{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:27:52Z","timestamp":1787066872591,"version":"build-2736575974"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T00:00:00Z","timestamp":1379721600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Severe dehydration is generally believed to be a cause of significant hyperbilirubinemia in newborn babies. This study aimed to analyze the weight loss of healthy term newborn infants at 24, 48 and 72\u00a0hours after birth to predict significant hyperbilirubinemia at 72\u00a0hours.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>From January 2007 to December 2008, we conducted this retrospective chart review by measuring total bilirubin (transcutaneous and serum) in 343 healthy, term newborns with a birth body weight of more than 2500\u00a0g. We then analyzed the association between body weight loss (BWL) and significant hyperbilirubinemia (total bilirubin more than 15\u00a0mg\/dL) 72\u00a0hours after birth. Receiver operating characteristic curves were used to evaluate the appropriate cutoff BWL percentages on the first three days after birth for the prediction of neonatal hyperbilirubinemia 72\u00a0hours after birth.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 115 (33.5%) neonates presented with significant hyperbilirubinemia 72\u00a0hours after birth, and the percentages of BWL on the first three days were all higher than those in the non-significant hyperbilirubinemia group (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Breastfeeding was not statistically correlated with significant hyperbilirubinemia (\n                      <jats:italic>p=<\/jats:italic>\n                      0.86). To predict significant hyperbilirubinemia 72\u00a0hours after birth, receiver operating characteristic curve analysis showed that the optimum cutoff BWL percentages were 4.48% on the first day of life (sensitivity: 43%, specificity: 70%, positive likelihood ratio [LR\n                      <jats:sup>+<\/jats:sup>\n                      ]: 1.43, and negative likelihood ratio [LR\n                      <jats:sup>-<\/jats:sup>\n                      ]: 0.82), 7.60% on day 2 (sensitivity: 47%, specificity: 74%, LR\n                      <jats:sup>+<\/jats:sup>\n                      : 1.81, LR\n                      <jats:sup>-<\/jats:sup>\n                      : 0.72), and 8.15% on day 3 (sensitivity: 57%, specificity: 70%, LR\n                      <jats:sup>+<\/jats:sup>\n                      : 1.92, LR\n                      <jats:sup>-<\/jats:sup>\n                      : 0.61) (all\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>BWL on the first three days after birth may be a predisposing factor for neonatal hyperbilirubinemia, and may also serve as a helpful clinical factor to prevent significant hyperbilirubinemia 72\u00a0hours after birth. The optimal BWL cutoff percentages on the first three days after birth presented in this study may predict hyperbilirubinemia and indicate the need for supplementary feeding.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1186\/1471-2431-13-145","type":"journal-article","created":{"date-parts":[[2013,9,21]],"date-time":"2013-09-21T15:03:16Z","timestamp":1379775796000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Bodyweight loss in predicting neonatal hyperbilirubinemia 72\u00a0hours after birth in term newborn infants"],"prefix":"10.1186","volume":"13","author":[{"given":"Wen-Chieh","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu-Lu","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Cheng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Hua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Ching","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Ping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,9,21]]},"reference":[{"key":"878_CR1","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1542\/peds.112.6.1264","volume":"112","author":"RH Chou","year":"2003","unstructured":"Chou RH, Ezhuthachan S: Management of hyperbilirubinemia in newborns: measuring performance by using a benchmarking model. Pediatrics. 2003, 112: 1264-1273. 10.1542\/peds.112.6.1264.","journal-title":"Pediatrics"},{"key":"878_CR2","first-page":"51","volume-title":"Pediatrics: a primary care approach","author":"CD Berkowitz","year":"2000","unstructured":"Berkowitz CD: Pediatrics: a primary care approach. 