{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T23:10:45Z","timestamp":1772752245477,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T00:00:00Z","timestamp":1378857600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-2474-14-264","type":"journal-article","created":{"date-parts":[[2013,9,11]],"date-time":"2013-09-11T12:55:29Z","timestamp":1378904129000},"source":"Crossref","is-referenced-by-count":21,"title":["Prevalence of genetic risk factors related with thrombophilia and hypofibrinolysis in patients with osteonecrosis of the femoral head in Poland"],"prefix":"10.1186","volume":"14","author":[{"given":"Jacek","family":"Gagala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Buraczynska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomasz","family":"Mazurkiewicz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrzej","family":"Ksiazek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,9,11]]},"reference":[{"key":"1902_CR1","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1053\/sarh.2002.33724b","volume":"32","author":"Y Assouline-Dayan","year":"2002","unstructured":"Assouline-Dayan Y, Chang C, Greenspan A, Shoenfeld Y, Gershwin ME: Pathogenesis and natural history of osteonecrosis. Semin Arthritis Rheum. 2002, 32: 94-124.","journal-title":"Semin Arthritis Rheum"},{"key":"1902_CR2","first-page":"43","volume-title":"Osteonecrosis: etiology, diagnosis, and treatment","author":"TP Vail","year":"1997","unstructured":"Vail TP, Covington DB: The incidence of osteonecrosis. Osteonecrosis: etiology, diagnosis, and treatment. Edited by: Urbaniak JR, Jones JPJr. 1997, Rosemont IL: The American Orthopaedic Association, 43-49."},{"key":"1902_CR3","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1302\/0301-620X.73B1.1991778","volume":"73","author":"K Ohzono","year":"1991","unstructured":"Ohzono K, Saito M, Takaoka K, Ono K, Saito S, Nishina T, Kadowaki T: Natural history of nontraumatic avascular necrosis of the femoral head. J Bone Joint Surg (Br). 1991, 73: 68-77.","journal-title":"J Bone Joint Surg (Br)"},{"key":"1902_CR4","first-page":"41","volume":"277","author":"JP Jones Jr","year":"1992","unstructured":"Jones JP: Intravascular coagulation and osteonecrosis. Clin Orthop Relat Res. 1992, 277: 41-53.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR5","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1097\/00003086-199701000-00007","volume":"334","author":"CJ Glueck","year":"1997","unstructured":"Glueck CJ, Freiberg R, Tracy T, Stroop D, Wang P: Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis. Clin Orthop Relat Res. 1997, 334: 43-56.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR6","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1097\/00003086-200105000-00004","volume":"386","author":"CJ Glueck","year":"2001","unstructured":"Glueck CJ, Freiberg RA, Fontaine RN, Tracy T, Wang P: Hypofibrinolysis, thrombophilia, osteonecrosis. Clin Orthop Relat Res. 2001, 386: 19-33.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR7","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1007\/s11999-008-0148-0","volume":"466","author":"CJ Glueck","year":"2008","unstructured":"Glueck CJ, Freiberg RA, Wang P: Heritable thrombophilia-hypofibrinolysis and osteonecrosis of the femoral head. Clin Orthop Relat Res. 2008, 466: 1034-1040. 10.1007\/s11999-008-0148-0.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR8","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1055\/s-0037-1614564","volume":"81","author":"VV Balasa","year":"1999","unstructured":"Balasa VV, Gruppo RA, Glueck CJ, Stroop D, Becker A, Pillow A, Wang P: The relationship of mutations in the MTHFR, prothrombin, and PAI-1 genes to plasma levels of homocysteine, prothrombin, and PAI-1 in children and adults. Thromb Haemost. 1999, 81: 739-744.","journal-title":"Thromb Haemost"},{"key":"1902_CR9","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.2106\/00004623-200412000-00009","volume":"86","author":"VV Balasa","year":"2004","unstructured":"Balasa VV, Gruppo RA, Glueck CJ, Wang P, Roy DR, Wall EJ, Mehlman CT, Crawford AH: Legg-Calv\u00e9-Perthes disease and thrombophilia. J Bone Joint Surg (Am). 