{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:13:54Z","timestamp":1791893634883,"version":"4.3.4"},"reference-count":58,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T00:00:00Z","timestamp":1374796800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2013,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>The biological mechanisms involved in non-contact musculoskeletal soft tissue injuries (NCMSTI) are poorly understood. Genetic risk factors may be associated with susceptibility to injuries, and may exert marked influence on recovery times.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Data on type and degree of injury and recovery time were collected in 73 male professional soccer players (43 White, 11 Black Africans and 19 Hispanics) who suffered total of 242 injuries (203 muscle, 24 ligament, and 15 tendon injuries). One single nucleotide polymorphism (SNPs) in the following genes were analyzed: Elastin (ELN); Titin (TTN); SRY-related HMG-box (SOX15); Insulin-like growth factor 2 (IGF2); Chemokine, CC motif, ligand 2 (CCL2); Collagen type 1 alpha 1(COL1A1); Collagen type 5 alpha 1 (COL5A1), and Tenascin C (TNC).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>There was evidence of a statistically significant association between the degree of injury and the IGF2 genotype (P\u2009=\u20090.034). In addition, there was evidence of a statistically significant association between the degree of muscle injury and CCL2 (P\u2009=\u20090.026) Finally, there was evidence of a statistically significant association between ELN and degree of injury (p\u2009=\u20090.009) and recovery time (P\u2009=\u20090.043). There was no evidence of a statistically significant association between any of the genes studied and degree of injury or recovery time for tendon injuries.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusion<\/jats:title>\n            <jats:p>SNPs in the IGF2, CCL2, and ELN genes may be associated to the degree and recovery time of NCMSTI.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1186\/1471-2474-14-221","type":"journal-article","created":{"date-parts":[[2013,7,26]],"date-time":"2013-07-26T18:17:33Z","timestamp":1374862653000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":76,"title":["Single nucleotide polymorphisms associated with non-contact soft tissue injuries in elite professional soccer players: influence on degree of injury and recovery time"],"prefix":"10.1186","volume":"14","author":[{"given":"Ricard","family":"Pruna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Artells","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi","family":"Ribas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Montoro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesc","family":"Cos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carme","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Rodas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Maffulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,7,26]]},"reference":[{"key":"1854_CR1","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1097\/00042752-199407000-00004","volume":"4","author":"WH Meeuwisse","year":"1994","unstructured":"Meeuwisse WH: Assessing causation in sport injury: a multifactorial model. Clin J Sport Med. 1994, 4: 166-170. 10.1097\/00042752-199407000-00004.","journal-title":"Clin J Sport Med"},{"key":"1854_CR2","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1136\/bjsm.2009.058040","volume":"44","author":"M Collins","year":"2010","unstructured":"Collins M: Genetic risk factors for soft-tissue injuries 101: a practical summary to help clinicians understand the role of genetics and \u2018personalised medicine\u2019. Br J Sports Med. 2010, 44: 915-917. 