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Mp and host defense proteins short palate, lung, and nasal epithelial clone 1 (SPLUNC1) and \u03b2-defensin-2 were quantified. Expression of \u03b22-adrenergic receptors was also measured by real-time quantitative RT-PCR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>(R)- or racemic albuterol and (R,R)- or racemic formoterol significantly decreased Mp levels in normal and asthma epithelial cells. Normal cells treated with Mp and (R)- or racemic albuterol showed an increase in SPLUNC1, but not in \u03b2-defensin-2. COPD cells did not respond to drug treatment with a significant decrease in Mp or an increase in SPLUNC1. IL-13 attenuated drug effects on Mp, and markedly decreased SPLUNC1 and \u03b22-adrenergic receptors.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>These results for the first time show that \u03b22-agonists enhance host defense functions of primary bronchial epithelial cells from normal and asthma subjects, which is attenuated by IL-13.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2466-10-30","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T18:15:57Z","timestamp":1273860957000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["\u03b22-agonists promote host defense against bacterial infection in primary human bronchial epithelial cells"],"prefix":"10.1186","volume":"10","author":[{"given":"Claire A","family":"Gross","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P","family":"Bowler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca M","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew R","family":"Weinberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Wei","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,14]]},"reference":[{"key":"200_CR1","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1164\/ajrccm.162.3.9912134","volume":"162","author":"L Wu","year":"2000","unstructured":"Wu L, Skinner SJM, Lambie N, Vuletic JC, Blasi R, Black PN: Immunohistochemical staining for Chlamydia pneumoniae is increased in lung tissue from subjects with chronic obstructive pulmonary disease. 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