{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T04:54:28Z","timestamp":1780635268729,"version":"3.54.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T00:00:00Z","timestamp":1357171200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1186\/1471-2474-14-6","type":"journal-article","created":{"date-parts":[[2013,1,3]],"date-time":"2013-01-03T21:14:24Z","timestamp":1357247664000},"source":"Crossref","is-referenced-by-count":11,"title":["Time course of 25(OH)D3 vitamin D3 as well as PTH (parathyroid hormone) during fracture healing of patients with normal and low bone mineral density (BMD)"],"prefix":"10.1186","volume":"14","author":[{"given":"Christoph","family":"W\u00f6fl","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Englert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arash A","family":"Moghaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerald","family":"Zimmermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Schmidt-Gayk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"H\u00f6ner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aidan","family":"Hogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Lehnhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Gr\u00fctzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila","family":"Kolios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"1565_CR1","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1016\/j.amjmed.2003.12.029","volume":"1","author":"HA Bischoff-Farrari","year":"2004","unstructured":"Bischoff-Farrari HA, Dietrich T, Orav EJ, Dawson-Hughes B: Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study on younger and older adults. Am J Med. 2004, 1: 634-639.","journal-title":"Am J Med"},{"key":"1565_CR2","doi-asserted-by":"publisher","first-page":"1244","DOI":"10.1210\/jc.2008-1832","volume":"94","author":"NO Kuchuk","year":"2009","unstructured":"Kuchuk NO, Pluijm SM, van Schoor NM, Looman CW, Smit JH, Lips P: Relationships of serum 25-hydroxyvitamin D to bone mineral density and serum parathyroid hormone and markers of bone turnover in older persons. J Clin Endocrinol Metab. 2009, 94: 1244-1250. 10.1210\/jc.2008-1832.","journal-title":"J Clin Endocrinol Metab"},{"key":"1565_CR3","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1111\/j.1365-2796.2006.01685.x","volume":"260","author":"P Lips","year":"2006","unstructured":"Lips P, Hosking D, Lippuner K, Norquist JM, Wehren L, Maalouf G: The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation. J Int Med. 2006, 260: 245-254. 10.1111\/j.1365-2796.2006.01685.x.","journal-title":"J Int Med"},{"key":"1565_CR4","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1210\/edrv.22.4.0437","volume":"22","author":"P Lips","year":"2001","unstructured":"Lips P: Vitamin D, deficiency and secondary hyperparathyroidism in the elderly: consequences for bone loss and fractures and therapeutic implications. Endocr Rev. 2001, 22: 477-501. 10.1210\/edrv.22.4.0437.","journal-title":"Endocr Rev"},{"key":"1565_CR5","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1016\/S8756-3282(02)00692-0","volume":"30","author":"AC Looker","year":"2002","unstructured":"Looker AC, Dawson-Hughes B, Calvo MS, Gunter EW, Sahyoun NR: Serum 25-hydroxyvitamin D status of adolescents and adults in two seasonal subpopulations from NHANES III. Bone. 2002, 30: 771-777. 10.1016\/S8756-3282(02)00692-0.","journal-title":"Bone"},{"key":"1565_CR6","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1093\/ajcn\/75.4.611","volume":"75","author":"HC Janssen","year":"2002","unstructured":"Janssen HC, Samson MM, Verhaar HJ: Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr. 2002, 75: 611-615.","journal-title":"Am J Clin Nutr"},{"key":"1565_CR7","first-page":"1","volume":"176","author":"PN Sambrook","year":"2002","unstructured":"Sambrook PN, Seeman E, Phillips SR, Ebeling PR: Preventing osteoporosis: outcomes of the Australian Fracture Prevention Summit. The Medical Journal of Australia. 