{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:15:53Z","timestamp":1790518553379,"version":"4.1.0"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,7,5]],"date-time":"2014-07-05T00:00:00Z","timestamp":1404518400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Psychiatry"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-244x-14-192","type":"journal-article","created":{"date-parts":[[2014,7,4]],"date-time":"2014-07-04T21:01:37Z","timestamp":1404507697000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Telomere shortening in leukocyte subpopulations in depression"],"prefix":"10.1186","volume":"14","author":[{"given":"Alexander","family":"Karabatsiakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris-Tatjana","family":"Kolassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kolassa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K Lenhard","family":"Rudolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef E","family":"Dietrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,5]]},"reference":[{"key":"1692_CR1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.18632\/aging.100007","volume":"1","author":"ES Epel","year":"2008","unstructured":"Epel ES, Merkin SS, Cawthon R, Blackburn EH, Adler NE, Pletcher MJ: The rate of leukocyte telomere shortening predicts mortality from cardiovascular disease in elderly men. Aging. 2008, 1: 81-88.","journal-title":"Aging"},{"key":"1692_CR2","first-page":"57","volume":"32","author":"M Massie","year":"2011","unstructured":"Massie M, Lloyd-Williams M: The prevalence of depression in people with cancer. J Natl Cancer Inst. 2011, 32: 57-71.","journal-title":"J Natl Cancer Inst"},{"key":"1692_CR3","doi-asserted-by":"publisher","first-page":"197","DOI":"10.2174\/1566524053586545","volume":"5","author":"T Von Zglinicki","year":"2005","unstructured":"Von Zglinicki T, Martin-Ruiz CM: Telomeres as biomarkers for ageing and age-related diseases. Curr Mol Med. 2005, 5: 197-203.","journal-title":"Curr Mol Med"},{"key":"1692_CR4","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.4049\/jimmunol.165.3.1191","volume":"165","author":"NH Son","year":"2000","unstructured":"Son NH, Murray S, Yanovski J, Hodes RJ, Weng N: Lineage-specific telomere shortening and unaltered capacity for telomerase expression in human T and B lymphocytes with age. J Immunol. 2000, 165: 1191-1196.","journal-title":"J Immunol"},{"key":"1692_CR5","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1001\/jama.2010.897","volume":"304","author":"P Willeit","year":"2010","unstructured":"Willeit P, Willeit J, Mayr A, Weger S, Oberhollenzer F, Brandst\u00e4tter A: Telomere length and risk of incident cancer and cancer mortality. JAMA. 2010, 304: 69-75.","journal-title":"JAMA"},{"key":"1692_CR6","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1098\/rsbl.2006.0594","volume":"3","author":"A Kotrschal","year":"2007","unstructured":"Kotrschal A, Ilmonen P, Penn DJ: Stress impacts telomere dynamics. Biology Lett. 2007, 3: 128-130.","journal-title":"Biology Lett"},{"key":"1692_CR7","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1016\/j.bbi.2008.11.006","volume":"23","author":"A O\u2019Donovan","year":"2009","unstructured":"O\u2019Donovan A, Lin J, Dhabhar FS, Wolkowitz O, Tillie JM, Blackburn E: Pessimism correlates with leukocyte telomere shortness and elevated interleukin-6 in post-menopausal women. Brain Behav Immun. 2009, 23: 446-449.","journal-title":"Brain Behav Immun"},{"key":"1692_CR8","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/j.biopsych.2011.01.035","volume":"70","author":"A O\u2019Donovan","year":"2011","unstructured":"O\u2019Donovan A, Epel E, Lin J, Wolkowitz O, Cohen B, Maguen S: Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorder. Biol Psychiat. 