{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T20:55:51Z","timestamp":1791147351909,"version":"4.1.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T00:00:00Z","timestamp":1421625600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1186\/1471-2415-15-5","type":"journal-article","created":{"date-parts":[[2015,6,18]],"date-time":"2015-06-18T03:40:45Z","timestamp":1434598845000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Square-edge intraocular lenses and epithelial lens cell proliferation: implications on posterior capsule opacification in an in vitro model"],"prefix":"10.1186","volume":"15","author":[{"given":"Rita","family":"Mencucci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Favuzza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Boccalini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Jacques","family":"Gicquel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Raimondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,19]]},"reference":[{"key":"531_CR1","doi-asserted-by":"publisher","first-page":"1050","DOI":"10.1016\/j.jcrs.2010.12.060","volume":"37","author":"AR Vasavada","year":"2011","unstructured":"Vasavada AR, Raj SM, Shah A, Shah G, Vasavada V, Vasavada V: Comparison of posterior capsule opacification with hydrophobic acrylic and hydrophilic acrylic intraocular lenses.J Cataract Refract Surg 2011, 37:1050\u20139. 10.1016\/j.jcrs.2010.12.060","journal-title":"J Cataract Refract Surg"},{"key":"531_CR2","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.jcrs.2009.12.040","volume":"36","author":"DR Nixon","year":"2010","unstructured":"Nixon DR, Woodcock MG: Pattern of posterior capsule opacification models 2\u00a0years postoperatively with 2 single-piece acrylic intraocular lenses.J Cataract Refract Surg 2010, 36:929\u201334. 10.1016\/j.jcrs.2009.12.040","journal-title":"J Cataract Refract Surg"},{"key":"531_CR3","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/S0886-3350(99)00352-1","volume":"26","author":"Q Peng","year":"2000","unstructured":"Peng Q, Visessook N, Apple DJ, Pandey SK, Werner L, Escobar-Gomez M, et al.: Surgical prevention of posterior capsule opacification. Part 3: intraocular lens optic barrier effect as a second line of defense.J Cataract Refract Surg 2000, 26:198\u2013213. 10.1016\/S0886-3350(99)00352-1","journal-title":"J Cataract Refract Surg"},{"key":"531_CR4","doi-asserted-by":"publisher","first-page":"1537","DOI":"10.1016\/S0886-3350(00)00309-6","volume":"26","author":"HS Chung","year":"2000","unstructured":"Chung HS, Lim SJ, Kim HB: Effect of mitomycin-C on posterior capsule opacification in rabbit eyes.J Cataract Refract Surg 2000, 26:1537\u201342. 10.1016\/S0886-3350(00)00309-6","journal-title":"J Cataract Refract Surg"},{"key":"531_CR5","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/S0886-3350(00)00326-6","volume":"26","author":"WR Meacock","year":"2000","unstructured":"Meacock WR, Spalton DJ, Hollick EJ, Boyce JF, Barman S, Sanguinetti G: Double-masked prospective ocular safety study of a lens epithelial cell antibody to prevent posterior capsule opacification.J Cataract Refract Surg 2000, 26:716\u201321. 10.1016\/S0886-3350(00)00326-6","journal-title":"J Cataract Refract Surg"},{"key":"531_CR6","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S0886-3350(99)00353-3","volume":"26","author":"DJ Apple","year":"2000","unstructured":"Apple DJ, Peng Q, Visessook N, Werner L, Pandey SK, Escobar-Gomez M, et al.: Surgical prevention of posterior capsule opacification. Part 1: progress in eliminating this complication of cataract surgery.J Cataract Refract Surg 2000, 26:180\u20137. 10.1016\/S0886-3350(99)00353-3","journal-title":"J Cataract Refract Surg"},{"key":"531_CR7","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1136\/bjo.82.10.1182","volume":"82","author":"EJ Hollick","year":"1998","unstructured":"Hollick EJ, Spalton DJ, Ursell PG, Pande MV: Lens epithelial cell regression on the posterior capsule with different intraocular lens materials.Br J Ophthalmol 1998, 82:1182\u20138. 