{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:04:13Z","timestamp":1761059053807},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Aspirin-intolerant asthma (AIA), which is caused by non-steroidal anti-inflammatory drugs (NSAIDs) such as aspirin, causes lung inflammation and reversal bronchi reduction, leading to difficulty in breathing. Aspirin is known to affect various parts inside human body, ranging from lung to spermatogenesis. <jats:italic>FSIP1<\/jats:italic>, also known as <jats:italic>HDS10<\/jats:italic>, is a recently discovered gene that encodes fibrous sheath interacting protein 1, and is regulated by amyloid beta precursor protein (APP). Recently, it has been reported that a peptide derived from APP is cleaved by \u03b1 disintegrin and metalloproteinase 33 (<jats:italic>ADAM33<\/jats:italic>), which is an asthma susceptibility gene. It has also been known that the <jats:italic>FSIP1<\/jats:italic> gene is expressed in airway epithelium.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Objectives<\/jats:title>\n            <jats:p>Aim of this study is to find out whether <jats:italic>FSIP1<\/jats:italic> polymorphisms affect the onset of AIA in Korean population, since it is known that AIA is genetically affected by various genes.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>We conducted association study between 66 single nucleotide polymorphisms (SNPs) of the <jats:italic>FSIP1<\/jats:italic> gene and AIA in total of 592 Korean subjects including 163 AIA and 429 aspirin-tolerant asthma (ATA) patients. Associations between polymorphisms of <jats:italic>FSIP1<\/jats:italic> and AIA were analyzed with sex, smoking status, atopy, and body mass index (BMI) as covariates.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>Initially, 18 SNPs and 4 haplotypes showed associations with AIA. However, after correcting the data for multiple testing, only one SNP showed an association with AIA (corrected <jats:italic>P<\/jats:italic>-value = 0.03, OR = 1.63, 95% CI = 1.23-2.16), showing increased susceptibility to AIA compared with that of ATA cases. Our findings suggest that <jats:italic>FSIP1<\/jats:italic> gene might be a susceptibility gene for aspirin intolerance in asthmatics.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Although our findings did not suggest that SNPs of <jats:italic>FSIP1<\/jats:italic> had an effect on the reversibility of lung function abnormalities in AIA patients, they did show significant evidence of association between the variants in <jats:italic>FSIP1<\/jats:italic> and AIA occurrence among asthmatics in a Korean population.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2466-10-34","type":"journal-article","created":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T06:14:28Z","timestamp":1275372868000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Positive Association between Aspirin-Intolerant Asthma and Genetic Polymorphisms of FSIP1: a Case-Case Study"],"prefix":"10.1186","volume":"10","author":[{"given":"Jason Yongha","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joon Seol","family":"Bae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Sol","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charisse Flerida","family":"Pasaje","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Lae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sub","family":"Cheong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong-Sook","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Woo","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Taek","family":"Uh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mi-Kyeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inseon S","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Heon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byoung Whui","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Choon-Sik","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Doo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,6,1]]},"reference":[{"key":"204_CR1","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1056\/NEJMra0804579","volume":"360","author":"CH Fanta","year":"2009","unstructured":"Fanta CH: Asthma. N Engl J Med. 2009, 360: 1002-1014. 