{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T13:57:08Z","timestamp":1765807028095},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Bronchiolitis is the most common reason for admission of infants to hospital in developed countries. Fluid replacement therapy is required in about 30% of children admitted with bronchiolitis. There are currently two techniques of fluid replacement therapy that are used with the same frequency-intravenous (IV) or nasogastric (NG).<\/jats:p>\n            <jats:p>The evidence to determine the optimum route of hydration therapy for infants with bronchiolitis is inadequate. This randomised trial will be the first to provide good quality evidence of whether nasogastric rehydration (NGR) offers benefits over intravenous rehydration (IVR) using the clinically relevant continuous outcome measure of duration of hospital admission.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods\/Design<\/jats:title>\n            <jats:p>A prospective randomised multi-centre trial in Australia and New Zealand where children between 2 and 12 months of age with bronchiolitis, needing non oral fluid replacement, are randomised to receive either intravenous (IV) or nasogastric (NG) rehydration.<\/jats:p>\n            <jats:p>750 patients admitted to participating hospitals will be recruited, and will be followed daily during the admission and by telephone 1 week after discharge. Patients with chronic respiratory, cardiac, or neurological disease; choanal atresia; needing IV fluid resuscitation; needing an IV for other reasons, and those requiring CPAP or ventilation are excluded.<\/jats:p>\n            <jats:p>The primary endpoint is duration of hospital admission. Secondary outcomes are complications, need for ICU admission, parental satisfaction, and an economic evaluation. Results will be analysed using t-test for continuous data, and chi squared for categorical data. Non parametric data will be log transformed.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Discussion<\/jats:title>\n            <jats:p>This trial will define the role of NGR and IVR in bronchiolitis<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Trail registration<\/jats:title>\n            <jats:p>The trial is registered with the Australian and New Zealand Clinical Trials Registry - ACTRN12605000033640<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2431-10-37","type":"journal-article","created":{"date-parts":[[2012,5,2]],"date-time":"2012-05-02T13:36:53Z","timestamp":1335965813000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A prospective randomised trial comparing nasogastric with intravenous hydration in children with bronchiolitis (protocol) The comparative rehydration in bronchiolitis study (CRIB)"],"prefix":"10.1186","volume":"10","author":[{"name":"The Paediatric Research in Emergency Departments International Collaborative (PREDICT)","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ed","family":"Oakley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz E","family":"Babl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason","family":"Acworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meredith","family":"Borland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Kreiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyn","family":"Neutze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theane","family":"Theophilos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Donath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"South","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"issue":"4","key":"349_CR1","doi-asserted-by":"publisher","first-page":"1774","DOI":"10.1542\/peds.2006-1925","volume":"118","author":"American Academy of Pediatrics","year":"2006","unstructured":"American Academy of Pediatrics: Diagnosis and management of bronchiolitis. Pediatrics. 2006, 118 (4): 1774-1793. 10.1542\/peds.2006-2223.","journal-title":"Pediatrics"},{"issue":"7628","key":"349_CR2","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1136\/bmj.39374.600081.AD","volume":"335","author":"A Bush","year":"2007","unstructured":"Bush A, Thomson AH: Acute bronchiolitis.[see comment]. BMJ. 2007, 335 (7628): 1037-1041. 10.1136\/bmj.39374.600081.AD.","journal-title":"BMJ"},{"issue":"5 suppl","key":"349_CR3","doi-asserted-by":"publisher","first-page":"s127","DOI":"10.1067\/S0022-3476(03)00510-9","volume":"143","author":"S Leader","year":"2003","unstructured":"Leader S, Kolhase K: Recent trends in severe respiratory syncytial virus (RSV) among US infants, 1997-2000. J Pediatr. 2003, 143 (5 suppl): s127-s132.","journal-title":"J Pediatr"},{"key":"349_CR4","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1001\/jama.282.15.1440","volume":"282","author":"DK Shay","year":"1999","unstructured":"Shay DK: Bronchiolitis-associated hospitalisations among US children, 1980-1996. JAMA. 1999, 282: 1440-1446. 