2004, 86: 2642-2647.","journal-title":"J Bone Joint Surg (Am)"},{"key":"1902_CR10","first-page":"53","volume-title":"Ischemia and necrosis of bone","author":"RP Ficat","year":"1984","unstructured":"Ficat RP, Arlet J: Necrosis of the femoral head. Ischemia and necrosis of bone. Edited by: Hungerford DS. 1984, Baltimore: Wiliams&Wilkins, 53-74."},{"key":"1902_CR11","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1002\/ajmg.1320270216","volume":"27","author":"L Madisen","year":"1987","unstructured":"Madisen L, Hoar LD, Holroyd CD, Crisp M, Hodes ME: DNA banking: the effect of storage of blood and isolated DNA on integrity of DNA. Am J Med Genet. 1987, 27: 379-390. 10.1002\/ajmg.1320270216.","journal-title":"Am J Med Genet"},{"key":"1902_CR12","doi-asserted-by":"publisher","first-page":"2521","DOI":"10.1172\/JCI117623","volume":"94","author":"B Zoller","year":"1994","unstructured":"Zoller B, Svensson PJ, He X, Dahlback B: Identification of the same factor V gene mutation in 47 out of 50 thrombosis-prone families with inherited resistance to activated protein C. J Clin Invest. 1994, 94: 2521-2524. 10.1172\/JCI117623.","journal-title":"J Clin Invest"},{"key":"1902_CR13","doi-asserted-by":"crossref","first-page":"3698","DOI":"10.1182\/blood.V88.10.3698.bloodjournal88103698","volume":"88","author":"SR Poort","year":"1996","unstructured":"Poort SR, Rosendaal FR, Reitsma PH, Bertina RM: A common genetic variation in the 3-untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous thrombosis. Blood. 1996, 88: 3698-3703.","journal-title":"Blood"},{"key":"1902_CR14","first-page":"1656","volume":"129","author":"G Friedman","year":"1999","unstructured":"Friedman G, Friedman N, Goldschmidt Y, Friedlander A, Ben-Yehuda J, Selhub S, Babaey M, Mendel M, Kidron M, Bar-On H: A common mutation A1298C in human methylenetetrahydrofolate reductase gene: association with plasma total homocysteine and folate concentrations. Am Soc Nutr Sci. 1999, 129: 1656-1661.","journal-title":"Am Soc Nutr Sci"},{"key":"1902_CR15","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/BF02346186","volume":"97","author":"SA Tishkoff","year":"1996","unstructured":"Tishkoff SA, Ruano G, Kidd JR, Kidd KK: Distribution and frequency of a polymorphic Alu insertion at the plasminogen activator locus in humans. Hum Genet. 1996, 97: 759-764. 10.1007\/BF02346186.","journal-title":"Hum Genet"},{"key":"1902_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1038\/369064a0","volume":"369","author":"RM Bertina","year":"1994","unstructured":"Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma PH: Mutation in blood coagulation factor V associated with resistance to activated protein C. Nature. 1994, 369: 64-67. 10.1038\/369064a0.","journal-title":"Nature"},{"key":"1902_CR17","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1016\/S0140-6736(95)91803-5","volume":"346","author":"DC Rees","year":"1995","unstructured":"Rees DC, Cox M, Clegg JB: World distribution of factor V Leiden. Lancet. 1995, 346: 1133-1134. 10.1016\/S0140-6736(95)91803-5.","journal-title":"Lancet"},{"key":"1902_CR18","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/01.blo.0000127921.13253.e3","volume":"422","author":"CG Zalavras","year":"2004","unstructured":"Zalavras CG, Vartholomatos G, Dokou E, Malizos KN: Genetic background of osteonecrosis. Associated with thrombophilic mutations?. Clin Orthop Relat Res. 2004, 422: 251-255.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR19","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1097\/00003086-200408000-00023","volume":"425","author":"A Bj\u00f6rkman","year":"2004","unstructured":"Bj\u00f6rkman A, Svensson PJ, Hillarp A, Burtscher IM, R\u00fcnow A, Benoni G: Factor V Leiden and Prothrombin Gene Mutation Risk Factors for Osteonecrosis of the Femoral Head in Adults. Clin Orthop Relat Res. 2004, 425: 168-172.