{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:27:41Z","timestamp":1791217661172,"version":"4.1.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T00:00:00Z","timestamp":1241568000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pediatr"],"published-print":{"date-parts":[[2009,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Most patients with childhood non-organic growth hormone (GH) deficiency (GHD) produce a normal GH peak as young adults. Our objectives were to better define this transient GHD and evaluate the factors influencing the growth response of patients with pituitary stalk interruption syndrome (PSIS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 72 prepubertal patients with a GH peak &lt; 6.7 ng\/ml after 2 stimulation tests, treated with 0.2 mg GH\/kg\/w for at least 3 years. Group 1 (n = 53, 4.7 \u00b1 4.0 years) had PSIS and Group 2 (n = 19, 9.2 \u00b1 3.0 years) had transient GHD and normal pituitary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At diagnosis, 64% of Group 1 and one Group 2 were &lt; 5 years old. The growth rate of 59% Group 1 and two Group 2 patients was \u2264 -2 SDS. The GH peak of 64% Group 1 patients and no Group 2 patients was &lt; 3 ng\/ml. The plasma insulin-like growth factor-1 of all Group 1 and all but one Group 2 patients was \u2264 -2 z scores.<\/jats:p><jats:p>During the first year of GH treatment, the growth rate was \u2265 2 SDS in 81% Group 1 and 37% Group 2 patients. In Group 1, it was negatively correlated with the GH peak before treatment (P &lt; 0.03), and with the difference between the target and adult heights (P &lt; 0.01).<\/jats:p><jats:p>The height gain SDSs between diagnosis and adult height were 1.7 \u00b1 1.2 in Group 1 (n = 30) and 1.08 \u00b1 0.8 in Group 2 (n = 12, P = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The factors of the growth response to GH treatment should be analysed separately for each population: with and without PSIS or other markers.<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2431-9-29","type":"journal-article","created":{"date-parts":[[2009,5,6]],"date-time":"2009-05-06T18:16:53Z","timestamp":1241633813000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Diagnosis of growth hormone (GH) deficiency: comparison of pituitary stalk interruption syndrome and transient GH deficiency"],"prefix":"10.1186","volume":"9","author":[{"given":"Murielle","family":"Louvel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Marcu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Trivin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Souberbielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raja","family":"Brauner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,5,6]]},"reference":[{"key":"260_CR1","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/S0022-3476(05)81955-9","volume":"120","author":"M Argyropoulou","year":"1992","unstructured":"Argyropoulou M, P\u00e9rignon F, Brauner R, Brunelle F: Magnetic resonance imaging in the diagnosis of growth hormone deficiency. J Pediatr. 1992, 120: 886-891. 10.1016\/S0022-3476(05)81955-9.","journal-title":"J Pediatr"},{"key":"260_CR2","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.tem.2004.06.004","volume":"15","author":"A Badaru","year":"2004","unstructured":"Badaru A, Wilson DM: Alternatives to growth hormone stimulation testing in children. Trends in Endocrinol Metab. 2004, 15: 252-258. 10.1016\/j.tem.2004.06.004.","journal-title":"Trends in Endocrinol Metab"},{"key":"260_CR3","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1159\/000065489","volume":"58","author":"C Castro","year":"2002","unstructured":"Castro C, Trivin C, Souberbielle JC, Zerah M, Brauner R: Growth hormone deficiency: permanence and diagnosis in young adults. Horm Res. 2002, 58: 165-171. 10.1159\/000065489.","journal-title":"Horm Res"},{"key":"260_CR4","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1515\/jpem-2006-190405","volume":"19","author":"C Trivin","year":"2006","unstructured":"Trivin C, Souberbielle JC, Aubertin G, Lawson-Body E, Adan L, Brauner R: Diagnosis of idiopathic growth hormone deficiency: contributions of data on the acid-labile subunit, insulin-like growth factors (IGF) I & II and IGF binding protein \u2013 3. J Pediatr Endocrinol Metab. 