10.1001\/jama.282.15.1440.","journal-title":"JAMA"},{"key":"349_CR5","doi-asserted-by":"publisher","first-page":"2418","DOI":"10.1542\/peds.2006-1193","volume":"118","author":"AJ Pelletier","year":"2006","unstructured":"Pelletier AJ, Mansbach JM, Camargo CA: Direct Medical Costs of Bronchiolitis Hospitalizations in the United States. Pediatrics. 2006, 118: 2418-2423. 10.1542\/peds.2006-1193.","journal-title":"Pediatrics"},{"issue":"5","key":"349_CR6","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1097\/01.PCC.0000128891.54799.67","volume":"5","author":"C Davison","year":"2004","unstructured":"Davison C, Ventre KM, Luchetti M, Randolph AG: Efficacy of interventions for bronchiolitis in critically ill infants: a systematic review and meta-analysis.[see comment]. Pediatric Critical Care Medicine. 2004, 5 (5): 482-489. 10.1097\/01.PCC.0000128891.54799.67.","journal-title":"Pediatric Critical Care Medicine"},{"key":"349_CR7","first-page":"CD001266","volume":"3","author":"AM Gadomski","year":"2006","unstructured":"Gadomski AM, Bhasale AL: Bronchodilators for bronchiolitis.[update of Cochrane Database Syst Rev. 2000;(2):CD001266; PMID: 10796626]. Cochrane Database of Systematic Reviews. 2006, 3: CD001266-","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"4","key":"349_CR8","doi-asserted-by":"publisher","first-page":"E44","DOI":"10.1542\/peds.105.4.e44","volume":"105","author":"MM Garrison","year":"2000","unstructured":"Garrison MM, Christakis DA, Harvey E, Cummings P, Davis RL: Systemic corticosteroids in infant bronchiolitis: A meta-analysis. Pediatrics. 2000, 105 (4): E44-10.1542\/peds.105.4.e44.","journal-title":"Pediatrics"},{"issue":"1","key":"349_CR9","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1067\/mpd.2002.120271","volume":"140","author":"S Schuh","year":"2002","unstructured":"Schuh S, Coates AL, Binnie R, Allin T, Goia C, Corey M, Dick PT: Efficacy of oral dexamethasone in outpatients with acute bronchiolitis.[see comment]. J Pediatr. 2002, 140 (1): 27-32. 10.1067\/mpd.2002.120271.","journal-title":"J Pediatr"},{"key":"349_CR10","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/S0140-6736(06)69077-6","volume":"368","author":"R Smyth","year":"2006","unstructured":"Smyth R, Openshaw P: Bronchiolitis. Lancet. 2006, 368: 312-322. 10.1016\/S0140-6736(06)69077-6.","journal-title":"Lancet"},{"issue":"4","key":"349_CR11","doi-asserted-by":"publisher","first-page":"e49","DOI":"10.1542\/peds.110.4.e49","volume":"110","author":"DW Johnson","year":"2002","unstructured":"Johnson DW, Adair C, Brant R, Holmwood J, Mitchell I: Differences in admission rates of children with bronchiolitis by pediatric and general emergency departments. Pediatrics. 2002, 110 (4): e49-10.1542\/peds.110.4.e49.","journal-title":"Pediatrics"},{"issue":"2","key":"349_CR12","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1046\/j.1440-1754.2003.t01-5-00121.x","volume":"39","author":"WL Yiu","year":"2003","unstructured":"Yiu WL, Smith AL, Catto-Smith AG: Nasogastric rehydration in acute gastroenteritis. J Paediatr Child Health. 2003, 39 (2): 159-161. 10.1046\/j.1440-1754.2003.t01-5-00121.x.","journal-title":"J Paediatr Child Health"},{"issue":"5","key":"349_CR13","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1001\/archpedi.158.5.483","volume":"158","author":"BK Fonseca","year":"2004","unstructured":"Fonseca BK, Holdgate A, Craig JC: Enteral vs intravenous rehydration therapy for children with gastroenteritis: a meta-analysis of randomized controlled trials. Arch Pediatr Adolesc Med. 2004, 158 (5): 483-490. 10.1001\/archpedi.158.5.483.","journal-title":"Arch Pediatr Adolesc Med"},{"doi-asserted-by":"crossref","unstructured":"Khoshoo V, Edell D: Previously Healthy Infants May Have Increased Risk of Aspiration During Respiratory Syncytial Viral Bronchiolitis. Pediatrics. 1999 (104): 1389-1390.","key":"349_CR14","DOI":"10.1542\/peds.104.6.1389"},{"key":"349_CR15","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1136\/adc.71.5.393","volume":"71","author":"R Sporik","year":"1994","unstructured":"Sporik R: Why block a small hole? The adverse effects of nasogastric tubes. Arch Dis Child. 1994, 71: 393-394. 10.1136\/adc.71.5.393.","journal-title":"Arch Dis Child"},{"key":"349_CR16","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/adc.55.1.17","volume":"55","author":"J Stocks","year":"1980","unstructured":"Stocks J: Effect of nasogastric tubes on nasal resistance during infancy. Arch Dis Child. 1980, 55: 17-21. 10.1136\/adc.55.1.17.","journal-title":"Arch Dis Child"},{"key":"349_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/S0022-3476(88)80130-6","volume":"112","author":"RJ Martin","year":"1988","unstructured":"Martin RJ, Siner B, Carlo W, Lough M, Miller MJ: Effect of head position on distribution of nasal airflow in preterm infants. J Pediatr. 1988, 112: 99-103. 10.1016\/S0022-3476(88)80130-6.","journal-title":"J Pediatr"},{"issue":"4","key":"349_CR18","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1002\/ppul.1950080408","volume":"8","author":"JS Greenspan","year":"1990","unstructured":"Greenspan JS, Wolfson MR, Holt WJ, Shaffer TH: Neonatal gastric intubation: differential respiratory effects between nasogastric and orogastric tubes. Pediatr Pulmonol. 