{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T04:54:49Z","timestamp":1778302489379,"version":"3.51.4"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T00:00:00Z","timestamp":1360108800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The relationship between intraocular pressure (IOP) changes and hemodialysis has been evaluated for several decades. However, no report on an IOP rise in uveitis patients during hemodialysis has been previously documented. This report describes the case of an uveitis patient with repetitive IOP spikes associated with severe ocular pain during hemodialysis sessions, which resolved after glaucoma filtering surgery.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Case presentation<\/jats:title>\n            <jats:p>A 47-year-old male with diabetes and hypertension had complained of recurrent ocular pain in the left eye during hemodialysis sessions. A slit-lamp examination showed diffuse corneal epithelial edema with several white keratic precipitates and inflammatory cells (Grade 3+) in the anterior chamber of the left eye. No visible neovascularization or synechiae were visible on the iris or angle. Topical glaucoma eye-drops and intravenous mannitol before hemodialysis did not prevent subsequent painful IOP spikes in the left eye. At the end of hemodialysis, IOP averaged ~40 mmHg. After trabeculectomy with mitomycin C in the left eye, his IOP stabilized in the low-teens (range, 10\u201314 mmHg) and no painful IOP spikes occurred during hemodialysis over the first postoperative year.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>We present a case of recurrent painful IOP spikes during hemodialysis in a patient with unilateral anterior uveitis unresponsive to conventional medical treatment prior to hemodialysis. To our knowledge, this is the first case report of repetitive symptomatic IOP rise during hemodialysis in an uveitic glaucoma patient. This case highlights the importance of the awareness of the possibility that IOP may rise intolerably during hemodialysis in uveitis patients with a compromised outflow facility.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2415-13-3","type":"journal-article","created":{"date-parts":[[2013,2,6]],"date-time":"2013-02-06T09:14:18Z","timestamp":1360142058000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Recurrent symptomatic intraocular pressure spikes during hemodialysis in a patient with unilateral anterior uveitis"],"prefix":"10.1186","volume":"13","author":[{"given":"Su-Ho","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junhyuk","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Cheol","family":"Cha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,2,6]]},"reference":[{"key":"299_CR1","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1007\/s10792-009-9339-2","volume":"30","author":"UA Dinc","year":"2010","unstructured":"Dinc UA, Ozdek S, Aktas Z, Guz G, Onol M: Changes in intraocular pressure, and corneal and retinal nerve fiber layer thickness during hemodialysis. Int Ophthalmol. 2010, 30: 337-340. 10.1007\/s10792-009-9339-2.","journal-title":"Int Ophthalmol"},{"key":"299_CR2","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1007\/s00417-012-2032-6","volume":"251","author":"JW Jung","year":"2013","unstructured":"Jung JW, Yoon MH, Lee SW, Chin HS: Effect of hemodialysis (HD) on intraocular pressure, ocular surface, and macular change in patients with chronic renal failure: effect of hemodialysis on the ophthalmologic findings. Graefes Arch Clin Exp Ophthalmol. 2013, 251: 153-162. 10.1007\/s00417-012-2032-6.","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"299_CR3","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1038\/eye.2009.33","volume":"24","author":"A Samsudin","year":"2010","unstructured":"Samsudin A, Mimiwati Z, Soong T, Fauzi MS, Zabri K: Effect of haemodialysis on intraocular pressure. Eye (Lond). 2010, 24: 70-73. 10.1038\/eye.2009.33.","journal-title":"Eye (Lond)"},{"key":"299_CR4","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1038\/sj.eye.6701755","volume":"19","author":"J Levy","year":"2005","unstructured":"Levy J, Tovbin D, Lifshitz T, Zlotnik M, Tessler Z: Intraocular pressure during haemodialysis: a review. Eye (Lond). 2005, 19: 1249-1256. 10.1038\/sj.eye.6701755.","journal-title":"Eye (Lond)"},{"key":"299_CR5","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1080\/02713689808951214","volume":"17","author":"A Tawara","year":"1998","unstructured":"Tawara A, Kobata H, Fujisawa K, Abe T, Ohnishi Y: Mechanism of intraocular pressure elevation during hemodialysis. Curr Eye Res. 1998, 17: 339-347. 10.1080\/02713689808951214.","journal-title":"Curr Eye Res"},{"key":"299_CR6","doi-asserted-by":"publisher","first-page":"1375","DOI":"10.1038\/eye.2011.155","volume":"25","author":"L Steeples","year":"2011","unstructured":"Steeples L, Mercieca K, Sioras E: Recurrent intradialytic elevation of intraocular pressure in a case of neovascular glaucoma. Eye (Lond). 2011, 25: 1375-","journal-title":"Eye (Lond)"},{"key":"299_CR7","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1016\/S0002-9394(99)00438-9","volume":"129","author":"H Masuda","year":"2000","unstructured":"Masuda H, Shibuya Y, Ohira A: Markedly increased unilateral intraocular pressure during hemodialysis in a patient with ipsilateral exfoliative glaucoma. Am J Ophthalmol. 