{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:52:35Z","timestamp":1791355955780,"version":"4.3.1"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T00:00:00Z","timestamp":1222387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Pulm Med"],"published-print":{"date-parts":[[2008,12]]},"DOI":"10.1186\/1471-2466-8-19","type":"journal-article","created":{"date-parts":[[2008,9,26]],"date-time":"2008-09-26T18:19:44Z","timestamp":1222453184000},"source":"Crossref","is-referenced-by-count":111,"title":["Early intestinal Bacteroides fragilis colonisation and development of asthma"],"prefix":"10.1186","volume":"8","author":[{"given":"Carl","family":"Vael","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Nelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stijn L","family":"Verhulst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herman","family":"Goossens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine N","family":"Desager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2008,9,26]]},"reference":[{"key":"110_CR1","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1056\/NEJM199501193320301","volume":"332","author":"FD Martinez","year":"1995","unstructured":"Martinez FD, Wright AL, Taussig LM, Holberg CJ, Halonen M, Morgan WJ: Asthma and wheezing in the first six years of life. The Group Health Medical Associates. N Engl J Med. 1995, 332: 133-138. 10.1056\/NEJM199501193320301.","journal-title":"N Engl J Med"},{"key":"110_CR2","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1136\/bmj.299.6710.1259","volume":"299","author":"DP Strachan","year":"1989","unstructured":"Strachan DP: Hay fever, hygiene, and household size. BMJ. 1989, 299: 1259-1260.","journal-title":"BMJ"},{"key":"110_CR3","doi-asserted-by":"publisher","first-page":"552","DOI":"10.1097\/00001574-200011000-00016","volume":"16","author":"SH Murch","year":"2000","unstructured":"Murch SH: The immunologic basis for intestinal food allergy. Curr Opin Gastroenterol. 2000, 16: 552-557. 10.1097\/00001574-200011000-00016.","journal-title":"Curr Opin Gastroenterol"},{"key":"110_CR4","doi-asserted-by":"publisher","first-page":"3733","DOI":"10.4049\/jimmunol.164.7.3733","volume":"164","author":"M Miettinen","year":"2000","unstructured":"Miettinen M, Lehtonen A, Julkunen I, Matikainen S: Lactobacilli and Streptococci activate NF-kappa B and STAT signaling pathways in human macrophages. J Immunol. 2000, 164: 3733-3740.","journal-title":"J Immunol"},{"key":"110_CR5","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1067\/mai.2001.111237","volume":"107","author":"M Kalliomaki","year":"2001","unstructured":"Kalliomaki M, Kirjavainen P, Eerola E, Kero P, Salminen S, Isolauri E: Distinct patterns of neonatal gut microflora in infants in whom atopy was and was not developing. J Allergy Clin Immunol. 2001, 107: 129-134. 10.1067\/mai.2001.111237.","journal-title":"J Allergy Clin Immunol"},{"key":"110_CR6","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1067\/mai.2001.115754","volume":"108","author":"AC Ouwehand","year":"2001","unstructured":"Ouwehand AC, Isolauri E, He F, Hashimoto H, Benno Y, Salminen S: Differences in Bifidobacterium flora composition in allergic and healthy infants. J Allergy Clin Immunol. 2001, 108: 144-145. 10.1067\/mai.2001.115754.","journal-title":"J Allergy Clin Immunol"},{"key":"110_CR7","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1183\/09031936.93.06101455","volume":"6","author":"N Pearce","year":"1993","unstructured":"Pearce N, Weiland S, Keil U, Langridge P, Anderson HR, Strachan D, Bauman A, Young L, Gluyas P, Ruffin D: Self-reported prevalence of asthma symptoms in children in Australia, England, Germany and New Zealand: an international comparison using the ISAAC protocol. Eur Respir J. 1993, 6: 1455-1461.","journal-title":"Eur Respir J"},{"key":"110_CR8","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","volume":"162","author":"JA Castro-Rodriguez","year":"2000","unstructured":"Castro-Rodriguez JA, Holberg CJ, Wright AL, Martinez FD: A Clinical Index to Define Risk of Asthma in Young Children with Recurrent Wheezing. Am J Respir Crit Care. 2000, 162: 1403-1406.","journal-title":"Am J Respir Crit Care"},{"key":"110_CR9","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0167-7012(99)00031-7","volume":"36","author":"R Hartemink","year":"1999","unstructured":"Hartemink R, Rombouts FM: Comparison of media for the detection of bifidobacteria, lactobacilli and total anaerobes from faecal samples. J Microbiol Methods. 