2011, 70: 465-471.","journal-title":"Biol Psychiat"},{"key":"1692_CR9","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/mp.2011.53","volume":"17","author":"SS Drury","year":"2011","unstructured":"Drury SS, Theall K, Gleason MM, Smyke AT, De Vivo I, Wong JYY: Telomere length and early severe social deprivation: linking early adversity and cellular aging. Mol Psychiatr. 2011, 17: 719-727.","journal-title":"Mol Psychiatr"},{"key":"1692_CR10","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1016\/j.biopsych.2006.02.004","volume":"60","author":"NM Simon","year":"2006","unstructured":"Simon NM, Smoller JW, McNamara KL, Maser RS, Zalta AK, Pollack MH: Telomere shortening and mood disorders: preliminary support for a chronic stress model of accelerated aging. Biol Psychiat. 2006, 60: 432-435.","journal-title":"Biol Psychiat"},{"key":"1692_CR11","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1016\/j.biopsych.2011.09.015","volume":"71","author":"M Wikgren","year":"2012","unstructured":"Wikgren M, Maripuu M, Karlsson T, Nordfj\u00e4ll K, Bergdahl J, Hultdin J: Short telomeres in depression and the general population are associated with a hypocortisolemic state. Biol Psychiat. 2012, 71: 294-300.","journal-title":"Biol Psychiat"},{"key":"1692_CR12","doi-asserted-by":"publisher","first-page":"17312","DOI":"10.1073\/pnas.0407162101","volume":"101","author":"ES Epel","year":"2004","unstructured":"Epel ES, Blackburn EH, Lin J, Dhabhar FS, Adler NE, Morrow JD: Accelerated telomere shortening in response to life stress. PNAS. 2004, 101: 17312-17315.","journal-title":"PNAS"},{"key":"1692_CR13","first-page":"w13659","volume":"142","author":"K Brieger","year":"2012","unstructured":"Brieger K, Schiavone S, Miller FJ, Krause KH: Reactive oxygen species: from health to disease. Swiss Med Wkly. 2012, 142: w13659-","journal-title":"Swiss Med Wkly"},{"key":"1692_CR14","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/S0968-0004(02)02110-2","volume":"27","author":"T Von Zglinicki","year":"2002","unstructured":"Von Zglinicki T: Oxidative stress shortens telomeres. Trends Biochem Sci. 2002, 27: 339-344.","journal-title":"Trends Biochem Sci"},{"key":"1692_CR15","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.biocel.2006.07.001","volume":"39","author":"M Valko","year":"2007","unstructured":"Valko M, Leibfritz D, Moncol J, Cronin MTD, Mazur M, Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell B. 2007, 39: 44-84.","journal-title":"Int J Biochem Cell B"},{"key":"1692_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/brbi.2001.0654","volume":"16","author":"M Irwin","year":"2002","unstructured":"Irwin M: Psychoneuroimmunology of depression: clinical implications. Brain Behav Immun. 2002, 16: 1-16.","journal-title":"Brain Behav Immun"},{"key":"1692_CR17","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jim.2009.09.012","volume":"352","author":"J Lin","year":"2010","unstructured":"Lin J, Epel E, Cheon J, Kroenke C, Sinclair E, Bigos M: Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenance. J Immunol Methods. 2010, 352: 71-80.","journal-title":"J Immunol Methods"},{"key":"1692_CR18","doi-asserted-by":"publisher","first-page":"4249","DOI":"10.4049\/jimmunol.179.6.4249","volume":"179","author":"AK Damjanovic","year":"2007","unstructured":"Damjanovic AK, Yang Y, Glaser R, Kiecolt-Glaser JK, Nguyen H, Laskowski B: Accelerated telomere erosion is associated with a declining immune function of caregivers of Alzheimer\u2019s disease patients. J Immunol. 2007, 179: 4249-4254.","journal-title":"J Immunol"},{"key":"1692_CR19","unstructured":"Beck AT: Beck Depression Inventory. Bellack AS & Hersen M, editors. 2006, Depression 2-4"},{"key":"1692_CR20","volume-title":"Beck Depression-Inventar 2 (BDI 2)","author":"M Hautzinger","year":"2006","unstructured":"Hautzinger M, Keller F, Kuehner C: Beck Depression-Inventar 2 (BDI 2). 