10.1136\/bjsm.2009.058040.","journal-title":"Br J Sports Med"},{"key":"1854_CR3","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1093\/rheumatology\/keg448","volume":"43","author":"G Riley","year":"2004","unstructured":"Riley G: The pathogenesis of tendinopathy. A molecular perspective. Rheumatology. 2004, 43: 131-142.","journal-title":"Rheumatology"},{"key":"1854_CR4","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1016\/S0278-5919(03)00004-8","volume":"22","author":"N Maffulli","year":"2003","unstructured":"Maffulli N, Wong J, Almekinders LC: Types and epidemiology of tendinopathy. Clin Sports Med. 2003, 22: 675-692. 10.1016\/S0278-5919(03)00004-8.","journal-title":"Clin Sports Med"},{"key":"1854_CR5","doi-asserted-by":"publisher","first-page":"1226","DOI":"10.1177\/0363546510395879","volume":"39","author":"J Ekstrand","year":"2011","unstructured":"Ekstrand J, H\u00e4gglund M, Wald\u00e9n M: Epidemiology of muscle injuries in professional football (soccer). Am J Sports Med. 2011, 39: 1226-1232. 10.1177\/0363546510395879.","journal-title":"Am J Sports Med"},{"key":"1854_CR6","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1136\/bjsm.2009.060582","volume":"45","author":"J Ekstrand","year":"2011","unstructured":"Ekstrand J, H\u00e4gglund M, Wald\u00e9n M: Injury incidence and injury patterns in professional football: the UEFA injury study. Br J Sports Med. 2011, 45: 553-558. 10.1136\/bjsm.2009.060582.","journal-title":"Br J Sports Med"},{"key":"1854_CR7","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1136\/bjsports-2011-090155","volume":"46","author":"J Ekstrand","year":"2012","unstructured":"Ekstrand J, Healy JC, Wald\u00e9n M, Lee JC, English B: Hamstring muscle injuries in professional football: the correlation of MRI findings with return to play. Br J Sports Med. 2012, 46: 112-117. 10.1136\/bjsports-2011-090155.","journal-title":"Br J Sports Med"},{"key":"1854_CR8","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1136\/bjsm.2006.027623","volume":"40","author":"J Ekstrand","year":"2006","unstructured":"Ekstrand J, Timpka T, H\u00e4gglund M: Risk of injury in elite football played on artificial turf versus natural grass: a prospective two-cohort study. Br J Sports Med. 2006, 40: 975-980. 10.1136\/bjsm.2006.027623.","journal-title":"Br J Sports Med"},{"key":"1854_CR9","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1177\/1938640011412944","volume":"4","author":"GW Hess","year":"2011","unstructured":"Hess GW: Ankle impingement syndromes: a review of etiology and related implications. Foot Ankle Spec. 2011, 4: 290-297. 10.1177\/1938640011412944.","journal-title":"Foot Ankle Spec"},{"key":"1854_CR10","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jsams.2007.04.007","volume":"11","author":"M Magra","year":"2008","unstructured":"Magra M, Maffulli N: Genetic aspects of tendinopathy. J Sci Med Sport. 2008, 11: 243-247. 10.1016\/j.jsams.2007.04.007.","journal-title":"J Sci Med Sport"},{"key":"1854_CR11","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1007\/s00167-009-1002-y","volume":"18","author":"U Longo","year":"2010","unstructured":"Longo U, Fazio V, Poeta M, Rabitti C, Franceschi F: Bilateral consecutive rupture of the quadriceps tendon in a man with BstUI polymorphism of the COL5A1 gene. Knee Surg Sports Traumatol Arthrosc. 2010, 18: 514-518. 10.1007\/s00167-009-1002-y.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"1854_CR12","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1016\/j.matbio.2011.05.001","volume":"30","author":"M-J Laguette","year":"2011","unstructured":"Laguette M-J, Abrahams Y, Prince S, Collins M: Sequence variants within the 3\u2032-UTR of the COL5A1 gene alters mRNA stability: implications for musculoskeletal soft tissue injuries. Matrix Biol. 2011, 30: 338-345. 