{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:43:46Z","timestamp":1790671426178,"version":"4.1.0"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T00:00:00Z","timestamp":1366675200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Trabeculectomy remains the most efficient method of lowering he IOP applied for the treatment of glaucoma refractory to pharmacological treatment. Cataract is concerned as the most frequent late complication of trabeculectomy. The aim of the study was to analyse the effect of phacoemulsification with posterior chamber lens implantation on the morphology and function of filtering bleb in patients after previous successful trabeculectomy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>The retrospective study included 122 eyes treated for primary open angle glaucoma, 50 eyes (study group) in which, after a successful trabeculectomy with5-Fluorouracil, phacoemulsification with posterior chamber lens implantation was performed, and 72 eyes (control group), in which only a successful trabeculectomy was conducted. The surgical success of the trabeculectomy was expressed as IOP\u2009&lt;\u200917 mmHg.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>In the group of patients subjected to both trabeculectomy and phacoemulsification, mean IOP was significantly higher than in the group of patients who underwent trabeculectomy after 6 months (p\u2009=\u20090.003), 12 months (p\u2009=\u20090.01) and 18 months (p\u2009=\u20090.007) of observation. The filtering blebs after phacoemulsification in the study group were characterized by a greater reduction, compared to those in the control group. Cox regression survival success was 75% (SE\u2009=\u20095.9; 95% CI: 63.4 \u2013 86.6), 75% (SE\u2009=\u20095.9; 95% CI: 63.4 \u2013 86.6), 71% (SE\u2009=\u20095.4; 95% CI: 60.4 \u2013 81.6) in study group and 92% (SE\u2009=\u20091.8; 95% CI: 91.5 \u2013 98.5), 92% (SE\u2009=\u20091.9; 95% CI: 88.3 \u2013 95.7), 91% (SE\u2009=\u20092.0; 95% CI: 87.1 \u2013 94.9) in control group after 6, 12 and 18 months, respectively.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Phacoemulsification causes a significant elevation of IOP in the eyes after previous successful trabeculectomy and deterioration of filtering bleb morphology.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2415-13-17","type":"journal-article","created":{"date-parts":[[2013,4,23]],"date-time":"2013-04-23T16:17:08Z","timestamp":1366733828000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Deterioration of filtering bleb morphology and function after phacoemulsification"],"prefix":"10.1186","volume":"13","author":[{"given":"Monika","family":"Sa\u0142aga-Pylak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Kowal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomasz","family":"\u017barnowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,4,23]]},"reference":[{"key":"310_CR1","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/0002-9394(68)91288-9","volume":"66","author":"JE Cairns","year":"1968","unstructured":"Cairns JE: Trabeculectomy. Preliminary report of a new method. Am J Ophthalmol. 1968, 66: 673-679.","journal-title":"Am J Ophthalmol"},{"key":"310_CR2","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3928\/1542-8877-19980901-03","volume":"29","author":"RJ Derick","year":"1998","unstructured":"Derick RJ, Evans J, Baker ND: Combined phacoemulsification and trabeculectomy versus trabeculectomy alone: a comparison study using mitomycin-C. Ophthalmic Surg Lasers. 