10.1136\/bjo.82.10.1182","journal-title":"Br J Ophthalmol"},{"key":"531_CR8","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1016\/j.ophtha.2008.01.002","volume":"115","author":"T Kohnen","year":"2008","unstructured":"Kohnen T, Fabian E, Gerl R, Hunold W, H\u00fctz W, Strobel J, et al.: Optic edge design as long-term factor for posterior capsular opacification rates.Ophthalmology 2008, 115:1308\u201314. 1314.e1\u20133 10.1016\/j.ophtha.2008.01.002","journal-title":"Ophthalmology"},{"key":"531_CR9","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.ophtha.2004.07.032","volume":"112","author":"O Findl","year":"2005","unstructured":"Findl O, Menapace R, Sacu S, Buehl W, Rainer G: Effect of optic material on posterior capsule opacification in intraocular lenses with sharp-edge optics: randomized clinical trial.Ophthalmology 2005, 112:67\u201372. 10.1016\/j.ophtha.2004.07.032","journal-title":"Ophthalmology"},{"key":"531_CR10","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1167\/iovs.11-8851","volume":"53","author":"LJ Dawes","year":"2012","unstructured":"Dawes LJ, Illingworth CD, Wormstone I: A fully human in vitro capsular bag model to permit intraocular lens evaluation.Invest Ophthalmol Vis Sci 2012, 53:23\u20139. 10.1167\/iovs.11-8851","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"531_CR11","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.1016\/j.jcrs.2010.05.006","volume":"36","author":"G Cleary","year":"2010","unstructured":"Cleary G, Spalton DJ, Zhang JJ, Marshall J: In vitro lens capsule model for investigation of posterior capsule opacification.J Cataract Refract Surg 2010, 36:1249\u201352. 10.1016\/j.jcrs.2010.05.006","journal-title":"J Cataract Refract Surg"},{"key":"531_CR12","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1016\/j.jcrs.2008.03.040","volume":"34","author":"J Burger","year":"2008","unstructured":"Burger J, Kreutzer T, Alge CS, Strauss RW, Eibl K, Haritoglou C, et al.: Capsular tension ring-based in vitro capsule opacification model.J Cataract Refract Surg 2008, 34:1167\u201372. 10.1016\/j.jcrs.2008.03.040","journal-title":"J Cataract Refract Surg"},{"key":"531_CR13","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1016\/S0886-3350(03)00221-9","volume":"29","author":"AA El-Osta","year":"2003","unstructured":"El-Osta AA, Spalton DJ, Marshall J: In vitro model for the study of human posterior capsule opacification.J Cataract Refract Surg 2003, 29:1593\u2013600. 10.1016\/S0886-3350(03)00221-9","journal-title":"J Cataract Refract Surg"},{"key":"531_CR14","first-page":"906","volume":"37","author":"CS Liu","year":"1996","unstructured":"Liu CS, Wormstone IM, Duncan G, Marcantonio JM, Webb SF, Davies PD: A study of human lens cell growth in vitro. A model for posterior capsule opacification.Invest Ophthalmol Vis Sci 1996, 37:906\u201314.","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"531_CR15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1159\/000048322","volume":"34","author":"D Kurosaka","year":"2002","unstructured":"Kurosaka D, Obasawa M, Kurosaka H, Nakamura K: Inhibition of lens epithelial cell migration by an acrylic intraocular lens in vitro.Ophthalmic Res 2002, 34:29\u201337. 10.1159\/000048322","journal-title":"Ophthalmic Res"},{"key":"531_CR16","doi-asserted-by":"publisher","first-page":"4679","DOI":"10.1167\/iovs.07-0091","volume":"48","author":"N Gotoh","year":"2007","unstructured":"Gotoh N, Perdue NR, Matsushima H, Sage EH, Yan Q, Clark JI: An in vitro model of posterior capsular opacity: SPARC and TGF-beta2 minimize epithelial-to-mesenchymal transition in lens epithelium.Invest Ophthalmol Vis Sci 2007, 48:4679\u201387. 10.1167\/iovs.07-0091","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"531_CR17","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1016\/j.jcrs.2006.01.039","volume":"32","author":"Y Okajima","year":"2006","unstructured":"Okajima Y, Saika S, Sawa M: Effect of surface coating an acrylic intraocular lens with poly(2-methacryloyloxyethyl phosphorylcholine) polymer on lens epithelial cell line behavior.J Cataract Refract Surg 2006, 32:666\u201371. 