10.1016\/j.matbio.2011.05.001.","journal-title":"Matrix Biol"},{"key":"1854_CR13","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1093\/bmb\/ldp007","volume":"93","author":"G Lippi","year":"2010","unstructured":"Lippi G, Longo UG, Maffulli N: Genetics and sports. Br Med Bull. 2010, 93: 27-47. 10.1093\/bmb\/ldp007.","journal-title":"Br Med Bull"},{"key":"1854_CR14","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1016\/j.jsams.2009.07.004","volume":"13","author":"R Cupeiro","year":"2010","unstructured":"Cupeiro R, Benito PJ, Maffulli N, Calder\u00f3n FJ, Gonz\u00e1lez-Lamu\u00f1o D: MCT1 genetic polymorphism influence in high intensity circuit training: a pilot study. J Sci Med Sport. 2010, 13: 526-530. 10.1016\/j.jsams.2009.07.004.","journal-title":"J Sci Med Sport"},{"issue":"6","key":"1854_CR15","doi-asserted-by":"publisher","first-page":"1779","DOI":"10.1152\/japplphysiol.00633.2010","volume":"109","author":"BT Harmon","year":"2010","unstructured":"Harmon BT, Orkunoglu-Suer EF, Adham K, Larkin JS, Gordish-Dressman H: CCL2 and CCR2 variants are associated with skeletal muscle strength and change in strength with resistance training. J Appl Physiol. 2010, 109 (6): 1779-1785. 10.1152\/japplphysiol.00633.2010.","journal-title":"J Appl Physiol"},{"key":"1854_CR16","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1097\/JSM.0b013e3180425879","volume":"17","author":"M Magra","year":"2007","unstructured":"Magra M, Maffulli N: Genetics: does it play a role in tendinopathy?. Clin J Sport Med. 2007, 17: 231-233. 10.1097\/JSM.0b013e3180425879.","journal-title":"Clin J Sport Med"},{"key":"1854_CR17","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1177\/0363546504271986","volume":"33","author":"GG Mokone","year":"2005","unstructured":"Mokone GG, Gajjar M, September AV, Schwellnus MP, Greenberg J: The guanine-thymine dinucleotide repeat polymorphism within the tenascin-C gene is associated with achilles tendon injuries. Am J Sports Med. 2005, 33: 1016-1021. 10.1177\/0363546504271986.","journal-title":"Am J Sports Med"},{"key":"1854_CR18","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1136\/bjsm.2006.033035","volume":"41","author":"AV September","year":"2007","unstructured":"September AV, Schwellnus MP, Collins M: Tendon and ligament injuries: the genetic component. Br J Sports Med. 2007, 41: 241-246. 10.1136\/bjsm.2006.033035.","journal-title":"Br J Sports Med"},{"key":"1854_CR19","doi-asserted-by":"publisher","first-page":"2234","DOI":"10.1177\/0363546509338266","volume":"37","author":"M Posthumus","year":"2009","unstructured":"Posthumus M, September AV, O\u2019Cuinneagain D, van der Merwe W, Schwellnus MP: The COL5A1 gene is associated with increased risk of anterior cruciate ligament ruptures in female participants. Am J Sports Med. 2009, 37: 2234-2240. 10.1177\/0363546509338266.","journal-title":"Am J Sports Med"},{"key":"1854_CR20","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1007\/s00421-008-0728-4","volume":"104","author":"C Yamin","year":"2008","unstructured":"Yamin C, Duarte J, Oliveira J, Amir O, Sagiv M: IL6 (\u2212174) and TNFA (\u2212308) promoter polymorphisms are associated with systemic creatine kinase response to eccentric exercise. Eur J Appl Physiol. 2008, 104: 579-586.","journal-title":"Eur J Appl Physiol"},{"key":"1854_CR21","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/path.1639","volume":"204","author":"D Paulin","year":"2004","unstructured":"Paulin D, Huet A, Khanamyrian L, Xue Z: Desminopathies in muscle disease. J Pathol. 2004, 204: 418-427. 