1998, 29: 707-713.","journal-title":"Ophthalmic Surg Lasers"},{"key":"310_CR3","doi-asserted-by":"publisher","first-page":"1902","DOI":"10.1016\/S0161-6420(02)01267-8","volume":"109","author":"DS Friedman","year":"2002","unstructured":"Friedman DS, Jampel HD, Lubomski LH: Surgical strategies for coexisting glaucoma and cataract: an evidence-based update. Ophthalmology. 2002, 109: 1902-1913. 10.1016\/S0161-6420(02)01267-8.","journal-title":"Ophthalmology"},{"key":"310_CR4","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1016\/S0886-3350(97)80215-5","volume":"23","author":"KJ Yang","year":"1997","unstructured":"Yang KJ, Moster MR, Azuara-Blanco A, Wilson RP, Araujo SV, Schmidt CM: Mitomycin-C supplemented trabeculectomy, phacoemulsification, and foldable lens implantation. J Cataract Refract Surg. 1997, 23: 565-569. 10.1016\/S0886-3350(97)80215-5.","journal-title":"J Cataract Refract Surg"},{"key":"310_CR5","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1016\/j.ajo.2005.11.039","volume":"141","author":"H Fontana","year":"2006","unstructured":"Fontana H, Nouri-Mahdavi K, Caprioli J: Trabeculectomy with mitomycin C in pseudophakic patients with open-angle glaucoma: outcomes and risk factors for failure. Am J Ophthalmol. 2006, 141: 652-659. 10.1016\/j.ajo.2005.11.039.","journal-title":"Am J Ophthalmol"},{"key":"310_CR6","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1177\/112067210901900612","volume":"19","author":"A Alwitry","year":"2009","unstructured":"Alwitry A, Abedin A, Patel V, Moodie J, Rotchford A, King AJ: Primary low-risk trabeculectomy augmented with low-dose mitomycin-C. Eur J Ophthalmol. 2009, 19: 971-976.","journal-title":"Eur J Ophthalmol"},{"key":"310_CR7","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1016\/S0161-6420(96)30578-2","volume":"103","author":"JS Mora","year":"1996","unstructured":"Mora JS, Nguyen N, Iwach AG, Gaffney MM, Hetherington J: Trabeculectomy with intraoperative sponge 5-fluorouracil. Ophthalmology. 1996, 103: 963-970.","journal-title":"Ophthalmology"},{"key":"310_CR8","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.ophtha.2008.08.009","volume":"116","author":"AM Palanca-Capistrano","year":"2009","unstructured":"Palanca-Capistrano AM, Hall J, Cantor LB, Morgan L, Hoop J, WuDunn D: Long-term outcomes of intraoperative 5-fluorouracil versus intraoperative mitomycin C in primary trabeculectomy surgery. Ophthalmology. 2009, 116: 185-190. 10.1016\/j.ophtha.2008.08.009.","journal-title":"Ophthalmology"},{"key":"310_CR9","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1007\/s003470170098","volume":"98","author":"G Picht","year":"2001","unstructured":"Picht G, Mutsch Y, Grehn F: Follow-up of trabeculectomy. Complications and therapeutic consequences. Ophthalmologe. 2001, 98: 629-634. 10.1007\/s003470170098.","journal-title":"Ophthalmologe"},{"key":"310_CR10","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.ajo.2005.02.013","volume":"140","author":"HD Jampel","year":"2005","unstructured":"Jampel HD, Musch DC, Gillespie BW, Lichter PR, Wright MM, Guire KE: Perioperative complications of trabeculectomy in the collaborative initial glaucoma treatment study (CIGTS). Am J Ophthalmol. 2005, 140: 16-22. 10.1016\/j.ajo.2005.02.013.","journal-title":"Am J Ophthalmol"},{"key":"310_CR11","doi-asserted-by":"publisher","first-page":"1029","DOI":"10.1007\/s00347-009-2071-5","volume":"106","author":"CP Jonescu-Cuypers","year":"2009","unstructured":"Jonescu-Cuypers CP, Seitz B: Postoperative complications and management of filtration surgery. Ophthalmologe. 2009, 106: 1029-1039. 10.1007\/s00347-009-2071-5.","journal-title":"Ophthalmologe"},{"key":"310_CR12","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1755-3768.1991.tb04818.x","volume":"69","author":"V Popovic","year":"1991","unstructured":"Popovic V, Sj\u00f6strand J: Long-term outcome following trabeculectomy: I Retrospective analysis of intraocular pressure regulation and cataract formation. Acta Ophthalmol (Copenh). 