2006, Testhandbuch. Frankfurt a.M: Harcourt Test Service"},{"key":"1692_CR21","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/S0091-679X(01)64007-X","volume":"64","author":"SS Poon","year":"2001","unstructured":"Poon SS, Lansdorp PM: Measurements of telomere length on individual chromosomes by image cytometry. Method Cell Biol. 2001, 64: 69-96.","journal-title":"Method Cell Biol"},{"key":"1692_CR22","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013","unstructured":"R Core Team: R: A Language and Environment for Statistical Computing. 2013, Vienna, Austria: R Foundation for Statistical Computing, URL: http:\/\/www.R-project.org\/"},{"key":"1692_CR23","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1093\/biomet\/52.3-4.591","volume":"2","author":"SS Shapiro","year":"1965","unstructured":"Shapiro SS, Wilk MB: An analysis of variance test for normality (complete samples). Biometrika. 1965, 2: 591-611.","journal-title":"Biometrika"},{"key":"1692_CR24","doi-asserted-by":"publisher","first-page":"80","DOI":"10.2307\/3001968","volume":"1","author":"F Wilcoxon","year":"1945","unstructured":"Wilcoxon F: Individual comparisons by ranking methods. Biometrics Bull. 1945, 1: 80-83.","journal-title":"Biometrics Bull"},{"key":"1692_CR25","doi-asserted-by":"publisher","first-page":"912","DOI":"10.2307\/3803199","volume":"64","author":"DR Anderson","year":"2000","unstructured":"Anderson DR, Burnham KP, Thompson WL: Null hypothesis Testing: Problems, Prevalence, and an Alternative. J Wildlife Manage. 2000, 64: 912-923.","journal-title":"J Wildlife Manage"},{"key":"1692_CR26","first-page":"2","volume":"53","author":"BD Naliboff","year":"1997","unstructured":"Naliboff BD, Benton D, Solomon GF, Morley JE, Fahey JL, Bloom ET, Makinodan T, Gilmore SL: Immunological changes in young and old adults during brief laboratory stress. Psychosom Med. 1997, 53: 2-","journal-title":"Psychosom Med"},{"key":"1692_CR27","doi-asserted-by":"publisher","first-page":"742","DOI":"10.1038\/nm1578","volume":"13","author":"Z Ju","year":"2007","unstructured":"Ju Z, Jiang H, Jaworski M, Rathinam C, Gompf A, Klein C: Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med. 2007, 13: 742-747.","journal-title":"Nat Med"},{"key":"1692_CR28","first-page":"1","volume-title":"Mol Psychiatr","author":"JE Verhoeven","year":"2013","unstructured":"Verhoeven JE, Revesz D, Epel ES, Lin J, Wolkowitz OM, Penninx BWJH: Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol Psychiatr. 2013, 1-7."},{"key":"1692_CR29","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1001\/archpsyc.63.4.375","volume":"63","author":"EW Freeman","year":"2006","unstructured":"Freeman EW, Sammel MD, Lin H, Nelson DB: Associations of hormones and menopausal status with depressed mood in women with no history of depression. Arch Gen Psychiat. 2006, 63: 375-382.","journal-title":"Arch Gen Psychiat"},{"key":"1692_CR30","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1002\/da.20749","volume":"12","author":"N Hartmann","year":"2010","unstructured":"Hartmann N, Boehner M, Groenen F, Kalb R: Telomere length of patients with major depression is shortened but independent from therapy and severity of the disease. Depress Anxiety. 2010, 12: 1111-1116.","journal-title":"Depress Anxiety"},{"key":"1692_CR31","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1016\/S0278-5846(02)00226-9","volume":"26","author":"GA Fava","year":"2002","unstructured":"Fava GA, Fabbri S, Sonino N: Residual symptoms in depression: an emerging therapeutic target. Prog Neuro-psychoph. 2002, 26: 1019-1027.","journal-title":"Prog Neuro-psychoph"},{"key":"1692_CR32","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/S0165-0327(03)00054-5","volume":"80","author":"N Kennedy","year":"2004","unstructured":"Kennedy N, Paykel ES: Residual symptoms at remission from depression: impact on long-term outcome. J Affect Disorders. 