10.1056\/NEJMra0804579.","journal-title":"N Engl J Med"},{"key":"204_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.2500\/108854193778774065","volume":"14","author":"F Widal","year":"1993","unstructured":"Widal F, Abrami P, Lermoyez J: Anaphylaxie et idiosyncrasie. 1992 [Anaphylaxis and idiosyncrasy. 1992]. Allergy Proc. 1993, 14: 373-376. 10.2500\/108854193778774065. discussion 371-372","journal-title":"Allergy Proc"},{"key":"204_CR3","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1378\/chest.118.5.1470","volume":"118","author":"KS Babu","year":"2000","unstructured":"Babu KS, Salvi SS: Aspirin and asthma. Chest. 2000, 118: 1470-1476. 10.1378\/chest.118.5.1470.","journal-title":"Chest"},{"key":"204_CR4","doi-asserted-by":"publisher","first-page":"85","DOI":"10.2217\/14622416.9.1.85","volume":"9","author":"SH Kim","year":"2008","unstructured":"Kim SH, Hur GY, Choi JH, Park HS: Pharmacogenetics of aspirin-intolerant asthma. Pharmacogenomics. 2008, 9: 85-91. 10.2217\/14622416.9.1.85.","journal-title":"Pharmacogenomics"},{"key":"204_CR5","doi-asserted-by":"publisher","first-page":"356","DOI":"10.1016\/j.rmed.2008.10.008","volume":"103","author":"SH Kim","year":"2009","unstructured":"Kim SH, Kim YK, Park HW, Kim SH, Kim SH, Ye YM, Min KU, Park HS: Adenosine deaminase and adenosine receptor polymorphisms in aspirin-intolerant asthma. Respir Med. 2009, 103: 356-363. 10.1016\/j.rmed.2008.10.008.","journal-title":"Respir Med"},{"key":"204_CR6","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.2217\/14622416.8.9.1143","volume":"8","author":"SH Kim","year":"2007","unstructured":"Kim SH, Ye YM, Hur GY, Lee SK, Sampson AP, Lee HY, Park HS: CysLTR1 promoter polymorphism and requirement for leukotriene receptor antagonist in aspirin-intolerant asthma patients. Pharmacogenomics. 2007, 8: 1143-1150. 10.2217\/14622416.8.9.1143.","journal-title":"Pharmacogenomics"},{"key":"204_CR7","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1097\/01.fpc.0000239977.61841.fe","volume":"17","author":"SH Kim","year":"2007","unstructured":"Kim SH, Kim YK, Park HW, Jee YK, Kim SH, Bahn JW, Chang YS, Kim SH, Ye YM, Shin ES, et al: Association between polymorphisms in prostanoid receptor genes and aspirin-intolerant asthma. Pharmacogenet Genomics. 2007, 17: 295-304. 10.1097\/01.fpc.0000239977.61841.fe.","journal-title":"Pharmacogenet Genomics"},{"key":"204_CR8","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1111\/j.1398-9995.2009.01989.x","volume":"64","author":"SH Kim","year":"2009","unstructured":"Kim SH, Yang EM, Lee HN, Cho BY, Ye YM, Park HS: Combined effect of IL-10 and TGF-beta1 promoter polymorphisms as a risk factor for aspirin-intolerant asthma and rhinosinusitis. Allergy. 2009, 64: 1221-1225. 10.1111\/j.1398-9995.2009.01989.x.","journal-title":"Allergy"},{"key":"204_CR9","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1111\/j.1365-2222.2008.02965.x","volume":"38","author":"TH Kim","year":"2008","unstructured":"Kim TH, Chang HS, Park SM, Nam BY, Park JS, Rhim T, Park HS, Kim MK, Choi IS, Cho SH, et al: Association of angiotensin I-converting enzyme gene polymorphisms with aspirin intolerance in asthmatics. Clin Exp Allergy. 