2002, 176: 1-16.","journal-title":"The Medical Journal of Australia"},{"key":"1565_CR8","first-page":"1","volume-title":"Clinical guidelines for Prevention and Treatment. Update on Pharmacological Interventions and an Algorithm for Management","author":"Party Writing Group. Osteoporosis","year":"2001","unstructured":"Party Writing Group. Osteoporosis: Clinical guidelines for Prevention and Treatment. Update on Pharmacological Interventions and an Algorithm for Management. 2001, London: Royal College of Physicians, 1-14."},{"key":"1565_CR9","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1359\/jbmr.1997.12.4.598","volume":"12","author":"EG Seo","year":"1997","unstructured":"Seo EG, Norman AW: Three-fold induction of renal 25-hydroxyvitamin D3-24-hydroxylase activity and increased serum 24,25-dihydroxyvitamin D3 levels are correlated with the healing process after chick tibial fracture. J Bone Miner Res. 1997, 12: 598-606. 10.1359\/jbmr.1997.12.4.598.","journal-title":"J Bone Miner Res"},{"key":"1565_CR10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1302\/0301-620X.71B1.2783695","volume":"71","author":"D Alkalay","year":"1989","unstructured":"Alkalay D, Shany S, Dekel S: Serum and bone vitamin D metabolites in elective patients and patients after fracture. J Bone Joint Surg Br. 1989, 71: 85-87.","journal-title":"J Bone Joint Surg Br"},{"key":"1565_CR11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1097\/00003086-198403000-00035","volume":"183","author":"Y Meller","year":"1984","unstructured":"Meller Y, Kestenbaum RS, Shany S, Galinsky D, Zuili I: Parathyroid hormone, calcitonin and vitamin D metabolites during normal fracture healing in humans a preliminary report. Clinical Orthopedics and Related Research. 1984, 183: 238-245.","journal-title":"Clinical Orthopedics and Related Research"},{"key":"1565_CR12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1097\/00003086-198510000-00039","volume":"199","author":"Y Meller","year":"1985","unstructured":"Meller Y, Kestenbaum RS, Shany S, Galinsky D, Zuili I: Parathhormone, calcitonin and vitamin D metabolites during normal fracture healing in geriatric patients. Clinical Orthopedics and Related Research. 1985, 199: 272-274.","journal-title":"Clinical Orthopedics and Related Research"},{"key":"1565_CR13","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1196\/annals.1346.024","volume":"1068","author":"NC Partridge","year":"2006","unstructured":"Partridge NC, Li X, Qin L: Understanding parathyroid hormone action. Annals of the New York Acededmy of Science. 2006, 1068: 187-193. 10.1196\/annals.1346.024.","journal-title":"Annals of the New York Acededmy of Science"},{"issue":"4","key":"1565_CR14","first-page":"635","volume":"3","author":"C Gagnon","year":"2008","unstructured":"Gagnon C, Li V, Eberling PR: Osteoporosis in men: its pathophysiology and the role of teriparatide in its treatment. Clin Interv Aging. 2008, 3 (4): 635-645.","journal-title":"Clin Interv Aging"},{"key":"1565_CR15","doi-asserted-by":"publisher","first-page":"1803","DOI":"10.1172\/JCI113275","volume":"80","author":"GJ Strewler","year":"1987","unstructured":"Strewler GJ, Stern PH, Jacobs JW, Eveloff L, Klein RF, Leung SC: Parathyroid hormonelike protein from human renal carcinoma cells. Structural and functional homology with parathyroid hormone. J Clin Invest. 1987, 80: 1803-1807. 10.1172\/JCI113275.","journal-title":"J Clin Invest"},{"key":"1565_CR16","doi-asserted-by":"publisher","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","volume":"289","author":"SL Teitelbaum","year":"2000","unstructured":"Teitelbaum SL: Bone resorption by osteoclasts. Science. 2000, 289: 1504-1508. 10.1126\/science.289.5484.1504.","journal-title":"Science"},{"key":"1565_CR17","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1359\/jbmr.080318","volume":"23","author":"R Samadfam","year":"2008","unstructured":"Samadfam R, Xia Q, Miao D, Hendy GN, Goltzman D: Exogenous PTH and endogenous 1,25-dihydroxyvitamin D Are complementary in inducing an anabolic effect on bone. J Bone Miner Res. 2008, 23: 1257-1266. 10.1359\/jbmr.080318.","journal-title":"J Bone Miner Res"},{"key":"1565_CR18","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1210\/endo-110-2-506","volume":"110","author":"CS Tam","year":"1982","unstructured":"Tam CS, Heersche JN, Murray TM, Parsons JA: Parathyroid hormone stimulates the bone apposition rate independently of ist resorptive action: differential effects of intermittent and continuous administration. Endocrinology. 