1991, 69: 299-304.","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"310_CR13","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0161-6420(02)01769-4","volume":"110","author":"RA Adelman","year":"2003","unstructured":"Adelman RA, Brauner SC, Afshari NA, Grosskreutz CL: Cataract formation after initial trabeculectomy in young patients. Ophthalmology. 2003, 110: 625-629.","journal-title":"Ophthalmology"},{"key":"310_CR14","doi-asserted-by":"publisher","first-page":"1771","DOI":"10.1001\/archopht.119.12.1771","volume":"119","author":"Advanced Glaucoma Intervention Study (AGIS) Investigators","year":"2001","unstructured":"Advanced Glaucoma Intervention Study (AGIS) Investigators: Advanced Glaucoma Intervention Study: 8. Risk of cataract formation after trabeculectomy. Arch Ophthalmol. 2001, 119: 1771-1779.","journal-title":"Arch Ophthalmol"},{"key":"310_CR15","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1016\/0002-9394(70)93414-8","volume":"69","author":"HS Sugar","year":"1970","unstructured":"Sugar HS: Postoperative cataract in successfully filtering glaucomatous eyes. Am J Ophthalmol. 1970, 69: 740-746.","journal-title":"Am J Ophthalmol"},{"key":"310_CR16","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1136\/bjo.65.11.790","volume":"65","author":"KB Mills","year":"1981","unstructured":"Mills KB: Trabeculectomy a retrospective long-term follow-up of 444 cases. Br J Ophthalmol. 1981, 65: 790-795. 10.1136\/bjo.65.11.790.","journal-title":"Br J Ophthalmol"},{"key":"310_CR17","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1111\/j.1755-3768.1993.tb08599.x","volume":"71","author":"E Vesti","year":"1993","unstructured":"Vesti E: Development of cataract after trabeculectomy. Acta Ophthalmol (Copenh). 1993, 71: 777-781.","journal-title":"Acta Ophthalmol (Copenh)"},{"key":"310_CR18","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1097\/00061198-200210000-00011","volume":"11","author":"R Casson","year":"2002","unstructured":"Casson R, Rahman R, Salmon JF: Phacoemulsification with intraocular lens implantation after trabeculectomy. J Glaucoma. 2002, 11: 429-433. 10.1097\/00061198-200210000-00011.","journal-title":"J Glaucoma"},{"key":"310_CR19","doi-asserted-by":"publisher","first-page":"2248","DOI":"10.1016\/S0161-6420(02)01246-0","volume":"109","author":"G Rebolleda","year":"2002","unstructured":"Rebolleda G, Mu\u00f1oz-Negrete FJ: Phacoemulsification in eyes with functioning filtering blebs: a prospective study. Ophthalmology. 2002, 109: 2248-2255. 10.1016\/S0161-6420(02)01246-0.","journal-title":"Ophthalmology"},{"key":"310_CR20","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1111\/j.1600-0420.2005.00497.x","volume":"83","author":"A Inal","year":"2005","unstructured":"Inal A, Bayraktar S, Inal B, Bayraktar Z, Yilmaz QF: Intraocular pressure control after clear corneal phacoemulsification in eyes with previous trabeculectomy: a controlled study. Acta Ophthalmol Scand. 2005, 83: 554-560. 10.1111\/j.1600-0420.2005.00497.x.","journal-title":"Acta Ophthalmol Scand"},{"key":"310_CR21","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1097\/00061198-200102000-00008","volume":"10","author":"AC Crichton","year":"2001","unstructured":"Crichton AC, Kirker AW: Intraocular pressure and medication control after clear corneal phacoemulsification and AcrySoft posterior chamber intraocular lens implantation in patients with filtering blebs. J Glaucoma. 2001, 10: 38-46. 