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR20","doi-asserted-by":"publisher","first-page":"1041","DOI":"10.1007\/s11999-008-0147-1","volume":"466","author":"J-D Chang","year":"2008","unstructured":"Chang J-D, Hur M, Lee S-S, Yoo J-H, Lee KM: Genetic background of nontraumatic osteonecrosis of the femoral head in the Korean population. Clin Ortop Relat Res. 2008, 466: 1041-1046. 10.1007\/s11999-008-0147-1.","journal-title":"Clin Ortop Relat Res"},{"key":"1902_CR21","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1055\/s-0037-1615049","volume":"79","author":"FR Rosendaal","year":"1998","unstructured":"Rosendaal FR, Doggen CJ, Zivelin A, Arruda VR, Aiach M, Siscovick DS, Hillarp A, Watzke HH, Bernardi F, Cumming AM, Preston FE, Reitsma PH: Geographic distribution of the 20210 G to A prothrombin variant. Thromb Haemost. 1998, 79: 706-708.","journal-title":"Thromb Haemost"},{"key":"1902_CR22","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1056\/NEJM199804093381507","volume":"338","author":"GN Welch","year":"1998","unstructured":"Welch GN, Loscalzo J: Homocysteine and atherothrombosis. N Engl J Med. 1998, 338: 1042-1050. 10.1056\/NEJM199804093381507.","journal-title":"N Engl J Med"},{"key":"1902_CR23","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1182\/blood.V75.4.895.895","volume":"75","author":"GM Rodgers","year":"1990","unstructured":"Rodgers GM, Conn MT: Homocysteine, an atherogenic stimulus, reduces protein C activation by arterial and venous endothelial cells. Blood. 1990, 75: 895-901.","journal-title":"Blood"},{"key":"1902_CR24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1038\/ng0595-111","volume":"10","author":"P Frosst","year":"1995","unstructured":"Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuve LP: A candidate genetic risk factor for vascular disease: a common mutation in methylenetetrahydrofolate reductase. Nat Genet. 1995, 10: 111-113. 10.1038\/ng0595-111.","journal-title":"Nat Genet"},{"key":"1902_CR25","first-page":"111","volume":"87","author":"CG Zalavras","year":"2002","unstructured":"Zalavras CG, Malizos KN, Dokou E, Vartholomatos G: The 677C\u2192T mutation of the methylene-tetrahydrofolate reductase gene in the pathogenesis of osteonecrosis of the femoral head. Haematologica. 2002, 87: 111-112.","journal-title":"Haematologica"},{"issue":"2","key":"1902_CR26","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1097\/01.TP.0000101433.99651.96","volume":"77","author":"T Asano","year":"2004","unstructured":"Asano T, Takahashi KA, Fujioka M, Inoue S, Ueshima K, Hirata T, Okamoto M, Satomi Y, Nishino H, Tanaka T, Hirota Y, Kubo T: Relationship between postrenal transplant osteonecrosis of the femoral head and gene polymorphisms related to the coagulation and fibrinolytic systems in Japanese subjects. Transplantation. 2004, 77 (2): 220-225. 10.1097\/01.TP.0000101433.99651.96.","journal-title":"Transplantation"},{"key":"1902_CR27","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1007\/s10059-010-0054-7","volume":"29","author":"T-H Kim","year":"2010","unstructured":"Kim T-H, Hong JM, Kim HJ, Park EK, Kim S-Y: Lack of association of MTHFR gene polymorphisms with the risk of osteonecrosis of the femoral head in a Korean population. Mol Cells. 2010, 29: 343-348. 10.1007\/s10059-010-0054-7.","journal-title":"Mol Cells"},{"key":"1902_CR28","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1093\/rheumatology\/ken206","volume":"47","author":"C S\u00e9guin","year":"2008","unstructured":"S\u00e9guin C, Kassis J, Busque L, Bestawros A, Theodoropoulos J, Alonso M-L, Harvey EJ: Non-traumatic necrosis of bone (osteonecrosis) is associated with endothelial cell activation but not thrombophilia. Rheumatology. 2008, 47: 1151-1155. 10.1093\/rheumatology\/ken206.","journal-title":"Rheumatology"},{"issue":"2","key":"1902_CR29","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.jbspin.2008.04.019","volume":"76","author":"N Mehsen","year":"2009","unstructured":"Mehsen N, Barnetche T, Redonnet-Vernhet I, Gu\u00e9rin V, Bentaberry F, Gonnet-Gracia C, Schaeverbeke T: Coagulopathies frequency in aseptic osteonecrosis patients. Joint Bone Spine. 2009, 76 (2): 166-169. 