1990, 8 (4): 254-258. 10.1002\/ppul.1950080408.","journal-title":"Pediatr Pulmonol"},{"issue":"4","key":"349_CR19","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1111\/j.1651-2227.2003.tb00573.x","volume":"92","author":"S Hanna","year":"2003","unstructured":"Hanna S, Tibby SM, Durward A, Murdoch IA: Incidence of hyponatraemia and hyponatraemic seizures in severe respiratory syncytial virus bronchiolitis. Acta Paediatr. 2003, 92 (4): 430-434.","journal-title":"Acta Paediatr"},{"issue":"7630","key":"349_CR20","doi-asserted-by":"publisher","first-page":"1109","DOI":"10.1136\/bmj.39409.367234.BE","volume":"335","author":"M Eisenhut","year":"2007","unstructured":"Eisenhut M: Acute bronchiolitis: Risk of hyponatraemia.[comment]. BMJ. 2007, 335 (7630): 1109-10.1136\/bmj.39409.367234.BE.","journal-title":"BMJ"},{"issue":"3","key":"349_CR21","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1136\/adc.2004.068916","volume":"90","author":"N Kennedy","year":"2005","unstructured":"Kennedy N, Flanagan N: Is nasogastric fluid therapy a safe alternative to the intravenous route in infants with bronchiolitis?. Arch Dis Child. 2005, 90 (3): 320-321. 10.1136\/adc.2004.068916.","journal-title":"Arch Dis Child"},{"issue":"1","key":"349_CR22","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1046\/j.1440-1754.2003.00069.x","volume":"39","author":"AM Vogel","year":"2003","unstructured":"Vogel AM, Lennon DR, Harding JE, Pinnock RE, Graham DA, Grimwood K, Pattemore PK: Variations in bronchiolitis management between five New Zealand hospitals: can we do better?. J Paediatr Child Health. 2003, 39 (1): 40-45. 10.1046\/j.1440-1754.2003.00069.x.","journal-title":"J Paediatr Child Health"},{"key":"349_CR23","volume-title":"Pediatr Emerg Care","author":"FE Babl","year":"2008","unstructured":"Babl FE, Sheriff N, Neutze J, Borland M, Oakley E: Bronchiolitis Management in Pediatric Emergency Departments in Australia and New Zealand: A PREDICT Study. Pediatr Emerg Care. 2008,"},{"issue":"3","key":"349_CR24","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1046\/j.1440-1754.2002.t01-1-00859.x","volume":"38","author":"L Sammartino","year":"2002","unstructured":"Sammartino L, James D, Goutzamanis J, Lines D: Nasogastric rehydration does have a role in acute paediatric bronchiolitis. J Paediatr Child Health. 2002, 38 (3): 321-322. 10.1046\/j.1440-1754.2002.t01-1-00859.x.","journal-title":"J Paediatr Child Health"},{"issue":"4","key":"349_CR25","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1097\/00129804-200207000-00009","volume":"25","author":"S Callaghan","year":"2002","unstructured":"Callaghan S, Copnell B, Johnston L: Comparison of two methods of peripheral intravenous cannula securement in the pediatric setting. Journal of Infusion Nursing. 2002, 25 (4): 256-264. 10.1097\/00129804-200207000-00009.","journal-title":"Journal of Infusion Nursing"},{"issue":"4","key":"349_CR26","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1097\/00129804-200607000-00009","volume":"29","author":"GJ Schears","year":"2006","unstructured":"Schears GJ: Summary of product trials for 10, 164 patients: comparing an intravenous stabilizing device to tape.[erratum appears in J Infus Nurs. 2006 Sep-Oct;29(5):242]. Journal of Infusion Nursing. 2006, 29 (4): 225-231. 10.1097\/00129804-200607000-00009.","journal-title":"Journal of Infusion Nursing"},{"issue":"5","key":"349_CR27","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1016\/j.ijnurstu.2006.02.003","volume":"44","author":"J Webster","year":"2007","unstructured":"Webster J, Lloyd S, Hopkins T, Osborne S, Yaxley M: Developing a Research base for Intravenous Peripheral cannula re-sites (DRIP trial). A randomised controlled trial of hospital in-patients. Int J Nurs Stud. 2007, 44 (5): 664-671. 10.1016\/j.ijnurstu.2006.02.003.","journal-title":"Int J Nurs Stud"},{"issue":"8","key":"349_CR28","first-page":"733","volume":"48","author":"M Nassaji-Zavareh","year":"2007","unstructured":"Nassaji-Zavareh M, Ghorbani R: Peripheral intravenous catheter-related phlebitis and related risk factors. Singapore Med J. 2007, 48 (8): 733-736.","journal-title":"Singapore Med J"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-10-37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2431-10-37\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-10-37","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-10-37.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:49:11Z","timestamp":1630496951000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/1471-2431-10-37"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["349"],"URL":"https:\/\/doi.org\/10.1186\/1471-2431-10-37","relation":{},"ISSN":["1471-2431"],"issn-type":[{"type":"electronic","value":"1471-2431"}],"subject":[],"published":{"date-parts":[[2010,6,1]]},"assertion":[{"value":"30 December 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"37"}}