1999, 36: 181-192. 10.1016\/S0167-7012(99)00031-7.","journal-title":"J Microbiol Methods"},{"key":"110_CR10","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1128\/jcm.7.5.448-453.1978","volume":"7","author":"SJ Livingston","year":"1978","unstructured":"Livingston SJ, Kominos SD, Yee RB: New medium for selection and presumptive identification of the Bacteroides fragilis group. J Clin Microbiol. 1978, 7: 448-453.","journal-title":"J Clin Microbiol"},{"key":"110_CR11","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/S0167-7012(00)00205-0","volume":"43","author":"V Rada","year":"2000","unstructured":"Rada V, Petr J: A new selective medium for the isolation of glucose non-fermenting bifidobacteria from hen caeca. J Microbiol Methods. 2000, 43: 127-132. 10.1016\/S0167-7012(00)00205-0.","journal-title":"J Microbiol Methods"},{"key":"110_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0167-7012(97)00025-0","volume":"29","author":"R Hartemink","year":"1997","unstructured":"Hartemink R, Domenech VR, Rombouts FM: LAMVAB \u2013 a new selective medium for the isolation of lactobacilli from faeces. J Microbiol Methods. 1997, 29: 77-84. 10.1016\/S0167-7012(97)00025-0.","journal-title":"J Microbiol Methods"},{"key":"110_CR13","volume-title":"Models for Discrete Longitudinal Data","author":"G Molenberghs","year":"2005","unstructured":"Molenberghs G, Verbeke G: Models for Discrete Longitudinal Data. 2005, New-York: Springer-Verlag, 1","edition":"1"},{"key":"110_CR14","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.4049\/jimmunol.159.4.1739","volume":"159","author":"N Sudo","year":"1997","unstructured":"Sudo N, Sawamura S, Tanaka K, Aiba Y, Kubo C, Koga Y: The requirement of intestinal bacterial flora for the development of an IgE production system fully susceptible to oral tolerance induction. J Immunol. 1997, 159: 1739-1745.","journal-title":"J Immunol"},{"issue":"Suppl 2","key":"110_CR15","doi-asserted-by":"publisher","first-page":"SII12","DOI":"10.1016\/S0140-6736(99)90437-3","volume":"354","author":"FD Martinez","year":"1999","unstructured":"Martinez FD, Holt PG: Role of microbial burden in aetiology of allergy and asthma. Lancet. 1999, 354 (Suppl 2): SII12-SII15. 10.1016\/S0140-6736(99)90437-3.","journal-title":"Lancet"},{"key":"110_CR16","doi-asserted-by":"publisher","first-page":"999","DOI":"10.1136\/bmj.314.7086.999","volume":"314","author":"PM Matricardi","year":"1997","unstructured":"Matricardi PM, Rosmini F, Ferrigno L, Nisini R, Rapicetta M, Chionne P, Stroffolini T, Pasquini P, D'Amelio R: Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis A virus. BMJ. 1997, 314: 999-1003.","journal-title":"BMJ"},{"key":"110_CR17","first-page":"32","volume":"8","author":"B Bjorksten","year":"1997","unstructured":"Bjorksten B: The environment and sensitisation to allergens in early childhood. Pediatr Allergy Immunol. 1997, 8: 32-39.","journal-title":"Pediatr Allergy Immunol"},{"key":"110_CR18","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1046\/j.1365-2222.1999.00560.x","volume":"29","author":"B Bjorksten","year":"1999","unstructured":"Bjorksten B, Naaber P, Sepp E, Mikelsaar M: The intestinal microflora in allergic Estonian and Swedish 2-year-old children. Clin Exp Allergy. 1999, 29: 342-346. 10.1046\/j.1365-2222.1999.00560.x.","journal-title":"Clin Exp Allergy"},{"key":"110_CR19","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1067\/mai.2001.118130","volume":"108","author":"B Bjorksten","year":"2001","unstructured":"Bjorksten B, Sepp E, Julge K, Voor T, Mikelsaar M: Allergy development and the intestinal microflora during the first year of life. J Allergy Clin Immunol. 2001, 108: 516-520. 10.1067\/mai.2001.118130.","journal-title":"J Allergy Clin Immunol"},{"key":"110_CR20","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.cell.2005.05.007","volume":"122","author":"SK Mazmanian","year":"2005","unstructured":"Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL: An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005, 122: 107-118. 