{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:31:33Z","timestamp":1790404293042,"version":"4.1.0"},"reference-count":33,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T00:00:00Z","timestamp":1284508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1186\/1471-2474-11-210","type":"journal-article","created":{"date-parts":[[2010,9,15]],"date-time":"2010-09-15T18:15:09Z","timestamp":1284574509000},"source":"Crossref","is-referenced-by-count":40,"title":["Silencing Dkk1 expression rescues dexamethasone-induced suppression of primary human osteoblast differentiation"],"prefix":"10.1186","volume":"11","author":[{"given":"Joseph S","family":"Butler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M","family":"Queally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M","family":"Devitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P","family":"Doran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,9,15]]},"reference":[{"issue":"6","key":"956_CR1","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1001\/jama.285.6.785","volume":"285","author":"NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis Therapy","year":"2001","unstructured":"NIH Consensus Development Panel on Osteoporosis Prevention Diagnosis Therapy: Osteoporosis prevention, diagnosis, and therapy. JAMA. 2001, 285 (6): 785-95. 10.1001\/jama.285.6.785.","journal-title":"JAMA"},{"key":"956_CR2","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/1471-2474-8-12","volume":"8","author":"CJ Hurson","year":"2007","unstructured":"Hurson CJ, Butler JS, Keating DT, Murray DW, Sadlier DM, O'Byrne JM, Doran PP: Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis. BMC Musculoskelet Disord. 2007, 8: 12-10.1186\/1471-2474-8-12.","journal-title":"BMC Musculoskelet Disord"},{"key":"956_CR3","doi-asserted-by":"publisher","first-page":"1644","DOI":"10.1126\/science.1071549","volume":"296","author":"RT Moon","year":"2002","unstructured":"Moon RT, Bowerman B, Boutros M, Perrimon N: The promise and perils of Wnt signaling through beta-catenin. Science. 2002, 296: 1644-6. 10.1126\/science.1071549.","journal-title":"Science"},{"issue":"10","key":"956_CR4","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1002\/bies.10164","volume":"24","author":"P Pandur","year":"2002","unstructured":"Pandur P, Maurus D, Kuhl M: Increasingly complex: new players enter the Wnt signaling network. Bioessays. 2002, 24 (10): 881-4. 10.1002\/bies.10164.","journal-title":"Bioessays"},{"key":"956_CR5","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1146\/annurev.cellbio.20.010403.113126","volume":"20","author":"CY Logan","year":"2004","unstructured":"Logan CY, Nusse R: The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol. 2004, 20: 781-810. 10.1146\/annurev.cellbio.20.010403.113126.","journal-title":"Annu Rev Cell Dev Biol"},{"issue":"1","key":"956_CR6","first-page":"REVIEWS3001","volume":"3","author":"JR Miller","year":"2002","unstructured":"Miller JR: The Wnts. Genome Biol. 2002, 3 (1): REVIEWS3001-Epub 2001 Dec 28","journal-title":"Genome Biol"},{"key":"956_CR7","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1016\/S0092-8674(01)00571-2","volume":"107","author":"YQ Gong","year":"2001","unstructured":"Gong YQ, Slee RB, Fukai N, Rawadi G, Roman-Roman S, Reginato AM, et al.: LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell. 2001, 107: 513-23. 10.1016\/S0092-8674(01)00571-2.","journal-title":"Cell"},{"key":"956_CR8","first-page":"146","volume":"59","author":"YQ Gong","year":"1996","unstructured":"Gong YQ, Vikkula M, Boon L, Liu J, Beighton P, Ramesar R, et al.: Osteoporosis-pseudoglioma syndrome, a disorder affecting skeletal strength and vision, is assigned to chromosome region 11q12-13. Am J Hum Genet. 1996, 59: 146-51.","journal-title":"Am J Hum Genet"},{"key":"956_CR9","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1056\/NEJMoa013444","volume":"346","author":"LM Boyden","year":"2002","unstructured":"Boyden LM, Mao JH, Belsky J, Mitzner L, Farhi A, Mitnick MA, et al.: High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002, 346: 1513-21. 10.1056\/NEJMoa013444.","journal-title":"N Engl J Med"},{"key":"956_CR10","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1086\/338450","volume":"70","author":"RD Little","year":"2002","unstructured":"Little RD, Carulli JP, Del Mastro RG, Dupuis J, Osborne M, Folz C, et al.: A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait. Am J Hum Genet. 2002, 70: 11-9. 10.1086\/338450.","journal-title":"Am J Hum Genet"},{"key":"956_CR11","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1086\/368277","volume":"72","author":"L Van Wesenbeeck","year":"2003","unstructured":"Van Wesenbeeck L, Cleiren E, Gram J, Beals RK, Benichou O, Scopelliti D, et al.: Six novel missense mutations in the LDL receptor-related protein 5 (LRP5) gene in different conditions with an increased bone density. Am J Hum Genet. 