1982, 110: 506-512. 10.1210\/endo-110-2-506.","journal-title":"Endocrinology"},{"key":"1565_CR19","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.abb.2008.03.003","volume":"473","author":"D Goltzman","year":"2008","unstructured":"Goltzman D: Studies on the mechanisms of the skeletal anabolic action of endogenous and exogenous parathyroid hormone. Arch Biochem Biophys. 2008, 473: 218-224. 10.1016\/j.abb.2008.03.003.","journal-title":"Arch Biochem Biophys"},{"key":"1565_CR20","first-page":"232","volume":"21","author":"T Sone","year":"1995","unstructured":"Sone T, Fukunaga M, Ono S, Nishiyama T: A small dose of human parathyroid hormone(1-34) increased bone mass in the lumbar vertebrae in patients with senile osteoporosis. Miner Electrolyte Metab. 1995, 21: 232-235.","journal-title":"Miner Electrolyte Metab"},{"key":"1565_CR21","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1210\/er.2004-0006","volume":"26","author":"AB Hodsman","year":"2005","unstructured":"Hodsman AB, Bauer DC, Dempster D, Dian L, Hanley DA, Harris ST: Parathyroid hormone and teriparatide fort he treatment of osteoporosis: a review of the evidence and suggested guidelines for its use. Endocr Rev. 2005, 26: 688-703. 10.1210\/er.2004-0006.","journal-title":"Endocr Rev"},{"key":"1565_CR22","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/j.bone.2010.05.013","volume":"47","author":"M Komrakova","year":"2010","unstructured":"Komrakova M, Stuermer EK, Werner C, Wicke M, Kolios L, Sehmisch S: Effect of human parathyroid hormone hPTH (1-34) applied at different regimes on fracture healing and muscle in ovariectomized and healthy rats. Bone. 2010, 47: 480-492. 10.1016\/j.bone.2010.05.013.","journal-title":"Bone"},{"key":"1565_CR23","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.mce.2011.05.018","volume":"347","author":"R St-Arnaud","year":"2011","unstructured":"St-Arnaud R, Naja RP: Vitamin D metabolism, cartilage and bone fracture repair. Mol Cel Endocr. 2011, 347: 48-54. 10.1016\/j.mce.2011.05.018.","journal-title":"Mol Cel Endocr"},{"key":"1565_CR24","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1359\/jbmr.1998.13.3.325","volume":"13","author":"MR Haussler","year":"1998","unstructured":"Haussler MR, Whitfield GK, Haussler CA, Hsieh JC, Thompson PD, Selznick SH: The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J Bone Miner Res. 1998, 13: 325-349. 10.1359\/jbmr.1998.13.3.325.","journal-title":"J Bone Miner Res"},{"key":"1565_CR25","doi-asserted-by":"publisher","first-page":"5542","DOI":"10.1210\/en.2006-0946","volume":"147","author":"AW Norman","year":"2006","unstructured":"Norman AW: Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology. 2006, 147: 5542-5548. 10.1210\/en.2006-0946.","journal-title":"Endocrinology"},{"key":"1565_CR26","volume-title":"Osteoporos Int","author":"A Arabi","year":"2011","unstructured":"Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G: PTH level but not 25 (OH) vitamin D level predicts bone loss rates in the elderly. Osteoporos Int. 2011, 10.1007\/s00198-011-1659-1. published online 08 June"},{"key":"1565_CR27","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1006\/bbrc.1996.1154","volume":"225","author":"EG Seo","year":"1196","unstructured":"Seo EG, Kato A, Norman AW: Evidence for a 24R, 25(OH)2-vitamin D3 receptor\/binding protein in a membrane fraction isolated from a chick tibial fracture-healing callus. Biochem Biophys Res Commun. 1196, 225: 203-208.","journal-title":"Biochem Biophys Res Commun"},{"key":"1565_CR28","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S8756-3282(98)00085-4","volume":"23","author":"A Kato","year":"1998","unstructured":"Kato A, Seo EG, Einhorn TA, Bishop JE, Norman AW: Studies on 24R, 25-dihydroxyvitamin D3: evidence for a nonnuclear membrane receptor in the chick tibial fracture-healing callus. Bone. 1998, 23: 141-146. 10.1016\/S8756-3282(98)00085-4.","journal-title":"Bone"},{"key":"1565_CR29","doi-asserted-by":"publisher","first-page":"602","DOI":"10.4103\/0256-4947.87097","volume":"31","author":"M Sadat-Ali","year":"2011","unstructured":"Sadat-Ali M, Al Elq AH, Al-Turki HA, AL-Mulhim FA, Al-Ali AK: Influence of vitamin D levels on bone mineral density and osteoporosis. Ann Saudi Med. 2011, 31: 602-608. 