{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T20:18:40Z","timestamp":1783455520228,"version":"3.55.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2014,3,24]],"date-time":"2014-03-24T00:00:00Z","timestamp":1395619200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/2.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMC Musculoskelet Disord"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1186\/1471-2474-15-99","type":"journal-article","created":{"date-parts":[[2014,3,25]],"date-time":"2014-03-25T04:46:45Z","timestamp":1395722805000},"source":"Crossref","is-referenced-by-count":22,"title":["Relationship between CTX-II and patient characteristics, patient-reported outcome, muscle strength, and rehabilitation in patients with a focal cartilage lesion of the knee: a prospective exploratory cohort study of 48 patients"],"prefix":"10.1186","volume":"15","author":[{"given":"Jan Harald","family":"R\u00f8tterud","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn P","family":"Reinholt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Johanne","family":"Beckstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"May Arna","family":"Risberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asbj\u00f8rn","family":"\u00c5r\u00f8en","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,3,24]]},"reference":[{"key":"2073_CR1","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1177\/0363546503259345","volume":"32","author":"A \u00c5r\u00f8en","year":"2004","unstructured":"\u00c5r\u00f8en A, L\u00f8ken S, Heir S, Alvik E, Ekeland A, Granlund OG, Engebretsen L: Articular cartilage lesions in 993 consecutive knee arthroscopies. Am J Sports Med. 2004, 32: 211-215. 10.1177\/0363546503259345.","journal-title":"Am J Sports Med"},{"key":"2073_CR2","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/0363546509352157","volume":"38","author":"S Heir","year":"2010","unstructured":"Heir S, Nerhus TK, R\u00f8tterud JH, L\u00f8ken S, Ekeland A, Engebretsen L, \u00c5r\u00f8en A: Focal cartilage defects in the knee impair quality of life as much as severe osteoarthritis: a comparison of knee injury and osteoarthritis outcome score in 4 patient categories scheduled for knee surgery. Am J Sports Med. 2010, 38: 231-237. 10.1177\/0363546509352157.","journal-title":"Am J Sports Med"},{"key":"2073_CR3","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3109\/17453674.2010.519166","volume":"81","author":"S L\u00f8ken","year":"2010","unstructured":"L\u00f8ken S, Heir S, Holme I, Engebretsen L, \u00c5r\u00f8en A: 6-year follow-up of 84 patients with cartilage defects in the knee. Knee scores improved but recovery was incomplete. Acta Orthop. 2010, 81: 611-618. 10.3109\/17453674.2010.519166.","journal-title":"Acta Orthop"},{"key":"2073_CR4","doi-asserted-by":"publisher","first-page":"2105","DOI":"10.2106\/JBJS.G.00003","volume":"89","author":"G Knutsen","year":"2007","unstructured":"Knutsen G, Drogset JO, Engebretsen L, Gr\u00f8ntvedt T, Isaksen V, Ludvigsen TC, Roberts S, Solheim E, Strand T, Johansen O: A randomized trial comparing autologous chondrocyte implantation with microfracture. Findings at five years. J Bone Joint Surg Am. 2007, 89: 2105-2112. 10.2106\/JBJS.G.00003.","journal-title":"J Bone Joint Surg Am"},{"key":"2073_CR5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.csm.2008.08.004","volume":"28","author":"HG Potter","year":"2009","unstructured":"Potter HG, Black BR, Chong LR: New techniques in articular cartilage imaging. Clin Sports Med. 2009, 28: 77-94. 10.1016\/j.csm.2008.08.004.","journal-title":"Clin Sports Med"},{"key":"2073_CR6","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/S8756-3282(01)00504-X","volume":"29","author":"S Christgau","year":"2001","unstructured":"Christgau S, Garnero P, Fledelius C, Moniz C, Ensig M, Gineyts E, Rosenquist C, Qvist P: Collagen type II C-telopeptide fragments as an index of cartilage degradation. Bone. 2001, 29: 209-215. 10.1016\/S8756-3282(01)00504-X.","journal-title":"Bone"},{"key":"2073_CR7","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1016\/j.joca.2009.06.001","volume":"17","author":"MF Sowers","year":"2009","unstructured":"Sowers MF, Karvonen-Gutierrez CA, Yosef M, Jannausch M, Jiang Y, Garnero P, Jacobson J: Longitudinal changes of serum COMP and urinary CTX-II predict X-ray defined knee osteoarthritis severity and stiffness in women. Osteoarthritis Cartilage. 2009, 17: 1609-1614. 