{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:10:21Z","timestamp":1776913821606,"version":"3.51.2"},"reference-count":24,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T00:00:00Z","timestamp":1407369600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2466-14-129","type":"journal-article","created":{"date-parts":[[2014,8,7]],"date-time":"2014-08-07T01:01:40Z","timestamp":1407373300000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Seasonal variation of serum KL-6 concentrations is greater in patients with hypersensitivity pneumonitis"],"prefix":"10.1186","volume":"14","author":[{"given":"Hiroshi","family":"Ohnishi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shintaro","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Kawase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihito","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,8,7]]},"reference":[{"key":"574_CR1","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1378\/chest.96.1.68","volume":"96","author":"N Kohno","year":"1989","unstructured":"Kohno N, Kyoizumi S, Awaya Y, Fukuhara H, Yamakido M, Akiyama M: New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest. 1989, 96: 68-73.","journal-title":"Chest"},{"key":"574_CR2","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1164\/ajrccm.165.3.2107134","volume":"165","author":"H Ohnishi","year":"2002","unstructured":"Ohnishi H, Yokoyama A, Kondo K, Hamada H, Abe M, Nishimura K, Hiwada K, Kohno N: Comparative study of KL-6, surfactant protein-A, surfactant protein-D, and monocyte chemoattractant protein-1 as serum markers for interstitial lung diseases. Am J Respir Crit Care Med. 2002, 165: 378-381.","journal-title":"Am J Respir Crit Care Med"},{"key":"574_CR3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.resinv.2012.02.001","volume":"50","author":"N Ishikawa","year":"2012","unstructured":"Ishikawa N, Hattori N, Yokoyama A, Kohno N: Utility of KL-6\/MUC1 in the clinical management of interstitial lung diseases. Respir Investig. 2012, 50: 3-13.","journal-title":"Respir Investig"},{"key":"574_CR4","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1136\/thorax.58.10.872","volume":"58","author":"H Ohnishi","year":"2003","unstructured":"Ohnishi H, Yokoyama A, Yasuhara Y, Watanabe A, Naka T, Hamada H, Abe M, Nishimura K, Higaki J, Ikezoe J, Kohno N: Circulating KL-6 levels in patients with drug induced pneumonitis. Thorax. 2003, 58: 872-875.","journal-title":"Thorax"},{"key":"574_CR5","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1378\/chest.118.2.445","volume":"118","author":"T Takahashi","year":"2000","unstructured":"Takahashi T, Munakata M, Ohtsuka Y, Satoh-Kamachi A, Sato R, Homma Y, Kawakami Y: Serum KL-6 concentrations in dairy farmers. Chest. 2000, 118: 445-450.","journal-title":"Chest"},{"key":"574_CR6","first-page":"51","volume":"22","author":"R Janssen","year":"2005","unstructured":"Janssen R, Grutters JC, Sato H, van Velzen-Blad H, Zanen P, Kohno N, Welsh KI, du Bois RM, van den Bosch JM: Analysis of KL-6 and SP-D as disease markers in bird fancier\u2019s lung. Sarcoidosis Vasc Diffuse Lung Dis. 2005, 22: 51-57.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"574_CR7","doi-asserted-by":"publisher","first-page":"1680","DOI":"10.1164\/ajrccm.158.5.9803115","volume":"158","author":"A Yokoyama","year":"1998","unstructured":"Yokoyama A, Kohno N, Hamada H, Sakatani M, Ueda E, Kondo K, Hirasawa Y, Hiwada K: Circulating KL-6 predicts the outcome of rapidly progressive idiopathic pulmonary fibrosis. Am J Respir Crit Care Med. 1998, 158: 1680-1684.","journal-title":"Am J Respir Crit Care Med"},{"key":"574_CR8","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1111\/j.1440-1843.2006.00834.x","volume":"11","author":"A Yokoyama","year":"2006","unstructured":"Yokoyama A, Kondo K, Nakajima M, Matsushima T, Takahashi T, Nishimura M, Bando M, Sugiyama Y, Totani Y, Ishizaki T, Ichiyasu H, Suga M, Hamada H, Kohno N: Prognostic value of circulating KL-6 in idiopathic pulmonary fibrosis. Respirology. 