10.1016\/j.jbspin.2008.04.019.","journal-title":"Joint Bone Spine"},{"key":"1902_CR30","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1007\/BF00215671","volume":"88","author":"M Ludwig","year":"1992","unstructured":"Ludwig M, Wohn KD, Schleuning WD, Olek K: Allelic dimorphism in the human tissue-type plasminogen activator (TPA) gene as a result of an Alu insertion\/deletion event. Hum Genet. 1992, 88: 388-392. 10.1007\/BF00215671.","journal-title":"Hum Genet"},{"key":"1902_CR31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1161\/01.ATV.19.2.454","volume":"19","author":"C Jern","year":"1999","unstructured":"Jern C, Ladenvall P, Wall U, Jern S: Gene polymorphism of t-PA is associated with forearm vascular release rate of t-PA. Arterioscler Thromb Vasc Biol. 1999, 19: 454-459. 10.1161\/01.ATV.19.2.454.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1902_CR32","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1161\/ATVB.17v09.1687","volume":"17","author":"PM Ridker","year":"1997","unstructured":"Ridker PM, Baker MT, Hennekens CH, Stampfer MJ, Vaughn DE: Alu-repeat polymorphism in the gene coding for tissue-type plasminogen activator (TPA) and risks of myocardial infarction among middle-aged men. Arterioscler Thromb Vasc Biol. 1997, 17: 1687-1690.","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"1902_CR33","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1055\/s-0037-1615106","volume":"79","author":"R Steeds","year":"1998","unstructured":"Steeds R, Adams M, Smith P, Channer K, Samani NJ: Distribution of tissue plasminogen activator insertion\/deletion polymorphism in myocardial infarction and control subjects. Thromb Haemost. 1998, 79: 980-984.","journal-title":"Thromb Haemost"},{"key":"1902_CR34","doi-asserted-by":"publisher","first-page":"2623","DOI":"10.1161\/01.CIR.95.12.2623","volume":"95","author":"JG van der Bom","year":"1997","unstructured":"van der Bom JG, de Knijff P, Haverkate F, Bots ML, Meijer P, de Jong PT, Hofman A, Kluft C, Grobbee DE: Tissue plasminogen activator and risk of myocardial infarction: the Rotterdam Study. Circulation. 1997, 95: 2623-2627. 10.1161\/01.CIR.95.12.2623.","journal-title":"Circulation"},{"key":"1902_CR35","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S0049-3848(00)00236-X","volume":"99","author":"WC Hooper","year":"2000","unstructured":"Hooper WC, Lally C, Austin H, Renshaw M, Dilley A, Wenger NK, Phillips DJ, Whitsett C, Rawlins P, Evatt BL: The role of the t-PA I\/D and PAI-1 4G\/5G polymorphisms in African-American adults with a diagnosis of myocardial infarction or venous thromboembolism. Thromb Res. 2000, 99: 223-230. 10.1016\/S0049-3848(00)00236-X.","journal-title":"Thromb Res"},{"key":"1902_CR36","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1097\/00003086-199909000-00017","volume":"366","author":"CJ Glueck","year":"1999","unstructured":"Glueck CJ, Fontaine RN, Gruppo R, Stroop D, Sieve-Smith L, Tracy T, Wang P: The plasminogen activator inhibitor-1 gene, hypofibrinolysis, and osteonecrosis. Clin Orthop Relat Res. 1999, 366: 133-146.","journal-title":"Clin Orthop Relat Res"},{"key":"1902_CR37","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1186\/1471-2474-12-160","volume":"12","author":"H Kim","year":"2011","unstructured":"Kim H, Cho C, Cho Y, Cho S, Yoon K, Kim K: Significant associations of PAI-1 genetic polymorphisms with osteonecrosis of the femoral head. BMC Muskuloskelet Disord. 2011, 12: 160-10.1186\/1471-2474-12-160. doi:10. 1186\/1471-2474-12-160","journal-title":"BMC Muskuloskelet Disord"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-264.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-14-264\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-264","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,3]],"date-time":"2020-08-03T20:40:11Z","timestamp":1596487211000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-14-264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9,11]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1902"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-14-264","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9,11]]},"article-number":"264"}}