10.1097\/00061198-200102000-00008.","journal-title":"J Glaucoma"},{"key":"310_CR22","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S0886-3350(01)01189-0","volume":"28","author":"A Derbolav","year":"2002","unstructured":"Derbolav A, Vass C, Menapace R, Schmetterer K, Wedrich A: Long-term effect of phacoemulsification on intraocular pressure after trabeculectomy. J Cataract Refract Surg. 2002, 28: 425-430. 10.1016\/S0886-3350(01)01189-0.","journal-title":"J Cataract Refract Surg"},{"key":"310_CR23","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/S0886-3350(03)00133-0","volume":"29","author":"BJ Shingleton","year":"2003","unstructured":"Shingleton BJ, O\u2019Donoghue MW, Hall PE: Results of phacoemulsification in eyes with pre-existing glaucoma filters. J Cataract Refract Surg. 2003, 29: 1093-1096. 10.1016\/S0886-3350(03)00133-0.","journal-title":"J Cataract Refract Surg"},{"key":"310_CR24","doi-asserted-by":"publisher","first-page":"674","DOI":"10.1016\/j.ophtha.2003.08.025","volume":"111","author":"K Swamynathan","year":"2004","unstructured":"Swamynathan K, Capistrano AP, Cantor LB, WuDunn D: Effect of temporal corneal phacoemulsification on intraocular pressure in eyes with prior trabeculectomy with an antimetabolite. Ophthalmology. 2004, 111: 674-678. 10.1016\/j.ophtha.2003.08.025.","journal-title":"Ophthalmology"},{"key":"310_CR25","doi-asserted-by":"publisher","first-page":"2215","DOI":"10.1016\/S0161-6420(02)01439-2","volume":"109","author":"HD Jampel","year":"2002","unstructured":"Jampel HD, Friedman DS, Lubomski LH, Kempen JH, Quigley H: Effect of technique on intraocular pressure after combined cataract and glaucoma surgery: An evidence-based review. Ophthalmology. 2002, 109: 2215-2224. 10.1016\/S0161-6420(02)01439-2.","journal-title":"Ophthalmology"},{"key":"310_CR26","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/S0886-3350(99)00107-8","volume":"25","author":"BJ Shingleton","year":"1999","unstructured":"Shingleton BJ, Gamell LS, O\u2019Donoghue MW, Baylus SL, King R: Long-term changes in intraocular pressure after clear corneal phacoemulsification: normal patients versus glaucoma suspect and glaucoma patients. J Cataract Refract Surg. 1999, 25: 885-890. 10.1016\/S0886-3350(99)00107-8.","journal-title":"J Cataract Refract Surg"},{"key":"310_CR27","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1016\/S0161-6420(00)00007-5","volume":"107","author":"K Hayashi","year":"2000","unstructured":"Hayashi K, Hayashi H, Nakao F, Hayashi F: Changes in anterior chamber angle width and depth after intraocular lens implantation in eyes with glaucoma. Ophthalmology. 2000, 107: 698-703. 10.1016\/S0161-6420(00)00007-5.","journal-title":"Ophthalmology"},{"key":"310_CR28","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1111\/j.1600-0420.1997.tb00778.x","volume":"75","author":"R Perasalo","year":"1992","unstructured":"Perasalo R: Phacoemulsification of cataract in eyes with glaucoma. Acta Ophthalmol Scand. 1992, 75: 299-300.","journal-title":"Acta Ophthalmol Scand"},{"key":"310_CR29","first-page":"124","volume":"8","author":"F El-Sayyad","year":"1999","unstructured":"El-Sayyad F, El-Rashood A, Helal M, Hisham M, El-Maghraby A: Fornix-based versus limbal-based conjunctival flaps in initial trabeculectomy with postoperative 5-fluorouracil: four-year follow-up findings. J Glaucoma. 1999, 8: 124-128.","journal-title":"J Glaucoma"},{"key":"310_CR30","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1007\/s00417-009-1051-4","volume":"247","author":"I Keiichiro","year":"2009","unstructured":"Keiichiro I, Masaru I, Minako OI, Yuji T, Hidenobu T: Restricted post-trabeculectomy bleb formation by conjunctival scarring. Graefes Arch Clin Exp Ophthalmol. 2009, 247: 1095-1101. 10.1007\/s00417-009-1051-4.