2006, 11: 164-168.","journal-title":"Respirology"},{"key":"574_CR9","doi-asserted-by":"publisher","first-page":"L1088","DOI":"10.1152\/ajplung.00420.2002","volume":"286","author":"A Ishizaka","year":"2004","unstructured":"Ishizaka A, Matsuda T, Albertine KH, Koh H, Tasaka S, Hasegawa N, Kohno N, Kotani T, Morisaki H, Takeda J, Nakamura M, Fang X, Martin TR, Matthay MA, Hashimoto S: Elevation of KL-6, a lung epithelial cell marker, in plasma and epithelial lining fluid in acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol. 2004, 286: L1088-L1094.","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"574_CR10","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1164\/rccm.201203-0513CI","volume":"186","author":"M Selman","year":"2012","unstructured":"Selman M, Pardo A, King TE: Hypersensitivity pneumonitis: insights in diagnosis and pathobiology. Am J Respir Crit Care Med. 2012, 186: 314-324.","journal-title":"Am J Respir Crit Care Med"},{"key":"574_CR11","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S1081-1206(10)61047-2","volume":"96","author":"N Inase","year":"2006","unstructured":"Inase N, Ohtani Y, Sumi Y, Umino T, Usui Y, Miyake S, Yoshizawa Y: A clinical study of hypersensitivity pneumonitis presumably caused by feather duvets. Ann Allergy Asthma Immunol. 2006, 96: 98-104.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"574_CR12","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1016\/0091-6749(91)90423-L","volume":"87","author":"M Ando","year":"1991","unstructured":"Ando M, Konishi K, Yoneda R, Tamura M: Difference in the phenotypes of bronchoalveolar lavage lymphocytes in patients with summer-type hypersensitivity pneumonitis, farmer\u2019s lung, ventilation pneumonitis, and bird fancier\u2019s lung: report of a nationwide epidemiologic study in Japan. J Allergy Clin Immunol. 1991, 87: 1002-1009.","journal-title":"J Allergy Clin Immunol"},{"key":"574_CR13","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.resinv.2013.03.004","volume":"51","author":"T Okamoto","year":"2013","unstructured":"Okamoto T, Miyazaki Y, Ogura T, Chida K, Kohno N, Kohno S, Taniguchi H, Akagawa S, Mochizuki Y, Yamauchi K, Takahashi H, Johkoh T, Homma S, Kishi K, Ikushima S, Konno S, Mishima M, Ohta K, Nishioka Y, Yoshimura N, Munakata M, Watanabe K, Miyashita Y, Inase N: A nationwide epidemiological survey of chronic hypersensitivity pneumonitis in Japan. Respir Investig. 2013, 51: 191-199.","journal-title":"Respir Investig"},{"key":"574_CR14","first-page":"1045","volume":"46","author":"Y Hara","year":"2008","unstructured":"Hara Y, Kobayashi H, Osoreda H, Kanoh S, Motoyoshi K, Ozeki Y: Bird-related chronic hypersensitivity pneumonitis demonstrating the fluctuation of disease activity accompanied with environmental changes. Nihon Kokyuki Gakkai Zasshi. 2008, 46: 1045-1049. Japanese","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"574_CR15","first-page":"1433","volume":"58","author":"T Takao","year":"2009","unstructured":"Takao T, Hanehira T, Zenke Y, Shikama J, Igei H, Inoue E, Yoshizawa Y: The sequential changes of the serum levels of KL-6, SP-D, and DLCO were followed for a long term in a case of acute bird fancier\u2019s lung. Arerugi. 2009, 58: 1433-1440. Japanese","journal-title":"Arerugi"},{"key":"574_CR16","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1164\/ajrccm.165.2.ats01","volume":"165","author":"American Thoracic Society; European Respiratory Society","year":"2002","unstructured":"American Thoracic Society; European Respiratory Society: American Thoracic Society\/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias. This joint statement of the American Thoracic Society (ATS), and the European Respiratory Society (ERS) was adopted by the ATS board of directors, June 2001 and by the ERS Executive Committee, June 2001. Am J Respir Crit Care Med. 2002, 165: 277-304.","journal-title":"Am J Respir Crit Care Med"},{"key":"574_CR17","doi-asserted-by":"publisher","first-page":"788","DOI":"10.1164\/rccm.2009-040GL","volume":"183","author":"G Raghu","year":"2011","unstructured":"Raghu G, Collard HR, Egan JJ, Martinez FJ, Behr J, Brown KK, Colby TV, Cordier JF, Flaherty KR, Lasky JA, Lynch DA, Ryu JH, Swigris JJ, Wells AU, Ancochea J, Bouros D, Carvalho C, Costabel U, Ebina M, Hansell DM, Johkoh T, Kim DS, King