2008, 38: 1727-1737. 10.1111\/j.1365-2222.2008.02965.x.","journal-title":"Clin Exp Allergy"},{"key":"204_CR10","doi-asserted-by":"publisher","first-page":"1132","DOI":"10.1016\/j.rmed.2008.03.017","volume":"102","author":"NS Palikhe","year":"2008","unstructured":"Palikhe NS, Kim SH, Cho BY, Ye YM, Hur GY, Park HS: Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma. Respir Med. 2008, 102: 1132-1139. 10.1016\/j.rmed.2008.03.017.","journal-title":"Respir Med"},{"key":"204_CR11","doi-asserted-by":"publisher","first-page":"2241","DOI":"10.1095\/biolreprod.102.013466","volume":"68","author":"PR Brown","year":"2003","unstructured":"Brown PR, Miki K, Harper DB, Eddy EM: A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Biol Reprod. 2003, 68: 2241-2248. 10.1095\/biolreprod.102.013466.","journal-title":"Biol Reprod"},{"key":"204_CR12","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s00109-006-0103-z","volume":"85","author":"BG Harvey","year":"2007","unstructured":"Harvey BG, Heguy A, Leopold PL, Carolan BJ, Ferris B, Crystal RG: Modification of gene expression of the small airway epithelium in response to cigarette smoking. J Mol Med. 2007, 85: 39-53. 10.1007\/s00109-006-0103-z.","journal-title":"J Mol Med"},{"key":"204_CR13","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0006-8993(02)03354-1","volume":"954","author":"GY Wen","year":"2002","unstructured":"Wen GY, Yang SY, Kaczmarski W, He XY, Pappas KS: Presence of hydroxysteroid dehydrogenase type 10 in amyloid plaques (APs) of Hsiao's APP-Sw transgenic mouse brains, but absence in APs of Alzheimer's disease brains. Brain Res. 2002, 954: 115-122. 10.1016\/S0006-8993(02)03354-1.","journal-title":"Brain Res"},{"key":"204_CR14","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1007\/s10038-006-0081-6","volume":"52","author":"T Sakagami","year":"2007","unstructured":"Sakagami T, Jinnai N, Nakajima T, Sekigawa T, Hasegawa T, Suzuki E, Inoue I, Gejyo F: ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet. 2007, 52: 66-72. 10.1007\/s10038-006-0081-6.","journal-title":"J Hum Genet"},{"key":"204_CR15","doi-asserted-by":"publisher","first-page":"9818","DOI":"10.1074\/jbc.M309696200","volume":"279","author":"J Zou","year":"2004","unstructured":"Zou J, Zhu F, Liu J, Wang W, Zhang R, Garlisi CG, Liu YH, Wang S, Shah H, Wan Y, et al: Catalytic activity of human ADAM33. J Biol Chem. 2004, 279: 9818-9830. 10.1074\/jbc.M309696200.","journal-title":"J Biol Chem"},{"key":"204_CR16","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1164\/ajrccm.161.1.ats11-99","volume":"161","author":"RO Crapo","year":"2000","unstructured":"Crapo RO, Casaburi R, Coates AL, Enright PL, Hankinson JL, Irvin CG, MacIntyre NR, McKay RT, Wanger JS, Anderson SD, et al: Guidelines for methacholine and exercise challenge testing-1999. This official statement of the American Thoracic Society was adopted by the ATS Board of Directors, July 1999. Am J Respir Crit Care Med. 2000, 161: 309-329.","journal-title":"Am J Respir Crit Care Med"},{"key":"204_CR17","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1164\/rccm.200505-740OC","volume":"173","author":"SH Lee","year":"2006","unstructured":"Lee SH, Rhim T, Choi YS, Min JW, Kim SH, Cho SY, Paik YK, Park CS: Complement C3a and C4a increased in plasma of patients with aspirin-induced asthma. Am J Respir Crit Care Med. 2006, 173: 370-378. 10.1164\/rccm.200505-740OC.","journal-title":"Am J Respir Crit Care Med"},{"key":"204_CR18","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1111\/j.1365-2222.2005.02261.x","volume":"35","author":"LJ Cormican","year":"2005","unstructured":"Cormican LJ, Farooque S, Altmann DR, Lee TH: Improvements in an oral aspirin challenge protocol for the diagnosis of aspirin hypersensitivity. Clin Exp Allergy. 