2003, 72: 763-71. 10.1086\/368277.","journal-title":"Am J Hum Genet"},{"issue":"9","key":"956_CR12","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1038\/nrg1427","volume":"5","author":"RT Moon","year":"2004","unstructured":"Moon RT, Kohn AD, De Ferrari GV, Kaykas A: WNT and beta-catenin signalling: diseases and therapies. Nat Rev Genet. 2004, 5 (9): 691-701. 10.1038\/nrg1427.","journal-title":"Nat Rev Genet"},{"issue":"5","key":"956_CR13","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1172\/JCI28551","volume":"116","author":"V Krishnan","year":"2006","unstructured":"Krishnan V, Bryant HU, Macdougald OA: Regulation of bone mass by Wnt signaling. J Clin Invest. 2006, 116 (5): 1202-9. 10.1172\/JCI28551.","journal-title":"J Clin Invest"},{"key":"956_CR14","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/S0070-2153(06)76004-5","volume":"76","author":"R Baron","year":"2006","unstructured":"Baron R, Rawadi G, Roman-Roman S: Wnt signaling: a key regulator of bone mass. Curr Top Dev Biol. 2006, 76: 103-27. 10.1016\/S0070-2153(06)76004-5.","journal-title":"Curr Top Dev Biol"},{"key":"956_CR15","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.gene.2004.06.044","volume":"341","author":"JJ Westendorf","year":"2004","unstructured":"Westendorf JJ, Kahler RA, Schroeder TM: Wnt signaling in osteoblasts and bone diseases. Gene. 2004, 341: 19-39. 10.1016\/j.gene.2004.06.044.","journal-title":"Gene"},{"issue":"4","key":"956_CR16","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1517\/14728220902841961","volume":"13","author":"LH Hoeppner","year":"2009","unstructured":"Hoeppner LH, Secreto FJ, Westendorf JJ: Wnt signaling as a therapeutic target for bone diseases. Expert Opin Ther Targets. 2009, 13 (4): 485-96. 10.1517\/14728220902841961.","journal-title":"Expert Opin Ther Targets"},{"issue":"7","key":"956_CR17","doi-asserted-by":"publisher","first-page":"581","DOI":"10.2174\/138945008784911778","volume":"9","author":"G Rawadi","year":"2008","unstructured":"Rawadi G: Wnt signaling and potential applications in bone diseases. Curr Drug Targets. 2008, 9 (7): 581-90. 10.2174\/138945008784911778.","journal-title":"Curr Drug Targets"},{"issue":"11","key":"956_CR18","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1359\/JBMR.040816","volume":"19","author":"ML Johnson","year":"2004","unstructured":"Johnson ML, Harnish K, Nusse R, Van Hul W: LRP5 and Wnt signaling: a union made for bone. J Bone Miner Res. 2004, 19 (11): 1749-57. 10.1359\/JBMR.040816. Epub 2004 Aug 23","journal-title":"J Bone Miner Res"},{"issue":"5","key":"956_CR19","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1093\/hmg\/10.5.537","volume":"10","author":"W Balemans","year":"2001","unstructured":"Balemans W, Ebeling M, Patel N, Van Hul E, Olson P, Dioszegi M, et al.: Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST). Hum Mol Genet. 2001, 10 (5): 537-43. 10.1093\/hmg\/10.5.537.","journal-title":"Hum Mol Genet"},{"issue":"2","key":"956_CR20","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1002\/ajmg.10401","volume":"110","author":"K Staehling-Hampton","year":"2002","unstructured":"Staehling-Hampton K, Proll S, Paeper BW, Zhao L, Charmley P, et al.: A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population. Am J Genet. 2002, 110 (2): 144-52. 10.1002\/ajmg.10401.","journal-title":"Am J Genet"},{"key":"956_CR21","doi-asserted-by":"publisher","first-page":"683","DOI":"10.1038\/35083081","volume":"3","author":"A Bafico","year":"2001","unstructured":"Bafico A, Liu GZ, Yaniv A, Gazit A, Aaronson SA: Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow. Nat Cell Biol. 2001, 3: 683-6. 10.1038\/35083081.","journal-title":"Nat Cell Biol"},{"key":"956_CR22","doi-asserted-by":"publisher","first-page":"5587","DOI":"10.1242\/dev.00154","volume":"129","author":"G Davidson","year":"2002","unstructured":"Davidson G, Mao BY, Barrantes ID, Niehrs C: Kremen proteins interact with Dickkopf1 to regulate anteroposterior CNS patterning. Development. 2002, 129: 5587-96. 10.1242\/dev.00154.","journal-title":"Development"},{"key":"956_CR23","doi-asserted-by":"publisher","first-page":"28067","DOI":"10.1074\/jbc.M300373200","volume":"278","author":"CA Gregory","year":"2003","unstructured":"Gregory CA, Singh H, Perry AS, Prockop DJ: The Wnt signaling inhibitor dickkopf-1 is required for reentry into the cell cycle of human adult stem cells from bone marrow. J Biol Chem. 2003, 278: 28067-78. 