10.1002\/path.1639.","journal-title":"J Pathol"},{"key":"1854_CR22","first-page":"605","volume":"51","author":"J Rosenbloom","year":"1984","unstructured":"Rosenbloom J: Elastin: relation of protein and gene structure to disease. Lab Invest. 1984, 51: 605-","journal-title":"Lab Invest"},{"key":"1854_CR23","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1007\/s11357-009-9103-6","volume":"31","author":"M Sherratt","year":"2009","unstructured":"Sherratt M: Tissue elasticity and the ageing elastic fibre. Age. 2009, 31: 305-325. 10.1007\/s11357-009-9103-6.","journal-title":"Age"},{"key":"1854_CR24","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1006\/bbrc.2002.6448","volume":"291","author":"M Itoh-Satoh","year":"2002","unstructured":"Itoh-Satoh M, Hayashi T, Nishi H, Koga Y, Arimura T: Titin mutations as the molecular basis for dilated cardiomyopathy. Biochem Biophys Res Commun. 2002, 291: 385-393. 10.1006\/bbrc.2002.6448.","journal-title":"Biochem Biophys Res Commun"},{"key":"1854_CR25","doi-asserted-by":"publisher","first-page":"8428","DOI":"10.1128\/MCB.24.19.8428-8436.2004","volume":"24","author":"HJ Lee","year":"2004","unstructured":"Lee HJ, Goring W, Ochs M, Muhlfeld C, Steding G: Sox15 is required for skeletal muscle regeneration. Mol Cell Biol. 2004, 24: 8428-10.1128\/MCB.24.19.8428-8436.2004.","journal-title":"Mol Cell Biol"},{"key":"1854_CR26","doi-asserted-by":"publisher","first-page":"1815","DOI":"10.1152\/japplphysiol.01165.2006","volume":"102","author":"JM Devaney","year":"2007","unstructured":"Devaney JM, Hoffman EP, Gordish-Dressman H, Kearns A, Zambraski E: IGF-II gene region polymorphisms related to exertional muscle damage. J Appl Physiol. 2007, 102: 1815-1823. 10.1152\/japplphysiol.01165.2006.","journal-title":"J Appl Physiol"},{"key":"1854_CR27","doi-asserted-by":"publisher","first-page":"1651","DOI":"10.1152\/japplphysiol.00361.2009","volume":"108","author":"MJ Hubal","year":"2010","unstructured":"Hubal MJ, Devaney JM, Hoffman EP, Zambraski EJ, Gordish-Dressman H: CCL2 and CCR2 polymorphisms are associated with markers of exercise-induced skeletal muscle damage. J Appl Physiol. 2010, 108: 1651-1658. 10.1152\/japplphysiol.00361.2009.","journal-title":"J Appl Physiol"},{"key":"1854_CR28","first-page":"49","volume":"54","author":"M Collins","year":"2009","unstructured":"Collins M, Raleigh SM: Genetic risk factors for musculoskeletal soft tissue injuries. Med Sport Sci. 2009, 54: 49-","journal-title":"Med Sport Sci"},{"key":"1854_CR29","doi-asserted-by":"publisher","first-page":"229","DOI":"10.2174\/187221512802717321","volume":"6","author":"M Kambouris","year":"2012","unstructured":"Kambouris M, Ntalouka F, Ziogas G, Maffulli N: Predictive genomics DNA profiling for athletic performance. Recent Pat DNA Gene Seq. 2012, 6: 229-239. 10.2174\/187221512802717321.","journal-title":"Recent Pat DNA Gene Seq"},{"key":"1854_CR30","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1136\/bjsm.2005.018267","volume":"39","author":"M H\u00e4gglund","year":"2005","unstructured":"H\u00e4gglund M, Wald\u00e9n M, Bahr R, Ekstrand J: Methods for epidemiological study of injuries to professional football players: developing the UEFA model. Br J Sports Med. 2005, 39: 340-346. 10.1136\/bjsm.2005.018267.","journal-title":"Br J Sports Med"},{"issue":"11","key":"1854_CR31","doi-asserted-by":"publisher","first-page":"2356","DOI":"10.1007\/s00167-012-2118-z","volume":"20","author":"O Chan","year":"2012","unstructured":"Chan O, Del Buono A, Best TM, Maffulli N: Acute muscle strain injuries: a proposed new classification system. Knee Surg Sports Traumatol Arthrosc. 2012, 20 (11): 2356-2362. 10.1007\/s00167-012-2118-z.