10.1016\/j.cell.2005.05.007.","journal-title":"Cell"},{"key":"110_CR21","doi-asserted-by":"publisher","first-page":"1778","DOI":"10.1126\/science.1106469","volume":"307","author":"MJ Coyne","year":"2005","unstructured":"Coyne MJ, Reinap B, Lee MM, Comstock LE: Human symbionts use a host-like pathway for surface fucosylation. Science. 2005, 307: 1778-1781. 10.1126\/science.1106469.","journal-title":"Science"},{"key":"110_CR22","doi-asserted-by":"publisher","first-page":"2052","DOI":"10.1002\/eji.200425229","volume":"34","author":"MG Netea","year":"2004","unstructured":"Netea MG, Kullberg BJ, de Jong DJ, Franke B, Sprong T, Naber TH, Drenth JP, Meer van der JW: NOD2 mediates anti-inflammatory signals induced by TLR2 ligands: implications for Crohn's disease. Eur J Immunol. 2004, 34: 2052-2059. 10.1002\/eji.200425229.","journal-title":"Eur J Immunol"},{"key":"110_CR23","doi-asserted-by":"publisher","first-page":"4984","DOI":"10.4049\/jimmunol.171.10.4984","volume":"171","author":"S Agrawal","year":"2003","unstructured":"Agrawal S, Agrawal A, Doughty B, Gerwitz A, Blenis J, Van Dyke T, Pulendran B: Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol. 2003, 171: 4984-4989.","journal-title":"J Immunol"},{"key":"110_CR24","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/S1054-139X(03)00539-1","volume":"35","author":"S Fukuda","year":"2004","unstructured":"Fukuda S, Ishikawa H, Koga Y, Aiba Y, Nakashima K, Cheng L, Shirakawa T: Allergic symptoms and microflora in schoolchildren. J Adolesc Health. 2004, 35: 156-158.","journal-title":"J Adolesc Health"},{"key":"110_CR25","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1136\/gut.51.1.51","volume":"51","author":"PV Kirjavainen","year":"2002","unstructured":"Kirjavainen PV, Arvola T, Salminen SJ, Isolauri E: Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning?. Gut. 2002, 51: 51-55. 10.1136\/gut.51.1.51.","journal-title":"Gut"},{"key":"110_CR26","doi-asserted-by":"publisher","first-page":"1141","DOI":"10.1111\/j.1365-2222.2005.02315.x","volume":"35","author":"E Sepp","year":"2005","unstructured":"Sepp E, Julge K, Mikelsaar M, Bjorksten B: Intestinal microbiota and immunoglobulin E responses in 5-year-old Estonian children. Clin Exp Allergy. 2005, 35: 1141-1146. 10.1111\/j.1365-2222.2005.02315.x.","journal-title":"Clin Exp Allergy"},{"key":"110_CR27","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1046\/j.1365-2222.2002.01430.x","volume":"32","author":"N Sudo","year":"2002","unstructured":"Sudo N, Yu XN, Aiba Y, Oyama N, Sonoda J, Koga Y, Kubo C: An oral introduction of intestinal bacteria prevents the development of a long-term Th2-skewed immunological memory induced by neonatal antibiotic treatment in mice. Clin Exp Allergy. 2002, 32: 1112-1116. 10.1046\/j.1365-2222.2002.01430.x.","journal-title":"Clin Exp Allergy"},{"key":"110_CR28","first-page":"92","volume":"17","author":"T Odamaki","year":"2007","unstructured":"Odamaki T, Xiao JZ, Iwabuchi N, Sakamoto M, Takahashi N, Kondo S, Iwatsuki K, Kokubo S, Togashi H, Enomoto T, Benno Y: Fluctuation of fecal microbiota in individuals with Japanese cedar pollinosis during the pollen season and influence of probiotic intake. J Investig Allergol Clin Immunol. 2007, 17: 92-100.","journal-title":"J Investig Allergol Clin Immunol"}],"container-title":["BMC Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2466-8-19\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-8-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-8-19","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2466-8-19.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,20]],"date-time":"2023-05-20T04:34:27Z","timestamp":1684557267000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcpulmmed.biomedcentral.com\/articles\/10.1186\/1471-2466-8-19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9,26]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,12]]}},"alternative-id":["110"],"URL":"https:\/\/doi.org\/10.1186\/1471-2466-8-19","relation":{},"ISSN":["1471-2466"],"issn-type":[{"value":"1471-2466","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,9,26]]},"article-number":"19"}}