10.1016\/j.jcrs.2006.01.039","journal-title":"J Cataract Refract Surg"},{"key":"531_CR18","doi-asserted-by":"publisher","first-page":"2171","DOI":"10.1016\/j.jcrs.2005.01.025","volume":"31","author":"M Tetz","year":"2005","unstructured":"Tetz M, Wildeck A: Evaluating and defining the sharpness of intraocular lenses. Part 1: influence of optic design on the growth of the lens epithelial cells in vitro.J Cataract Refract Surg 2005, 31:2171\u20139.","journal-title":"J Cataract Refract Surg"},{"key":"531_CR19","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1016\/j.jcrs.2005.05.031","volume":"31","author":"O Nishi","year":"2005","unstructured":"Nishi O, Nishi K, Osakabe Y: Evaluation of posterior capsule opacification using a new posterior view method in rabbits. Single-piece acrylic versus 3-piece acrylic intraocular lens.J Cataract Refract Surg 2005, 31:2369\u201374. 10.1016\/j.jcrs.2005.05.031","journal-title":"J Cataract Refract Surg"},{"key":"531_CR20","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1016\/j.jcrs.2010.11.036","volume":"37","author":"PJ Ness","year":"2011","unstructured":"Ness PJ, Werner L, Maddula S, Davis D, Zaugg B, Stringham J, et al.: Pathology of 219 human cadaver eyes with 1-piece or 3-piece hydrophobic acrylic intraocular lenses: capsular bag opacification and sites of square-edged barrier breach.J Cataract Refract Surg 2011, 37:923\u201330. 10.1016\/j.jcrs.2010.11.036","journal-title":"J Cataract Refract Surg"},{"key":"531_CR21","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.ajo.2006.05.049","volume":"142","author":"DR Nixon","year":"2006","unstructured":"Nixon DR, Apple DJ: Evaluation of lens epithelial cell migration in vivo at the haptic-optic junction of a one-piece hydrophobic acrylic intraocular lens.Am J Ophthalmol 2006, 142:557\u201362. 10.1016\/j.ajo.2006.05.049","journal-title":"Am J Ophthalmol"},{"key":"531_CR22","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.jcrs.2004.06.088","volume":"31","author":"L Werner","year":"2005","unstructured":"Werner L, Mamalis N, Izak AM: Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.J Cataract Refract Surg 2005, 31:805\u201311. 10.1016\/j.jcrs.2004.06.088","journal-title":"J Cataract Refract Surg"},{"key":"531_CR23","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","volume":"65","author":"T Mosmann","year":"1983","unstructured":"Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays.J Immunol Methods 1983, 65:55\u201363. 10.1016\/0022-1759(83)90303-4","journal-title":"J Immunol Methods"},{"key":"531_CR24","doi-asserted-by":"publisher","first-page":"1976","DOI":"10.1016\/j.jcrs.2008.07.029","volume":"34","author":"W Buehl","year":"2008","unstructured":"Buehl W, Findl O: Effect of intraocular lens design on posterior capsule opacification.J Cataract Refract Surg 2008, 34:1976\u201385. 10.1016\/j.jcrs.2008.07.029","journal-title":"J Cataract Refract Surg"},{"key":"531_CR25","doi-asserted-by":"publisher","first-page":"408","DOI":"10.1016\/j.jcrs.2012.09.020","volume":"39","author":"MM Roshdy","year":"2013","unstructured":"Roshdy MM, Riad RF, Morkos FF, Hassouna AK, Wahba SS: Effect of a single-piece aspheric hydrophobic acrylic intraocular lens design on centration and rotation.J Cataract Refract Surg 2013, 39:408\u201313. 10.1016\/j.jcrs.2012.09.020","journal-title":"J Cataract Refract Surg"}],"container-title":["BMC Ophthalmology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-15-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2415-15-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2415-15-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T22:23:27Z","timestamp":1548195807000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcophthalmol.biomedcentral.com\/articles\/10.1186\/1471-2415-15-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,19]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["531"],"URL":"https:\/\/doi.org\/10.1186\/1471-2415-15-5","relation":{},"ISSN":["1471-2415"],"issn-type":[{"value":"1471-2415","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,19]]},"assertion":[{"value":"24 July 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 January 2015","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 January 2015","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"5"}}