2005, 35: 717-722. 10.1111\/j.1365-2222.2005.02261.x.","journal-title":"Clin Exp Allergy"},{"key":"204_CR19","doi-asserted-by":"crossref","unstructured":"Oliphant A, Barker DL, Stuelpnagel JR, Chee MS: BeadArray technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques. 2002, 56-58. 60-51, Suppl","DOI":"10.2144\/jun0207"},{"key":"204_CR20","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","volume":"21","author":"JC Barrett","year":"2005","unstructured":"Barrett JC, Fry B, Maller J, Daly MJ: Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005, 21: 263-265. 10.1093\/bioinformatics\/bth457.","journal-title":"Bioinformatics"},{"key":"204_CR21","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1086\/319501","volume":"68","author":"M Stephens","year":"2001","unstructured":"Stephens M, Smith NJ, Donnelly P: A new statistical method for haplotype reconstruction from population data. Am J Hum Genet. 2001, 68: 978-989. 10.1086\/319501.","journal-title":"Am J Hum Genet"},{"key":"204_CR22","unstructured":"Single Nucleotide Polymorphism Spectral Decomposition (SNPSpD). [http:\/\/genepi.qimr.edu.au\/general\/daleN\/SNPSpD\/]"},{"key":"204_CR23","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-60327-411-1_1","volume":"578","author":"BS Shastry","year":"2009","unstructured":"Shastry BS: SNPs: impact on gene function and phenotype. Methods Mol Biol. 2009, 578: 3-22. full_text.","journal-title":"Methods Mol Biol"},{"key":"204_CR24","doi-asserted-by":"publisher","first-page":"471","DOI":"10.1002\/humu.20238","volume":"26","author":"M Barenboim","year":"2005","unstructured":"Barenboim M, Jamison DC, Vaisman II: Statistical geometry approach to the study of functional effects of human nonsynonymous SNPs. Hum Mutat. 2005, 26: 471-476. 10.1002\/humu.20238.","journal-title":"Hum Mutat"},{"key":"204_CR25","doi-asserted-by":"publisher","first-page":"836","DOI":"10.1073\/pnas.85.3.836","volume":"85","author":"RL Brinster","year":"1988","unstructured":"Brinster RL, Allen JM, Behringer RR, Gelinas RE, Palmiter RD: Introns increase transcriptional efficiency in transgenic mice. Proc Natl Acad Sci USA. 1988, 85: 836-840. 10.1073\/pnas.85.3.836.","journal-title":"Proc Natl Acad Sci USA"},{"key":"204_CR26","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1038\/nrg1327","volume":"5","author":"F Pagani","year":"2004","unstructured":"Pagani F, Baralle FE: Genomic variants in exons and introns: identifying the splicing spoilers. Nat Rev Genet. 2004, 5: 389-396. 10.1038\/nrg1327.","journal-title":"Nat Rev Genet"},{"key":"204_CR27","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1378\/chest.08-1595","volume":"135","author":"JS Jung","year":"2009","unstructured":"Jung JS, Park BL, Cheong HS, Bae JS, Kim JH, Chang HS, Rhim T, Park JS, Jang AS, Lee YM, et al: Association of IL-17RB gene polymorphism with asthma. Chest. 2009, 135: 1173-1180. 10.1378\/chest.08-1595.","journal-title":"Chest"},{"key":"204_CR28","doi-asserted-by":"publisher","first-page":"756","DOI":"10.2310\/JIM.0b013e3181b91a83","volume":"57","author":"RJ Freishtat","year":"2009","unstructured":"Freishtat RJ, Benton AS, Watson AM, Wang Z, Rose MC, Hoffman EP: Delineation of a gene network underlying the pulmonary response to oxidative stress in asthma. J Investig Med. 2009, 57: 756-764.","journal-title":"J Investig Med"},{"key":"204_CR29","doi-asserted-by":"crossref","unstructured":"Fouladkou F, Lu C, Jiang C, Zhou L, She Y, Walls JR, Kawabe H, Brose N, Henkelman RM, Huang A, et al: The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1. J Biol Chem. 285: 6770-6780. 