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There is also some limited evidence that vitamin D influences insulin resistance, and thus the early stages of the development of type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighty-four women of South Asian origin, living in Auckland, New Zealand, were randomised to receive either a supplement (4000IU 25(OH)D<jats:sub>3<\/jats:sub>per day) or a placebo for 6 months. At baseline, all participants were vitamin D deficient (serum 25(OH)D<jats:sub>3<\/jats:sub>&lt;50 nmol\/L), insulin resistant (HOMA-IR &gt; 1.93) and\/or hyperinsulinaemic, hyperglycemic or had clinical signs of dislipidaemia. Changes in HOMA-IR, lipids, parathyroid hormone, calcium and bone markers were monitored at 3 months and 6 months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This randomised, controlled trial will be the first to investigate the effect of vitamin D supplementation on insulin resistance in non-diabetic subjects. It will subsequently contribute to the growing body of evidence about the role of vitamin D in metabolic syndrome.Registered clinical.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration<\/jats:title><jats:p>Registered clinical trial \u2013 Registration No. ACTRN12607000642482<\/jats:p><\/jats:sec>","DOI":"10.1186\/1471-2458-8-267","type":"journal-article","created":{"date-parts":[[2008,7,31]],"date-time":"2008-07-31T06:13:46Z","timestamp":1217484826000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Study Protocol \u2013 Metabolic syndrome, vitamin D and bone status in South Asian women living in Auckland, New Zealand: A randomised, placebo-controlled, double-blind vitamin D intervention"],"prefix":"10.1186","volume":"8","author":[{"given":"Pamela R","family":"von Hurst","sequence":"first","affiliation":[]},{"given":"Welma","family":"Stonehouse","sequence":"additional","affiliation":[]},{"given":"Christophe","family":"Matthys","sequence":"additional","affiliation":[]},{"given":"Cathryn","family":"Conlon","sequence":"additional","affiliation":[]},{"given":"Marlena C","family":"Kruger","sequence":"additional","affiliation":[]},{"given":"Jane","family":"Coad","sequence":"additional","affiliation":[]}],"member":"297","published-online":{"date-parts":[[2008,7,31]]},"reference":[{"issue":"12","key":"1237_CR1","doi-asserted-by":"publisher","first-page":"1641","DOI":"10.1007\/s00198-005-1888-2","volume":"16","author":"JA Lucas","year":"2005","unstructured":"Lucas JA, Bolland MJ, Grey AB, Ames RW, Mason BH, Horne AM, Gamble GD, Reid IR: Determinants of vitamin D status in older women living in a subtropical climate. 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