10.4103\/0256-4947.87097.","journal-title":"Ann Saudi Med"},{"key":"1565_CR30","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1016\/j.bone.2006.09.026","volume":"40","author":"P GArnero","year":"2007","unstructured":"GArnero P, Munoz F, Sornay-Rendu E, Delmas PD: Associations of vitamin D status with bone mineral density, bone turnover, bone loss and fracture risk in healthy postmenopausal women. The OFELY study. Bone. 2007, 40: 716-722. 10.1016\/j.bone.2006.09.026.","journal-title":"Bone"},{"key":"1565_CR31","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1007\/s00774-007-0791-7","volume":"26","author":"F Hosseinpanah","year":"2008","unstructured":"Hosseinpanah F, Rambod M, Hossein-nejad A, Larijani B, Azizi F: Association between vitamin D and bone mineral density in Iranian postmenopausal women. J Bone Miner Metab. 2008, 26: 86-92. 10.1007\/s00774-007-0791-7.","journal-title":"J Bone Miner Metab"},{"key":"1565_CR32","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1007\/s00198-008-0746-4","volume":"20","author":"N Akhter","year":"2009","unstructured":"Akhter N, Sinnott B, Mahmood K, Rao S, Kukreja S, Barengolts E: Effects of vitamin D insufficiency on bone mineral density in African American men. Osteoporos Int. 2009, 20: 745-750. 10.1007\/s00198-008-0746-4.","journal-title":"Osteoporos Int"},{"key":"1565_CR33","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0378-1119(01)00798-3","volume":"282","author":"JT Swarthout","year":"2002","unstructured":"Swarthout JT, D\u2019Alonzo RC, Selvamuruga N, Partridge NC: Parathyroid hormone-dependent signaling pathways regulating genes in bone cells. Gene. 2002, 282: 1-17. 10.1016\/S0378-1119(01)00798-3.","journal-title":"Gene"},{"key":"1565_CR34","doi-asserted-by":"publisher","first-page":"2732","DOI":"10.1073\/pnas.89.7.2732","volume":"89","author":"AB Abou-Samra","year":"1992","unstructured":"Abou-Samra AB, Juppner H, Force T, Freeman MW, Kong XF, Schipani E: Espression cloning of s common receptor for parathyroid hormone and parathyroid hormone-related peptide from rat osteoblast-like cells; a single receptor stimulates intracellular accumulation of both cAMP and inositol triphosphates and increases intracellular free calcium. Proc Natl Acad Sci USA. 1992, 89: 2732-2736. 10.1073\/pnas.89.7.2732.","journal-title":"Proc Natl Acad Sci USA"},{"key":"1565_CR35","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1152\/physrev.1984.64.3.985","volume":"64","author":"JF Habener","year":"1984","unstructured":"Habener JF, Rosenblatt M, Potts JT: Parathyroid hormone: biochemical aspects of biosynthesis, secretion, action, and metabolism. Physiol Rev. 1984, 64: 985-1053.","journal-title":"Physiol Rev"},{"key":"1565_CR36","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1210\/endo-129-1-421","volume":"129","author":"L Mosekilde","year":"1991","unstructured":"Mosekilde L, Sogaard CH, Danielsen CC, Torring O: The anabolic effects of human parathyroid hormone (hPTH) on rat vertebral body mass are also reflected in the quality of bone, assessed by biomechanical testing: a comparison study between hPTH-(1-34) and hPTH-(1-84). Endocrinology. 1991, 129: 421-428. 10.1210\/endo-129-1-421.","journal-title":"Endocrinology"}],"updated-by":[{"DOI":"10.1186\/1471-2474-15-70","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2014,3,7]],"date-time":"2014-03-07T00:00:00Z","timestamp":1394150400000}}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-14-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-14-6","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,5]],"date-time":"2022-02-05T05:08:48Z","timestamp":1644037728000},"score":1,"resource":{"primary":{"URL":"http:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-14-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,3]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,12]]}},"alternative-id":["1565"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-14-6","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,3]]},"article-number":"6"}}