAK in interferon gamma-stimulated monocyte cytotoxicity. J Exp Med. 2000, 192: 1373-1380. 10.1084\/jem.192.9.1373.","journal-title":"J Exp Med"},{"key":"1014_CR35","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/j.smim.2006.04.006","volume":"18","author":"C Bossen","year":"2006","unstructured":"Bossen C, Schneider P: BAFF, APRIL and their receptors: structure, function and signaling. Semin Immunol. 2006, 18: 263-275. 10.1016\/j.smim.2006.04.006.","journal-title":"Semin Immunol"},{"key":"1014_CR36","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/S1359-6101(03)00021-2","volume":"14","author":"PW Dempsey","year":"2003","unstructured":"Dempsey PW, Doyle SE, He JQ, Cheng G: The signaling adaptors and pathways activated by TNF superfamily. Cytokine Growth Factor Rev. 2003, 14: 193-209. 10.1016\/S1359-6101(03)00021-2.","journal-title":"Cytokine Growth Factor Rev"},{"key":"1014_CR37","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1038\/sj.cdd.4401647","volume":"12","author":"J Hendriks","year":"2005","unstructured":"Hendriks J, Planelles L, de Jong-Odding J, Hardenberg G, Pals ST, Hahne M, Spaargaren M, Medema JP: Heparan sulfate proteoglycan binding promotes APRIL-induced tumor cell proliferation. Cell Death Differ. 2005, 12: 637-648. 10.1038\/sj.cdd.4401647.","journal-title":"Cell Death Differ"},{"key":"1014_CR38","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1172\/JCI200113530","volume":"108","author":"JD Esko","year":"2001","unstructured":"Esko JD, Lindahl U: Molecular diversity of heparan sulfate. J Clin Invest. 2001, 108: 169-173.","journal-title":"J Clin Invest"},{"key":"1014_CR39","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1172\/JCI13713","volume":"108","author":"JT Gallagher","year":"2001","unstructured":"Gallagher JT: Heparan sulfate: growth control with a restricted sequence menu. J Clin Invest. 2001, 108: 357-361.","journal-title":"J Clin Invest"},{"key":"1014_CR40","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1038\/35008000","volume":"404","author":"N Perrimon","year":"2000","unstructured":"Perrimon N, Bernfield M: Specificities of heparan sulphate proteoglycans in developmental processes. Nature. 2000, 404: 725-728. 10.1038\/35008000.","journal-title":"Nature"},{"key":"1014_CR41","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1084\/jem.20042309","volume":"201","author":"K Ingold","year":"2005","unstructured":"Ingold K, Zumsteg A, Tardivel A, Huard B, Steiner QG, Cachero TG, Qiang F, Gorelik L, Kalled SL, Acha-Orbea H, et al: Identification of proteoglycans as the APRIL-specific binding partners. J Exp Med. 2005, 201: 1375-1383. 10.1084\/jem.20042309.","journal-title":"J Exp Med"},{"key":"1014_CR42","doi-asserted-by":"crossref","first-page":"2961","DOI":"10.1182\/blood-2006-08-041772","volume":"109","author":"D Sakurai","year":"2007","unstructured":"Sakurai D, Hase H, Kanno Y, Kojima H, Okumura K, Kobata T: TACI regulates IgA production by APRIL in collaboration with HSPG. Blood. 2007, 109: 2961-2967.","journal-title":"Blood"},{"key":"1014_CR43","doi-asserted-by":"publisher","first-page":"3235","DOI":"10.1182\/blood-2005-01-0256","volume":"107","author":"D Bischof","year":"2006","unstructured":"Bischof D, Elsawa SF, Mantchev G, Yoon J, Michels GE, Nilson A, Sutor SL, Platt JL, Ansell SM, von Bulow G, Bram RJ: Selective activation of TACI by syndecan-2. Blood. 2006, 107: 3235-3242. 10.1182\/blood-2005-01-0256.","journal-title":"Blood"},{"key":"1014_CR44","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1189\/jlb.1105655","volume":"80","author":"P Mhawech-Fauceglia","year":"2006","unstructured":"Mhawech-Fauceglia P, Kaya G, Sauter G, McKee T, Donze O, Schwaller J, Huard B: The source of APRIL up-regulation in human solid tumor lesions. J Leukoc Biol. 2006, 80: 697-704. 10.1189\/jlb.1105655.","journal-title":"J Leukoc Biol"},{"key":"1014_CR45","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1146\/annurev.biochem.68.1.729","volume":"68","author":"M Bernfield","year":"1999","unstructured":"Bernfield M, Gotte M, Park PW, Reizes O, Fitzgerald ML, Lincecum J, Zako M: Functions of cell surface heparan sulfate proteoglycans. Annu Rev Biochem. 1999, 68: 729-777. 10.1146\/annurev.biochem.68.1.729.","journal-title":"Annu Rev Biochem"},{"key":"1014_CR46","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1182\/blood-2006-04-015958","volume":"109","author":"A Chiu","year":"2007","unstructured":"Chiu A, Xu W, He B, Dillon SR, Gross JA, Sievers E, Qiao X, Santini P, Hyjek E, Lee JW, et al: Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL. Blood. 2007, 109: 729-739. 10.1182\/blood-2006-04-015958.","journal-title":"Blood"},{"key":"1014_CR47","volume-title":"Trends Immunol","author":"A Schaffler","year":"2007","unstructured":"Schaffler A, Scholmerich J, Salzberger B: Adipose tissue as an immunological organ: Toll-like receptors, C1q\/TNFs and CTRPs. Trends Immunol. 2007"},{"key":"1014_CR48","volume-title":"Cell Death Differ","author":"WP Cawthorn","year":"2007","unstructured":"Cawthorn WP, Heyd F, Hegyi K, Sethi JK: Tumour necrosis factor-alpha inhibits adipogenesis via a beta-catenin\/TCF4(TCF7L2)-dependent pathway. Cell Death Differ. 2007"},{"key":"1014_CR49","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.2174\/0929867054864886","volume":"12","author":"C Nelson-Dooley","year":"2005","unstructured":"Nelson-Dooley C, Della-Fera MA, Hamrick M, Baile CA: Novel treatments for obesity and osteoporosis: targeting apoptotic pathways in adipocytes. Curr Med Chem. 2005, 12: 2215-2225. 10.2174\/0929867054864886.","journal-title":"Curr Med Chem"}],"container-title":["BMC Cancer"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-8-76.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2407-8-76\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-8-76","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2407-8-76.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T02:15:06Z","timestamp":1630462506000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmccancer.biomedcentral.com\/articles\/10.1186\/1471-2407-8-76"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3,20]]},"references-count":49,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["1014"],"URL":"https:\/\/doi.org\/10.1186\/1471-2407-8-76","relation":{},"ISSN":["1471-2407"],"issn-type":[{"value":"1471-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,3,20]]},"assertion":[{"value":"15 October 2007","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2008","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 March 2008","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"76"}}