10.1074\/jbc.M300373200.","journal-title":"J Biol Chem"},{"key":"956_CR24","doi-asserted-by":"publisher","first-page":"4819","DOI":"10.1242\/dev.01347","volume":"131","author":"EY Chu","year":"2004","unstructured":"Chu EY, Hens J, Andl T, Kairo A, Yamaguchi TP, Brisken C, et al.: Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis. Development. 2004, 131: 4819-29. 10.1242\/dev.01347.","journal-title":"Development"},{"key":"956_CR25","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1073\/pnas.2536800100","volume":"101","author":"F Kuhnert","year":"2004","unstructured":"Kuhnert F, Davis CR, Wang HT, Chu P, Lee M, Yuan J, et al.: Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc Natl Acad Sci USA. 2004, 101: 266-71. 10.1073\/pnas.2536800100.","journal-title":"Proc Natl Acad Sci USA"},{"key":"956_CR26","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1038\/ng1614","volume":"37","author":"XF Li","year":"2005","unstructured":"Li XF, Liu P, Liu WZ, Maye P, Zhang JH, Zhang YH, et al.: Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005, 37: 945-52. 10.1038\/ng1614.","journal-title":"Nat Genet"},{"key":"956_CR27","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1056\/NEJMoa030847","volume":"349","author":"E Tian","year":"2003","unstructured":"Tian E, Zhan FH, Walker R, Rasmussen E, Ma YP, Barlogie B, et al.: The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med. 2003, 349: 2483-94. 10.1056\/NEJMoa030847.","journal-title":"N Engl J Med"},{"issue":"4","key":"956_CR28","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1016\/j.bone.2006.03.017","volume":"39","author":"J Li","year":"2006","unstructured":"Li J, Sarosi I, Cattley RC, Pretorius J, Asuncion F, Grisanti M, et al.: Dkk1-mediated inhibition of Wnt signaling in bone results in osteopenia. Bone. 2006, 39 (4): 754-66. 10.1016\/j.bone.2006.03.017. Epub 2006 May 26","journal-title":"Bone"},{"issue":"6","key":"956_CR29","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1359\/jbmr.060311","volume":"21","author":"F Morvan","year":"2006","unstructured":"Morvan F, Boulukos K, Cl\u00e9ment-Lacroix P, Roman Roman S, et al.: Deletion of a single allele of the Dkk1 gene leads to an increase in bone formation and bone mass. J Bone Miner Res. 2006, 21 (6): 934-45. 10.1359\/jbmr.060311.","journal-title":"J Bone Miner Res"},{"issue":"3","key":"956_CR30","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.bone.2007.05.009","volume":"41","author":"BT MacDonald","year":"2007","unstructured":"MacDonald BT, Joiner DM, Oyserman SM, Sharma P, Goldstein SA: Bone mass is inversely proportional to Dkk1 levels in mice. Bone. 2007, 41 (3): 331-9. 10.1016\/j.bone.2007.05.009. Epub 2007 Jun 5","journal-title":"Bone"},{"issue":"4","key":"956_CR31","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1210\/en.2007-0910","volume":"149","author":"FS Wang","year":"2008","unstructured":"Wang FS, Ko JY, Yeh DW, Ke HC, Wu HL: Modulation of Dickkopf-1 attenuates glucocorticoid induction of osteoblast apoptosis, adipocytic differentiation, and bone mass loss. Endocrinology. 2008, 149 (4): 1793-801. 10.1210\/en.2007-0910. Epub 2008 Jan 3","journal-title":"Endocrinology"},{"issue":"1","key":"956_CR32","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.bbrc.2004.04.025","volume":"318","author":"K Ohnaka","year":"2004","unstructured":"Ohnaka K, Taniguchi H, Kawate H, Nawata H, Takayanagi R: Glucocorticoid enhances the expression of dickkopf-1 in human osteoblasts: novel mechanism of glucocorticoid-induced osteoporosis. Biochem Biophys Res Commun. 2004, 318 (1): 259-64. 10.1016\/j.bbrc.2004.04.025.","journal-title":"Biochem Biophys Res Commun"},{"issue":"1","key":"956_CR33","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.bbrc.2005.01.117","volume":"329","author":"K Ohnaka","year":"2005","unstructured":"Ohnaka K, Tanabe M, Kawate H, Nawata H, Takayanagi R: Glucocorticoid suppresses the canonical Wnt signal in cultured human osteoblasts. Biochem Biophys Res Commun. 2005, 329 (1): 177-81. 10.1016\/j.bbrc.2005.01.117.","journal-title":"Biochem Biophys Res Commun"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-11-210\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-11-210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-11-210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-11-210.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T14:05:49Z","timestamp":1548165949000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-11-210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9,15]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["956"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-11-210","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,9,15]]},"article-number":"210"}}