{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T15:45:07Z","timestamp":1772811907677,"version":"3.50.1"},"reference-count":14,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2007,4,26]],"date-time":"2007-04-26T00:00:00Z","timestamp":1177545600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Ophthalmol"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To describe an episode of thyroid associated orbitopathy (TAO) following the initiation of thiazolidinedione (TZD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>We report a female patient with a history of Graves' disease and stabilised thyroid associated orbitopathy for 2.5 years, who experienced rapid progression of TAO after the initiation of thiazolidinedione for glycemic control. Following the discontinuation of TZD, the patient experienced subsequent stabilisation of disease and normalization of vision. The medical history, ophthalmic findings, and clinical course are discussed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Thiazolidinediones may exacerbate TAO, and this should be taken into consideration when selecting treatment for diabetic patients with a history of autoimmune thyroid disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2415-7-8","type":"journal-article","created":{"date-parts":[[2007,4,30]],"date-time":"2007-04-30T11:57:12Z","timestamp":1177934232000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Thiazolidinedione induced thyroid associated orbitopathy"],"prefix":"10.1186","volume":"7","author":[{"given":"Seongmu","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Tsirbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D","family":"McCann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2007,4,26]]},"reference":[{"key":"108_CR1","doi-asserted-by":"crossref","unstructured":"Yki-J\u00e4rvinen H: Drug Therapy: Thiazolidinediones. N Engl J Med. 351 (11): 1106-18. 10.1056\/NEJMra041001. 2004 Sep 9;","DOI":"10.1056\/NEJMra041001"},{"key":"108_CR2","first-page":"477","volume":"92","author":"GB Bartley","year":"1994","unstructured":"Bartley GB: The epidemiologic characteristics and clinical course of ophthalmopathy associated with autoimmune thyroid disease in Olmsted County, Minnesota. Trans Am Ophthalmol Soc. 1994, 92: 477-588.","journal-title":"Trans Am Ophthalmol Soc"},{"key":"108_CR3","doi-asserted-by":"crossref","unstructured":"Bartalena L, Marcocci C, Bogazzi F, Hegedus L: Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy. N Engl J Med. 338 (2): 73-8. 10.1056\/NEJM199801083380201. 1998 Jan 8;","DOI":"10.1056\/NEJM199801083380201"},{"key":"108_CR4","doi-asserted-by":"crossref","unstructured":"Tallstedt L, Lundell G, Torring O, Wallin G, Ljunggren JG, Blomgren H, Taube A: Occurrence of ophthalmopathy after treatment for Graves' hyperthyroidism. The Thyroid Study Group. 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