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The aim of this study was to determine if a collagen-enriched environment, similar to <jats:italic>in vivo<\/jats:italic> conditions, altered \u03b2-catenin accumulation by primary DD cells in the presence or absence of Transforming Growth Factor-\u03b2.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Primary DD and patient matched, phenotypically normal palmar fascia (PF) cells were cultured in the presence or absence of type-1 collagen and Transforming Growth Factor-\u03b21. \u03b2-catenin and \u03b1-smooth muscle actin levels were assessed by western immunoblotting and immunofluorescence microscopy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>DD cells display a rapid depletion of cellular \u03b2-catenin not evident in patient-matched PF cells. This effect was not evident in either cell type when cultured in the absence of type-1 collagen. Exogenous addition of Transforming Growth Factor-\u03b21 to DD cells in collagen culture negates the loss of \u03b2-catenin accumulation. Transforming Growth Factor-\u03b21-induced \u03b1-smooth muscle actin, a marker of myofibroblast differentiation, is attenuated by the inclusion of type-1 collagen in cultures of DD and PF cells.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>Our findings implicate type-1 collagen as a previously unrecognized regulator of \u03b2-catenin accumulation and a modifier of TGF-\u03b21 signaling specifically in primary DD cells. These data have implications for current treatment modalities as well as the design of <jats:italic>in vitro<\/jats:italic> models for research into the molecular mechanisms of DD.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2474-10-72","type":"journal-article","created":{"date-parts":[[2009,6,23]],"date-time":"2009-06-23T06:14:38Z","timestamp":1245737678000},"update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Type-1 Collagen differentially alters \u03b2-catenin accumulation in primary Dupuytren's Disease cord and adjacent palmar fascia cells"],"prefix":"10.1186","volume":"10","author":[{"given":"Linda","family":"Vi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Njarlangattil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing Siang","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David B","family":"O'Gorman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2009,6,19]]},"reference":[{"issue":"9378","key":"650_CR1","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0140-6736(03)13871-8","volume":"362","author":"KG Gudmundsson","year":"2003","unstructured":"Gudmundsson KG, Jonsson T, Arngrimsson R: Guillaume Dupuytren and finger contractures. 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