2004, 80: 135-144.","journal-title":"J Affect Disorders"},{"key":"1692_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1159\/000029018","volume":"31","author":"ES Paykel","year":"1998","unstructured":"Paykel ES: Remission and residual symptomatology in major depression. Psychopathology. 1998, 31: 5-14.","journal-title":"Psychopathology"},{"key":"1692_CR34","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1037\/0021-843X.98.2.107","volume":"98","author":"PM Lewinsohn","year":"1989","unstructured":"Lewinsohn PM, Zeiss AM, Duncan EM: Probability of relapse after recovery from an episode of depression. J Abnorm Psychol. 1989, 98: 107-116.","journal-title":"J Abnorm Psychol"},{"key":"1692_CR35","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/ni1033","volume":"5","author":"PJ Linton","year":"2004","unstructured":"Linton PJ, Dorshkind K: Age-related changes in lymphocyte development and function. Nat Immunol. 2004, 5: 133-139.","journal-title":"Nat Immunol"},{"key":"1692_CR36","doi-asserted-by":"publisher","first-page":"1117","DOI":"10.1016\/j.bbi.2009.07.003","volume":"23","author":"A Sommershof","year":"2009","unstructured":"Sommershof A, Aichinger H, Adenauer H, Catani C, Boneberg E, Engler H, Elbert T, Groettrup M, Kolassa IT: Substantial reduction of na\u00efve and regulatory T cells following traumatic stress. Brain Behav Immun. 2009, 23: 1117-1124.","journal-title":"Brain Behav Immun"},{"key":"1692_CR37","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1016\/j.bbi.2007.12.004","volume":"22","author":"J Choi","year":"2008","unstructured":"Choi J, Fauce SR, Effros RB: Reduced telomerase activity in human T lymphocytes exposed to cortisol. Brain Behav Immun. 2008, 22: 600-605.","journal-title":"Brain Behav Immun"},{"key":"1692_CR38","doi-asserted-by":"publisher","first-page":"e10826","DOI":"10.1371\/journal.pone.0010826","volume":"5","author":"L Kananen","year":"2010","unstructured":"Kananen L, Surakka I, Pirkola S, Suvisaari J, L\u00f6nnqvist J, Peltonen L: Childhood adversities are associated with shorter telomere length at adult age both in individuals with an anxiety disorder and controls. PLOS ONE. 2010, 5: e10826-","journal-title":"PLOS ONE"},{"key":"1692_CR39","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1111\/j.1447-0594.2010.00605.x","volume":"10","author":"K Takubo","year":"2010","unstructured":"Takubo K, Aida J, Izumiyama-Shimomura N, Ishikawa N, Sawabe M, Kurabayashi R: Changes of telomere length with aging. Geriatr Gerontol Int. 2010, 10: 197-206.","journal-title":"Geriatr Gerontol Int"},{"key":"1692_CR40","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1203\/00006450-200209000-00012","volume":"52","author":"K Okuda","year":"2002","unstructured":"Okuda K, Bardeguez A, Gardner JP, Rodriguez P, Ganesh V, Kimura M: Telomere length in the newborn. Pediatr Res. 2002, 52: 377-381.","journal-title":"Pediatr Res"}],"container-title":["BMC Psychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-244X-14-192.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-244X-14-192\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-244X-14-192","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,7,10]],"date-time":"2016-07-10T07:52:13Z","timestamp":1468137133000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcpsychiatry.biomedcentral.com\/articles\/10.1186\/1471-244X-14-192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,5]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["1692"],"URL":"https:\/\/doi.org\/10.1186\/1471-244x-14-192","relation":{},"ISSN":["1471-244X"],"issn-type":[{"value":"1471-244X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,5]]},"article-number":"192"}}