2000, 129: 534-536. 10.1016\/S0002-9394(99)00438-9.","journal-title":"Am J Ophthalmol"},{"key":"299_CR8","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1136\/bjo.57.7.511","volume":"57","author":"RA Burn","year":"1973","unstructured":"Burn RA: Intraocular pressure during haemodialysis. Br J Ophthalmol. 1973, 57: 511-513. 10.1136\/bjo.57.7.511.","journal-title":"Br J Ophthalmol"},{"key":"299_CR9","doi-asserted-by":"publisher","first-page":"e51","DOI":"10.3129\/i09-132","volume":"44","author":"A Ghaffariyeh","year":"2009","unstructured":"Ghaffariyeh A, Honarpisheh N, Pishva E: High vitreous urea rebound in a glaucoma patient with increased intraocular pressure during hemodialysis. Can J Ophthalmol. 2009, 44: e51-10.3129\/i09-132.","journal-title":"Can J Ophthalmol"},{"key":"299_CR10","doi-asserted-by":"publisher","first-page":"294","DOI":"10.3121\/cmr.4.4.294","volume":"4","author":"KG Ooi","year":"2006","unstructured":"Ooi KG, Galatowicz G, Calder VL, Lightman SL: Cytokines and chemokines in uveitis: is there a correlation with clinical phenotype?. Clin Med Res. 2006, 4: 294-309. 10.3121\/cmr.4.4.294.","journal-title":"Clin Med Res"},{"key":"299_CR11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3928\/1542-8877-20001101-06","volume":"31","author":"YH Yoon","year":"2000","unstructured":"Yoon YH, Sohn JH, Lee SE, Lee YB, Kim JY, Kook MS: Increases in intraocular pressure during hemodialysis in eyes during early postvitrectomy period. Ophthalmic Surg Lasers. 2000, 31: 467-473.","journal-title":"Ophthalmic Surg Lasers"},{"key":"299_CR12","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1159\/000166710","volume":"3","author":"B Rever","year":"1983","unstructured":"Rever B, Fox L, Christensen R, Bar-Khayim Y, Nissenson AR: Adverse ocular effects of acetate hemodialysis. Am J Nephrol. 1983, 3: 199-204. 10.1159\/000166710.","journal-title":"Am J Nephrol"},{"key":"299_CR13","first-page":"702","volume":"303","author":"P Jaeger","year":"1980","unstructured":"Jaeger P, Morisod L, Wauters JP, Faggioni R: Prevention of glaucoma during hemodialysis by mannitol and acetazolamide. N Engl J Med. 1980, 303: 702-","journal-title":"N Engl J Med"},{"key":"299_CR14","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1097\/ICU.0b013e32834bbd68","volume":"22","author":"A Sallam","year":"2011","unstructured":"Sallam A, Taylor SR, Lightman S: Review and update of intraocular therapy in noninfectious uveitis. Curr Opin Ophthalmol. 2011, 22: 517-522. 10.1097\/ICU.0b013e32834bbd68.","journal-title":"Curr Opin Ophthalmol"},{"key":"299_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.3341\/kjo.2006.20.2.109","volume":"20","author":"WK Song","year":"2006","unstructured":"Song WK, Ha SJ, Yeom HY, Seoung GJ, Hong YJ: Recurrent intraocular pressure elevation during hemodialysis in a patient with neovascular glaucoma. Korean J Ophthalmol. 2006, 20: 109-112. 10.3341\/kjo.2006.20.2.109.","journal-title":"Korean J Ophthalmol"},{"key":"299_CR16","first-page":"5","volume":"84","author":"W Sawaki","year":"2009","unstructured":"Sawaki W, Kinouchi R, Kato Y, Takahashi T, Kawai M, Yoshida A: Case in which the unilateral intraocular pressure before hemodialysis was higher than the day following hemodialysis. Hokkaido Igaku Zasshi. 2009, 84: 5-8.","journal-title":"Hokkaido Igaku Zasshi"},{"key":"299_CR17","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1076\/ocii.7.2.103.4022","volume":"7","author":"P Stavrou","year":"1999","unstructured":"Stavrou P, Murray PI: Does trabeculectomy influence the course of uveitis?. Ocul Immunol Inflamm. 1999, 7: 103-108. 10.1076\/ocii.7.2.103.4022.","journal-title":"Ocul Immunol Inflamm"},{"key":"299_CR18","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1016\/S0161-6420(87)33430-X","volume":"94","author":"RN Weinreb","year":"1987","unstructured":"Weinreb RN: Adjusting the dose of 5-fluorouracil after filtration surgery to minimize side effects. Ophthalmology. 1987, 94: 564-570.","journal-title":"Ophthalmology"},{"key":"299_CR19","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1001\/archopht.1991.01080010014005","volume":"109","author":"A Ophir","year":"1991","unstructured":"Ophir A, Ticho U: Remission of anterior uveitis by subconjunctival fluorouracil. Arch Ophthalmol. 1991, 109: 12-13.","journal-title":"Arch Ophthalmol"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2415-13-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-13-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T22:13:40Z","timestamp":1630534420000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/1471-2415-13-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,6]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["299"],"URL":"https:\/\/doi.org\/10.1186\/1471-2415-13-3","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,6]]},"assertion":[{"value":"14 October 2012","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 January 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 February 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"3"}}