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"1854_CR32","volume-title":"Med Clin (Barc)","author":"R Pruna","year":"2013","unstructured":"Pruna R, Medina D, Rodas G, Artells R: Patellar tendinopathy. Therapeutic model in the sport. Med Clin (Barc). 2013, 10.1016\/j.medcli.2012.12.006."},{"key":"1854_CR33","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/S1886-6581(09)70129-X","volume":"44","author":"RP Gil Rodas","year":"2009","unstructured":"Gil Rodas RP, Lluis T, Carles M: Guia de pr\u00e1ctica Clinica de las lesiones musculares. Epidemiologia, diagn\u00f3stico, tratamiento y prevenci\u00f3n. APUNTS MEDICINA DE L'ESPORT. 2009, 44: 179-203.","journal-title":"APUNTS MEDICINA DE L'ESPORT"},{"key":"1854_CR34","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1249\/JSR.0b013e31821ac0eb","volume":"10","author":"MP Schwellnus","year":"2011","unstructured":"Schwellnus MP: Genetics and soft-tissue injuries in sport: clinical commentary. Curr Sports Med Rep. 2011, 10: 126-127. 110.1249\/JSR.1240b1013e31821ac31820eb","journal-title":"Curr Sports Med Rep"},{"key":"1854_CR35","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0925-7535(97)00058-1","volume":"27","author":"CW Fuller","year":"1997","unstructured":"Fuller CW, Hawkins RD: Assessment of football grounds for player safety. Safety Science. 1997, 27: 115-128. 10.1016\/S0925-7535(97)00058-1.","journal-title":"Safety Science"},{"key":"1854_CR36","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/bjsports-2011-090634","volume":"46","author":"CW Fuller","year":"2012","unstructured":"Fuller CW, Junge A, Dvorak J: Risk management: FIFA's approach for protecting the health of football players. Br J Sports Med. 2012, 46: 11-17. 10.1136\/bjsports-2011-090634.","journal-title":"Br J Sports Med"},{"key":"1854_CR37","volume-title":"The guide","author":"Sport U Staging major sports events","year":"2005","unstructured":"Sport U Staging major sports events: The guide. 2005, London: UK Sport"},{"key":"1854_CR38","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1111\/j.1600-0838.2010.01221.x","volume":"20","author":"R Maughan","year":"2010","unstructured":"Maughan R, Shirreffs S, Ozg\u00fcnen K, Kurdak S, Ers\u00f6z G: Living, training and playing in the heat: challenges to the football player and strategies for coping with environmental extremes. Scand J Med Sci Sports. 2010, 20: 117-124.","journal-title":"Scand J Med Sci Sports"},{"key":"1854_CR39","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/j.1600-0838.2008.00835.x","volume":"18","author":"B Levine","year":"2008","unstructured":"Levine B, Stray-Gundersen J, Mehta R: Effect of altitude on football performance. Scand J Med Sci Sports. 2008, 18: 76-84.","journal-title":"Scand J Med Sci Sports"},{"key":"1854_CR40","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1136\/bjsm.33.3.196","volume":"33","author":"RD Hawkins","year":"1999","unstructured":"Hawkins RD, Fuller CW: A prospective epidemiological study of injuries in four English professional football clubs. Br J Sports Med. 1999, 33: 196-203. 10.1136\/bjsm.33.3.196.","journal-title":"Br J Sports Med"},{"key":"1854_CR41","doi-asserted-by":"publisher","first-page":"S-51","DOI":"10.1177\/28.suppl_5.S-51","volume":"28","author":"L Peterson","year":"2000","unstructured":"Peterson L, Junge A, Chomiak J, Graf-Baumann T, Dvorak J: Incidence of football injuries and complaints in different age groups and skill-level groups. Am J Sports Med. 2000, 28: S-51-S-57.","journal-title":"Am J Sports Med"},{"key":"1854_CR42","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1177\/036354659101900311","volume":"19","author":"S Schmidt-Olsen","year":"1991","unstructured":"Schmidt-Olsen S, J\u00f8rgensen U, Kaalund S, S\u00f8rensen J: Injuries among young soccer players. Am J Sports Med. 1991, 19: 273-275. 