2000, Philadelphia: WB Saunders Company, 51-52. 2","edition":"2"},{"key":"878_CR3","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0022-3476(73)80014-9","volume":"82","author":"HM Maurer","year":"1973","unstructured":"Maurer HM, Shumway CN, Draper DA, Hossaini AA: Controlled trial comparing agar, intermittent phototherapy, and continuous phototherapy for reducing neonatal hyperbilirubinemia. J Pediatr. 1973, 82: 73-76. 10.1016\/S0022-3476(73)80014-9.","journal-title":"J Pediatr"},{"key":"878_CR4","doi-asserted-by":"publisher","first-page":"E11","DOI":"10.2174\/1874104500802010011","volume":"2","author":"J Noel-Weiss","year":"2008","unstructured":"Noel-Weiss J, Gourant G, Woodend AK: Physiological weight loss in the breastfed neonate: a systematic review. Open Medicine. 2008, 2: E11-E22. 10.2174\/1874104500802010011.","journal-title":"Open Medicine"},{"key":"878_CR5","doi-asserted-by":"publisher","first-page":"F158","DOI":"10.1136\/fn.87.3.F158","volume":"87","author":"IA Laing","year":"2002","unstructured":"Laing IA, Wong CM: Hypernatremia in the first few days: is the incidence rising?. Arch Dis Child Fetal Neonatal Ed. 2002, 87: F158-F162. 10.1136\/fn.87.3.F158.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"878_CR6","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1542\/peds.110.1.61","volume":"110","author":"WD Engle","year":"2002","unstructured":"Engle WD, Jackson GL, Sendelbach D, Manning D, Frawley WH: Assessment of a transcutaneous device in the evaluation of neonatal hyperbilirubinemia in a primarily hispanic population. Pediatrics. 2002, 110: 61-67. 10.1542\/peds.110.1.61.","journal-title":"Pediatrics"},{"key":"878_CR7","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1542\/peds.109.4.e53","volume":"109","author":"SU Sarici","year":"2002","unstructured":"Sarici SU, Yurdak\u00f6k M, Serdar MA, Oran O, Erdem G, Tekinalp G, et al: An early (sixth-hour) serum bilirubin measurement is useful in predicting the development of significant hyperbilirubinemia and severe ABO hemolytic disease in a selective high-risk population of newborns with ABO incompatibility. Pediatrics. 2002, 109: e53-10.1542\/peds.109.4.e53.","journal-title":"Pediatrics"},{"key":"878_CR8","doi-asserted-by":"publisher","first-page":"1140","DOI":"10.1001\/archpedi.154.11.1140","volume":"154","author":"TB Newman","year":"2000","unstructured":"Newman TB, Xiong B, Gonzales VM, Escobar GJ: Prediction and prevention of extreme neonatal hyperbilirubinemia in a mature health maintenance organization. Arch Pediatr Adolesc Med. 2000, 154: 1140-1147. 10.1001\/archpedi.154.11.1140.","journal-title":"Arch Pediatr Adolesc Med"},{"key":"878_CR9","doi-asserted-by":"publisher","first-page":"801","DOI":"10.3109\/14767050902994499","volume":"22","author":"AA Zuppa","year":"2009","unstructured":"Zuppa AA, Sindico P, Antichi E, Carducci C, Alighieri G, Cardiello V, et al: Weight loss and jaundice in healthy term newborns in partial and full rooming-in. J Matern Fetal Neonatal Med. 2009, 22: 801-805. 10.3109\/14767050902994499.","journal-title":"J Matern Fetal Neonatal Med"},{"key":"878_CR10","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S0031-3955(05)70295-9","volume":"48","author":"RJ Schanler","year":"2001","unstructured":"Schanler RJ: The use of human milk for premature infants. Pediatr Clin North Am. 2001, 48: 207-219. 10.1016\/S0031-3955(05)70295-9.","journal-title":"Pediatr Clin North Am"},{"key":"878_CR11","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/S0031-3955(05)70288-1","volume":"48","author":"MJ Heinig","year":"2001","unstructured":"Heinig MJ: Host defense benefits of breastfeeding for the infant: effect of breastfeeding duration and exclusivity. Pediatr Clin North Am. 2001, 48: 105-123. 10.1016\/S0031-3955(05)70288-1.","journal-title":"Pediatr Clin North Am"},{"key":"878_CR12","first-page":"22","volume":"89","author":"RS Horne","year":"2004","unstructured":"Horne RS, Parslow PM, Ferens D, Watts AM, Adamson TM: Comparison of evoked arousability in breast and formula fed infants. Arch Dis Child. 