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"5","key":"310_CR31","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.preteyeres.2009.06.004","volume":"28","author":"DY Yu","year":"2009","unstructured":"Yu DY, Morgan WH, Sun X, Su EN, Cringle SJ: The critical role of the conjunctiva in glaucoma filtration surgery. Prog Retin Eye Res. 2009, 28 (5): 303-328. 10.1016\/j.preteyeres.2009.06.004.","journal-title":"Prog Retin Eye Res"},{"key":"310_CR32","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3928\/1542-8877-19970801-08","volume":"28","author":"T Wygnanski-Jaffe","year":"1997","unstructured":"Wygnanski-Jaffe T, Barak A, Melamed S, Glovinsky Y: Intraocular pressure increments after cataract extraction in glaucomatous eyes with functioning filtering blebs. Ophthalmic Surg Lasers. 1997, 28: 657-661.","journal-title":"Ophthalmic Surg Lasers"},{"key":"310_CR33","first-page":"71","volume":"38","author":"S Yamagami","year":"1994","unstructured":"Yamagami S, Araie M, Mori M, Mishima K: Posterior chamber intraocular lens implantation in filtered or non-filtered glaucoma eyes. Jpn J Ophthalmol. 1994, 38: 71-79.","journal-title":"Jpn J Ophthalmol"},{"key":"310_CR34","doi-asserted-by":"publisher","first-page":"1928","DOI":"10.1016\/S0161-6420(98)91044-2","volume":"105","author":"PP Chen","year":"1998","unstructured":"Chen PP, Weaver YK, Budenz DL, Feuer WJ, Parrish RK: Trabeculectomy function after cataract extraction. Ophthalmology. 1998, 105: 1928-1935. 10.1016\/S0161-6420(98)91044-2.","journal-title":"Ophthalmology"},{"key":"310_CR35","first-page":"11","volume":"100","author":"T \u017barnowski","year":"1998","unstructured":"\u017barnowski T, Chmiel M, Haszcz D, Zag\u00f3rski Z: Evaluation of the induced astigmatism and the blood-aqueous barrier breakdown following procedures in the anterior segment of the eye. Klin Oczna. 1998, 100: 11-14.","journal-title":"Klin Oczna"},{"key":"310_CR36","doi-asserted-by":"crossref","first-page":"587","DOI":"10.3928\/1542-8877-19960701-05","volume":"27","author":"SK Seah","year":"1996","unstructured":"Seah SK, Jap A, Prata JAJ, Baerveldt G, Lee PP: Cataract surgery after trabeculectomy. Ophthalmic Surg Lasers. 1996, 27: 587-594.","journal-title":"Ophthalmic Surg Lasers"},{"key":"310_CR37","doi-asserted-by":"publisher","first-page":"1854","DOI":"10.1016\/S0886-3350(01)01127-0","volume":"27","author":"RJ Casson","year":"2001","unstructured":"Casson RJ, Salmon JF: Combined surgery in the treatment of patients with cataract and primary open-angle glaucoma. J Cataract Refract Surg. 2001, 27: 1854-1863. 10.1016\/S0886-3350(01)01127-0.","journal-title":"J Cataract Refract Surg"},{"key":"310_CR38","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1097\/00055735-200402000-00012","volume":"15","author":"C Vass","year":"2004","unstructured":"Vass C, Menapace R: Surgical strategies in patients with combined cataract and glaucoma. Curr Opin Ophthalmol. 2004, 15: 61-66. 10.1097\/00055735-200402000-00012.","journal-title":"Curr Opin Ophthalmol"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2415-13-17\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-17","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-17.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T23:18:29Z","timestamp":1630538309000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/1471-2415-13-17"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,4,23]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["310"],"URL":"https:\/\/doi.org\/10.1186\/1471-2415-13-17","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,4,23]]},"assertion":[{"value":"6 December 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 April 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"17"}}