10.1016\/j.joca.2009.06.001.","journal-title":"Osteoarthritis Cartilage"},{"key":"2073_CR8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.joca.2008.07.009","volume":"17","author":"EB Dam","year":"2009","unstructured":"Dam EB, Byrjalsen I, Karsdal MA, Qvist P, Christiansen C: Increased urinary excretion of C-telopeptides of type II collagen (CTX-II) predicts cartilage loss over 21\u00a0months by MRI. Osteoarthritis Cartilage. 2009, 17: 384-389. 10.1016\/j.joca.2008.07.009.","journal-title":"Osteoarthritis Cartilage"},{"key":"2073_CR9","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1007\/s00296-012-2463-8","volume":"33","author":"J Kumm","year":"2013","unstructured":"Kumm J, Tamm A, Lintrop M, Tamm A: The value of cartilage biomarkers in progressive knee osteoarthritis: cross-sectional and 6-year follow-up study in middle-aged subjects. Rheumatol Int. 2013, 33: 903-911. 10.1007\/s00296-012-2463-8.","journal-title":"Rheumatol Int"},{"key":"2073_CR10","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1186\/1471-2474-14-115","volume":"14","author":"MA Hunt","year":"2013","unstructured":"Hunt MA, Pollock CL, Kraus VB, Saxne T, Peters S, Huebner JL, Sayre EC, Cibere J: Relationships amongst osteoarthritis biomarkers, dynamic knee joint load, and exercise: results from a randomized controlled pilot study. BMC Musculoskelet Disord. 2013, 14: 115-10.1186\/1471-2474-14-115.","journal-title":"BMC Musculoskelet Disord"},{"key":"2073_CR11","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1016\/j.joca.2012.07.014","volume":"20","author":"TL Chmielewski","year":"2012","unstructured":"Chmielewski TL, Trumble TN, Joseph AM, Shuster J, Indelicato PA, Moser MW, Cicuttini FM, Leeuwenburgh C: Urinary CTX-II concentrations are elevated and associated with knee pain and function in subjects with ACL reconstruction. Osteoarthritis Cartilage. 2012, 20: 1294-1301. 10.1016\/j.joca.2012.07.014.","journal-title":"Osteoarthritis Cartilage"},{"key":"2073_CR12","doi-asserted-by":"publisher","first-page":"310","DOI":"10.2519\/jospt.2013.4354","volume":"43","author":"B Wondrasch","year":"2013","unstructured":"Wondrasch B, \u00c5r\u00f8en A, R\u00f8tterud JH, H\u00f8ysveen T, B\u00f8lstad K, Risberg MA: The feasibility of a 3-month active rehabilitation program for patients with knee full-thickness articular cartilage lesions: the oslo cartilage active rehabilitation and education study. J Orthop Sports Phys Ther. 2013, 43: 310-324. 10.2519\/jospt.2013.4354.","journal-title":"J Orthop Sports Phys Ther"},{"key":"2073_CR13","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.2106\/00004623-200406000-00004","volume":"86-A","author":"MS Kocher","year":"2004","unstructured":"Kocher MS, Steadman JR, Briggs KK, Sterett WI, Hawkins RJ: Reliability, validity, and responsiveness of the Lysholm knee scale for various chondral disorders of the knee. J Bone Joint Surg Am. 2004, 86-A: 1139-1145.","journal-title":"J Bone Joint Surg Am"},{"key":"2073_CR14","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.1007\/s00330-004-2312-6","volume":"14","author":"M Kothari","year":"2004","unstructured":"Kothari M, Guermazi A, von Ingersleben G, Miaux Y, Sieffert M, Block JE, Stevens R, Peterfy CG: Fixed-flexion radiography of the knee provides reproducible joint space width measurements in osteoarthritis. Eur Radiol. 2004, 14: 1568-1573.","journal-title":"Eur Radiol"},{"key":"2073_CR15","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1136\/ard.16.4.494","volume":"16","author":"JH Kellgren","year":"1957","unstructured":"Kellgren JH, Lawrence JS: Radiological assessment of osteo-arthrosis. Ann Rheum Dis. 1957, 16: 494-502. 10.1136\/ard.16.4.494.","journal-title":"Ann Rheum Dis"},{"key":"2073_CR16","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1186\/1477-7525-1-64","volume":"1","author":"EM Roos","year":"2003","unstructured":"Roos EM, Lohmander LS: The Knee injury and Osteoarthritis Outcome Score (KOOS): from joint injury to osteoarthritis. Health Qual Life Outcomes. 2003, 1: 64-10.1186\/1477-7525-1-64.","journal-title":"Health Qual Life Outcomes"},{"key":"2073_CR17","doi-asserted-by":"publisher","first-page":"1434","DOI":"10.1016\/j.joca.2009.04.019","volume":"17","author":"JE Bekkers","year":"2009","unstructured":"Bekkers JE, de Windt TS, Raijmakers NJ, Dhert WJ, Saris DB: Validation of the Knee Injury and Osteoarthritis Outcome Score (KOOS) for the treatment of focal cartilage lesions. Osteoarthritis Cartilage. 2009, 17: 1434-1439. 