2004, 89: 22-25.","journal-title":"Arch Dis Child"},{"key":"878_CR13","doi-asserted-by":"crossref","first-page":"837e43","DOI":"10.1542\/peds.78.5.837","volume":"78","author":"MJ Maisels","year":"1986","unstructured":"Maisels MJ, Gifford K: Normal serum bilirubin levels in the newborn and the effect of breast-feeding. Pediatrics. 1986, 78: 837e43-","journal-title":"Pediatrics"},{"key":"878_CR14","doi-asserted-by":"publisher","first-page":"104e9","DOI":"10.1159\/000243979","volume":"64","author":"FF Rubaltelli","year":"1993","unstructured":"Rubaltelli FF: Unconjugated and conjugated bilirubin pigments during perinatal development: IV: the influence of breastfeeding on neonatal hyperbilirubinemia. Biol Neonate. 1993, 64: 104e9-","journal-title":"Biol Neonate"},{"key":"878_CR15","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1093\/ajcn\/75.6.993","volume":"75","author":"A Singghal","year":"2002","unstructured":"Singghal A, Farooqi IS, O\u2019Rahilly S, Cole TJ, Fewtrell M, Lucas A: Early nutrition and leptin concentrations in later life. Am J Clin Nutr. 2002, 75: 993-999.","journal-title":"Am J Clin Nutr"},{"key":"878_CR16","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1067\/mai.2003.127","volume":"111","author":"PC Chulada","year":"2003","unstructured":"Chulada PC, Arbes SJ, Dunson D, Zeldin DC: Breast-feeding and the prevalence of asthma and wheeze in children: analyses from the third national health and nutrition examination survey, 1988-1994. J Allergy Clin Immunol. 2003, 111: 328-336. 10.1067\/mai.2003.127.","journal-title":"J Allergy Clin Immunol"},{"key":"878_CR17","doi-asserted-by":"publisher","first-page":"2037","DOI":"10.1172\/JCI105078","volume":"43","author":"IM Arias","year":"1964","unstructured":"Arias IM, Gartner LM, Seifter S, Furman M: Prolonged neonatal unconjugated hyperbilirubinemia associated with breast feeding and a steroid, pregnane-3(alpha), 20(beta)-diol, in maternal milk that inhibits glucuronide formation in vitro. J Clin Invest. 1964, 43: 2037-2047. 10.1172\/JCI105078.","journal-title":"J Clin Invest"},{"key":"878_CR18","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1542\/peds.81.6.882","volume":"81","author":"MJ Maisels","year":"1988","unstructured":"Maisels MJ, Gifford K, Antle CE, Leib GR: Jaundice in the healthy newborn infant: a new approach to an old problem. Pediatrics. 1988, 81: 505-511.","journal-title":"Pediatrics"},{"key":"878_CR19","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1111\/j.1440-1754.2005.00688.x","volume":"41","author":"A Tarcan","year":"2005","unstructured":"Tarcan A, Tiker F, Vatandas NS, Haberal A, Gurakan B: Weight loss and hypernatremia in breast-fed babies: frequency in neonates with non-hemolytic jaundice. J Paediatr Child Health. 2005, 41: 484-487. 10.1111\/j.1440-1754.2005.00688.x.","journal-title":"J Paediatr Child Health"},{"key":"878_CR20","doi-asserted-by":"publisher","first-page":"F472","DOI":"10.1136\/fn.88.6.F472","volume":"88","author":"PD Macdonald","year":"2003","unstructured":"Macdonald PD, Ross SR, Grant L, Young D: Neonatal weight loss in breast and formula fed infants. Arch Dis Child Fetal Neonatal Ed. 2003, 88: F472-F476. 10.1136\/fn.88.6.F472.","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"878_CR21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.47102\/annals-acadmedsg.V38N3p217","volume":"38","author":"A Huang","year":"2009","unstructured":"Huang A, Tai BC, Wong LY, Lee J, Yong EL: Differential risk for early breastfeeding jaundice in a multi-ethnic Asian cohort. Ann Acad Med Singap. 2009, 38: 217-224.","journal-title":"Ann Acad Med Singap"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-13-145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2431-13-145\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-13-145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-13-145.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T14:56:46Z","timestamp":1688482606000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/1471-2431-13-145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,21]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["878"],"URL":"https:\/\/doi.org\/10.1186\/1471-2431-13-145","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,21]]},"assertion":[{"value":"1 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 September 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 September 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"145"}}