{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T16:22:54Z","timestamp":1772814174600,"version":"3.50.1"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2006,3,17]],"date-time":"2006-03-17T00:00:00Z","timestamp":1142553600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Monitoring plasma gentamicin concentrations in neonates 24 hours after a once daily dose (4 mg\/kg) often necessitates additional blood sampling. In adults a nomogram has been developed enabling evaluation of gentamicin doses by sampling concentrations with other blood tests, 4 \u2013 16 hours after administration. We attempted to develop a similar nomogram for neonates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>In addition to standard 24 hour sampling to monitor trough concentrations, one additional \"random\" gentamicin concentration was measured in each of 50 neonates &lt;4 days of age (median gestation 33 weeks [28\u201341]), when other blood samples were clinically necessary, 4 \u2013 20 hours after gentamicin administration. 24 hour concentrations of &gt;1 mg\/L were considered high, and an indication to extend the dosing interval.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Highest correlation (r<jats:sup>2<\/jats:sup> = 0.51) of plasma gentamicin concentration against time (4 to 20 hours) was with logarithmic regression. A line drawn 0.5 mg\/L below the true regression line resulted in all babies with 24 hr gentamicin concentrations &gt;1 mg\/L having the additional \"random\" test result above that line, i.e. 100% sensitivity for 24 hour concentrations&gt;1 mg\/L, though only 58% specificity. Having created the nomogram, 39 further babies (median gestation 34 weeks [28\u201341]), were studied and results tested against the nomogram. In this validation group, sensitivity of the nomogram for 24 hr concentrations &gt;1 mg\/L was 92%; specificity 14%, positive predictive value 66%, and negative predictive value 50%.<\/jats:p>\n            <jats:p>Prematurity (\u2264 37 weeks) was a more sensitive (94%) and specific (61%) indicator of high 24-hour concentrations. 62 (87%) of 71 preterm babies had high 24-hour concentrations.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>It was not possible to construct a nomogram to predict gentamicin concentrations at 24 hours in neonates with a variety of gestational ages. Dosage tailored to gestation with monitoring of trough concentrations remains management of choice.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2431-6-8","type":"journal-article","created":{"date-parts":[[2006,4,6]],"date-time":"2006-04-06T12:47:27Z","timestamp":1144327647000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["\"Random\" gentamicin concentrations do not predict trough levels in neonates receiving once daily fixed dose regimens"],"prefix":"10.1186","volume":"6","author":[{"given":"Elaine M","family":"Boyle","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isobel","family":"Brookes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Nye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mike","family":"Watkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F Andrew I","family":"Riordan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,3,17]]},"reference":[{"key":"110_CR1","volume-title":"Grune & Stratton","author":"GH McCracken Jr","year":"1983","unstructured":"McCracken GH, Nelson JD: Antimicrobial Therapy for Newborns. 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