10.1016\/j.joca.2009.04.019.","journal-title":"Osteoarthritis Cartilage"},{"key":"2073_CR18","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1177\/0363546512457646","volume":"40","author":"L Engelhart","year":"2012","unstructured":"Engelhart L, Nelson L, Lewis S, Mordin M, Demuro-Mercon C, Uddin S, McLeod L, Cole B, Farr J: Validation of the knee injury and osteoarthritis outcome score subscales for patients with articular cartilage lesions of the knee. Am J Sports Med. 2012, 40: 2264-2272. 10.1177\/0363546512457646.","journal-title":"Am J Sports Med"},{"key":"2073_CR19","doi-asserted-by":"publisher","first-page":"88","DOI":"10.2519\/jospt.1998.28.2.88","volume":"28","author":"EM Roos","year":"1998","unstructured":"Roos EM, Roos HP, Lohmander LS, Ekdahl C, Beynnon BD: Knee Injury and Osteoarthritis Outcome Score (KOOS)\u2013development of a self-administered outcome measure. J Orthop Sports Phys Ther. 1998, 28: 88-96. 10.2519\/jospt.1998.28.2.88.","journal-title":"J Orthop Sports Phys Ther"},{"key":"2073_CR20","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.joca.2004.11.007","volume":"13","author":"C Ding","year":"2005","unstructured":"Ding C, Garnero P, Cicuttini F, Scott F, Cooley H, Jones G: Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown. Osteoarthritis Cartilage. 2005, 13: 198-205. 10.1016\/j.joca.2004.11.007.","journal-title":"Osteoarthritis Cartilage"},{"key":"2073_CR21","doi-asserted-by":"publisher","first-page":"1372","DOI":"10.1002\/art.24473","volume":"60","author":"J Cibere","year":"2009","unstructured":"Cibere J, Zhang H, Garnero P, Poole AR, Lobanok T, Saxne T, Kraus VB, Way A, Thorne A, Wong H, Singer J, Kopec J, Guermazi A, Peterfy C, Nicolaou S, Munk PL, Esdaile JM: Association of biomarkers with pre-radiographically defined and radiographically defined knee osteoarthritis in a population-based study. Arthritis Rheum. 2009, 60: 1372-1380. 10.1002\/art.24473.","journal-title":"Arthritis Rheum"},{"key":"2073_CR22","doi-asserted-by":"publisher","first-page":"619","DOI":"10.1136\/ard.60.6.619","volume":"60","author":"P Garnero","year":"2001","unstructured":"Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E: Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis. 2001, 60: 619-626. 10.1136\/ard.60.6.619.","journal-title":"Ann Rheum Dis"},{"key":"2073_CR23","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1136\/ard.62.4.332","volume":"62","author":"U Mouritzen","year":"2003","unstructured":"Mouritzen U, Christgau S, Lehmann HJ, Tanko LB, Christiansen C: Cartilage turnover assessed with a newly developed assay measuring collagen type II degradation products: influence of age, sex, menopause, hormone replacement therapy, and body mass index. Ann Rheum Dis. 2003, 62: 332-336. 10.1136\/ard.62.4.332.","journal-title":"Ann Rheum Dis"},{"key":"2073_CR24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1159\/000074419","volume":"71","author":"M Jung","year":"2004","unstructured":"Jung M, Christgau S, Lukoschek M, Henriksen D, Richter W: Increased urinary concentration of collagen type II C-telopeptide fragments in patients with osteoarthritis. Pathobiology. 2004, 71: 70-76. 10.1159\/000074419.","journal-title":"Pathobiology"},{"key":"2073_CR25","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1177\/1947603510373917","volume":"1","author":"CN Engen","year":"2010","unstructured":"Engen CN, Engebretsen L, \u00c5r\u00f8en A: Knee cartilage defect patients enrolled in randomized controlled trials are not representative of patients in orthopedic practice. Cartilage. 2010, 1: 312-319. 10.1177\/1947603510373917.","journal-title":"Cartilage"}],"container-title":["BMC Musculoskeletal Disorders"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1186\/1471-2474-15-99\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-15-99.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-15-99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1186\/1471-2474-15-99.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T17:52:40Z","timestamp":1548179560000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmcmusculoskeletdisord.biomedcentral.com\/articles\/10.1186\/1471-2474-15-99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3,24]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["2073"],"URL":"https:\/\/doi.org\/10.1186\/1471-2474-15-99","relation":{},"ISSN":["1471-2474"],"issn-type":[{"value":"1471-2474","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3,24]]},"article-number":"99"}}