2006, 19: 481-489.","journal-title":"J Pediatr Endocrinol Metab"},{"key":"260_CR5","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1210\/jc.79.2.537","volume":"79","author":"G Marin","year":"1994","unstructured":"Marin G, Domen\u00e9 HM, Barnes KM, Blackwell BJ, Cassorla FG, Cutler GB: The effects of estrogen priming and puberty on the growth hormone response to standardized treadmill exercise and arginine-insulin in normal girls and boys. J Clin Endocrinol Metab. 1994, 79: 537-541. 10.1210\/jc.79.2.537.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR6","volume-title":"Th\u00e9raplix, Paris","author":"M Semp\u00e9","year":"1979","unstructured":"Semp\u00e9 M, P\u00e9dron G, Roy-Pernot MP: Auxologie, m\u00e9thode et s\u00e9quence. Th\u00e9raplix, Paris. 1979"},{"key":"260_CR7","first-page":"13","volume":"45","author":"MF Rolland-Cachera","year":"1991","unstructured":"Rolland-Cachera MF, Cole TJ, Semp\u00e9 M, Trichet J, Rossignol C, Charrand A: Body mass index variations: centiles from birth to 87 years. Eur J Clin Nutr. 1991, 45: 13-21.","journal-title":"Eur J Clin Nutr"},{"key":"260_CR8","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1136\/adc.45.244.755","volume":"47","author":"JM Tanner","year":"1970","unstructured":"Tanner JM, Goldstein H, Whitehouse RH: Standards for children's height at ages 2\u20139 years allowing for height of parents. Arch Dis Child. 1970, 47: 755-762. 10.1136\/adc.45.244.755.","journal-title":"Arch Dis Child"},{"key":"260_CR9","volume-title":"Radiographic atlas of skeletal development of the hand and wrist","author":"W Greulich","year":"1959","unstructured":"Greulich W, Pyle S: Radiographic atlas of skeletal development of the hand and wrist. 1959, University Press, Stanford, 2","edition":"2"},{"key":"260_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/eje.1.02186","volume":"155","author":"PJ Trainer","year":"2006","unstructured":"Trainer PJ, Barth J, Sturgeon C, Wieringaon G: Consensus statement o the standardization of GH assays. Eur J Endocrinol. 2006, 155: 1-2. 10.1530\/eje.1.02186.","journal-title":"Eur J Endocrinol"},{"key":"260_CR11","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-2265.2000.00999.x","volume":"52","author":"L Bussi\u00e8res","year":"2000","unstructured":"Bussi\u00e8res L, Souberbielle JC, Pinto G, Adan L, No\u00ebl M, Brauner R: The use of insulin like growth factor 1 reference values for the diagnosis of growth hormone deficiency in prepubertal children. Clin Endocrinol. 2000, 52: 735-739. 10.1046\/j.1365-2265.2000.00999.x.","journal-title":"Clin Endocrinol"},{"issue":"1","key":"260_CR12","first-page":"MT5","volume":"15","author":"P Lemaire","year":"2009","unstructured":"Lemaire P, Brauner N, Hammer P, Trivin C, Souberbielle JC, Brauner R: Improved screening for growth hormone deficiency using logical analysis data. Med Sci Monit. 2009, 15 (1): MT5-10.","journal-title":"Med Sci Monit"},{"key":"260_CR13","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1067\/mpd.2002.122729","volume":"140","author":"S Loche","year":"2002","unstructured":"Loche S, Bizzarri C, Maghnie M, Faedda A, Tzialla C, Autelli M, Casini MR, Cappa M: Results of early reevaluation of growth hormone secretion in short children with apparent growth hormone deficiency. J Pediatr. 2002, 140: 445-449. 10.1067\/mpd.2002.122729.","journal-title":"J Pediatr"},{"key":"260_CR14","doi-asserted-by":"publisher","first-page":"4649","DOI":"10.1210\/jcem.86.10.7962","volume":"86","author":"R Coutant","year":"2001","unstructured":"Coutant R, Rouleau S, Despert F, Magontier N, Loisel D, Limal JM: Growth and adult height in GH-treated children with nonacquired GH deficiency and idiopathic short stature: the influence of pituitary magnetic resonance imaging findings. J Clin Endocrinol Metab. 2001, 86: 4649-4654. 10.1210\/jc.86.10.4649.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1046\/j.1365-2265.2003.01768.x","volume":"58","author":"D Zenaty","year":"2003","unstructured":"Zenaty D, Garel C, Limoni C, Czernichow P, L\u00e9ger J: Presence of magnetic resonance imaging abnormalities of the hypothalamic-pituitary axis is a significant determinant of the first 3 years growth response to human growth hormone treatment in prepubertal children with nonacquired growth hormone deficiency. Clin Endocr. 