10.1177\/036354659101900311.","journal-title":"Am J Sports Med"},{"key":"1854_CR43","doi-asserted-by":"publisher","first-page":"i20","DOI":"10.1136\/bjsm.2007.037267","volume":"41","author":"CW Fuller","year":"2007","unstructured":"Fuller CW, Dick RW, Corlette J, Schmalz R: Comparison of the incidence, nature and cause of injuries sustained on grass and new generation artificial turf by male and female football players. Part 1: match injuries. Br J Sports Med. 2007, 41: i20-i26. 10.1136\/bjsm.2007.037267.","journal-title":"Br J Sports Med"},{"key":"1854_CR44","doi-asserted-by":"publisher","first-page":"i27","DOI":"10.1136\/bjsm.2007.037275","volume":"41","author":"CW Fuller","year":"2007","unstructured":"Fuller CW, Dick RW, Corlette J, Schmalz R: Comparison of the incidence, nature and cause of injuries sustained on grass and new generation artificial turf by male and female football players. Part 2: training injuries. Br J Sports Med. 2007, 41: i27-i32. 10.1136\/bjsm.2007.037275.","journal-title":"Br J Sports Med"},{"key":"1854_CR45","doi-asserted-by":"publisher","first-page":"S-69","DOI":"10.1177\/28.suppl_5.S-69","volume":"28","author":"J Dvorak","year":"2000","unstructured":"Dvorak J, Junge A, Chomiak J, Graf-Baumann T, Peterson L: Risk factor analysis for injuries in football players. Am J Sports Med. 2000, 28: S-69-S-74.","journal-title":"Am J Sports Med"},{"key":"1854_CR46","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1080\/15438620500528380","volume":"14","author":"MJ Falvo","year":"2006","unstructured":"Falvo MJ, Bloomer RJ: Review of exercise-induced muscle injury: relevance for athletic populations. Res Sports Med. 2006, 14: 65-82. 10.1080\/15438620500528380.","journal-title":"Res Sports Med"},{"key":"1854_CR47","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1007\/s12687-011-0037-1","volume":"2","author":"I Ahmad","year":"2011","unstructured":"Ahmad I, Narang R, Venkatraman A, Das N: Frequency distribution of the single-nucleotide -108C\/T polymorphism at the promoter region of the PON1 gene in Asian Indians and its relationship with coronary artery disease. J Community Genet. 2011, 2: 27-32. 10.1007\/s12687-011-0037-1.","journal-title":"J Community Genet"},{"key":"1854_CR48","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.4238\/2011.October.25.7","volume":"10","author":"W Zeng","year":"2011","unstructured":"Zeng W, Liu L, Tong Y, Liu H, Dai L: A66G and C524T polymorphisms of the methionine synthase reductase gene are associated with congenital heart defects in the Chinese Han population. Genet Mol Res. 2011, 10: 2597-2605. 10.4238\/2011.October.25.7.","journal-title":"Genet Mol Res"},{"key":"1854_CR49","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1249\/00005768-198315030-00014","volume":"15","author":"J Ekstrand","year":"1983","unstructured":"Ekstrand J, Gillquist J: Soccer injuries and their mechanisms: a prospective study. Med Sci Sports Exerc. 1983, 15: 267-270. 10.1249\/00005768-198315030-00014.","journal-title":"Med Sci Sports Exerc"},{"key":"1854_CR50","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1152\/japplphysiol.01264.2001","volume":"93","author":"GR Adams","year":"2002","unstructured":"Adams GR: Invited review: autocrine\/paracrine IGF-I and skeletal muscle adaptation. J Appl Physiol. 2002, 93: 1159-1167.","journal-title":"J Appl Physiol"},{"key":"1854_CR51","doi-asserted-by":"publisher","first-page":"S146","DOI":"10.1097\/00003086-200210001-00017","volume":"403","author":"G Goldspink","year":"2002","unstructured":"Goldspink G, Williams P, Simpson H: Gene expression in response to muscle stretch. Clin Orthop Relat Res. 2002, 403: S146-","journal-title":"Clin Orthop Relat Res"},{"key":"1854_CR52","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1002\/(SICI)1097-4598(199903)22:3<347::AID-MUS7>3.0.CO;2-6","volume":"22","author":"HL Keller","year":"1999","unstructured":"Keller HL, St Pierre Schneider B, Eppihimer LA, Cannon JG: Association of IGF-I and IGF-II with myofiber regeneration in vivo. Muscle Nerve. 