TE, Kondoh Y, Myers J, M\u00fcller NL, Nicholson AG, Richeldi L, Selman M, Dudden RF, Griss BS, Protzko SL, Sch\u00fcnemann HJ, ATS\/ERS\/JRS\/ALAT Committee on Idiopathic Pulmonary Fibrosis: An official ATS\/ERS\/JRS\/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011, 183: 788-824.","journal-title":"Am J Respir Crit Care Med"},{"key":"574_CR18","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1183\/09031936.05.00021005","volume":"26","author":"V Cottin","year":"2005","unstructured":"Cottin V, Nunes H, Brillet PY, Delaval P, Devouassoux G, Tillie-Leblond I, Israel-Biet D, Court-Fortune I, Valeyre D, Cordier JF, Groupe d\u2019Etude et de Recherche sur les Maladies Orphelines Pulmonaires (GERM O P): Combined pulmonary fibrosis and emphysema: a distinct underrecognised entity. Eur Respir J. 2005, 26: 586-593.","journal-title":"Eur Respir J"},{"key":"574_CR19","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.2169\/internalmedicine.41.1179","volume":"41","author":"H Ohnishi","year":"2002","unstructured":"Ohnishi H, Yokoyama A, Hamada H, Manabe S, Ito R, Watanabe A, Katayama H, Yasuhara Y, Ikezoe J, Higaki J: Humidifier lung: possible contribution of endotoxin-induced lung injury. Intern Med. 2002, 41: 1179-1182.","journal-title":"Intern Med"},{"key":"574_CR20","first-page":"141","volume":"24","author":"N Inase","year":"2007","unstructured":"Inase N, Ohtani Y, Usui Y, Miyazaki Y, Takemura T, Yoshizawa Y: Chronic summer-type hypersensitivity pneumonitis: clinical similarities to idiopathic pulmonary fibrosis. Sarcoidosis Vasc Diffuse Lung Dis. 2007, 24: 141-147.","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"574_CR21","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1148\/radiol.2453061881","volume":"246","author":"CI Silva","year":"2008","unstructured":"Silva CI, M\u00fcller NL, Lynch DA, Curran-Everett D, Brown KK, Lee KS, Chung MP, Churg A: Chronic hypersensitivity pneumonitis: differentiation from idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia by using thin-section CT. Radiology. 2008, 246: 288-297.","journal-title":"Radiology"},{"key":"574_CR22","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1016\/S2213-2600(13)70191-7","volume":"1","author":"F Morell","year":"2013","unstructured":"Morell F, Villar A, Montero M\u00c1, Mu\u00f1oz X, Colby TV, Pipvath S, Cruz MJ, Raghu G: Chronic hypersensitivity pneumonitis in patients diagnosed with idiopathic pulmonary fibrosis: a prospective case-cohort study. Lancet Respir Med. 2013, 1: 685-694.","journal-title":"Lancet Respir Med"},{"key":"574_CR23","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/S1081-1206(10)61863-7","volume":"90","author":"Y Ohtani","year":"2003","unstructured":"Ohtani Y, Saiki S, Sumi Y, Inase N, Miyake S, Costabel U, Yoshizawa Y: Clinical features of recurrent and insidious chronic bird fancier\u2019s lung. Ann Allergy Asthma Immunol. 2003, 90: 604-610.","journal-title":"Ann Allergy Asthma Immunol"},{"key":"574_CR24","doi-asserted-by":"publisher","first-page":"497","DOI":"10.1159\/000326411","volume":"48","author":"KC Linssen","year":"2004","unstructured":"Linssen KC, Jacobs JA, Poletti VE, van Mook W, Cornelissen EI, Drent M: Reactive type II pneumocytes in bronchoalveolar lavage fluid. Acta Cytol. 2004, 48: 497-504.","journal-title":"Acta Cytol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-14-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2466-14-129\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-14-129","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-14-129.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T04:15:45Z","timestamp":1548216945000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/1471-2466-14-129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,8,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["574"],"URL":"https:\/\/doi.org\/10.1186\/1471-2466-14-129","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,8,7]]},"assertion":[{"value":"25 April 2014","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 July 2014","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2014","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"129"}}