2003, 58: 647-652.","journal-title":"Clin Endocr"},{"key":"260_CR16","doi-asserted-by":"publisher","first-page":"2900","DOI":"10.1210\/jc.2006-0050","volume":"91","author":"M Maghnie","year":"2006","unstructured":"Maghnie M, Ambrosini L, Cappa M, Pozzobon G, Ghizzoni L, Ubertini MG, di Iorgi N, Tinelli C, Pilia S, Chiumello G, Lorini R, Loche S: Adult height in patients with permanent growth hormone deficiency with and without multiple pituitary hormone deficiencies. J Clin Endocrinol Metab. 2006, 91: 2900-2905. 10.1210\/jc.2006-0050.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR17","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1210\/jcem.82.2.3734","volume":"82","author":"SL Blethen","year":"1997","unstructured":"Blethen SL, Baptista J, Kuntze J, Foley T, LaFranchi S, Johanson A, on behalf of the Genentech Growth Study Group: Adult height in growth hormone (GH)-deficient children treated with biosynthetic GH. J Clin Endocrinol Metab. 1997, 82: 418-420. 10.1210\/jc.82.2.418.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR18","doi-asserted-by":"publisher","first-page":"2047","DOI":"10.1210\/jc.2005-2284","volume":"91","author":"EO Reiter","year":"2006","unstructured":"Reiter EO, Price DA, Wilton P, Albertsson-Wikland K, Ranke MB: Effect of growth hormone (GH) treatment on the near-final height of 1258 patients with idiopathic GH deficiency: analysis of a large international database. J Clin Endocrinol Metab. 2006, 91: 2047-2054. 10.1210\/jc.2005-2284.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR19","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1210\/jc.2006-1259","volume":"92","author":"MAJ De Ridder","year":"2007","unstructured":"De Ridder MAJ, Stijnen T, Hokken-Koelega ACS: Prediction of adult height in growth-hormone-treated children with growth hormone deficiency. J Clin Endocrinol Metab. 2007, 92: 925-931. 10.1210\/jc.2006-1259.","journal-title":"J Clin Endocrinol Metab"},{"key":"260_CR20","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1136\/adc.2003.043406","volume":"89","author":"TJ Cole","year":"2004","unstructured":"Cole TJ, Hindmarsh PC, Dunger DB: Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency. Arch Dis Child. 2004, 89: 1024-1027. 10.1136\/adc.2003.043406.","journal-title":"Arch Dis Child"},{"key":"260_CR21","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1159\/000053182","volume":"53","author":"J Van den Broeck","year":"2000","unstructured":"Broeck Van den J, Arends N, Hokken-Koelega A: Growth response to recombinant human growth hormone (GH) in children with idiopathic growth retardation by level of maximum GH peak during GH stimulation tests. Horm Res. 2000, 53: 267-273. 10.1159\/000053182.","journal-title":"Horm Res"},{"key":"260_CR22","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1016\/j.ghir.2005.06.005","volume":"15","author":"DM Wilson","year":"2005","unstructured":"Wilson DM, Frane J: A brief review of the use and utility of growth hormone stimulation testing in the NCGS: Do we need to do provocative GH testing?. Growth Horm & IGF Res. 2005, 15: S21-S25. 10.1016\/j.ghir.2005.06.005.","journal-title":"Growth Horm & IGF Res"},{"key":"260_CR23","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1542\/peds.104.S5.1028","volume":"104","author":"GM Bright","year":"1999","unstructured":"Bright GM, Julius JR, Lima J, Blethen S: Growth hormone stimulation test results as predictors of recombinant human growth hormone treatment outcomes: preliminary analysis of the National Cooperative Growth Study Database. Pediatrics. 1999, 104: 1028-1031.","journal-title":"Pediatrics"}],"container-title":["BMC Pediatrics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-9-29.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2431-9-29\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-9-29","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2431-9-29.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,13]],"date-time":"2024-03-13T05:27:04Z","timestamp":1710307624000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpediatr.biomedcentral.com\/articles\/10.1186\/1471-2431-9-29"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5,6]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["260"],"URL":"https:\/\/doi.org\/10.1186\/1471-2431-9-29","relation":{},"ISSN":["1471-2431"],"issn-type":[{"value":"1471-2431","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,5,6]]},"assertion":[{"value":"24 January 2009","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2009","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 May 2009","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"29"}}