1999, 22: 347-354. 10.1002\/(SICI)1097-4598(199903)22:3<347::AID-MUS7>3.0.CO;2-6.","journal-title":"Muscle Nerve"},{"key":"1854_CR53","doi-asserted-by":"publisher","first-page":"3991","DOI":"10.1113\/jphysiol.2008.152090","volume":"586","author":"L Yahiaoui","year":"2008","unstructured":"Yahiaoui L, Gvozdic D, Danialou G, Mack M, Petrof BJ: CC family chemokines directly regulate myoblast responses to skeletal muscle injury. J Physiol. 2008, 586: 3991-4004. 10.1113\/jphysiol.2008.152090.","journal-title":"J Physiol"},{"key":"1854_CR54","doi-asserted-by":"publisher","first-page":"1955","DOI":"10.1242\/jcs.03453","volume":"120","author":"KE Kadler","year":"2007","unstructured":"Kadler KE, Baldock C, Bella J, Boot-Handford RP: Collagens at a glance. J Cell Sci. 2007, 120: 1955-1958. 10.1242\/jcs.03453.","journal-title":"J Cell Sci"},{"key":"1854_CR55","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/JES.0b013e318224e853","volume":"39","author":"M Collins","year":"2011","unstructured":"Collins M: Posthumus M Type V Collagen Genotype and Exercise-Related Phenotype Relationships: A Novel Hypothesis. Exerc Sport Sci Rev. 2011, 39: 191-","journal-title":"Exerc Sport Sci Rev"},{"issue":"4","key":"1854_CR56","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1123\/ijspp.6.4.485","volume":"6","author":"JC Brown","year":"2011","unstructured":"Brown JC, Miller CJ, Posthumus M, Schwellnus MP, Collins M: The COL5A1 gene, ultra-marathon running performance, and range of motion. Int J Sports Physiol Perform. 2011, 6 (4): 485-496.","journal-title":"Int J Sports Physiol Perform"},{"key":"1854_CR57","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1139\/O09-161","volume":"88","author":"LDMLD Muiznieks","year":"2010","unstructured":"Muiznieks LDMLD, Weiss ASWAS, Keeley FWKFW: Structural disorder and dynamics of elastin. Biochem Cell Biol. 2010, 88: 239-250. 10.1139\/O09-161. This paper is one of a selection of papers published in this special issue entitled \u201cCanadian Society of Biochemistry, Molecular & Cellular Biology. 52nd Annual Meeting-Protein Folding: Principles and Diseases\u201d and has undergone the Journal's usual peer review process","journal-title":"Biochem Cell Biol"},{"key":"1854_CR58","doi-asserted-by":"publisher","first-page":"1185","DOI":"10.1161\/hy1101.096802","volume":"38","author":"O Hanon","year":"2001","unstructured":"Hanon O, Luong V, Mourad JJ, Bortolotto LA, Jeunemaitre X: Aging, carotid artery distensibility, and the Ser422Gly elastin gene polymorphism in humans. Hypertension. 2001, 38: 1185-1189. 10.1161\/hy1101.096802.","journal-title":"Hypertension"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-14-221\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-221.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:49:59Z","timestamp":1630543799000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-14-221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7,26]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1854"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-14-221","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,7,26]]},"assertion":[{"value":"12 June 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 July 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 July 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}}],"article-number":"221"}}