10.1074\/jbc.M109.082347.","DOI":"10.1074\/jbc.M109.082347"},{"key":"204_CR30","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.gde.2009.05.001","volume":"19","author":"ST Weiss","year":"2009","unstructured":"Weiss ST, Raby BA, Rogers A: Asthma genetics and genomics 2009. Curr Opin Genet Dev. 2009, 19: 279-282. 10.1016\/j.gde.2009.05.001.","journal-title":"Curr Opin Genet Dev"},{"key":"204_CR31","doi-asserted-by":"publisher","first-page":"860","DOI":"10.1111\/j.1365-2222.2004.01977.x","volume":"34","author":"JH Lee","year":"2004","unstructured":"Lee JH, Park HS, Park SW, Jang AS, Uh ST, Rhim T, Park CS, Hong SJ, Holgate ST, Holloway JW, et al: ADAM33 polymorphism: association with bronchial hyper-responsiveness in Korean asthmatics. Clin Exp Allergy. 2004, 34: 860-865. 10.1111\/j.1365-2222.2004.01977.x.","journal-title":"Clin Exp Allergy"},{"key":"204_CR32","first-page":"205","volume":"26","author":"T Thongngarm","year":"2008","unstructured":"Thongngarm T, Jameekornrak A, Limwongse C, Sangasapaviliya A, Jirapongsananuruk O, Assawamakin A, Chaiyaratana N, Luangwedchakarn V, Thongnoppakhun W: Association between ADAM33 polymorphisms and asthma in a Thai population. Asian Pac J Allergy Immunol. 2008, 26: 205-211.","journal-title":"Asian Pac J Allergy Immunol"},{"key":"204_CR33","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1111\/j.1365-2222.2006.02471.x","volume":"36","author":"E Noguchi","year":"2006","unstructured":"Noguchi E, Ohtsuki Y, Tokunaga K, Yamaoka-Sageshima M, Ichikawa K, Aoki T, Shibasaki M, Arinami T: ADAM33 polymorphisms are associated with asthma susceptibility in a Japanese population. Clin Exp Allergy. 2006, 36: 602-608. 10.1111\/j.1365-2222.2006.02471.x.","journal-title":"Clin Exp Allergy"},{"key":"204_CR34","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1186\/1471-2350-9-82","volume":"9","author":"D Su","year":"2008","unstructured":"Su D, Zhang X, Sui H, Lu F, Jin L, Zhang J: Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population. BMC Med Genet. 2008, 9: 82-10.1186\/1471-2350-9-82.","journal-title":"BMC Med Genet"},{"key":"204_CR35","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1465-9921-10-21","volume":"10","author":"A Sadeghnejad","year":"2009","unstructured":"Sadeghnejad A, Ohar JA, Zheng SL, Sterling DA, Hawkins GA, Meyers DA, Bleecker ER: Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers. Respir Res. 2009, 10: 21-10.1186\/1465-9921-10-21.","journal-title":"Respir Res"},{"key":"204_CR36","doi-asserted-by":"publisher","first-page":"898","DOI":"10.1111\/j.1398-9995.2009.01939.x","volume":"64","author":"NE Reijmerink","year":"2009","unstructured":"Reijmerink NE, Kerkhof M, Koppelman GH, Gerritsen J, de Jongste JC, Smit HA, Brunekreef B, Postma DS: Smoke exposure interacts with ADAM33 polymorphisms in the development of lung function and hyperresponsiveness. Allergy. 2009, 64: 898-904. 10.1111\/j.1398-9995.2009.01939.x.","journal-title":"Allergy"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-10-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2466-10-34\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-10-34","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-10-34.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T11:43:28Z","timestamp":1630496608000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/1471-2466-10-34"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6,1]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["204"],"URL":"https:\/\/doi.org\/10.1186\/1471-2466-10-34","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,6,1]]},"assertion":[{"value":"4 March 2010","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2010","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 June 2010","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"34"}}